Joeri W van Straalen, Gabriella Giancane, Yasmine Amazrhar, Nikolay Tzaribachev, Calin Lazar, Yosef Uziel, Albena Telcharova-Mihaylovska, Claudio A Len, Angela Miniaci, Alina L Boteanu, Giovanni Filocamo, Mariel V Mastri, Thaschawee Arkachaisri, Maria G Magnolia, Esther Hoppenreijs, Sytze de Roock, Nico M Wulffraat, Nicolino Ruperto, Joost F Swart
OBJECTIVE: To build a prediction model for uveitis in children with JIA for use in current clinical practice. METHODS: Data from the international observational Pharmachild registry were used. Adjusted risk factors as well as predictors for JIA-associated uveitis (JIA-U) were determined using multivariable logistic regression models. The prediction model was selected based on the Akaike information criterion. Bootstrap resampling was used to adjust the final prediction model for optimism...
December 4, 2020: Rheumatology
Charlie Bridegwood, Kassem Sharif, Jane Freeston, Benazir Saleem, Tobias Russell, Abdulla Watad, Almas Khan, Peter Loughenbury, Abhay Rao, Miriam Wittmann, Dennis McGonagle
OBJECTIVES: Dupilumab blocks the IL-4 receptor (IL-4R) and thus signalling of the 'Th2' cytokines IL-4 and IL-13. It has a license to treat atopic eczema and was recently linked to emergent enthesitis and psoriasis. We investigated the cellular and functional basis for how IL-4/IL-13 regulates the IL-23-IL-17 axis in entheseal stromal, myeloid and lymphocyte cells. METHODS: Immunohistochemistry was performed on healthy enthesis samples from patients undergoing elective spinal surgery to investigate entheseal tissue IL-4R expression and cytokine expression by intracellular flow cytometry for IL-4 and IL-13...
November 30, 2020: Rheumatology
Gabriella Giancane, Chiara Campone, Maria Francesca Gicchino, Alessandra Alongi, Cecilia Bava, Silvia Rosina, Yaryna Boyko, Neil Martin, Yasser El Miedany, Miroslav Harjacek, Soad Hashad, Maka Ioseliani, Ruben Burgos-Vargas, Rik Joos, Christiaan Scott, Manel Mejbri, Zoilo Morel Ayala, Maria Ekelund, Safiya Al-Abrawi, Maya-Feriel Aiche, Ximena Norambuena, Jose Antonio Melo-Gomes, Nicolino Ruperto, Alessandro Consolaro, Angelo Ravelli
OBJECTIVE: To assess concordance among criteria for inactive disease (ID) and low disease activity (LDA) in juvenile idiopathic arthritis (JIA), and to seek for factors driving discordance. METHODS: The frequency of fulfillment of existing criteria was evaluated in 10,186 patients extracted from three cross-sectional datasets. Patients were divided in the "functional phenotypes" of oligoarthritis and polyarthritis. Concordance between criteria was examined through weighted Venn diagrams...
August 16, 2020: Arthritis Care & Research
Kai Liang Teh, Manasita Tanya, Lena Das, Sook Fun Hoh, Xiaocong Gao, Thaschawee Arkachaisri
OBJECTIVE: To assess short- and long-term outcomes and predictors of juvenile idiopathic arthritis (JIA) children treated with contemporary therapy and compare those with reports elsewhere. METHODS: Children with JIA were recruited from our web-based REgistry for Childhood Onset Rheumatic Diseases (RECORD) from 1997 to 2015. Disease status was defined using modified Wallace criteria. Nonparametric statistics described the data. Kaplan-Meier survival and logistic regression analyses were used to estimate probabilities and to determine predictors of outcomes...
