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"Richard" "Levitan"

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https://read.qxmd.com/read/32191349/inbreeding-shapes-the-evolution-of-marine-invertebrates
#1
Kevin C Olsen, Will H Ryan, Alice A Winn, Ellen T Kosman, Jose A Moscoso, Stacy A Krueger-Hadfield, Scott C Burgess, David B Carlon, Richard K Grosberg, Susan Kalisz, Don R Levitan
Inbreeding is a potent evolutionary force shaping the distribution of genetic variation within and among populations of plants and animals. Yet, our understanding of the forces shaping the expression and evolution of non-random mating in general, and inbreeding in particular, remains remarkably incomplete. Most research on plant mating systems focuses on self-fertilization and its consequences for automatic selection, inbreeding depression, purging, and reproductive assurance, whereas studies of animal mating systems have often assumed that inbreeding is rare, and that natural selection favors traits that promote outbreeding...
March 19, 2020: Evolution; International Journal of Organic Evolution
https://read.qxmd.com/read/32064741/shared-genetic-risk-between-eating-disorder-and-substance-use-related-phenotypes-evidence-from-genome-wide-association-studies
#2
Melissa A Munn-Chernoff, Emma C Johnson, Yi-Ling Chou, Jonathan R I Coleman, Laura M Thornton, Raymond K Walters, Zeynep Yilmaz, Jessica H Baker, Christopher Hübel, Scott Gordon, Sarah E Medland, Hunna J Watson, Héléna A Gaspar, Julien Bryois, Anke Hinney, Virpi M Leppä, Manuel Mattheisen, Stephan Ripke, Shuyang Yao, Paola Giusti-Rodríguez, Ken B Hanscombe, Roger A H Adan, Lars Alfredsson, Tetsuya Ando, Ole A Andreassen, Wade H Berrettini, Ilka Boehm, Claudette Boni, Vesna Boraska Perica, Katharina Buehren, Roland Burghardt, Matteo Cassina, Sven Cichon, Maurizio Clementi, Roger D Cone, Philippe Courtet, Scott Crow, James J Crowley, Unna N Danner, Oliver S P Davis, Martina de Zwaan, George Dedoussis, Daniela Degortes, Janiece E DeSocio, Danielle M Dick, Dimitris Dikeos, Christian Dina, Monika Dmitrzak-Weglarz, Elisa Docampo, Laramie E Duncan, Karin Egberts, Stefan Ehrlich, Geòrgia Escaramís, Tõnu Esko, Xavier Estivill, Anne Farmer, Angela Favaro, Fernando Fernández-Aranda, Manfred M Fichter, Krista Fischer, Manuel Föcker, Lenka Foretova, Andreas J Forstner, Monica Forzan, Christopher S Franklin, Steven Gallinger, Ina Giegling, Johanna Giuranna, Fragiskos Gonidakis, Philip Gorwood, Monica Gratacos Mayora, Sébastien Guillaume, Yiran Guo, Hakon Hakonarson, Konstantinos Hatzikotoulas, Joanna Hauser, Johannes Hebebrand, Sietske G Helder, Stefan Herms, Beate Herpertz-Dahlmann, Wolfgang Herzog, Laura M Huckins, James I Hudson, Hartmut Imgart, Hidetoshi Inoko, Vladimir Janout, Susana Jiménez-Murcia, Antonio Julià, Gursharan Kalsi, Deborah Kaminská, Leila Karhunen, Andreas Karwautz, Martien J H Kas, James L Kennedy, Anna Keski-Rahkonen, Kirsty Kiezebrink, Youl-Ri Kim, Kelly L Klump, Gun Peggy S Knudsen, Maria C La Via, Stephanie Le Hellard, Robert D Levitan, Dong Li, Lisa Lilenfeld, Bochao Danae Lin, Jolanta Lissowska, Jurjen Luykx, Pierre J Magistretti, Mario Maj, Katrin Mannik, Sara Marsal, Christian R Marshall, Morten Mattingsdal, Sara McDevitt, Peter McGuffin, Andres Metspalu, Ingrid Meulenbelt, Nadia Micali, Karen Mitchell, Alessio Maria Monteleone, Palmiero Monteleone, Benedetta Nacmias, Marie Navratilova, Ioanna Ntalla, Julie K O'Toole, Roel A Ophoff, Leonid Padyukov, Aarno Palotie, Jacques Pantel, Hana Papezova, Dalila Pinto, Raquel Rabionet, Anu Raevuori, Nicolas Ramoz, Ted Reichborn-Kjennerud, Valdo