William D Thompson, Robin N Beaumont, Alan Kuang, Nicole M Warrington, Yingjie Ji, Jessica Tyrrell, Andrew R Wood, Denise M Scholtens, Bridget A Knight, David M Evans, William L Lowe, Gillian Santorelli, Rafaq Azad, Dan Mason, Andrew T Hattersley, Timothy M Frayling, Hanieh Yaghootkar, Maria Carolina Borges, Deborah A Lawlor, Rachel M Freathy
AIMS/HYPOTHESIS: Higher maternal BMI during pregnancy is associated with higher offspring birthweight, but it is not known whether this is solely the result of adverse metabolic consequences of higher maternal adiposity, such as maternal insulin resistance and fetal exposure to higher glucose levels, or whether there is any effect of raised adiposity through non-metabolic (e.g. mechanical) factors. We aimed to use genetic variants known to predispose to higher adiposity, coupled with a favourable metabolic profile, in a Mendelian randomisation (MR) study comparing the effect of maternal 'metabolically favourable adiposity' on offspring birthweight with the effect of maternal general adiposity (as indexed by BMI)...
September 20, 2021: Diabetologia