Catherine E Oldenburg, Armin Hinterwirth, Millogo Ourohiré, Clarisse Dah, Moussa Ouédraogo, Ali Sié, Valentin Boudo, Cindi Chen, Kevin Ruder, Lina Zhong, Elodie Lebas, Fanice Nyatigo, Benjamin F Arnold, Kieran S O'Brien, Thuy Doan
A broad-spectrum antibiotic, typically amoxicillin, is included in many country guidelines as part of the management of uncomplicated severe acute malnutrition (SAM) in children without overt clinical symptoms of infection. Alternative antibiotics may be beneficial for children with SAM without increasing selection for beta-lactam resistance. We conducted a 1:1 randomized controlled trial of single dose azithromycin versus a 7-day course of amoxicillin for SAM. Children 6-59 months of age with uncomplicated SAM (mid-upper arm circumference < 11...
July 13, 2022: American Journal of Tropical Medicine and Hygiene