Ricca, Samuli Ripatti, Franziska Ritschel, Marion Roberts, Alessandro Rotondo, Dan Rujescu, Filip Rybakowski, Paolo Santonastaso, André Scherag, Stephen W Scherer, Ulrike Schmidt, Nicholas J Schork, Alexandra Schosser, Jochen Seitz, Lenka Slachtova, P Eline Slagboom, Margarita C T Slof-Op't Landt, Agnieszka Slopien, Sandro Sorbi, Beata Świątkowska, Jin P Szatkiewicz, Ioanna Tachmazidou, Elena Tenconi, Alfonso Tortorella, Federica Tozzi, Janet Treasure, Artemis Tsitsika, Marta Tyszkiewicz-Nwafor, Konstantinos Tziouvas, Annemarie A van Elburg, Eric F van Furth, Gudrun Wagner, Esther Walton, Elisabeth Widen, Eleftheria Zeggini, Stephanie Zerwas, Stephan Zipfel, Andrew W Bergen, Joseph M Boden, Harry Brandt, Steven Crawford, Katherine A Halmi, L John Horwood, Craig Johnson, Allan S Kaplan, Walter H Kaye, James Mitchell, Catherine M Olsen, John F Pearson, Nancy L Pedersen, Michael Strober, Thomas Werge, David C Whiteman, D Blake Woodside, Jakob Grove, Anjali K Henders, Janne T Larsen, Richard Parker, Liselotte V Petersen, Jennifer Jordan, Martin A Kennedy, Andreas Birgegård, Paul Lichtenstein, Claes Norring, Mikael Landén, Preben Bo Mortensen, Renato Polimanti, Jeanette N McClintick, Amy E Adkins, Fazil Aliev, Silviu-Alin Bacanu, Anthony Batzler, Sarah Bertelsen, Joanna M Biernacka, Tim B Bigdeli, Li-Shiun Chen, Toni-Kim Clarke, Franziska Degenhardt, Anna R Docherty, Alexis C Edwards, Jerome C Foo, Louis Fox, Josef Frank, Laura M Hack, Annette M Hartmann, Sarah M Hartz, Stefanie Heilmann-Heimbach, Colin Hodgkinson, Per Hoffmann, Jouke-Jan Hottenga, Bettina Konte, Jari Lahti, Marius Lahti-Pulkkinen, Dongbing Lai, Lannie Ligthart, Anu Loukola, Brion S Maher, Hamdi Mbarek, Andrew M McIntosh, Matthew B McQueen, Jacquelyn L Meyers, Yuri Milaneschi, Teemu Palviainen, Roseann E Peterson, Euijung Ryu, Nancy L Saccone, Jessica E Salvatore, Sandra Sanchez-Roige, Melanie Schwandt, Richard Sherva, Fabian Streit, Jana Strohmaier, Nathaniel Thomas, Jen-Chyong Wang, Bradley T Webb, Robbee Wedow, Leah Wetherill, Amanda G Wills, Hang Zhou, Jason D Boardman, Danfeng Chen, Doo-Sup Choi, William E Copeland, Robert C Culverhouse, Norbert Dahmen, Louisa Degenhardt, Benjamin W Domingue, Mark A Frye, Wolfgang Gäbel, Caroline Hayward, Marcus Ising, Margaret Keyes, Falk Kiefer, Gabriele Koller, John Kramer, Samuel Kuperman, Susanne Lucae, Michael T Lynskey, Wolfgang Maier, Karl Mann, Satu Männistö, Bertram Müller-Myhsok, Alison D Murray, John I Nurnberger, Ulrich Preuss, Katri Räikkönen, Maureen D Reynolds, Monika Ridinger, Norbert Scherbaum, Marc A Schuckit, Michael Soyka, Jens Treutlein, Stephanie H Witt, Norbert Wodarz, Peter Zill, Daniel E Adkins, Dorret I Boomsma, Laura J Bierut, Sandra A Brown, Kathleen K Bucholz, E Jane Costello, Harriet de Wit, Nancy Diazgranados, Johan G Eriksson, Lindsay A Farrer, Tatiana M Foroud, Nathan A Gillespie, Alison M Goate, David Goldman, Richard A Grucza, Dana B Hancock, Kathleen Mullan Harris, Victor Hesselbrock, John K Hewitt, Christian J Hopfer, William G Iacono, Eric O Johnson, Victor M Karpyak, Kenneth S Kendler, Henry R Kranzler, Kenneth Krauter, Penelope A Lind, Matt McGue, James MacKillop, Pamela A F Madden, Hermine H Maes, Patrik K E Magnusson, Elliot C Nelson, Markus M Nöthen, Abraham A Palmer, Brenda W J H Penninx, Bernice Porjesz, John P Rice, Marcella Rietschel, Brien P Riley, Richard J Rose, Pei-Hong Shen, Judy Silberg, Michael C Stallings, Ralph E Tarter, Michael M Vanyukov, Scott Vrieze, Tamara L Wall, John B Whitfield, Hongyu Zhao, Benjamin M Neale, Tracey D Wade, Andrew C Heath, Grant W Montgomery, Nicholas G Martin, Patrick F Sullivan, Jaakko Kaprio, Gerome Breen, Joel Gelernter, Howard J Edenberg, Cynthia M Bulik, Arpana Agrawal
