Hiroshi Araki, Motohiro Sekino, Yuri Hasegawa, Masaya Kurobe, Tetsufumi Motokawa, Akihiko Tanigawa, Takashi Egashira, Naoya Iwasaki, Miki Suzumura, Rintaro Yano, Sojiro Matsumoto, Taiga Ichinomiya, Ushio Higashijima, Naohiro Kanayama, Kiyonori Miura, Tetsuya Hara
RATIONALE: Amniotic fluid embolism (AFE) is a fatal obstetric condition that often rapidly leads to severe respiratory and circulatory failure. It is complicated by obstetric disseminated intravascular coagulation (DIC) with bleeding tendency; therefore, the introduction of venoarterial extracorporeal membrane oxygenation (VA-ECMO) is challenging. We report the case of a patient with AFE requiring massive blood transfusion, rescued using VA-ECMO without initial anticoagulation. PATIENTS CONCERNS: A 39-year-old pregnant patient was admitted with a complaint of abdominal pain...
May 17, 2024: Medicine (Baltimore)
Yaxin Ning, Linya He, Keqi Pan, Weiwen Zhang, Jian Luo, Yan Chen, Zubing Mei, Danqiong Wang
BACKGROUND: Severe acute lung failure (ALF) often necessitates veno-venous extracorporeal membrane oxygenation (VV-ECMO), where identifying predictors of weaning success and mortality remains crucial yet challenging. The study aims to identify predictors of weaning success and mortality in adults undergoing VV-ECMO for severe ALF, a gap in current clinical knowledge. METHODS AND ANALYSIS: PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials will be searched for cohort studies examining the predictive factors of successful weaning and mortality in adult patients on VV-ECMO due to severe ALF...
2024: PloS One
Tiffany Goh, Lingzi Gao, Jasneil Singh, Richard Totaro, Ruaidhri Carey, Kevin Yang, Bruce Cartwright, Mark Dennis, Lining Arnold Ju, Anna Waterhouse
Use of extracorporeal membrane oxygenation (ECMO) for cardiorespiratory failure remains complicated by blood clot formation (thrombosis), triggered by biomaterial surfaces and flow conditions. Thrombosis may result in ECMO circuit changes, cause red blood cell hemolysis, and thromboembolic events. Medical device thrombosis is potentiated by the interplay between biomaterial properties, hemodynamic flow conditions and patient pathology, however, the contribution and importance of these factors are poorly understood because many in vitro models lack the capability to customize material and flow conditions to investigate thrombosis under clinically relevant medical device conditions...
May 17, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Benjamin Stretch, Ben Singer
No abstract text is available yet for this article.
May 16, 2024: Anaesthesia
Syed Ameen Ahmad, Shrey Kapoor, Siam Muquit, Aaron Gusdon, Shivalika Khanduja, Wendy Ziai, Allen D Everett, Glenn Whitman, Sung-Min Cho, On Behalf Of Herald Investigators
INTRODUCTION: Early diagnosis of acute brain injury (ABI) is critical for patients on veno-arterial extracorporeal membrane oxygenation (V-A ECMO) to guide anticoagulation strategy; however, neurological assessment in ECMO is often limited by patient sedation. METHODS: In this pilot study of adults from June 2018 to May 2019, plasma samples of glial fibrillary acidic protein (GFAP), neurofilament light chain (NFL), and tubulin associated unit (Tau) were collected daily after V-A ECMO cannulation and measured using a multiplex platform...
May 17, 2024: Perfusion
Silvia Placidi, Paola Francalanci, Rachele Adorisio, Katia Girardi, Luciana Vinti, Mario Panebianco, Micol Rebonato, Antonio Amodeo, Giorgia Grutter
Findings of eosinophilic and lymphomonocytic inflammatory infiltrates in endomyocardial biopsies (EMBs) may help in myocardial disease diagnosis identification. Eosinophilic myocarditis (EM), a rare condition, is fatal if left untreated and has rarely been described in heart transplant recipients. An extensive work up is necessary to achieve an early etiological diagnosis; however, the underlying cause remains unexplained in nearly one-third of the patients. The cornerstone of treatment is corticosteroids, comprehensive therapy and heart failure management (including advanced mechanical support for fulminant myocarditis)...
