Łukasz M Milanowski, Jennifer A Lindemann, Dorota Hoffman-Zacharska, Alexandra I Soto-Beasley, Maria Barcikowska, Magdalena Boczarska-Jedynak, Angela Deutschlander, Gabriela Kłodowska, Jarosław Dulski, Lyuda Fedoryshyn, Andrzej Friedman, Zygmunt Jamrozik, Piotr Janik, Katherine Karpinsky, Dariusz Koziorowski, Anna Krygowska-Wajs, Barbara Jasińska-Myga, Grzegorz Opala, Anna Potulska-Chromik, Aleksander Pulyk, Irena Rektorova, Yanosh Sanotsky, Joanna Siuda, Jarosław Sławek, Katarzyna Śmiłowska, Lech Szczechowski, Monika Rudzińska-Bar, Ronald L Walton, Owen A Ross, Zbigniew K Wszolek
INTRODUCTION: Approximately 10% of patients with Parkinson disease (PD) present with early-onset disease (EOPD), defined as diagnosis before 50 years of age. Genetic factors are known to contribute to EOPD, with most commonly observed mutations in PRKN, PINK1, and DJ1 genes. The aim of our study was to analyze the frequency of PRKN, PINK1, and DJ1 mutations in an EOPD series from 4 neighboring European countries: Czech Republic, Germany, Poland, and Ukraine. METHODS: Diagnosis of PD was made based on UK Brain Bank diagnostic criteria in departments experienced in movement disorders (1 from Czech Republic, 1 from Germany, 9 from Poland, and 3 from Ukraine)...
April 2, 2021: Parkinsonism & related Disorders