Eating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [rg ], twin-based = 0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge eating, AN without binge eating, and a bulimia nervosa factor score), and eight substance-use-related phenotypes (drinks per week, alcohol use disorder [AUD], smoking initiation, current smoking, cigarettes per day, nicotine dependence, cannabis initiation, and cannabis use disorder) from eight studies were included...
February 16, 2020: Addiction Biology
https://read.qxmd.com/read/32059838/physical-activity-trends-and-metabolic-health-outcomes-in-people-living-with-hiv-in-the-us-2008-2015
#3
REVIEW
Amanda L Willig, Allison R Webel, Andrew O Westfall, Emily B Levitan, Heidi M Crane, Thomas W Buford, Greer A Burkholder, James H Willig, Aaron J Blashill, Richard D Moore, W Christopher Mathews, Anne Zinski, Josh Muhammad, Elvin H Geng, Sonia Napravnik, Joseph J Eron, Benigno Rodriguez, Marcas M Bamman, E Turner Overton
Despite its potential to improve metabolic health outcomes, longitudinal physical activity (PA) patterns and their association with cardiometabolic disease among people living with HIV (PLWH) have not been well characterized. We investigated this relationship among PLWH in the Centers for AIDS Research Network of Integrated Clinical Systems with at least one PA self-report between 2008 and 2015. The 4-item Lipid Research Clinics PA instrument was used to categorize habitual PA levels as: Very Low, Low, Moderate, or High...
February 11, 2020: Progress in Cardiovascular Diseases
https://read.qxmd.com/read/31786980/severity-of-hypertension-mediates-the-association-of-hyperuricemia-with-stroke-in-the-regards-case-cohort-study
#4
Ninad S Chaudhary, S Louis Bridges, Kenneth G Saag, Elizabeth J Rahn, Jeffrey R Curtis, Angelo Gaffo, Nita A Limdi, Emily B Levitan, Jasvinder A Singh, Lisandro D Colantonio, George Howard, Mary Cushman, Matthew L Flaherty, Suzanne Judd, Marguerite R Irvin, Richard J Reynolds
Previous studies do not widely support hyperuricemia as a risk factor for stroke and other cardiovascular diseases. We assessed the relationship between hyperuricemia and ischemic stroke (≈900 cases) using a large data set from the REGARDS study (Reasons for Geographic and Racial Differences in Stroke). We employed a case-cohort design (incident stroke cases and randomly selected cohort participants) and weighted Cox-proportional hazard models to estimate the association of serum urate level ≥6.8 mg/dL (ie, hyperuricemia) and 6...
January 2020: Hypertension
https://read.qxmd.com/read/31781762/letermovir-resistance-analysis-in-a-clinical-trial-of-cytomegalovirus-prophylaxis-for-hematopoietic-stem-cell-transplant-recipients
#5
Cameron M Douglas, Richard Barnard, Daniel Holder, Randi Leavitt, Diane Levitan, Maureen Maguire, David Nickle, Valerie Teal, Hong Wan, Dirk C J G van Alewijk, Leen-Jan van Doorn, Sunwen Chou, Julie Strizki
BACKGROUND: Letermovir (LET), a cytomegalovirus (CMV) deoxyribonucleic acid (DNA) terminase inhibitor, was recently approved for prophylaxis of CMV infection in adult CMV-seropositive recipients of allogeneic hematopoietic stem cell transplantation. Cytomegalovirus genotyping was performed to identify LET-resistance-associated variants (RAVs) among subjects in a Phase 3 trial. METHODS: The CMV UL56 and UL89 genes, encoding subunits of CMV DNA terminase, were sequenced from plasma collected from subjects with clinically significant CMV infection (CS-CMVi)...