2024: Frontiers in Cardiovascular Medicine
Tomohiro Morito, Yosuke Matsumura
Severe chest trauma often requires immediate intervention, typically involving open chest surgery. However, advancements in medical technology offer alternative approaches, such as endovascular therapy and venovenous extracorporeal membrane oxygenation (VV-ECMO). In a recent case, a middle-aged male cyclist was admitted after colliding with a vehicle, presenting in shock with multiple injuries, including cerebral contusion and rib fractures. Despite initial treatments such as chest tubes and blood transfusions, his condition remained unstable, with worsening respiratory failure and hemorrhagic shock...
April 2024: Curēus
Sagar B Dave, Eric Leiendecker, Christina Creel-Bulos, Casey Frost Miller, David W Boorman, Jeffrey Javidfar, Tamer Attia, Mani Daneshmand, Craig S Jabaley, Mark Caridi-Schieble
Refractory hypoxemia during veno-venous (V-V) extracorporeal membrane oxygenation (ECMO) may require an additional cannula (VV-V ECMO) to improve oxygenation. This intervention includes risk of recirculation and other various adverse events (AEs) such as injury to the lung, cannula malpositioning, bleeding, circuit or cannula thrombosis requiring intervention (i.e., clot), or cerebral injury. During the study period, 23 of 142 V-V ECMO patients were converted to VV-V utilizing two separate cannulas for bi-caval drainage with an additional upper extremity cannula placed for return...
May 17, 2024: Perfusion
Kodai Shibao, Tatsuhiro Shibata, Chisato Kitamura, Yoshihisa Matushima, Takumi Yoshiga, Toshiyuki Yanai, Takehiro Homma, Maki Otsuka, Kenta Murotani, Yoshihiro Fukumoto
Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is a therapeutic strategy for managing cardiogenic shock. However, it carries the risk of cardiogenic pulmonary edema, potentially leading to differential hypoxia. Although IMPELLA can mitigate pulmonary congestion, the combination of VA-ECMO and IMPELLA has frequently resulted in differential hypoxia, requiring a transition from VA-ECMO to veno-arteriovenous extracorporeal membrane oxygenation (VAV-ECMO). Therefore, this study aimed to examine the influence of IMPELLA on the incidence of differential hypoxia, necessitating a shift to VAV-ECMO...
May 17, 2024: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Jeremy C Grate, Tyler S Reynolds, Adam C Gordon, Sagar B Dave
Nosocomial infections and thrombosis are frequent complications during extracorporeal membrane oxygenation (ECMO). Preventative measures and close monitoring for early recognition of these complications are imperative in patients supported with ECMO. We report the case of a 41 year old female on veno-venous ECMO awaiting surgical thrombectomy for chronic thromboembolic pulmonary hypertension that developed profound bacteremia leading to gross purulence and thrombosis of the membrane oxygenator. Recannulation in addition to targeted antibiotics, frequent cultures, imaging, and surgery were diagnostic and therapeutic interventions that led to ultimate resolution...
May 17, 2024: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Biplab K Saha, J Michael Brewer, Marc O Maybauer
No abstract text is available yet for this article.
June 1, 2024: Critical Care Medicine
Asad Usman, Jeremy W Cannon
No abstract text is available yet for this article.
June 1, 2024: Critical Care Medicine
Abhimanyu Chandel, Kimberly D Fabyan, Sondra Mendelsohn, Nitin Puri, Emily Damuth, Craig R Rackley, Steven A Conrad, Christopher S King, Adam Green
OBJECTIVES: To examine trends in utilization and outcomes among patients with the acute respiratory distress syndrome (ARDS) requiring prolonged venovenous extracorporeal membrane oxygenation (VV ECMO) support. DESIGN: Retrospective observational cohort study. SETTING: Adult patients in the Extracorporeal Life Support Organization registry. PATIENTS: Thirteen thousand six hundred eighty-one patients that required ECMO for the support of ARDS between January 2012 and December 2022...
June 1, 2024: Critical Care Medicine
Bryan R Campbell, Alexandra S Rooney, Andrea Krzyzaniak, Richard Y Calvo, Kyle D Checchi, Alyssa N Carroll, Michael J Sise, Vishal Bansal, Michael J Krzyzaniak
BACKGROUND: Extracorporeal membrane oxygenation (ECMO) is resource intensive with high mortality. Identifying trauma patients most likely to derive a survival benefit remains elusive despite current ECMO guidelines. Our objective was to identify unique patient risk profiles using the largest database of trauma patients available. METHODS: ECMO patients ≥16 years were identified using Trauma Quality Improvement Program data (2010-2019). Machine learning K-median clustering (ML) utilized 101 variables including injury severity, demographics, comorbidities, and hospital stay information to generate unique patient risk profiles...
