Mohsen Mazidi, Neil Wright, Pang Yao, Christiana Kartsonaki, Iona Y Millwood, Hannah Fry, Saredo Said, Alfred Pozarickij, Pei Pei, Yiping Chen, Daniel Avery, Huaidong Du, Dan Valle Schmidt, Ling Yang, Jun Lv, Canqing Yu, Junshi Chen, Michael Hill, Michael V Holmes, Joanna M M Howson, Richard Peto, Rory Collins, Derrick A Bennett, Robin G Walters, Liming Li, Robert Clarke, Zhengming Chen
BACKGROUND: Integrated analyses of plasma proteomic and genetic markers in prospective studies can clarify the causal relevance of proteins and discover novel targets for ischemic heart disease (IHD) and other diseases. OBJECTIVES: The purpose of this study was to examine associations of proteomics and genetics data with IHD in population studies to discover novel preventive treatments. METHODS: We conducted a nested case-cohort study in the China Kadoorie Biobank (CKB) involving 1,971 incident IHD cases and 2,001 subcohort participants who were genotyped and free of prior cardiovascular disease...
November 14, 2023: Journal of the American College of Cardiology