Myltykbay S Rysmakhanov, Afshin Zare, Aibolat S Smagulov, Nurgul A Abenova, Nadiar M Mussin, Yerlan B Sultangereyev, Bazylbek S Zhakiyev, Gani K Kuttymuratov, Mehmet Haberal, Nazanin Jafari, Hanieh Baneshi, Shabnam Bakhshalizadeh, Mahdi Mahdipour, Farhad Rahmanifar, Amin Tamadon
BACKGROUND: Ischemia-Reperfusion Injury (IRI) is a complex pathophysiological process with severe consequences, including irreversible loss of renal function. Various intraoperative prevention methods have been proposed to mitigate the harmful effects of warm ischemia and kidney reperfusion. AIM: This comprehensive analysis provides an overview of pharmacological agents and intraoperative methods for preventing and treating renal IRI. METHODS: Our analysis revealed that eplerenone exhibited the highest binding affinity to crucial targets, including Aldehyde Dehydrogenase (AD), Estrogen Receptor (ER), Klotho protein, Mineralocorticoid Receptor (MR), and Toll-Like Receptor 4 (TLR4)...
April 26, 2024: Current Pharmaceutical Design