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JOURNAL ARTICLE
Tu H K Trinh, Chi N Duong, Tu H T Pham, Hao D T Au, Loc T Tran, Cuong V Nguyen, Han B G Nguyen, Nguyen M Tran, Quy Q Phan, Thu N A Le, Nga Nguyen
PURPOSE: Increasing seafood consumption is associated with more frequent reports of food allergy. Little is known about seafood allergy (SFA) among adults in Vietnam. We investigated the characteristics of individuals with SFA and the risk factors for severe SFA. PATIENTS AND METHODS: A cross-sectional, web-based survey was conducted among individuals aged ≥ 18 years from universities in Ho Chi Minh City (Vietnam) between December 2021 and July 2022. The survey was based on a structured, validated questionnaire related to FA...
2024: Journal of Asthma and Allergy
#22
JOURNAL ARTICLE
Benjamin Trouche-Estival, Joana Vitte, Audrey Martin-Blondel, Marine Michelet, Vianney Gruzelle, Alain Didier, Laurent Guilleminault, Claire Mailhol, Silvia Martinez Rivera, Anaïs De Lima Correia, Camille Taurus, Antoine Blancher, Julien Goret, Caroline Klingebiel, Pol André Apoil
BACKGROUND: The clinical interest of newly available platforms for specific IgE measurement must be evaluated. However, data are lacking for NOVEOS™ (Hycor), in particular for food allergens. OBJECTIVE: We compared technical and clinical performance of two platforms (ImmunoCAP™ and NOVEOS™) for the measurement of specific IgE to 10 food allergens. METHODS: Sera from 289 clinically-characterized patients were tested for IgE specific for six food allergen extracts (egg white, cow's milk, peanut, hazelnut, fish, shrimp) and four molecular allergens (Gal d 1, Bos d 8, Ara h 2, Cor a 14)...
March 6, 2024: Journal of Allergy and Clinical Immunology in Practice
#23
JOURNAL ARTICLE
Julian M Hendrich, Andreas Reuter, Thessa P Jacob, Hatice Kara, Sherine Amer, Katharina Rödel, Birgitta M Wöhrl
The hazel allergen Cor a 1 is a PR-10 protein, closely related to the major birch pollen allergen Bet v 1. Hazel allergies are caused by cross-reactive IgE antibodies originally directed against Bet v 1. Despite the importance of PR-10 proteins in allergy development, their function and localization in the plant remain largely elusive. Therefore, the presence of Cor a 1 mRNA and proteins was investigated in different tissues, i.e., the female flower, immature and mature nuts, catkins, and pollen. Four yet unknown Cor a 1 isoallergens, i...
March 7, 2024: Scientific Reports
#24
JOURNAL ARTICLE
Robert G Hamilton, Mark Holbreich, Charles Bronzert, Rebecca L Anderson, Nathan Schoettler, Carole Ober
BACKGROUND: Screening asthma patients for atopy facilitates management. Since 2010, the core biomarker for screening asthma subjects for atopic status has been the qualitative Phadiatop. multi-aeroallergen screen. A more quantitative macroarray, the Allergy Explorer (ALEX2 ), shows promise as an alternative. OBJECTIVE: The study's goal was to examine the pros and cons of the use of ALEX2 in the screening of asthma patients for atopic status. METHODS: We evaluated the atopic (IgE-sensitization) status in asthmatic Amish and Hutterite farm children using the ImmunoCAP and ALEX2 assays in Phadiatop equivocal and positive subjects...
March 5, 2024: Journal of Asthma
#25
JOURNAL ARTICLE
David Pesqué, Leopoldo Borrego, Violeta Zaragoza-Ninet, Tatiana Sanz-Sánchez, Francisco Javier Miquel-Miquel, Ricardo González-Pérez, Juan Francisco Silvestre, Susana Córdoba-Guijarro, José Manuel Carrascosa, María Elena Gatica-Ortega, Inmaculada Ruiz-González, Pedro Mercader-García, Fátima Tous-Romero, Francisco Javier Ortiz de Frutos, Esther Serra-Baldrich, María Antonia Pastor-Nieto, Mercedes Rodríguez-Serna, Javier Sánchez-Pérez, Araceli Sánchez-Gilo, Gemma Melé-Ninot, Paloma Sánchez-Pedreño Guillén, Ramon Maria Pujol, Ana María Giménez-Arnau
BACKGROUND: There is still limited clinical-practice data on specific clinical and patch test features, as well as on allergen clusters in polysensitization (PS). OBJECTIVES: To determine the frequency, relevance, symptoms duration and risk factors in polysensitized patients and to assess possible allergen aggregation. METHODS: Prospective multicentric study (January 2019-December 2022) conducted in setting of the Spanish Contact Dermatitis Register (REIDAC)...
