keyword
https://read.qxmd.com/read/38368748/white-matter-microstructural-alterations-in-patients-with-anti-n-methyl-d-aspartate-receptor-encephalitis-a-tract-based-spatial-statistics-study
#21
JOURNAL ARTICLE
Xiaoxuan Wang, Yi Yin, Xinzhi Wang, Guang Xu, Junzhang Tian, Xiaofen Ma
BACKGROUND: Cognitive impairment is common in patients with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis; however, neural mechanisms underlying this impairment remain unclear. Diffusion tensor imaging (DTI) is a potential method for studying the condition of white matter fibers in patients with anti-NMDAR encephalitis, allowing for an analysis of the neuroimaging mechanisms of cognitive impairment in conjunction with cognitive scales. This study aimed to explore white matter microstructural alterations and their correlation with cognitive function in patients with anti-NMDAR encephalitis...
February 12, 2024: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/38363500/functional-connectivity-changes-of-the-hippocampal-subregions-in-anti-n-methyl-d-aspartate-receptor-encephalitis
#22
JOURNAL ARTICLE
Yujie Yang, Shishun Fu, Guihua Jiang, Guang Xu, Junzhang Tian, Xiaofen Ma
The hippocampus plays an important role in the pathophysiological mechanism of Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis. Nevertheless, the connection between the resting-state activity of the hippocampal subregions and neuropsychiatric disorders in patients remains unclear. This study aimed to explore the changes in functional connectivity (FC) in the hippocampal subregions of patients with anti-NMDAR encephalitis and its association with clinical symptoms and cognitive performance. Twenty-three patients with anti-NMDAR encephalitis and 23 healthy controls (HC) were recruited...
February 16, 2024: Brain Imaging and Behavior
https://read.qxmd.com/read/38355204/ovarian-teratoma-associated-anti-nmda-receptor-encephalitis-with-severe-features
#23
JOURNAL ARTICLE
Antanina Voit, Ashley Graziano, Andrew Schomer, Danny Theodore
Anti-N-methyl-D-aspartame receptor (NMDAR) encephalitis is an uncommon clinical entity for the general intensivist or neurologist. Diagnosis can be made by the presence of cerebrospinal fluid IgG antibody against the GluNR1 and GluNR2 subunits of the NMDAR. We present a case of anti-NMDAR encephalitis in a young woman with an ovarian teratoma treated with surgical resection and multiple immunomodulatory therapies.
February 14, 2024: BMJ Case Reports
https://read.qxmd.com/read/38349905/pediatric-anti-n-methyl-d-aspartate-receptor-nmdar-encephalitis-exploring-psychosis-related-risk-factors-and-hospital-outcomes-in-a-nationwide-inpatient-sample-a-cross-sectional-study
#24
JOURNAL ARTICLE
Sanobar Jaka, Sukhnoor Singh, Sreshatha Vashist, Sandesh Pokhrel, Ericka Saldana, Albulena Sejdiu, Sanjana Taneja, Abimbola Arisoyin, Raja Mogallapu, Sasidhar Gunturu, Anil Bachu, Rikinkumar S Patel
OBJECTIVE: Our study aims to examine the risk factors for comorbid psychosis in pediatric patients hospitalized for anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis and its impact on hospital outcomes. METHODS: We conducted a cross-sectional study using the nationwide inpatient sample (NIS 2018-2019). We included 3,405 pediatric inpatients (age 6-17 years) with a primary discharge diagnosis of anti-NMDAR encephalitis. We used binomial logistic regression model to evaluate the odds ratio (OR) of variables (demographic and comorbidities) associated with comorbid psychosis...
2024: PloS One
https://read.qxmd.com/read/38322089/overview-of-paraneoplastic-autoantibody-mediated-cognitive-impairment-and-behavioral-changes-a-narrative-review
#25
REVIEW
Duaa Alkhayat, Zakaria Y Khawaji, Amal M Sunyur, Omnyah A Sanyour, Ahmad S Badawi
Cognitive dysfunction and behavioral change can be some of the manifestations of cancer, occurring as a part of paraneoplastic neurological syndrome, most commonly in small cell lung cancer. Paraneoplastic limbic encephalitis is the leading cause of cognitive disturbance and abnormal behavior in paraneoplastic syndromes, which is usually autoantibody-mediated. Autoantibodies are the main contributors to the development of cognitive dysfunction and behavioral change in cancer patients, with studies suggesting a higher liability for antibody-positive cancer patients to be affected...