November 29, 2019: Journal of Infectious Diseases
https://read.qxmd.com/read/31619989/factors-and-situations-affecting-the-value-of-patient-preference-studies-semi-structured-interviews-in-europe-and-the-us
#6
Chiara Whichello, Eline van Overbeeke, Rosanne Janssens, Karin Schölin Bywall, Selena Russo, Jorien Veldwijk, Irina Cleemput, Juhaeri Juhaeri, Bennett Levitan, Jürgen Kübler, Meredith Smith, Richard Hermann, Matthias Englbrecht, Axel J Hueber, Alina Comanescu, Sarah Harding, Steven Simoens, Isabelle Huys, Esther W de Bekker-Grob
Objectives: Patient preference information (PPI) is gaining recognition among the pharmaceutical industry, regulatory authorities, and health technology assessment (HTA) bodies/payers for use in assessments and decision-making along the medical product lifecycle (MPLC). This study aimed to identify factors and situations that influence the value of patient preference studies (PPS) in decision-making along the MPLC according to different stakeholders. Methods: Semi-structured interviews (n = 143) were conducted with six different stakeholder groups (physicians, academics, industry representatives, regulators, HTA/payer representatives, and a combined group of patients, caregivers, and patient representatives) from seven European countries (the United Kingdom, Sweden, Italy, Romania, Germany, France, and the Netherlands) and the United States...
2019: Frontiers in Pharmacology
https://read.qxmd.com/read/31308545/genome-wide-association-study-identifies-eight-risk-loci-and-implicates-metabo-psychiatric-origins-for-anorexia-nervosa
#7
Hunna J Watson, Zeynep Yilmaz, Laura M Thornton, Christopher Hübel, Jonathan R I Coleman, Héléna A Gaspar, Julien Bryois, Anke Hinney, Virpi M Leppä, Manuel Mattheisen, Sarah E Medland, Stephan Ripke, Shuyang Yao, Paola Giusti-Rodríguez, Ken B Hanscombe, Kirstin L Purves, Roger A H Adan, Lars Alfredsson, Tetsuya Ando, Ole A Andreassen, Jessica H Baker, Wade H Berrettini, Ilka Boehm, Claudette Boni, Vesna Boraska Perica, Katharina Buehren, Roland Burghardt, Matteo Cassina, Sven Cichon, Maurizio Clementi, Roger D Cone, Philippe Courtet, Scott Crow, James J Crowley, Unna N Danner, Oliver S P Davis, Martina de Zwaan, George Dedoussis, Daniela Degortes, Janiece E DeSocio, Danielle M Dick, Dimitris Dikeos, Christian Dina, Monika Dmitrzak-Weglarz, Elisa Docampo, Laramie E Duncan, Karin Egberts, Stefan Ehrlich, Geòrgia Escaramís, Tõnu Esko, Xavier Estivill, Anne Farmer, Angela Favaro, Fernando Fernández-Aranda, Manfred M Fichter, Krista Fischer, Manuel Föcker, Lenka Foretova, Andreas J Forstner, Monica Forzan, Christopher S Franklin, Steven Gallinger, Ina Giegling, Johanna Giuranna, Fragiskos Gonidakis, Philip Gorwood, Monica Gratacos Mayora, Sébastien Guillaume, Yiran Guo, Hakon Hakonarson, Konstantinos Hatzikotoulas, Joanna Hauser, Johannes Hebebrand, Sietske G Helder, Stefan Herms, Beate Herpertz-Dahlmann, Wolfgang Herzog, Laura M Huckins, James I Hudson, Hartmut Imgart, Hidetoshi Inoko, Vladimir Janout, Susana Jiménez-Murcia, Antonio Julià, Gursharan Kalsi, Deborah Kaminská, Jaakko Kaprio, Leila Karhunen, Andreas Karwautz, Martien J H Kas, James L Kennedy, Anna Keski-Rahkonen, Kirsty Kiezebrink, Youl-Ri Kim, Lars Klareskog, Kelly L Klump, Gun Peggy S Knudsen, Maria C La Via, Stephanie Le Hellard, Robert D Levitan, Dong Li, Lisa Lilenfeld, Bochao Danae Lin, Jolanta Lissowska, Jurjen Luykx, Pierre J Magistretti, Mario Maj, Katrin Mannik, Sara Marsal, Christian