"Richard" "Levitan" | Page 2

Vasanth Coorg, Rachel D Levitan, Richard D Gerkin, Jared Muenzer, Anne-Michelle Ruha
INTRODUCTION: Scorpion envenomation is potentially life-threatening and affects children in the Southwestern USA. An FDA-approved antivenom is available, but its high cost has led to use of off-label antivenom dosing or supportive care alone as alternatives to FDA-recommended dosing. This study sought to determine whether treatment approach influences outcomes in envenomated children. METHODS: A retrospective cohort study of children with grade III or IV scorpion envenomation evaluated in Phoenix Children's Hospital ED between September 1, 2011, and March 31, 2014...
March 2017: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
Carrie Huisingh, Emily B Levitan, Patricia Sawyer, Richard Kennedy, Cynthia J Brown, Gerald McGwin
The purpose of this study was to examine the trajectories of life-space before and after the transition to driving cessation among a diverse sample of community-dwelling older adults. Life-space scores and self-reported driving cessation were assessed at annual visits from baseline through Year 6 among participants in the University of Alabama at Birmingham Study of Aging. Approximately 58% of older adults reported having stopped driving during the 6 years of follow-up. After adjusting for potential confounders, results from a random intercept model indicate that mean life-space scores decreased about 1 to 2 points every year ( p = ...
December 2017: Journal of Applied Gerontology: the Official Journal of the Southern Gerontological Society
Xiaowen Liu, Tao Yang, Koya Suzuki, Sachiko Tsukita, Masaru Ishii, Shuping Zhou, Gang Wang, Luyang Cao, Feng Qian, Shalina Taylor, Myung-Jin Oh, Irena Levitan, Richard D Ye, Graeme K Carnegie, Yong Zhao, Asrar B Malik, Jingsong Xu
Neutrophils respond to invading bacteria by adopting a polarized morphology, migrating in the correct direction, and engulfing the bacteria. How neutrophils establish and precisely orient this polarity toward pathogens remains unclear. Here we report that in resting neutrophils, the ERM (ezrin, radixin, and moesin) protein moesin in its active form (phosphorylated and membrane bound) prevented cell polarization by inhibiting the small GTPases Rac, Rho, and Cdc42. Attractant-induced activation of myosin phosphatase deactivated moesin at the prospective leading edge to break symmetry and establish polarity...
February 9, 2015: Journal of Experimental Medicine
David R Buys, Virginia J Howard, Leslie A McClure, Katie Crawford Buys, Patricia Sawyer, Richard M Allman, Emily B Levitan
OBJECTIVES: We evaluated the effect of neighborhood disadvantage (ND) on older adults' prevalence, awareness, treatment, and control of hypertension. METHODS: Data were from the University of Alabama at Birmingham Study of Aging, an observational study of 1000 community-dwelling Black and White Alabamians aged 65 years and older, in 1999 to 2001. We assessed hypertension prevalence, awareness, treatment, and control with blood pressure measurements and self-report data...
June 2015: American Journal of Public Health
Huazhi Han, Avia Rosenhouse-Dantsker, Radhakrishnan Gnanasambandam, Yulia Epshtein, Zhenlong Chen, Frederick Sachs, Richard D Minshall, Irena Levitan
A growing number of studies show that different types of ion channels localize in caveolae and are regulated by the level of membrane cholesterol. Furthermore, it has been proposed that cholesterol-induced regulation of ion channels might be attributed to partitioning into caveolae and association with caveolin-1 (Cav-1). We tested, therefore, whether Cav-1 regulates the function of inwardly rectifying potassium channels Kir2.1 that play major roles in the regulation of membrane potentials of numerous mammalian cells...
September 15, 2014: Journal of Physiology
Bennett Levitan, Zhong Yuan, Alexander G G Turpie, Richard J Friedman, Martin Homering, Jesse A Berlin, Scott D Berkowitz, Rachel B Weinstein, Peter M DiBattiste
PURPOSE: Venous thromboembolism is a common complication after major orthopedic surgery. When prescribing anticoagulant prophylaxis, clinicians weigh the benefits of thromboprophylaxis against bleeding risk and other adverse events. Previous benefit-risk analyses of the REgulation of Coagulation in ORthopaedic surgery to prevent Deep vein thrombosis and pulmonary embolism (RECORD) randomized clinical studies of rivaroxaban versus enoxaparin after total hip (THA) or knee (TKA) arthroplasty generally used pooled THA and TKA results, counted fatal bleeding as both an efficacy and a safety event, and included the active and placebo-controlled portions of RECORD2, which might confound benefit-risk assessments...