May 16, 2024: American Surgeon
Issei Seike, Kengo Oshima, Hiroaki Baba, Hajime Kanamori, Tetsuji Aoyagi
The use of extracorporeal membrane oxygenation (ECMO) increased during the COVID-19 pandemic. However, complications associated with the long-term use of ECMO are poorly understood. This case report describes the autopsy findings of a perihepatic abscess in a patient with long-term COVID-19, which could not be diagnosed before death. In cases where the source of infection remains elusive but uncontrolled infections occur, we recommend the combined use of ultrasonography and contrast-enhanced computed tomography (CT) in patients with COVID-19 undergoing prolonged ECMO support, with particular consideration given to the potential development of cholecystitis...
April 2024: Curēus
Francesca Fiorelli, Vasileios Panoulas, Fernando Riesgo Gil, Carl Era, Alexander Rosenberg
BACKGROUND: The use of mechanical circulatory support (MCS) has markedly increased over the last decade, so have the inter-hospital transfers, with the aim of being able to offer advanced heart failure (AHF) therapies and centralizing patients to tertiary centres. CASE SUMMARY: In this article, we present the first in Europe long-distance air transfer of a patient supported by veno-arterial extracorporeal membrane oxygenator and Impella (ECPELLA), as a bridge to successful heart transplant...
May 2024: European Heart Journal. Case Reports
Paolo Zanatta, Federico Linassi, Nicola Gasparetto, Luigi Polesello, Matteo Bussola, Ennio Nascimben, Giuseppe Minniti, Carlo Cernetti, Matteo Angelini, Giuseppe Feltrin, Maurizio Romano, Giacomo Zanus, Francesco Benazzi, Gino Gerosa
BACKGROUND: Withdrawal of life-sustaining therapy (WLST) performed in the circulatory determination of death (DCD) donors leads to cardiac arrest, challenging the utilization of the myocardium for transplantation. The rapid initiation of normothermic regional perfusion or extracorporeal membrane oxygenation after death helps to optimize organs before implantation. However, additional strategies to mitigate the effects of stress response during WLST, hypoxic/ischemic injury, and reperfusion injury are required to allow myocardium recovery...
May 16, 2024: Transplantation
Simon Davidson
Extracorporeal membrane oxygenation (ECMO) is a type of circulatory life support for patients with severe lung failure. The use of ECMO has increased worldwide since the pandemic of H1N1 in 2009 and more recently SARS-CoV-2 in 2020 both of which caused severe respiratory failure. ECMO patients experience both increased risk of bleeding and thrombosis. This is due to the pathological insult that damages the lungs, the ECMO circuit, coagulopathy, inflammation and anticoagulation. ECMO presents unique demands on the coagulation laboratory both in tests required to manage the patients and result interpretation...
May 15, 2024: International Journal of Laboratory Hematology
Radu Galis, Diana Mudura, Paula Trif, Shivashankar Diggikar, Arun Prasath, Maria Livia Ognean, Jan Mazela, Adrian Lacatusu, Rangasamy Ramanathan, Boris W Kramer, Yogen Singh
Persistent pulmonary hypertension of the newborn (PPHN) is a common neonatal condition in newborns admitted to the neonatal intensive care units (NICUs). PPHN has still a high mortality and morbidity. Inhaled nitric oxide (iNO) is the first line vasodilator therapy for PPHN in high income countries. In low-to-middle income countries (LMICs), availability of iNO remains scarce and expensive. The purpose of this scoping review was to evaluate the current existing literature for milrinone therapy in PPHN and to identify the knowledge gaps in milrinone use in infants with PPHN...
May 14, 2024: Pediatric Research
Remigiusz Antończyk, Agnieszka Biełka, Mariusz Kalinowski, Magdalena Śmigiel-Iras, Agnieszka Kuczaj
OBJECTIVE: To evaluate the safety, feasibility and effectiveness of minimally invasive HeartMate 3 LVAD implantation. METHODOLOGY: Forty-seven patients who underwent the HeartMate 3 LVAD implantation by sternotomy and 26 ones who had implantation via minimally invasive method were analyzed. The observation lasted from November 2016 to May 2020. RESULTS: ECMO as a bridge to LVAD, was more usual in the sternotomy group (11% vs 0%, P = .03). In the minimally invasive group, a history of previous cardiac surgery was more common (54% vs 12%, P < ...
May 13, 2024: Transplantation Proceedings
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.