November 24, 2020: Clinical Rheumatology
Kaba Condé, Hugues Ghislain Atakla, Mamadou Ciré Barry, Mohamed Lamine Condé, Malé Doré
X-linked agammaglobulinemia (XLA) is a rare genetic disease caused by a mutation in the Bruton tyrosine kinase (BTK) gene. It is characterized by a profound deficiency of B cells and a decrease in all classes of immunoglobulins (Ig). We report one case in a 3-year-old boy seen for recurrent acute otitis media, perineal abscess, oligoarthritis. The serum immunoglobulin (Ig) assay showed an IgG level of 0.6g/l. IgM and IgA are indosable. Marrow immunophenotyping showed an absence of precursor B less than 1%. Molecular biology confirmed Burton's disease (stop mutation, C37C) in exon 2 of the BTK gene...
2020: Pan African Medical Journal
Yufan Yan, Karen L Rychlik, Marc B Rosenman, Michael L Miller
BACKGROUND: Children with JIA may experience difficulty with health related quality of life (HRQOL). The Patient Reported Outcomes Measurement Information System (PROMIS) a patient related outcome (PRO) measure, covers HRQOL domains that include physical function, mental health, and social interactions. During initial use, we found PROMIS identified children with symptoms of depression, sometimes before they shared those feelings with parents or members of the clinic team. We studied the use of PROMIS for this purpose, and to determine what demographic, clinical, and other characteristics might be related to higher depressive symptom scores...
November 23, 2020: Pediatric Rheumatology Online Journal
Junpei Tsuchiya, Naoki Kondo, Atsushi Fujimoto, Rie Kondo, Masahiko Yamada, Tatsuya Kuraishi, Takuya Yoda, Riichiro Abe, Naoto Endo
We report a case of psoriatic arthritis where oligoarthritis preceded the skin lesions. A 57-year-old man complained of left third-finger pain. Laboratory examinations were negative for anti-cyclic citrullinated peptide antibodies and rheumatoid factor; he was treated for suspected rheumatoid arthritis. Six years later, X-ray revealed enthesitis of his fingers and wrist joint. At 9.5 years after the initial visit, skin lesions appeared in the left auricular region and buttock and dermatopathology findings indicated psoriasis vulgaris...
October 2020: Acta Medica Okayama
F R Kasiem, J J Luime, M Vis, M R Kok, K Wervers, A H Gerards, Cwy Appels, W L van der Graaff, Mjf Starmans-Kool, Ypm Goekoop-Ruiterman, Jhlm van Groenendael, L-A Korswagen, J J Veris-van Dieren, Jmw Hazes, I Tchetverikov
Objective: This paper describes the baseline demographics, clinical characteristics, and patient-reported outcomes (PROs) according to clinical phenotype of patients with early psoriatic arthritis (PsA) for the purpose of creating a decision support system for daily clinical practice. Method: Patients with newly diagnosed PsA were included in the Dutch south west Early Psoriatic ARthritis (DEPAR) study. No classification criteria were applied, to ensure collection of real-world data on demographics, medication, clinical characteristics, and PROs...
October 21, 2020: Scandinavian Journal of Rheumatology
I Kötter
Behçet's syndrome (BS) in our latitude is a rare vasculitis of various vessels. It mainly consists of oral and genital aphthous ulcers, skin lesions, oligoarthritis and ocular manifestations, mostly a posterior uveitis with occlusive retinal vasculitis. This review article summarizes the diagnostic and classification criteria as well as possible differential diagnoses and current treatment recommendations.
October 14, 2020: Zeitschrift Für Rheumatologie
Hermine I Brunner, Robert Wong, Marleen Nys, Tzuyung D Kou, Alyssa Dominique, Alberto Martini, Daniel J Lovell, Nicolino Ruperto
Juvenile idiopathic arthritis (JIA) encompasses several forms of chronic inflammatory arthritis of unknown etiology presenting in children < 16 years of age, with a minimum symptom duration of 6 weeks. Approximately half of affected children have polyarticular-course JIA (pJIA), a functional concept related to several clinically and genetically heterogeneous JIA categories (systemic, extended oligoarthritis, polyarticular rheumatoid factor-positive or rheumatoid factor-negative, enthesitis-related arthritis, and psoriatic arthritis), which has as its defining feature the involvement of five or more joints during the disease course...