February 27, 2024: Journal of the European Academy of Dermatology and Venereology: JEADV
#26
JOURNAL ARTICLE
W T Luo, X H Zheng, J L Zhang, B Q Sun
With the increasing global prevalence of tree pollen allergies, there has been a significant impact on the quality of life for populations. In North and Central China, birch pollen, cypress pollen, and plane tree pollen are the most common allergens for springtime pollen allergy sufferers. The distribution of plants and patterns of pollen transmission in different geographical areas result in varying pollen exposure outcomes, further complicating the challenges in diagnosis and individualized treatment. This article delves into the research progress and clinical application of tree pollen allergies based on the "Molecular Allergology User's Guide 2...
February 6, 2024: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
#27
JOURNAL ARTICLE
Orlee Marini-Rapoport, Monica L Fernández-Quintero, Tarun Keswani, Guangning Zong, Jane Shim, Lars C Pedersen, Geoffrey A Mueller, Sarita U Patil
In peanut allergy, Arachis hypogaea 2 (Ara h 2) and Arachis hypogaea 6 (Ara h 6) are two clinically relevant peanut allergens with known structural and sequence homology and demonstrated cross-reactivity. We have previously utilized X-ray crystallography and epitope binning to define the epitopes on Ara h 2. We aimed to quantitatively characterize the cross-reactivity between Ara h 2 and Ara h 6 on a molecular level using human monoclonal antibodies (mAbs) and structural characterization of allergenic epitopes...
February 12, 2024: Clinical and Experimental Immunology
#28
Graey Wolfley, Brittanie Neaves, Christopher Coop
Cat, dog, and horse aeroallergens can cause allergic disease in susceptible individuals. Allergy cross-reactivity occurs when the body recognizes the protein of one allergen as being similar to a different protein, leading to an allergic response. Cross-reactivity has been demonstrated among animal species such as cat, dog, and horse. These allergens fall into the same protein families, with the lipocalin family predominating. We present a case demonstrating cross-reactivity among cat, dog, and horse allergens...
January 2024: Curēus
#29
JOURNAL ARTICLE
Jinlong Zhao, Mukeshimana Camus-Ela, Lili Zhang, Yuxin Wang, Gardiner Henric Rennie, Jin Wang, Vijaya Raghavan
Mangoes (Mangifera indica) are widely prized for their abundant nutritional content and variety of beneficial bioactive compounds and are popularly utilized in various foods, pharmaceuticals, and cosmetics industries. However, it is important to note that certain proteins present in mango can trigger various allergic reactions, ranging from mild oral allergy syndrome to severe life-threatening anaphylaxis. The immunoglobulin E-mediated hypersensitivity of mango is mainly associated with three major allergenic proteins: Man i 1 (class IV chitinase), Man i 2 (pathogenesis-related-10 protein; Bet v 1-related protein), and Man i 4 (profilin)...
March 2024: Comprehensive Reviews in Food Science and Food Safety
#30
JOURNAL ARTICLE
Hongkai Tan, Yu Qiu, Siyi Chen, Xintong Chen, Yong Wu, Shengfa He, Xin Li, Hongbing Chen
Although αs1-casein poses significant health risks to individuals with milk allergies, the availability of quantification methods for this allergen remains limited. In this study, we developed an immunomagnetic beads-based immunoassay (IMBs-ELISA) for the precise quantitative detection of bovine αs1-CN, specifically targeting epitope AA173-194. No cross-reactivity was observed with the other 7 food allergens including milk allergen. The linear detection range of the established IMBs-ELISA method was 0...
