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JOURNAL ARTICLE
Gifty Marley, Rayner Kay Jin Tan, Dan Wu, Tong Wang, Murong Sun, Qilei Sheng, Margaret Elizabeth Holly, Takhona Grace Hlatshwako, Cheng Wang, Weiming Tang, Rohit Ramaswamy, Ligang Yang, Danyang Luo, Sean S Sylvia, Kurt Gray, David Van Duin, Heping Zheng, Joseph D Tucker
BACKGROUND: Gonorrhea and chlamydia are the most common sexually transmitted diseases (STDs) among men who have sex with men (MSM) in China. Previous studies have shown pay-it-forward (PIF) interventions to be associated with a substantial increase in gonorrhea and chlamydia test uptake compared to standard-of-care. We propose a 'pay-it-forward' gonorrhea and chlamydia testing randomized controlled trial (PIONEER). The trial would evaluate the effectiveness of two pay-it-forward strategies in promoting testing uptake compared to the standard of care (in which men pay for their tests out-of-pocket) among MSM and male STD patients in China...
June 20, 2023: BMC Public Health
#42
JOURNAL ARTICLE
Olga M Dona Lemus, Sean Tanny, Michael Cummings, Matthew Webster, Joshua Wancura, Hyunuk Jung, Yuwei Zhou, Jihyung Yoon, Matthew Pacella, Dandan Zheng
PURPOSE: CBCT-guided online adaptive radiotherapy (oART) plans presently utilize daily synthetic CTs (sCT) that are automatically generated using deformable registration algorithms. These algorithms may have poor performance at reproducing variable volumes of gas present during treatment. Therefore, we have analyzed the air mapping error between the daily CBCTs and the corresponding sCT and explored its dosimetric effect on oART plan calculation. METHODS: Abdominopelvic air volume was contoured on both the daily CBCT images and the corresponding synthetic images for 207 online adaptive pelvic treatments...
June 5, 2023: Journal of Applied Clinical Medical Physics
#43
JOURNAL ARTICLE
Yuqiang Zeng, Buyi Zhang, Yanbao Fu, Fengyu Shen, Qiye Zheng, Divya Chalise, Ruijiao Miao, Sumanjeet Kaur, Sean D Lubner, Michael C Tucker, Vincent Battaglia, Chris Dames, Ravi S Prasher
The mass adoption of electric vehicles is hindered by the inadequate extreme fast charging (XFC) performance (i.e., less than 15 min charging time to reach 80% state of charge) of commercial high-specific-energy (i.e., >200 Wh/kg) lithium-ion batteries (LIBs). Here, to enable the XFC of commercial LIBs, we propose the regulation of the battery's self-generated heat via active thermal switching. We demonstrate that retaining the heat during XFC with the switch OFF boosts the cell's kinetics while dissipating the heat after XFC with the switch ON reduces detrimental reactions in the battery...
June 3, 2023: Nature Communications
#44
REVIEW
Chunxiao Qi, Richard Sean Bujaroski, Jonathan Baell, Xiangjian Zheng
Cerebral cavernous malformations (CCMs) are low-flow, hemorrhagic vascular lesions of the central nervous system of genetic origin, which can cause stroke-like symptoms and seizures. From the identification of CCM1, CCM2 and CCM3 as genes related to disease progression, molecular and cellular mechanisms for CCM pathogenesis have been established and the search for potential drugs to target CCM has begun. Broadly speaking, kinases are the major group signaling in CCM pathogenesis. These include the MEKK3/MEK5/ERK5 cascade, Rho/Rock signaling, CCM3/GCKIII signaling, PI3K/mTOR signaling, and others...
May 18, 2023: Biochimica et Biophysica Acta. Molecular Cell Research
#45
JOURNAL ARTICLE
Chen-Wei Zheng, Yi-Hao Luo, Xiangxing Long, Haiwei Gu, Jie Cheng, Lei Zhang, Yen Jung Sean Lai, Bruce E Rittmann
While most household surfactants are biodegradable in aerobic conditions, their biodegradability may obscure their environmental risks. The presence of surfactants in a biological treatment process can lead to the proliferation of antimicrobial-resistance genes (ARG) in the biomass. Surfactants can be cationic, anionic, or zwitterionic, and these different classes may have different effects on the proliferation ARG. Cationic hexadecyltrimethyl-ammonium (CTAB), anionic sodium dodecyl sulfate (SDS), and zwitterionic 3-(decyldimethylammonio)-propanesulfonate inner salt (DAPS) were used to represent the three classes of surfactants in domestic household clean-up products...
