Ana Marques, Bruno Pereira, Marion Simonetta-Moreau, Giovanni Castelnovo, Marie De Verdal, Frédérique Fluchère, Chloé Laurencin, Bertrand Degos, Mélissa Tir, Alexandre Kreisler, Geneviève Blanchet-Fourcade, Dominique Guehl, Olivier Colin, Aurelia Poujois, Sophie Sangla, Laurent Tatu, Philippe Derost, Dominique Gayraud, Christine Tranchant, David Amarantini, David Devos, Olivier Rascol, Jean-Christophe Corvol, Franck Durif, Isabelle Rieu
BACKGROUND: Local injections of botulinum toxin type A have been used to treat essential head tremor but have not been extensively studied in randomized trials. METHODS: In a multicenter, double-blind, randomized trial, we assigned, in a 1:1 ratio, adult patients with essential or isolated head tremor to receive botulinum toxin type A or placebo. Botulinum toxin or placebo was injected under electromyographic guidance into each splenius capitis muscle on the day of randomization (day 0) and during week 12...
November 9, 2023: New England Journal of Medicine