January 2024: Curēus
https://read.qxmd.com/read/38310417/anti-n-methyl-d-aspartate-receptor-encephalitis-following-chadox1-ncov-19-vaccination-a-case-report
#26
JOURNAL ARTICLE
Zahra Liyaghatdar, Amirhosein Rahimkhani, Amin Liaghatdar
As of December 2020, millions of people have been immunized using vaccines against SARS-CoV-2. A wide range of neurological adverse effects of SARS-CoV-2 vaccines have been reported so far. Here, we report a 23-year-old male who experienced psychiatric symptoms, loss of consciousness, language disintegration, and incontinency that happened 10 days after the first dosage of the COVID-19 AstraZeneca vaccine. Anti-NMDAR Encephalitis was diagnosed based on the results of the autoimmune panel. The patient responded to intravenous dexamethasone very well and experienced no other complications in 6 months of follow-up...
October 1, 2023: Archives of Iranian Medicine
https://read.qxmd.com/read/38298637/a-peptide-from-the-japanese-encephalitis-virus-failed-to-induce-the-production-of-anti-n-methyl-d-aspartate-receptor-antibodies-via-molecular-mimicry-in-mice
#27
JOURNAL ARTICLE
Hanyu Luo, Jiaxin Yang, Xiaoyue Yang, Ziyao Han, Zhixu Fang, Dishu Huang, Jianxiong Gui, Ran Ding, Hengsheng Chen, Li Cheng, Jiannan Ma, Li Jiang
BACKGROUND: The development of anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis following viral encephalitis, such as Japanese encephalitis, has received increasing attention in recent years. However, the mechanism of anti-NMDAR antibody production following Japanese encephalitis has not been explored. METHODS: A peptide from the Japanese encephalitis virus (JEV), which shares a similar amino acid sequence with GluN1, was identified by sequence comparison...
January 30, 2024: Heliyon
https://read.qxmd.com/read/38291273/blood-and-csf-anti-neuronal-antibodies-testing-in-psychotic-syndromes-a-retrospective-analysis-from-a-tertiary-psychiatric-hospital
#28
JOURNAL ARTICLE
Joana Lopes, Maria João Malaquias, Joana Freitas, Rodrigo Valido, Paula Carneiro, Esmeralda Neves, Ana Maria Moreira, Raquel Samões, Ernestina Santos, Ana Paula Correia
A Consensus of Psychoimmunology Experts (Pollak et al., 2019) established a set of red flags and proposed diagnostic criteria for psychosis of autoimmune origin (AIP). Previous studies on AIP are limited by the scarcity of CSF analysis, preventing the valorization of blood anti-neuronal antibodies (Ab). The aims of this study are to determine the relative frequency and characterize AIP in a cohort of psychotic patients that underwent CSF workup. This work is a retrospective study in a tertiary psychiatric hospital...
January 31, 2024: Immunologic Research
https://read.qxmd.com/read/38288050/paraneoplastic-nmda-encephalitis-a-case-report-and-an-extensive-review-of-available-literature
#29
Hamza Alzghoul, Ferdous Kadri, Mohamed F Ismail, Robeer Youssef, Mustafa Shamaileh, Ahmad R Al-Assi, Liliya Adzhieva, Bashar Alzghoul
Anti-N-methyl-D-aspartate receptor (NMDAr) encephalitis is a prevalent autoimmune condition marked by diverse neuropsychiatric symptoms, primarily impacting young females. The exact mechanisms underlying the development of NMDAr encephalitis have not been fully elucidated. Nonetheless, studies have demonstrated that auto-antibodies targeting the NR1-NR2 subunits of the NMDAr can trigger receptor dysfunction within the central nervous system, thus giving rise to the associated symptoms. Notably, an association exists between NMDAr encephalitis and an underlying neoplastic condition, with approximately 38% of cases exhibiting this paraneoplastic relationship with ovarian teratomas being the most commonly associated malignancy...
April 2024: Radiology Case Reports
https://read.qxmd.com/read/38285059/refractory-anti-n-methyl-d-aspartate-receptor-autoimmune-encephalitis-induced-by-ovarian-teratoma-a-case-report
#30
JOURNAL ARTICLE
Rui Zhang, Xuemei Zhao, Wenjing Li, Yu Gao
OBJECTIVE: Teratoma is a type of germ cell tumor that derived from early embryonic stem cells and germ cell lines, which can lead to a rare complication known as paraneoplastic encephalitis syndrome. Delayed removal of teratoma allows for continuing antigen presentation, inducing affinity maturation of the antibody and the generation of long-lived plasma cells that infiltrate both bone marrow and brain, which makes the patient nonresponsive to later removal of teratoma and refractory to immunotherapy...
