Sofia Ferreira-Gonzalez, Tak Yung Man, Hannah Esser, Rhona Aird, Alastair M Kilpatrick, Daniel Rodrigo-Torres, Nicholas Younger, Lara Campana, Victoria L Gadd, Benjamin Dwyer, Niya Aleksieva, Luke Boulter, Mark T Macmillan, Yinmiao Wang, Katie J Mylonas, David A Ferenbach, Timothy J Kendall, Wei-Yu Lu, Juan Carlos Acosta, Dominic Kurian, Stephen O'Neill, Gabriel C Oniscu, Jesus M Banales, Paul J Krimpenfort, Stuart J Forbes
Liver transplantation is the only curative option for patients with end-stage liver disease. Despite improvements in surgical techniques, nonanastomotic strictures (characterized by the progressive loss of biliary tract architecture) continue to occur after liver transplantation, negatively affecting liver function and frequently leading to graft loss and retransplantation. To study the biological effects of organ preservation before liver transplantation, we generated murine models that recapitulate liver procurement and static cold storage...
December 7, 2022: Science Translational Medicine