October 8, 2020: Paediatric Drugs
Paula Frid, Thomas A Augdal, Tore A Larheim, Josefine Halbig, Veronika Rypdal, Nils Thomas Songstad, Annika Rosén, Karin B Tylleskär, Johanna Rykke Berstad, Berit Flatø, Peter Stoustrup, Karen Rosendahl, Eva Kirkhus, Ellen Nordal
BACKGROUND: Intraarticular corticosteroids (IACs) have been used to treat temporomandibular joint (TMJ) arthritis. However, prospective clinical studies with magnetic resonance imaging (MRI) scoring are lacking. The aim of this study was to examine efficacy and safety of a single IAC in the TMJ in adolescents with juvenile idiopathic arthritis (JIA) in a clinical setting. METHODS: In this Norwegian prospective multicenter pilot study 15 patients with JIA (mostly persistent oligoarthritis or RF negative polyarthritis categories) and a clinically and MRI-verified diagnosis of TMJ arthritis were treated with IACs and followed for 2 years...
October 1, 2020: Pediatric Rheumatology Online Journal
Semanur Ozdel, Esra Baglan, Evrim Kargın Cakıcı, Fatma Yazılıtas, Hüsniye Yücel, Saliha Senel, Mehmet Bulbul
BACKGROUND: Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatologic disease of childhood. The various subtypes of JIA differ in clinical features and treatments. The aim of this study was to analyze the frequency of JIA subtypes, patient demographic and clinical features, as well as the rates of macrophage activation syndrome, uveitis, and remission in Turkish JIA patients treated at a single center, and to compare the findings to those in the literature. MATERIALS AND METHODS: The files of all JIA patients treated at our pediatric rheumatology department between January 2017 and January 2019 were retrospectively reviewed...
September 24, 2020: Pediatrics International: Official Journal of the Japan Pediatric Society
Georgios Pilianidis, Ariti Tsinari, Dimitrios Pandis, Hara Tsolakidou, Nikolaos Petridis
BACKGROUND: We report a case of a 30-year-old patient who presented with acute Mycoplasma pneumoniae infection that was complicated by reactive arthritis and asymmetric proximal myopathy and progressed to chronic spondyloarthropathy. Reactive arthritis and sacroiliitis are unusual extrapulmonary manifestations of M. pneumoniae infection, which is a common condition. CASE PRESENTATION: A 30-year-old Greek previously healthy man presented to our emergency department with fever, progressively worsening bilateral lower limb weakness, and asymmetric oligoarthritis...
September 17, 2020: Journal of Medical Case Reports
Rodrigo Cánovas, Joanna Cobb, Marta Brozynska, John Bowes, Yun R Li, Samantha Louise Smith, Hakon Hakonarson, Wendy Thomson, Justine A Ellis, Gad Abraham, Jane E Munro, Michael Inouye
OBJECTIVES: Juvenile idiopathic arthritis (JIA) is an autoimmune disease and a common cause of chronic disability in children. Diagnosis of JIA is based purely on clinical symptoms, which can be variable, leading to diagnosis and treatment delays. Despite JIA having substantial heritability, the construction of genomic risk scores (GRSs) to aid or expedite diagnosis has not been assessed. Here, we generate GRSs for JIA and its subtypes and evaluate their performance. METHODS: We examined three case/control cohorts (UK, US-based and Australia) with genome-wide single nucleotide polymorphism (SNP) genotypes...
September 4, 2020: Annals of the Rheumatic Diseases
John B Miller, John N Aucott
BACKGROUND/HISTORICAL PERSPECTIVE: Lyme arthritis was described in 1977, after an apparent outbreak of juvenile idiopathic arthritis in Lyme, Connecticut. The evolution of the disease has been meticulously described with presentation dependent on disease duration and previous therapy. SUMMARY INTEGRATING PUBLISHED LITERATURE: Erythema migrans is typically the first manifestation. Untreated patients often develop early disseminated disease, characterized by migratory polyarthralgia, potentially with cardiac and/or neurologic sequelae...