2014: Vascular Health and Risk Management
Richard M Levitan
The author describes a cricothyrotomy system that consists of two devices that, packaged together, are labeled the Control-Cric™ system. The Cric-Key™ was invented to verify tracheal location during surgical airway procedures?without the need for visualization, aspiration of air, or reliance on clinicians? fine motor skills. The Cric-Knife™ combines a scalpel with an overlying sliding hook to facilitate a smooth transition from membrane incision to hook insertion and tracheal control. In a recent test versus a traditional open technique, this system had a higher success rate and was faster to implement...
2014: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
Steven E Coutre, Megan Othus, Bayard Powell, Cheryl L Willman, Wendy Stock, Elisabeth Paietta, Denise Levitan, Meir Wetzler, Eyal C Attar, Jessica K Altman, Steven D Gore, Tracy Maher, Kenneth J Kopecky, Martin S Tallman, Richard A Larson, Frederick R Appelbaum
Aa total of 105 patients (age ≥18 years) with newly diagnosed low or intermediate risk acute promyelocytic leukaemia (APL) were treated with a standard induction and consolidation regimen including arsenic trioxide (ATO). Sixty-eight patients who were polymerase chain reaction (PCR) negative for PML-RARA post-consolidation were randomized to either 1 year of maintenance with tretinoin, mercaptopurine and methotrexate, or observation. Enrollment in this non-inferiority trial was stopped prematurely due to slow accrual...
May 2014: British Journal of Haematology
Diane Glogan, Rachel D Levitan, Daniel E Brooks, Richard D Gerkin
BACKGROUND: There are no guidelines for the management of accidental insulin administration. We hypothesized that home monitoring of asymptomatic patients (pts) was safe following unintentionally insulin administration. METHODS: Retrospective review of poison center (PCC) charts from 1/1/2000-12/31/2010 looking for accidental insulin administrations. INCLUSION CRITERIA: pt must be prescribed insulin. Information recorded from charts: pt age/gender, "intended" and "mistaken" insulin formulations/doses, use of oral diabetic agents, management site, Emergency Department (ED) referral, symptoms, blood glucose values, and treatments...
October 2013: Journal of Emergency Medicine
Richard M Levitan
No abstract text is available yet for this article.
April 2013: Annals of Emergency Medicine
Philip L McCarthy, Kouros Owzar, Craig C Hofmeister, David D Hurd, Hani Hassoun, Paul G Richardson, Sergio Giralt, Edward A Stadtmauer, Daniel J Weisdorf, Ravi Vij, Jan S Moreb, Natalie Scott Callander, Koen Van Besien, Teresa Gentile, Luis Isola, Richard T Maziarz, Don A Gabriel, Asad Bashey, Heather Landau, Thomas Martin, Muzaffar H Qazilbash, Denise Levitan, Brian McClune, Robert Schlossman, Vera Hars, John Postiglione, Chen Jiang, Elizabeth Bennett, Susan Barry, Linda Bressler, Michael Kelly, Michele Seiler, Cara Rosenbaum, Parameswaran Hari, Marcelo C Pasquini, Mary M Horowitz, Thomas C Shea, Steven M Devine, Kenneth C Anderson, Charles Linker
BACKGROUND: Data are lacking on whether lenalidomide maintenance therapy prolongs the time to disease progression after autologous hematopoietic stem-cell transplantation in patients with multiple myeloma. METHODS: Between April 2005 and July 2009, we randomly assigned 460 patients who were younger than 71 years of age and had stable disease or a marginal, partial, or complete response 100 days after undergoing stem-cell transplantation to lenalidomide or placebo, which was administered until disease progression...
May 10, 2012: New England Journal of Medicine
Peter J Bieling, Lance L Hawley, Richard T Bloch, Kathleen M Corcoran, Robert D Levitan, L Trevor Young, Glenda M Macqueen, Zindel V Segal
OBJECTIVE: To examine whether metacognitive psychological skills, acquired in mindfulness-based cognitive therapy (MBCT), are also present in patients receiving medication treatments for prevention of depressive relapse and whether these skills mediate MBCT's effectiveness. METHOD: This study, embedded within a randomized efficacy trial of MBCT, was the first to examine changes in mindfulness and decentering during 6-8 months of antidepressant treatment and then during an 18-month maintenance phase in which patients discontinued medication and received MBCT, continued on antidepressants, or were switched to a placebo...
June 2012: Journal of Consulting and Clinical Psychology
Scott D Weingart, Richard M Levitan
Patients requiring emergency airway management are at great risk of hypoxemic hypoxia because of primary lung pathology, high metabolic demands, anemia, insufficient respiratory drive, and inability to protect their airway against aspiration. Tracheal intubation is often required before the complete information needed to assess the risk of periprocedural hypoxia is acquired, such as an arterial blood gas level, hemoglobin value, or even a chest radiograph. This article reviews preoxygenation and peri-intubation oxygenation techniques to minimize the risk of critical hypoxia and introduces a risk-stratification approach to emergency tracheal intubation...