R Marshall, Morten Mattingsdal, Sara McDevitt, Peter McGuffin, Andres Metspalu, Ingrid Meulenbelt, Nadia Micali, Karen Mitchell, Alessio Maria Monteleone, Palmiero Monteleone, Melissa A Munn-Chernoff, Benedetta Nacmias, Marie Navratilova, Ioanna Ntalla, Julie K O'Toole, Roel A Ophoff, Leonid Padyukov, Aarno Palotie, Jacques Pantel, Hana Papezova, Dalila Pinto, Raquel Rabionet, Anu Raevuori, Nicolas Ramoz, Ted Reichborn-Kjennerud, Valdo Ricca, Samuli Ripatti, Franziska Ritschel, Marion Roberts, Alessandro Rotondo, Dan Rujescu, Filip Rybakowski, Paolo Santonastaso, André Scherag, Stephen W Scherer, Ulrike Schmidt, Nicholas J Schork, Alexandra Schosser, Jochen Seitz, Lenka Slachtova, P Eline Slagboom, Margarita C T Slof-Op 't Landt, Agnieszka Slopien, Sandro Sorbi, Beata Świątkowska, Jin P Szatkiewicz, Ioanna Tachmazidou, Elena Tenconi, Alfonso Tortorella, Federica Tozzi, Janet Treasure, Artemis Tsitsika, Marta Tyszkiewicz-Nwafor, Konstantinos Tziouvas, Annemarie A van Elburg, Eric F van Furth, Gudrun Wagner, Esther Walton, Elisabeth Widen, Eleftheria Zeggini, Stephanie Zerwas, Stephan Zipfel, Andrew W Bergen, Joseph M Boden, Harry Brandt, Steven Crawford, Katherine A Halmi, L John Horwood, Craig Johnson, Allan S Kaplan, Walter H Kaye, James E Mitchell, Catherine M Olsen, John F Pearson, Nancy L Pedersen, Michael Strober, Thomas Werge, David C Whiteman, D Blake Woodside, Garret D Stuber, Scott Gordon, Jakob Grove, Anjali K Henders, Anders Juréus, Katherine M Kirk, Janne T Larsen, Richard Parker, Liselotte Petersen, Jennifer Jordan, Martin Kennedy, Grant W Montgomery, Tracey D Wade, Andreas Birgegård, Paul Lichtenstein, Claes Norring, Mikael Landén, Nicholas G Martin, Preben Bo Mortensen, Patrick F Sullivan, Gerome Breen, Cynthia M Bulik
Characterized primarily by a low body-mass index, anorexia nervosa is a complex and serious illness1 , affecting 0.9-4% of women and 0.3% of men2-4 , with twin-based heritability estimates of 50-60%5 . Mortality rates are higher than those in other psychiatric disorders6 , and outcomes are unacceptably poor7 . Here we combine data from the Anorexia Nervosa Genetics Initiative (ANGI)8,9 and the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED) and conduct a genome-wide association study of 16,992 cases of anorexia nervosa and 55,525 controls, identifying eight significant loci...
August 2019: Nature Genetics
https://read.qxmd.com/read/31222436/patient-preferences-in-the-medical-product-life-cycle-what-do-stakeholders-think-semi-structured-qualitative-interviews-in-europe-and-the-usa
#8
Rosanne Janssens, Selena Russo, Eline van Overbeeke, Chiara Whichello, Sarah Harding, Jürgen Kübler, Juhaeri Juhaeri, Karin Schölin Bywall, Alina Comanescu, Axel Hueber, Matthias Englbrecht, Nikoletta Nikolenko, Gabriella Pravettoni, Steven Simoens, Hilde Stevens, Richard Hermann, Bennett Levitan, Irina Cleemput, Esther de Bekker-Grob, Jorien Veldwijk, Isabelle Huys
BACKGROUND: Patient preferences (PP), which are investigated in PP studies using qualitative or quantitative methods, are a growing area of interest to the following stakeholders involved in the medical product lifecycle: academics, health technology assessment bodies, payers, industry, patients, physicians, and regulators. However, the use of PP in decisions along the medical product lifecycle remains limited. As the adoption of PP heavily relies on these stakeholders, knowledge of their perceptions of PP is critical...