January 26, 2024: Food Chemistry
#31
JOURNAL ARTICLE
Wenting Luo, Jiale Zhang, Xianhui Zheng, Aoli Li, Miaoyuan Xv, Dongmei Zhou, Cunyin Yuan, YuBao Cui, Baoqing Sun
BACKGROUND: Blomia tropicalis (B. tropicalis) has been reported to impose an increased risk of allergic diseases. However, few characteristics of the unknown allergen components responsible for B. tropicalis allergy and clinical relevance have been fully identified. METHODS: We synthesized and characterized the physicochemical properties and cross-reactivity of the newly discovered recombinant B. tropicalis group 41 allergen (rBlo t 41). Subsequently, sera were collected from 107 B...
February 7, 2024: International Journal of Biological Macromolecules
#32
JOURNAL ARTICLE
Andrea Wangorsch, Annette Jamin, Jelena Spiric, Stefan Vieths, Stephan Scheurer, Vera Mahler, Silke C Hofmann
SCOPE: Edible insects contain allergens with potential cross-reactivity to other invertebrates. Here, this study examines IgE-reactive proteins in a house cricket snack (Acheta domesticus) leading to an allergic reaction in a 27-year old man followed by a similar reaction days later after eating shrimps. METHODS AND RESULTS: Prick to prick tests verify the IgE-mediated allergy to crickets and skin prick testing confirms a type I sensitization to house dust mite without any clinical relevance for the patient, and to shrimp extracts, but is negative for several other foods...
February 8, 2024: Molecular Nutrition & Food Research
#33
JOURNAL ARTICLE
Gabija Biliute, Monika Miskinyte, Asta Miskiniene, Aukse Zinkeviciene, Violeta Kvedariene
BACKGROUND: House dust mite (HDM) allergy is a prevalent global health concern, with varying sensitization profiles observed across populations. We aimed to provide a comprehensive assessment of molecular allergen sensitization patterns in the Lithuanian population, with a focus on Dermatophagoides pteronyssinus (Der p), and investigate patterns of concomitant reactivity among different allergens to enhance the accuracy of HDM allergy diagnostics. METHODS: A comprehensive analysis of 1520 patient test results in Lithuania from 2020 to 2022 was performed...
January 2024: Clinical and Translational Allergy
#34
JOURNAL ARTICLE
Mattia Giovannini, Isabel J Skypala, Jean Christoph Caubet, George Du Toit, Anna Nowak-Wegrzyn
Oral allergy syndrome or pollen food allergy syndrome (PFAS) represents a common clinical conundrum when the reported trigger food is a tree nut (usually almond or hazelnut) or peanut. The PFAS may give rise to uncertainty about the potential severity of the future reactions, indications for prescribing epinephrine, and the extent of the necessary dietary avoidance. As a food allergy, secondary to cross-reactivity with airborne pollen, PFAS usually manifests toward the end of the first decade of life as contact urticaria of the oropharyngeal mucous membranes...
January 25, 2024: Journal of Allergy and Clinical Immunology in Practice
#35
JOURNAL ARTICLE
Emily M Jerry, Shaymaviswanathan Karnaneedi, Thimo Ruethers, Dean R Jerry, Kelly Condon, Andreas L Lopata
Shellfish allergy affects ~2.5% of the global population and is a type I immune response resulting from exposure to crustacean and/or molluscan proteins. The Australian Redclaw crayfish ( Cherax quadricarinatus ) is a freshwater species endemic to and farmed in northern Australia and is becoming an aquaculture species of interest globally. Despite being consumed as food, allergenic proteins from redclaw have not been identified or characterised. In addition, as different body parts are often consumed, it is conceivable that redclaw tissues vary in allergenicity depending on tissue type and function...
January 19, 2024: Foods (Basel, Switzerland)
#36
JOURNAL ARTICLE
Filipa Matos Semedo, Catarina Martins, Elza Tomaz, Bárbara Cardoso, Sofia Farinha, Marta Martins, Ana Paula Pires, Filipe Inácio, Luís Taborda-Barata
BACKGROUND: Dust mites are the leading cause of respiratory allergic diseases worldwide. Allergy to storage mites (SMs) has mostly been related to occupational exposures. However, recent studies have shown that sensitisation to SM, such as Lepidoglyphus destructor (Lep d), is of considerable importance also in urban populations, with high prevalence in dust samples of domestic environments. Co-sensitisation between house dust mites (HDMs) and SM is now regarded as very frequent in some regions, and cross-reactivity between them seems to be narrow...