April 5, 2023: Water Research
#46
JOURNAL ARTICLE
Haifeng Zheng, Lauren Peri, Grace K Ward, Kenton M Sanders, Sean M Ward
The cell types and conductance that contribute to normal cardiac functions remain under investigation. We used mice that express an enhanced green fluorescent protein (eGFP)-histone 2B fusion protein driven off the cell-specific endogenous promoter for Pdgfra to investigate the distribution and functional role of PDGFRα+ cells in the heart. Cardiac PDGFRα+ cells were widely distributed within the endomysium of atria, ventricle, and sino-atrial node (SAN) tissues. PDGFRα+ cells formed a discrete network of cells, lying in close apposition to neighboring cardiac myocytes in mouse and Cynomolgus monkey (Macaca fascicularis) hearts...
May 2023: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
#47
Qi Ye, Juyeon Jo, Chih-Yen Wang, Heavin Oh, Tiffany J Choy, Kyoungin Kim, Angelo Dâ Alessandro, Yana K Reshetnyak, Sung Yun Jung, Zheng Chen, Sean P Marrelli, Hyun Kyoung Lee
Astrocytes play vital roles in blood-brain barrier (BBB) maintenance, yet how they support BBB integrity under normal or pathological conditions remains poorly defined. Recent evidence suggests pH homeostasis is a new cellular mechanism important for BBB integrity. In the current study, we investigated the function of an astrocyte-specific pH regulator, Slc4a4, in BBB maintenance and repair. We show that astrocytic Slc4a4 is required for normal astrocyte morphological complexity and BBB function. Multi-omics analyses identified increased astrocytic secretion of CCL2 coupled with dysregulated arginine-NO metabolism after Slc4a4 deletion...
April 3, 2023: bioRxiv
#48
JOURNAL ARTICLE
Shin Mei Chan, Gabe Weininger, Meagan Kozhimala, Brandon J Sumpio, Louis J Levine, Sean Harris, Sijin Zheng, Cassius Iyad Ochoa Chaar, Raul J Guzman, Bauer E Sumpio
OBJECTIVE: Median arcuate ligament syndrome (MALS) is a clinical syndrome caused by compression of the celiac artery by the median arcuate ligament (MAL) that often manifests with non-specific abdominal pain. Identification of this syndrome is often dependent on imaging of compression and upward bending of the celiac artery by lateral CTA, the so-called "hook sign." The purpose of this study was to assess the relationship of radiologic characteristicss of the celiac artery to clinically relevant MALS...
April 4, 2023: Annals of Vascular Surgery
#49
RANDOMIZED CONTROLLED TRIAL
Chad Tang, Alexander D Sherry, Cara Haymaker, Tharakeswara Bathala, Suyu Liu, Bryan Fellman, Lorenzo Cohen, Ana Aparicio, Amado J Zurita, Alexandre Reuben, Enrica Marmonti, Stephen G Chun, Jay P Reddy, Amol Ghia, Sean McGuire, Eleni Efstathiou, Jennifer Wang, Jianbo Wang, Patrick Pilie, Craig Kovitz, Weiliang Du, Samantha J Simiele, Rachit Kumar, Yerko Borghero, Zheng Shi, Brian Chapin, Daniel Gomez, Ignacio Wistuba, Paul G Corn
IMPORTANCE: Despite evidence demonstrating an overall survival benefit with up-front hormone therapy in addition to established synergy between hormone therapy and radiation, the addition of metastasis-directed therapy (MDT) to hormone therapy for oligometastatic prostate cancer, to date, has not been evaluated in a randomized clinical trial. OBJECTIVE: To determine in men with oligometastatic prostate cancer whether the addition of MDT to intermittent hormone therapy improves oncologic outcomes and preserves time with eugonadal testosterone compared with intermittent hormone therapy alone...
