Nicole Bracci, Alan Baer, Rafaela Flor, Kaylee Petraccione, Timothy Stocker, Weidong Zhou, Tatiana Ammosova, Rhoel R Dinglasan, Sergei Nekhai, Kylene Kehn-Hall
Rift Valley fever virus (RVFV) is an arbovirus in the Phenuiviridae family identified initially by the large 'abortion storms' observed among ruminants; RVFV can also infect humans. In humans, there is a wide variation of clinical symptoms ranging from subclinical to mild febrile illness to hepatitis, retinitis, delayed-onset encephalitis, or even hemorrhagic fever. The RVFV is a tri-segmented negative-sense RNA virus consisting of S, M, and L segments. The L segment encodes the RNA-dependent RNA polymerase (RdRp), termed the L protein, which is responsible for both viral mRNA synthesis and genome replication...
April 26, 2024: Antiviral Research