January 24, 2024: International Archives of Allergy and Immunology
#37
JOURNAL ARTICLE
Varshita Srivastava, Priya Godara, Sudip Prasad Jena, Biswajit Naik, Satyendra Singh, Vijay Kumar Prajapati, Dhaneswar Prusty
Dengue virus infection has significantly increased, with reported cases soaring from 505,430 in 2000 to 2,809,818 in 2022, emphasizing the need for effective treatments. Among the eleven structural and non-structural proteins of DENV, Non-structural protein 1 (NS1) has emerged as a promising target due to its diverse role in modulating the immune response, inducing vascular leakage, and facilitating viral replication and assembly. Monoclonal antibodies are the sole therapeutics to target NS1, but concerns about their cross-reactivity persist...
January 19, 2024: International Journal of Biological Macromolecules
#38
JOURNAL ARTICLE
Ekaterina Potapova, Salvatore Tripodi, Valentina Panetta, Stephanie Dramburg, Roberto Bernardini, Carlo Caffarelli, Antonella Casani, Rosa Cervone, Loredana Chini, Pasquale Comberiati, Giovanna De Castro, Michele Miraglia Del Giudice, Iride Dello Iacono, Andrea Di Rienzo Businco, Marcella Gallucci, Arianna Giannetti, Viviana Moschese, Ifigenia Sfika, Elena Varin, Riccardo Asero, Annamaria Bianchi, Mauro Calvani, Tullio Frediani, Francesco Macrì, Nunzia Maiello, Francesco Paravati, Umberto Pelosi, Diego Peroni, Giuseppe Pingitore, Mariangela Tosca, Anna Maria Zicari, Giampaolo Ricci, Gerald Reese, Linus Grabenhenrich, Katja Icke, Armin Grübl, Christoph Müller, Fred Zepp, Antje Schuster, Ulrich Wahn, Susanne Lau, Thomas Keil, Paolo Maria Matricardi
BACKGROUND: IgE antibodies to cross-reactive carbohydrate determinants (CCD) are usually clinically irrelevant but they can be a cause of false positive outcomes of allergen-specific IgE tests in vitro. Their prevalence and levels have been so far cross-sectionally examined among adult allergic patients and much less is known about their origins and relevance in childhood. METHODS: We examined CCD with a cross-sectional approach in 1263 Italian pollen allergic children (Panallergen in Paediatrics, PAN-PED), as well as with a longitudinal approach in 612 German children (Multicenter Allergy Study, MAS), whose cutaneous and IgE sensitization profile to a broad panel of allergen extracts and molecules was already known...
January 17, 2024: Clinical and Experimental Allergy
#39
RANDOMIZED CONTROLLED TRIAL
Natalia Ukleja-Sokołowska, Kinga Lis, Małgorzata Graczyk, Marcelina Bartuzi, Zbigniew Bartuzi
The symptoms of celery allergy are mainly presented as oral allergy symptom, but there are several case reports of patients who experienced anaphylaxis. Defensin (Api g 7), as a novel allergen in celery root, was described in 2022 r. The female patient had a history of several episodes of dyspnea and cough, associated with ingestion of spice mixes containing dried celery. Up to the point of hospitalization, there were no objective tests, either sIgE or skin prick tests, that would confirm celery sensitization...
2024: International Journal of Immunopathology and Pharmacology
#40
REVIEW
Franziska Ruëff
BACKGROUND: In Germany, honeybees (Apis mellifera) and various Vespula species (wasps) are primarily relevant for hypersensitivity reactions to stings. Hornets (Vespa crabro), bumblebees, paper wasps (Polistes) and yellowjackets (Dolichovespula) less frequently cause sting reactions. OBJECTIVE: What effects do intensive agricultural utilization and climate change have on the living conditions and occurrence of Hymenoptera and what consequences do they have for the diagnostics and treatment of hypersensitivity reactions to Hymenoptera stings...
February 2024: Dermatologie (Heidelb)
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