June 1, 2023: JAMA Oncology
#50
JOURNAL ARTICLE
Wu-Bing Xu, Wen-Yong Guo, Josep M Serra-Diaz, Franziska Schrodt, Wolf L Eiserhardt, Brian J Enquist, Brian S Maitner, Cory Merow, Cyrille Violle, Madhur Anand, Michaël Belluau, Hans Henrik Bruun, Chaeho Byun, Jane A Catford, Bruno E L Cerabolini, Eduardo Chacón-Madrigal, Daniela Ciccarelli, J Hans C Cornelissen, Anh Tuan Dang-Le, Angel de Frutos, Arildo S Dias, Aelton B Giroldo, Alvaro G Gutiérrez, Wesley Hattingh, Tianhua He, Peter Hietz, Nate Hough-Snee, Steven Jansen, Jens Kattge, Benjamin Komac, Nathan J B Kraft, Koen Kramer, Sandra Lavorel, Christopher H Lusk, Adam R Martin, Ke-Ping Ma, Maurizio Mencuccini, Sean T Michaletz, Vanessa Minden, Akira S Mori, Ülo Niinemets, Yusuke Onoda, Renske E Onstein, Josep Peñuelas, Valério D Pillar, Jan Pisek, Matthew J Pound, Bjorn J M Robroek, Brandon Schamp, Martijn Slot, Miao Sun, Ênio E Sosinski, Nadejda A Soudzilovskaia, Nelson Thiffault, Peter M van Bodegom, Fons van der Plas, Jingming Zheng, Jens-Christian Svenning, Alejandro Ordonez
As Earth's climate has varied strongly through geological time, studying the impacts of past climate change on biodiversity helps to understand the risks from future climate change. However, it remains unclear how paleoclimate shapes spatial variation in biodiversity. Here, we assessed the influence of Quaternary climate change on spatial dissimilarity in taxonomic, phylogenetic, and functional composition among neighboring 200-kilometer cells (beta-diversity) for angiosperm trees worldwide. We found that larger glacial-interglacial temperature change was strongly associated with lower spatial turnover (species replacements) and higher nestedness (richness changes) components of beta-diversity across all three biodiversity facets...
April 5, 2023: Science Advances
#51
JOURNAL ARTICLE
Samantha T Hung, Sean A Roget, Weizhong Zheng, Michael D Fayer
The dynamics of aqueous magnesium chloride solutions, from relatively dilute (0.5 m) to near saturated (4.2 m) concentrations, were investigated using ultrafast two dimensional infrared and polarization selective pump-probe spectroscopies. The experiments were performed on two spectrally distinct nitrile stretch frequencies of the selenocyanate vibrational probe, corresponding to the CN nitrogen lone pair being associated with water and with Mg2+ . No chemical exchange of the two species was observed over the experimental time scale (∼100 ps), enabling straightforward analysis of their dynamics...
March 30, 2023: Journal of Physical Chemistry. B
#52
JOURNAL ARTICLE
Kai Sen Tan, Sean Wei Xiang Ong, Ming Hui Koh, Douglas Jie Wen Tay, Daryl Zheng Hao Aw, Yi Wei Nah, Mohammed Ridzwan Bin Abdullah, Kristen K Coleman, Donald K Milton, Justin Jang Hann Chu, Vincent T K Chow, Paul Anantharajah Tambyah, Kwok Wai Tham
BACKGROUND: As the world transitions to COVID-19 endemicity, studies focusing on aerosol shedding of highly transmissible SARS-CoV-2 variants of concern (VOCs) are vital for the calibration of infection control measures against VOCs that are likely to circulate seasonally. OBJECTIVE: This follow-up G-II aerosol sampling study aims to compare the aerosol shedding patterns of Omicron VOC samples with pre-Omicron variants analyzed in our previous study. STUDY DESIGN: Coarse and fine aerosol samples from 47 SARS-CoV-2 infected patients were collected during various respiratory activities (passive breathing, talking, and singing) and analyzed via reverse transcription quantitative polymerase chain reaction (RT-qPCR) and virus culture...
March 20, 2023: International Journal of Infectious Diseases: IJID
#53
JOURNAL ARTICLE
Sarah E Lower, Gregory M Pask, Kyle Arriola, Sean Halloran, Hannah Holmes, Daphné C Halley, Yiyu Zheng, Douglas B Collins, Jocelyn G Millar
Firefly flashes are well-known visual signals used by these insects to find, identify, and choose mates. However, many firefly species have lost the ability to produce light as adults. These "unlighted" species generally lack developed adult light organs, are diurnal rather than nocturnal, and are believed to use volatile pheromones acting over a distance to locate mates. While cuticular hydrocarbons, which may function in mate recognition at close range, have been examined for a handful of the over 2000 extant firefly species, no volatile pheromone has ever been identified...
