Haruyo Aoyagi, Hiroko Iijima, Eman S Gaber, Takuma Zaitsu, Mami Matsuda, Kosho Wakae, Koichi Watashi, Ryosuke Suzuki, Takahiro Masaki, Jeffrey Kahn, Takeshi Saito, Mohamed El-Kassas, Noritomo Shimada, Keizo Kato, Masaru Enomoto, Kazuhiko Hayashi, Akihito Tsubota, Ayako Mimata, Yuriko Sakamaki, Shizuko Ichinose, Masamichi Muramatsu, Kenjiro Wake, Takaji Wakita, Hideki Aizaki
BACKGROUND AND AIMS: The future development of hepatocellular carcinoma (HCC) in patients after sustained virologic response (SVR) is an important issue. The purposes of this study were to investigate pathological alterations in organelle of the liver of SVR patients and to characterize organelle abnormalities that may be related to carcinogenesis after SVR. METHODS: The ultrastructure of liver biopsy specimens from patients with chronic hepatitis C (CHC) and SVR were compared to cell and mouse models and assessed semi-quantitatively using transmission electron microscopy...
June 13, 2023: Liver International: Official Journal of the International Association for the Study of the Liver