March 2012: Annals of Emergency Medicine
Paul Muntner, Cara Joyce, Emily B Levitan, Elizabeth Holt, Daichi Shimbo, Larry S Webber, Suzanne Oparil, Richard Re, Marie Krousel-Wood
OBJECTIVES: Secondary analysis of clinical trial data suggests visit-to-visit variability (VVV) of blood pressure is strongly associated with the incidence of cardiovascular disease. Measurement of blood pressure in usual practice settings may be subject to substantial error, calling into question the value of VVV in real-world settings. METHODS: We analyzed data on adults of at least 65 years of age with diagnosed hypertension who were taking antihypertensive medication from the Cohort Study of Medication Adherence among Older Adults (n = 772 with 14 or more blood pressure measurements)...
December 2011: Journal of Hypertension
Zindel V Segal, Peter Bieling, Trevor Young, Glenda MacQueen, Robert Cooke, Lawrence Martin, Richard Bloch, Robert D Levitan
CONTEXT: Mindfulness-based cognitive therapy (MBCT) is a group-based psychosocial intervention designed to enhance self-management of prodromal symptoms associated with depressive relapse. OBJECTIVE: To compare rates of relapse in depressed patients in remission receiving MBCT against maintenance antidepressant pharmacotherapy, the current standard of care. DESIGN: Patients who met remission criteria after 8 months of algorithm-informed antidepressant treatment were randomized to receive maintenance antidepressant medication, MBCT, or placebo and were followed up for 18 months...
December 2010: Archives of General Psychiatry
Richard M Levitan, James W Heitz, Michael Sweeney, Richard M Cooper
Intubation research on both direct laryngoscopy and alternative intubation devices has focused on laryngeal exposure and not the mechanics of actual endotracheal tube delivery or insertion. Although there are subtleties to tracheal intubation with direct laryngoscopy, the path of tube insertion and the direct line of sight are relatively congruent. With alternative intubation devices, this is not the case. Video or optical elements in alternative intubation devices permit looking around the curve of the tongue, without a direct line of sight to the glottic opening...
March 2011: Annals of Emergency Medicine
William T Cefalu, Jennifer Rood, Patricia Pinsonat, Jianhua Qin, Olga Sereda, Lilian Levitan, Richard A Anderson, Xian H Zhang, Julie M Martin, Corby K Martin, Zhong Q Wang, Bradley Newcomer
The objective of the study was to provide a comprehensive evaluation of chromium (Cr) supplementation on metabolic parameters in a cohort of type 2 diabetes mellitus subjects representing a wide phenotype range and to evaluate changes in "responders" and "nonresponders." After preintervention testing to assess glycemia, insulin sensitivity (assessed by euglycemic clamps), Cr status, and body composition, subjects were randomized in a double-blind fashion to placebo or 1000 microg Cr. A substudy was performed to evaluate 24-hour energy balance/substrate oxidation and myocellular/intrahepatic lipid content...
May 2010: Metabolism: Clinical and Experimental
Richard M Levitan, Charles D Bortle, Thomas A Snyder, David A Nitsch, James T Pisaturo, Kenneth H Butler
STUDY OBJECTIVES: We determine skill acquisition and performance by using a battery-operated, intraosseous needle driver in cadavers. METHODS: This was a prospective study of the EZ-IO, a battery-operated intraosseous needle driver (Vidacare Corp). Operators received a 5-minute presentation (with 1 insertion demonstration) and then performed 3 tibial insertions on a cadaver. Insertion time was measured from skin placement until stylet removal. Another participant recorded the time and determination of "success...
November 2009: Annals of Emergency Medicine
Paul Jolly, Gwen Garrison, John R Boulet, Thomas Levitan, Richard A Cooper
PURPOSE: To determine the size of the overall applicant pool for medical education (applicants to U.S. MD schools and DO schools, and to international medical schools) and to determine the degree of overlap of the three types of applicants. METHOD: A cooperative agreement among the Association of American Medical Colleges, the American Association of Colleges of Osteopathic Medicine, and the Educational Commission for Foreign Medical Graduates permitted the authors to uniquely identify applicants and students of all three types and to combine their data into a study file containing data on applicants for each year...
December 2008: Academic Medicine
Bennett Levitan, Chuen L Yee, Leo Russo, Richard Bayney, Adrian P Thomas, Stephen L Klincewicz
Spontaneous reporting of suspected adverse drug reactions (ADRs) has long been a cornerstone of pharmacovigilance. With the increasingly large volume of ADRs, regulatory agencies, scientific/academic organizations and marketing authorization holders have applied statistical tools to assist in signal detection by identifying disproportionate reporting relationships in spontaneous reporting databases. These tools have generated large numbers of signals defined as drug-ADR reporting associations that meet specified statistical criteria...
2008: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
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