March 15, 2023: Journal of Chemical Ecology
#54
JOURNAL ARTICLE
Ming Cui, Sami Shoucair, Quan Liao, Xiaoyan Qiu, Benedict Kinny-Köster, Joseph R Habib, Elie M Ghabi, Junke Wang, Eun Ji Shin, Sean X Leng, Syed Z Ali, Elizabeth D Thompson, Jacquelyn W Zimmerman, Christopher R Shubert, Kelly J Lafaro, Richard A Burkhart, William R Burns, Lei Zheng, Jin He, Yupei Zhao, Christopher L Wolfgang, Jun Yu
BACKGROUND: Neoadjuvant therapy (NAT) is increasingly applied in pancreatic ductal adenocarcinoma (PDAC); however, accurate prediction of therapeutic response to NAT remains a pressing clinical challenge. Cancer-cell-derived sialylated immunoglobulin G (SIA-IgG) was previously identified as a prognostic biomarker in PDAC. This study aims to explore whether SIA-IgG expression in treatment-naïve fine needle aspirate (FNA) biopsy specimens could predict the pathological response (PR) to NAT for PDAC...
February 1, 2023: International Journal of Surgery
#55
Rafik Tadros, Sean L Zheng, Christopher Grace, Paloma Jordà, Catherine Francis, Sean J Jurgens, Kate L Thomson, Andrew R Harper, Elizabeth Ormondroyd, Dominique M West, Xiao Xu, Pantazis I Theotokis, Rachel J Buchan, Kathryn A McGurk, Francesco Mazzarotto, Beatrice Boschi, Elisabetta Pelo, Michael Lee, Michela Noseda, Amanda Varnava, Alexa Mc Vermeer, Roddy Walsh, Ahmad S Amin, Marjon A van Slegtenhorst, Nicole Roslin, Lisa J Strug, Erika Salvi, Chiara Lanzani, Antonio de Marvao, Jason D Roberts, Maxime Tremblay-Gravel, Genevieve Giraldeau, Julia Cadrin-Tourigny, Philippe L L'Allier, Patrick Garceau, Mario Talajic, Yigal M Pinto, Harry Rakowski, Antonis Pantazis, John Baksi, Brian P Halliday, Sanjay K Prasad, Paul Jr Barton, Declan P O'Regan, Stuart A Cook, Rudolf A de Boer, Imke Christiaans, Michelle Michels, Christopher M Kramer, Carolyn Y Ho, Stefan Neubauer, Paul M Matthews, Arthur A Wilde, Jean-Claude Tardif, Iacopo Olivotto, Arnon Adler, Anuj Goel, James S Ware, Connie R Bezzina, Hugh Watkins
Hypertrophic cardiomyopathy (HCM) is an important cause of morbidity and mortality with both monogenic and polygenic components. We here report results from the largest HCM genome-wide association study (GWAS) and multi-trait analysis (MTAG) including 5,900 HCM cases, 68,359 controls, and 36,083 UK Biobank (UKB) participants with cardiac magnetic resonance (CMR) imaging. We identified a total of 70 loci (50 novel) associated with HCM, and 62 loci (32 novel) as sociated with relevant left ventricular (LV) structural or functional traits...
February 6, 2023: medRxiv
#56
REVIEW
Ryan Philip Jajosky, Shang-Chuen Wu, Leon Zheng, Audrey N Jajosky, Philip G Jajosky, Cassandra D Josephson, Marie A Hollenhorst, Robert Sackstein, Richard D Cummings, Connie M Arthur, Sean R Stowell
Enzymes catalyze biochemical reactions and play critical roles in human health and disease. Enzyme variants and deficiencies can lead to variable expression of glycans, which can affect physiology, influence predilection for disease, and/or directly contribute to disease pathogenesis. Although certain well-characterized enzyme deficiencies result in overt disease, some of the most common enzyme deficiencies in humans form the basis of blood groups. These carbohydrate blood groups impact fundamental areas of clinical medicine, including the risk of infection and severity of infectious disease, bleeding risk, transfusion medicine, and tissue/organ transplantation...
