Nancy Yi Yang, Anthony Y Y Hsieh, Zhuo Chen, Amber R Campbell, Izabella Gadawska, Fatima Kakkar, Laura Sauve, Ari Bitnun, Jason Brophy, Melanie C M Murray, Neora Pick, Mel Krajden, Hélène C F Côté, Cihr Team On Cellular Aging And Hiv Comorbidities In Women And Children Carma
BACKGROUND: Chronic/latent viral infections may accelerate immunological aging, particularly among people living with HIV (PLWH). We characterized chronic/latent virus infections across their lifespan and investigated their associations with leukocyte telomere length (LTL). METHODS: Participants enrolled in the CARMA cohort study were randomly selected to include n = 15 for each decade of age between 0 and >60 y, for each sex, and each HIV status. Cytomegalovirus (CMV), Epstein-Barr virus (EBV), human herpesvirus 8 (HHV-8), herpes simplex virus 1 (HSV-1), and HSV-2 infection were determined serologically; HIV, hepatitis C (HCV), and hepatitis B (HBV) were self-reported...
May 10, 2024: Viruses