August 17, 2020: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
Pinar Ozge Avar-Aydin, Serdar Nepesov, Kenan Barut, Sezgin Sahin, Amra Adrovic, Haluk Cezmi Cokugras, Ozgur Kasapcopur
Objectives: To determine the frequency of Th2-mediated allergic diseases (AD) in mainly Th1-driven juvenile idiopathic arthritis (JIA) subtypes. Methods: Ninty-nine JIA patients and 128 control subjects were enrolled in a prospective case-control study. All subjects were assessed with standard allergy questionnaire, complete blood cell count, and total serum immunoglobulin (sIg) E. sIgs G, A, M, Juvenile Arthritis Disease Activity Score-27 (JADAS27), and serum acute phase reactants (sAPR) were obtained in JIA...
August 20, 2020: Modern Rheumatology
Tobias Schmidt, Elisabet Berthold, Sabine Arve-Butler, Birgitta Gullstrand, Anki Mossberg, Fredrik Kahn, Anders A Bengtsson, Bengt Månsson, Robin Kahn
BACKGROUND: Juvenile idiopathic arthritis (JIA) is an umbrella term of inflammatory joint diseases in children. Oligoarthritis is the most common form in the Western world, representing roughly 60% of all patients. Monocytes and macrophages play an important role in adult arthritides, but their role in oligoarticular JIA is less studied. Polarization highly influences monocytes' and macrophages' effector functions, broadly separated into pro-inflammatory M1 or anti-inflammatory M2 phenotypes...
August 12, 2020: Arthritis Research & Therapy
Farhad Salehzadeh, Mehrdad Mirzarahimi
BACKGROUND: Recurrent and relapsing arthritis has been proposed to describe a group of arthritis with recurring and periodic nature, in which the joints are intermittently involved. This study reports three non-FMF patients with heterozygous MEFV gene mutations and an extraordinary arthritis as a recurrent synovitis of hip (RSH). METHODS: During 16-years from 2003 to 2019 at pediatric rheumatologic clinic among 195 recorded files with chronic oligoarthritis, 3 patients with diagnosis of recurrent synovitis of hip (RSH) were reviewed thoroughly...
August 10, 2020: Pediatric Rheumatology Online Journal
L von Schuckmann, J Klotsche, A Suling, B Kahl-Nieke, I Foeldvari
OBJECTIVE: To study the proportion of patients with temporomandibular joint (TMJ) involvement among patients with juvenile idiopathic arthritis (JIA), as well as associated clinical characteristics and signs/symptoms. METHOD: We performed a retrospective chart review on consecutive patients followed in the Hamburg Centre for Paediatric and Adolescent Rheumatology Eilbek between January 2010 and July 2012. TMJ involvement was diagnosed based on clinical examination; a subgroup of patients was also assessed by magnetic resonance imaging (MRI)...
July 2020: Scandinavian Journal of Rheumatology
Hannah den Braanker, Kim Wervers, Adriana M C Mus, Priyanka S Bangoer, Nadine Davelaar, Jolanda Luime, Ilja Tchetverikov, J M W Hazes, Marijn Vis, Erik Lubberts, Marc R Kok
OBJECTIVES: Methotrexate (MTX) is currently the recommended first-line therapy for treating psoriatic arthritis (PsA), despite lacking clear evidence. No estimates of efficacy of MTX in usual care and no clear MTX responsive clinical or laboratory variables are currently available. This study describes the response to MTX monotherapy in newly diagnosed patients with PsA in usual care. Second, we compared clinical variables and cytokine profiles in patients responding and not responding to MTX monotherapy...
July 2020: RMD Open
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