June 21, 2019: Patient
https://read.qxmd.com/read/30586736/potential-cardiovascular-disease-events-prevented-with-adoption-of-the-2017-american-college-of-cardiology-american-heart-association-blood-pressure-guideline
#9
COMPARATIVE STUDY
Adam P Bress, Lisandro D Colantonio, Richard S Cooper, Holly Kramer, John N Booth, Michelle C Odden, Kirsten Bibbins-Domingo, Daichi Shimbo, Paul K Whelton, Emily B Levitan, George Howard, Brandon K Bellows, Dawn Kleindorfer, Monika M Safford, Paul Muntner, Andrew E Moran
BACKGROUND: Over 10 years, achieving and maintaining 2017 ACC/AHA guideline goals could prevent 3.0 million (UR, 1.1-5.1 million), 0.5 million (UR, 0.2-0.7 million), and 1.4 million (UR, 0.6-2.0 million) cardiovascular disease (CVD) events compared with maintaining current blood pressure (BP) levels, achieving 2003 Seventh Joint National Committee Report goals, and achieving 2014 Eighth Joint National Committee goals, respectively. We estimated the number of cardiovascular disease events prevented and treatment-related serious adverse events incurred over 10 years among US adults with hypertension by achieving 2017 ACC/AHA guideline-recommended BP goals compared with (1) current BP levels, (2) achieving 2003 Seventh Joint National Committee Report BP goals, and (3) achieving 2014 Eighth Joint National Committee panel member report BP goals...
January 2, 2019: Circulation
https://read.qxmd.com/read/30051097/clinical-cadavers-as-a-simulation-resource-for-procedural-learning
#10
George Kovacs, Richard Levitan, Rob Sandeski
"See one, do one, teach one" remains an unofficial, unsanctioned framework for procedural skill learning in medicine. Appropriately, medical educators have sought alternative simulation venues for students to safely learn their craft. With the end goal of ensuring competence, educational programming will require the use of valid simulation with appropriate fidelity. While cadavers have been used for teaching anatomy for hundreds of years, more recently they are being repurposed as a "high-fidelity" procedural skill learning simulation resource...
July 2018: AEM Education and Training
https://read.qxmd.com/read/29729684/paramedics-perspectives-on-factors-impacting-on-scene-times-for-trauma-calls
#11
Mark Levitan, Madelyn P Law, Richard Ferron, Karen Lutz-Graul
IntroductionAccording to Ontario, Canada's Basic Life Support Patient Care Standards, Emergency Medical Services (EMS) on-scene time (OST) for trauma calls should not exceed 10 minutes, unless there are extenuating circumstances. The time to definitive care can have a significant impact on the morbidity and mortality of trauma patients. This is the first Canadian study to investigate why this is the case by giving a voice to those most involved in prehospital care: the paramedics themselves. It is also the first study to explore this issue from a complex, adaptive systems approach which recognizes that OSTs may be impacted by local, contextual features...
June 2018: Prehospital and Disaster Medicine
https://read.qxmd.com/read/29506743/net-clinical-benefit-of-rivaroxaban-compared-with-warfarin-in-atrial-fibrillation-results-from-rocket-af
#12
RANDOMIZED CONTROLLED TRIAL
Adam S Barnett, Derek D Cyr, Shaun G Goodman, Bennett S Levitan, Zhong Yuan, Graeme J Hankey, Daniel E Singer, Richard C Becker, Günter Breithardt, Scott D Berkowitz, Jonathan L Halperin, Werner Hacke, Kenneth W Mahaffey, Christopher C Nessel, Keith A A Fox, Manesh R Patel, Jonathan P Piccini
AIMS: The aim of this study was to determine the net clinical benefit (NCB) of rivaroxaban compared with warfarin in patients with atrial fibrillation. METHODS: This was a retrospective analysis of 14,236 patients included in ROCKET AF who received at least one dose of study drug. We analyzed NCB using four different methods: (1) composite of death, stroke, systemic embolism, myocardial infarction, and major bleeding; (2) method 1 with fatal or critical organ bleeding substituted for major bleeding; (3) difference between the rate of ischemic stroke or systemic embolism minus 1...