January 16, 2024: Clinical Neuropharmacology
https://read.qxmd.com/read/38280087/amyloid-and-tau-as-cerebrospinal-fluid-biomarkers-in-anti-n-methyl-d-aspartate-receptor-encephalitis
#31
JOURNAL ARTICLE
Qianmeng Hao, Zhe Gong, Yajun Song, Yali Wang, Weiwei Meng, Wei Wu, Yanfei Li, Yulin Zhang
INTRODUCTION: Neuroinfection is associated with the deposition of amyloid-beta (Aβ) peptides, and subsequent decrease in cerebrospinal fluid (CSF) amyloid levels. However, whether autoimmune encephalitis involves extracellular deposition of Aβ peptides in the brain is unreported. METHODS: We examined CSF amyloid and tau values in adults with anti-N-methyl-D-aspartate receptor encephalitis (NMDAR-E). Forty-two patients with NMDAR-E, 35 patients with viral and bacterial neuroinfections, and 16 controls were included...
January 27, 2024: Neurological Sciences
https://read.qxmd.com/read/38264516/n-methyl-d-aspartate-receptor-encephalitis-post-herpes-encephalitis-in-two-pediatric-cases
#32
Amna Al Futaisi, Wafa Bani Uraba, Naji Al Dhawi, Eiman Al Ajmi, Mahmood Al Kindi, Jalila Al Shukaili, Azza Al Adi
Commonly, herpes simplex virus (HSV) causes infectious encephalitis among children. A neurological relapse after primary HSV encephalitis in the weeks or months after presentation is well recognized. Relapsing symptoms of post-HSV encephalitis can present either as a true relapse or an immune-mediated disorder. A relationship is predicted between immune-mediated disorder and N-methyl-D-aspartate receptor (NMDAR) antibodies. This study presents two cases of patients suffering from anti-NMDAR encephalitis that appeared after treatment for proven HSV encephalitis...
November 2023: Oman Medical Journal
https://read.qxmd.com/read/38235029/anti-nmda-receptor-encephalitis-presenting-as-a-progression-of-disease-in-a-patient-with-underlying-congenital-leukodystrophy-case-report
#33
Garrett Friedman, James Hammock, Niki Holtzman-Hayes, Lauren Gluck
Anti-NMDA Receptor (NMDAR) Encephalitis (NMDARE) is an autoimmune disorder that is often debilitating and difficult to diagnose. Patients, especially those with underlying neuropsychiatric disorders, may experience delayed or misdiagnosis of NMDARE. Here, we report on a patient with known congenital leukodystrophy (CLD) and epilepsy with a challenging diagnosis of NMDARE. The patient first presented with progressive behavior changes and seizure-like episodes. Initial workup, including video EEG and brain MRI, were mostly unremarkable, and the patient's symptoms were resistant to treatment with multiple anti-epileptic drugs...
January 2024: Neurohospitalist
https://read.qxmd.com/read/38202213/a-near-fatal-encounter-with-acute-suicidal-behavior-in-anti-n-methyl-d-aspartate-autoimmune-encephalitis
#34
Eunmi Lee, Minjee Kim, Kyu-Hyouck Kyoung, Jin Yong Jun
Anti-N-methyl-D-aspartate receptor encephalitis (anti-NMDARE) is a complex neuropsychiatric syndrome known for its diverse neurological manifestations, often involving psychiatric symptoms and seizures that elevate the risk of suicidal ideation and behavior. We present a case illustrating the potentially lethal nature of anti-NMDARE, wherein an unexpected suicide attempt occurred 10 days after the onset of seizures in a 21-year-old man. Upon arrival at the emergency room, immediate interventions addressed hypovolemic shock, followed by subsequent neurosurgical and orthopedic procedures...
December 29, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/38194197/sudden-unexpected-death-in-epilepsy-and-ictal-asystole-in-patients-with-autoimmune-encephalitis-a-systematic-review
#35
JOURNAL ARTICLE
Alberto Vogrig, Fabrizio Bellizzi, Alessandra Burini, Gian Luigi Gigli, Luca Girardi, Jérôme Honnorat, Mariarosaria Valente
OBJECTIVE: As autoimmune encephalitis (AE) often involves the mesial temporal structures which are known to be involved in both sudden unexpected death in epilepsy (SUDEP) and ictal asystole (IA), it may represent a good model to study the physiopathology of these phenomena. Herein, we systematically reviewed the occurrence of SUDEP and IA in AE. METHODS: We searched 4 databases (MEDLINE, Scopus, Embase, and Web of Science) for studies published between database inception and December 20, 2022, according to the PRISMA guidelines...
