Ling-Kun Zhang, Li Liu, Qingpeng Liu, Yiquan Zhang, Ziqing Li, Haoming Xu, Weiwei Bai, Yiyan Guo, Dandan Zhang, Zhendong Chen, Kunwen Xia, Chu-Hua Li, Jian Ge, Yan-Qing Guan
Ischemic stroke is a neurological disease that leads to brain damage and severe cognitive impairment. In this study, extracellular vesicles(Ev) derived from mouse hippocampal cells (HT22) were used as carriers, and adenosine (Ad) was encapsulated to construct Ev-Ad to target the damaged hippocampus. The results showed that, Ev-Ad had significant antioxidant effect and inhibited apoptosis. In vivo, Ev-Ad reduced cell death and reversed inflammation in hippocampus of ischemic mice, and improved long-term memory and learning impairment by regulating the expression of the A1 receptor and the A2A receptor in the CA1 region...
January 6, 2024: Colloids and Surfaces. B, Biointerfaces