January 20, 2023: IScience
#57
JOURNAL ARTICLE
Meagan Kozhimala, Shin Mei Chan, Gabe Weininger, Brandon J Sumpio, Louis J Levine, Sean Harris, Sijin Zheng, Walter E Longo, Cassius Ochoa Chaar, Raul J Guzman, Bauer E Sumpio
BACKGROUND: Median arcuate ligament syndrome (MALS) is a frequent differential diagnosis in patients with postprandial abdominal symptoms, but diagnosis remains challenging. The aim of this study was to identify characteristics of patients who had MALS compared with non-MALS patients among a cohort of patients diagnosed with celiac artery compression (CAC). STUDY DESIGN: An IRB-approved retrospective chart review (2000 to 2021) of patients at our institution with a discharge diagnosis of CAC was performed...
June 1, 2023: Journal of the American College of Surgeons
#58
JOURNAL ARTICLE
Zaili Luo, Mingyang Xia, Wei Shi, Chuntao Zhao, Jiajia Wang, Dazhuan Xin, Xinran Dong, Yu Xiong, Feng Zhang, Kalen Berry, Sean Ogurek, Xuezhao Liu, Rohit Rao, Rui Xing, Lai Man Natalie Wu, Siying Cui, Lingli Xu, Yifeng Lin, Wenkun Ma, Shuaiwei Tian, Qi Xie, Li Zhang, Mei Xin, Xiaotao Wang, Feng Yue, Haizi Zheng, Yaping Liu, Charles B Stevenson, Peter de Blank, John P Perentesis, Richard J Gilbertson, Hao Li, Jie Ma, Wenhao Zhou, Michael D Taylor, Q Richard Lu
Medulloblastoma (MB) is the most common malignant childhood brain tumour1,2 , yet the origin of the most aggressive subgroup-3 form remains elusive, impeding development of effective targeted treatments. Previous analyses of mouse cerebella3-5 have not fully defined the compositional heterogeneity of MBs. Here we undertook single-cell profiling of freshly isolated human fetal cerebella to establish a reference map delineating hierarchical cellular states in MBs. We identified a unique transitional cerebellar progenitor connecting neural stem cells to neuronal lineages in developing fetal cerebella...
November 30, 2022: Nature
#59
JOURNAL ARTICLE
Mark Canney, Mohammad Atiquzzaman, Amanda M Cunningham, Yuyan Zheng, Lee Er, Steven Hawken, Yinshan Zhao, Sean J Barbour
BACKGROUND: Although case reports have described relapses of glomerular disease after COVID-19 vaccination, evidence of a true association is lacking. In this population-level analysis, we sought to determine relative and absolute risks of glomerular disease relapse after COVID-19 vaccination. METHODS: In this retrospective population-level cohort study, we used a centralized clinical and pathology registry (2000-2020) to identify 1105 adult patients in British Columbia, Canada, with biopsy-proven glomerular disease that was stable on December 14, 2020 (when COVID-19 vaccines first became available)...
December 2022: Journal of the American Society of Nephrology: JASN
#60
JOURNAL ARTICLE
Hengyou Weng, Feng Huang, Zhaojin Yu, Zhenhua Chen, Emily Prince, Yalin Kang, Keren Zhou, Wei Li, Jiacheng Hu, Chen Fu, Tursunjan Aziz, Hongzhi Li, Jingwen Li, Ying Yang, Li Han, Subo Zhang, Yuelong Ma, Mingli Sun, Huizhe Wu, Zheng Zhang, Mark Wunderlich, Sean Robinson, Daniel Braas, Johanna Ten Hoeve, Bin Zhang, Guido Marcucci, James C Mulloy, Keda Zhou, Hong-Fang Tao, Xiaolan Deng, David Horne, Minjie Wei, Huilin Huang, Jianjun Chen
N6 -Methyladenosine (m6 A) modification and its modulators play critical roles and show promise as therapeutic targets in human cancers, including acute myeloid leukemia (AML). IGF2BP2 was recently reported as an m6 A binding protein that enhances mRNA stability and translation. However, its function in AML remains largely elusive. Here we report the oncogenic role and the therapeutic targeting of IGF2BP2 in AML. High expression of IGF2BP2 is observed in AML and associates with unfavorable prognosis. IGF2BP2 promotes AML development and self-renewal of leukemia stem/initiation cells by regulating expression of critical targets (e...
December 12, 2022: Cancer Cell
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