January 9, 2024: Neurological Sciences
https://read.qxmd.com/read/38173540/anti-nmdar-encephalitis-clinical-practice-guideline-improving-time-to-diagnosis-treatment-and-hospital-length-of-stay
#36
JOURNAL ARTICLE
Kelsey M Barter, Catherine Fuchs, Thomas B Graham, Lindsay M Pagano, McKenzie Vater
BACKGROUND AND OBJECTIVES: A clinical practice guideline (CPG) was created to standardize evaluation and treatment for patients with suspected anti-methyl-d-aspartate receptor (NMDAR) autoimmune encephalitis (AE), the most common AE in children. The objective of this study was to evaluate the CPG effect on time to diagnosis, treatment, and hospital length of stay (LOS). METHODS: Patients with an inpatient consult to pediatric rheumatology for AE during a 4-year period (period 2) after CPG implementation were identified...
February 2024: Neurology. Clinical Practice
https://read.qxmd.com/read/38155066/electroconvulsive-therapy-for-catatonia-in-anti-nmda-receptor-encephalitis-a-case-series
#37
JOURNAL ARTICLE
Lara Wadi, Vishal Mandge
BACKGROUND: Anti-NMDAR encephalitis is the most common cause of immune-mediated catatonia. CASE SERIES: Three females presented with neuropsychiatric symptoms and were empirically treated with first-line immunotherapy and ovarian teratoma resection for suspected autoimmune encephalitis, preceding diagnostic confirmation via NMDAR antibody positivity. They required escalating large doses of benzodiazepines for refractory malignant catatonia resulting in ICU level care...
December 22, 2023: Journal of Neuroimmunology
https://read.qxmd.com/read/38152405/clinical-characteristics-and-prognosis-in-patients-with-neuronal-surface-antibody-mediated-autoimmune-encephalitis-a-single-center-cohort-study-in-china
#38
JOURNAL ARTICLE
Teng Huang, Fei Liu, Baojie Wang, Chunjuan Wang, Maolin Hao, Shougang Guo
OBJECTIVE: This retrospective observational study primarily aimed to analyse the clinical characteristics of patients with neuronal surface antibody-mediated autoimmune encephalitis (AE) in China and report their prognosis after immunotherapy. METHODS: Clinical characteristics, laboratory or imaging examinations, and treatment outcomes of 103 patients diagnosed with AE between 1 September 2014 and 31 December 2020 were collected. Univariate and multivariate logistic regression analyses were performed to determine the predictors of poor prognosis...
2023: Frontiers in Immunology
https://read.qxmd.com/read/38151160/examining-the-features-of-neuroleptic-malignant-syndrome-in-anti-nmda-receptor-encephalitis-a-case-control-study
#39
JOURNAL ARTICLE
Jesus Ramirez-Bermudez, Miguel Restrepo-Martinez, Mariana Espinola-Nadurille, Victoria Martinez-Angeles, Juan Carlos Lopez-Hernandez, Laura E Hernandez-Vanegas, Francisco Martinez-Carrillo, Ramiro Ruiz-Garcia, Veronica Rivas-Alonso, Jose Flores-Rivera, Thomas A Pollak
BACKGROUND: Anti-N-methyl-D-aspartate receptor encephalitis (ANMDARE) is a neuroimmunological disorder that frequently improves with immunotherapy. Symptomatic treatment with antipsychotics is common in the early stages when psychiatric symptoms predominate, and their use has been associated with serious side effects including neuroleptic malignant syndrome (NMS). The observation of an adverse response to antipsychotics, raising the suspicion of NMS, has been included as a criterion for possible autoimmune psychosis...
December 25, 2023: Journal of the Academy of Consultation—Liaison Psychiatry
https://read.qxmd.com/read/38145121/anti-nmdar-antibodies-the-blood-brain-barrier-and-anti-nmdar-encephalitis
#40
REVIEW
Xiarong Gong, Niya Wang, Hongyan Zhu, Ning Tang, Kunhua Wu, Qiang Meng
Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is an antibody-related autoimmune encephalitis. It is characterized by the existence of antibodies against NMDAR, mainly against the GluN1 subunit, in cerebrospinal fluid (CSF). Recent research suggests that anti-NMDAR antibodies may reduce NMDAR levels in this disorder, compromising synaptic activity in the hippocampus. Although anti-NMDAR antibodies are used as diagnostic indicators, the origin of antibodies in the central nervous system (CNS) is unclear...
2023: Frontiers in Neurology
keyword
keyword
112054
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.