Albert Grass, Atsuko Kasajima, Sebastian Foersch, Mark Kriegsmann, Alexander Brobeil, Maxime Schmitt, Daniel Wagner, Jelte Poppinga, Dominik Wiese, Elisabeth Maurer, Andreas Kirschbaum, Thomas Muley, Hauke Winter, Anja Rinke, Thomas M Gress, Markus Kremer, Matthias Evert, Bruno Märkl, Alexander Quaas, Markus Eckstein, Markus Tschurtschenthaler, Günter Klöppel, Carsten Denkert, Detlef K Bartsch, Moritz Jesinghaus
As Neuroendocrine Tumors (NET) often present as metastatic lesions, immunohistochemical assignment to a site of origin is one of the most important tasks in their pathological assessment. Since a fraction of NETs eludes the typical expression profiles of their primary localization, additional sensitive and specific markers are required to improve diagnostic certainty. We investigated the expression of the transcription factor Pituitary Homeobox 2 (PITX2) in a large-scale cohort of 909 NET and 248 Neuroendocrine Carcinomas (NEC) according to the Immunoreactive Score (IRS) and correlated PITX2 expression groups with general tumor groups and localization of the primary...
February 1, 2024: Modern Pathology