April 15, 2018: International Journal of Cardiology
https://read.qxmd.com/read/29062039/a-brain-penetrant-mutant-idh1-inhibitor-provides-in-vivo-survival-benefit
#13
Johnny Kopinja, Raquel S Sevilla, Diane Levitan, David Dai, Amy Vanko, Edward Spooner, Chris Ware, Robert Forget, Kun Hu, Astrid Kral, Peter Spacciapoli, Richard Kennan, Lata Jayaraman, Vincenzo Pucci, Samanthi Perera, Weisheng Zhang, Christian Fischer, Michael H Lam
Mutations in IDH1 are highly prevalent in human glioma. First line treatment is radiotherapy, which many patients often forego to avoid treatment-associated morbidities. The high prevalence of IDH1 mutations in glioma highlights the need for brain-penetrant IDH1 mutant-selective inhibitors as an alternative therapeutic option. Here, we have explored the utility of such an inhibitor in IDH1 mutant patient-derived models to assess the potential therapeutic benefits associated with intracranial 2-HG inhibition...
October 23, 2017: Scientific Reports
https://read.qxmd.com/read/29025707/proatherogenic-flow-increases-endothelial-stiffness-via-enhanced-cd36-mediated-uptake-of-oxidized-low-density-lipoproteins
#14
Elizabeth Le Master, Ru-Ting Huang, Chongxu Zhang, Yedida Bogachkov, Cassandre Coles, Tzu-Pin Shentu, Yue Sheng, Ibra S Fancher, Carlos Ng, Theodore Christoforidis, Pappasani V Subbaiah, Evgeny Berdyshev, Zhijian Qain, David T Eddington, James Lee, Michael Cho, Yun Fang, Richard D Minshall, Irena Levitan
OBJECTIVE: Disturbed flow (DF) is well-known to induce endothelial dysfunction and synergistically with plasma dyslipidemia facilitate plaque formation. Little is known, however, about the synergistic impact of DF and dyslipidemia on endothelial biomechanics. Our goal was to determine the impact of DF on endothelial stiffness and evaluate the role of dyslipidemia/oxLDL (oxidized low-density lipoprotein) in this process. APPROACH AND RESULTS: Endothelial elastic modulus of intact mouse aortas ex vivo and of human aortic endothelial cells exposed to laminar flow or DF was measured using atomic force microscopy...
January 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/28521765/inhibition-of-o-glcnacase-leads-to-elevation-of-o-glcnac-tau-and-reduction-of-tauopathy-and-cerebrospinal-fluid-tau-in-rtg4510-mice
#15
Nicholas B Hastings, Xiaohai Wang, Lixin Song, Brent D Butts, Diane Grotz, Richard Hargreaves, J Fred Hess, Kwok-Lam Karen Hong, Cathy Ruey-Ruey Huang, Lynn Hyde, Maureen Laverty, Julie Lee, Diane Levitan, Sherry X Lu, Maureen Maguire, Veeravan Mahadomrongkul, Ernest J McEachern, Xuesong Ouyang, Thomas W Rosahl, Harold Selnick, Michaela Stanton, Giuseppe Terracina, David J Vocadlo, Ganfeng Wang, Joseph L Duffy, Eric M Parker, Lili Zhang
BACKGROUND: Hyperphosphorylation of microtubule-associated protein tau is a distinct feature of neurofibrillary tangles (NFTs) that are the hallmark of neurodegenerative tauopathies. O-GlcNAcylation is a lesser known post-translational modification of tau that involves the addition of N-acetylglucosamine onto serine and threonine residues. Inhibition of O-GlcNAcase (OGA), the enzyme responsible for the removal of O-GlcNAc modification, has been shown to reduce tau pathology in several transgenic models...
May 18, 2017: Molecular Neurodegeneration
https://read.qxmd.com/read/28168630/airway-management-outside-the-operating-room-how-to-better-prepare
#16
Peter G Brindley, Martin Beed, J Adam Law, Orlando Hung, Richard Levitan, Michael F Murphy, Laura V Duggan
Airway management outside the operating room is associated with increased risks compared with airway management inside the operating room. Moreover, airway management-whether in the intensive care unit, emergency department, interventional radiology suite, or general wards-often requires mastery of not only the anatomically difficult airway but also the physiologically and situationally difficult airway. The 2015 Difficult Airway Society Guidelines encourage the airway team to "stop and think". This article provides a practical review of how that evidence applies during emergency airway management outside of the operating room...
May 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://read.qxmd.com/read/27730014/national-institute-of-biomedical-imaging-and-bioengineering-point-of-care-technology-research-network-advancing-precision-medicine
#17
Penny Ford Carleton, Steven Schachter, John A Parrish, John M Collins, J Benjamin Crocker, Ronald F Dixon, Susan Edgman-Levitan, Kent B Lewandrowski, James E Stahl, Catherine Klapperich, Mario Cabodi, Charlotte A Gaydos, Anne M Rompalo, Yukari Manabe, Tza-Huei Wang, Richard Rothman, Chris D Geddes, Lea Widdice, Joany Jackman, Rishi A Mathura, Tiffani Bailey Lash
To advance the development of point-of-care technology (POCT), the National Institute of Biomedical Imaging and Bioengineering established the POCT Research Network (POCTRN), comprised of Centers that emphasize multidisciplinary partnerships and close facilitation to move technologies from an early stage of development into clinical testing and patient use. This paper describes the POCTRN and the three currently funded Centers as examples of academic-based organizations that support collaborations across disciplines, institutions, and geographic regions to successfully drive innovative solutions from concept to patient care...
2016: IEEE Journal of Translational Engineering in Health and Medicine
https://read.qxmd.com/read/27487782/clinical-presentation-and-outcomes-associated-with-different-treatment-modalities-for-pediatric-bark-scorpion-envenomation
#18
Vasanth Coorg, Rachel D Levitan, Richard D Gerkin, Jared Muenzer, Anne-Michelle Ruha
INTRODUCTION: Scorpion envenomation is potentially life-threatening and affects children in the Southwestern USA. An FDA-approved antivenom is available, but its high cost has led to use of off-label antivenom dosing or supportive care alone as alternatives to FDA-recommended dosing. This study sought to determine whether treatment approach influences outcomes in envenomated children. METHODS: A retrospective cohort study of children with grade III or IV scorpion envenomation evaluated in Phoenix Children's Hospital ED between September 1, 2011, and March 31, 2014...
March 2017: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://read.qxmd.com/read/26912737/impact-of-driving-cessation-on-trajectories-of-life-space-scores-among-community-dwelling-older-adults
#19
Carrie Huisingh, Emily B Levitan, Patricia Sawyer, Richard Kennedy, Cynthia J Brown, Gerald McGwin
The purpose of this study was to examine the trajectories of life-space before and after the transition to driving cessation among a diverse sample of community-dwelling older adults. Life-space scores and self-reported driving cessation were assessed at annual visits from baseline through Year 6 among participants in the University of Alabama at Birmingham Study of Aging. Approximately 58% of older adults reported having stopped driving during the 6 years of follow-up. After adjusting for potential confounders, results from a random intercept model indicate that mean life-space scores decreased about 1 to 2 points every year ( p = ...
December 2017: Journal of Applied Gerontology: the Official Journal of the Southern Gerontological Society
https://read.qxmd.com/read/25601651/moesin-and-myosin-phosphatase-confine-neutrophil-orientation-in-a-chemotactic-gradient
#20
Xiaowen Liu, Tao Yang, Koya Suzuki, Sachiko Tsukita, Masaru Ishii, Shuping Zhou, Gang Wang, Luyang Cao, Feng Qian, Shalina Taylor, Myung-Jin Oh, Irena Levitan, Richard D Ye, Graeme K Carnegie, Yong Zhao, Asrar B Malik, Jingsong Xu
Neutrophils respond to invading bacteria by adopting a polarized morphology, migrating in the correct direction, and engulfing the bacteria. How neutrophils establish and precisely orient this polarity toward pathogens remains unclear. Here we report that in resting neutrophils, the ERM (ezrin, radixin, and moesin) protein moesin in its active form (phosphorylated and membrane bound) prevented cell polarization by inhibiting the small GTPases Rac, Rho, and Cdc42. Attractant-induced activation of myosin phosphatase deactivated moesin at the prospective leading edge to break symmetry and establish polarity...
February 9, 2015: Journal of Experimental Medicine
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