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2013: Kidney International Supplements
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2013: Kidney International Supplements
Juan P Valdevenito, Alejandro Mercado-Campero, Michel Naser, Daniela Castro, Marta Ledesma, Leandro Arribillaga
AIMS: To describe the voiding pattern (VP) of women with urinary incontinence but without voiding symptoms and compare their clinical and urodynamic features between those voiding with and without a measurable detrusor contraction (DET-cont). METHODS: Retrospective analysis of a prospectively built database of female urodynamic studies (UDS). Women with voiding symptoms and having medical history of different factors that could alter the lower urinary tract function were excluded...
August 7, 2020: Neurourology and Urodynamics
Demetria Smith-Graziani, Xiudong Lei, Sharon H Giordano, Hui Zhao, Meghan Karuturi, Mariana Chavez-MacGregor
BACKGROUND: Adjuvant chemotherapy benefits early-stage breast cancer (BC) patients. Older women receive guideline-adherent treatment less frequently and experience treatment delays more frequently. We evaluated factors associated with delaying adjuvant chemotherapy and the delays' survival impact in a large population-based cohort of elderly BC patients. METHODS: Patients age >66 years diagnosed 2001-2015 with localized or regional BC were identified in the SEER-Medicare and Texas Cancer Registry-Medicare databases...
August 7, 2020: Cancer Medicine
Barnali Mazumdar, Neila J Donovan, Asifa Sultana
BACKGROUND: A comprehensive aphasia assessment is necessary to diagnose the type and severity of aphasia differentially and guide appropriate interventions. One component of an aphasia assessment is the picture description task (PDT), designed to probe spontaneous speech fluency and information content. Most aphasia assessments use black-and-white line drawings (LD) to elicit spontaneous language samples from people with aphasia (PWA). However, recent studies reported two visuographic variables: (1) colour (over black and white) and (2) photograph (over LD), that tended to encourage easier and faster comprehension and increased overall naturalistic language production from neurologically healthy individuals as well as PWA...
August 7, 2020: International Journal of Language & Communication Disorders
Sara De Bruyn, Edwin Wouters, Koen Ponnet, Robert Tholen, Caroline Masquillier, Roy Remmen, Guido Van Hal
Students' use of prescription stimulants to enhance study performance is increasingly under the spotlight. Medical guidelines discourage general practitioners (GPs) from prescribing stimulants to students without a diagnosis; yet a considerable proportion of students acquire them from GPs. Building on Eisenberg's theoretical framework on clinical decision-making and Conrad's sociological concept of biomedical enhancement, this study examined the social context of GPs' off-label prescribing decisions for stimulants, using data from 21 semi-structured interviews, including vignettes, undertaken with Flemish GPs...
August 7, 2020: Sociology of Health & Illness
Tiina Heliö, Perry Elliott, Juha W Koskenvuo, Juan R Gimeno, Luigi Tavazzi, Michal Tendera, Juan Pablo Kaski, Nicolas Mansencal, Zofia Bilińska, Gerry Carr-White, Thibaud Damy, Andrea Frustaci, Ingrid Kindermann, Tomas Ripoll-Vera, Jelena Čelutkienė, Anna Axelsson, Massimiliano Lorenzini, Aly Saad, Aldo P Maggioni, Cécile Laroche, Alida L P Caforio, Philippe Charron
AIMS: Cardiomyopathies comprise a heterogeneous group of diseases, often of genetic origin. We assessed the current practice of genetic counselling and testing in the prospective European Society of Cardiology EURObservational Research Programme Cardiomyopathy Registry. METHODS AND RESULTS: A total of 3208 adult patients from 69 centres in 18 countries were enrolled. Genetic counselling was performed in 60.8% of all patients [75.4% in hypertrophic cardiomyopathy (HCM), 39...
August 7, 2020: ESC Heart Failure
Gregory J Walker, Vanessa Clifford, Nidhi Bansal, Alberto O Stella, Stuart Turville, Sacha Stelzer-Braid, Laura D Klein, William Rawlinson
AIM: As the COVID-19 pandemic evolves, human milk banks world-wide continue to provide donor human milk to vulnerable infants who lack access to mother's own milk. Under these circumstances, ensuring the safety of donor human milk is paramount, as the risk of vertical transmission of SARS-CoV-2 is not fully understood. Here, we investigate the inactivation of SARS-CoV-2 in human milk by pasteurisation and the stability of SARS-CoV-2 in human milk under cold storage. METHODS: SARS-CoV-2 was experimentally inoculated into human milk samples from healthy donors or into a control medium...
August 7, 2020: Journal of Paediatrics and Child Health
Inge Schjødt, Søren P Johnsen, Anna Strömberg, Jan B Valentin, Brian B Løgstrup
AIMS: Data on socioeconomic-related differences in heart failure (HF) care are sparse. Inequality in care may potentially contribute to a poor clinical outcome. We examined socioeconomic-related differences in quality of HF care among patients with incident HF with reduced ejection fraction (EF) (HFrEF). METHODS AND RESULTS: We conducted a nationwide population-based cohort study among patients with HFrEF (EF ≤40%) registered from January 2008 to October 2015 in the Danish Heart Failure Registry, a nationwide registry of patients with a first-time primary HF diagnosis...
August 7, 2020: ESC Heart Failure
Jammbe Z Musoro, Samantha C Sodergren, Corneel Coens, Alessia Pochesci, Mitsumi Terada, Madeleine T King, Mirjam Ag Sprangers, Mogens Groenvold, Kim Cocks, Galina Velikova, Hans-Henning Flechtner, Andrew Bottomley
BACKGROUND: The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) assesses health related quality of life of patients in cancer trials. There are currently no minimally important difference (MID) guidelines for the EORTC QLQ-C30 for colorectal cancer (CRC). METHODS: The data were obtained from three published EORTC trials that treated CRC patients using chemotherapy. Potential anchors were selected from clinical variables based on their correlation with EORTC QLQ-C30 scales...
August 7, 2020: Colorectal Disease
Songlin He, Jinhua Wang
BACKGROUND: The Child Oral Health Impact Profile - Preschool version (COHIP-PS) is the first validated questionnaire designed to assess the oral health-related quality of life (OHRQoL) of preschool children with varying oral health-related conditions. AIM: To cross-culturally adapt the original version of COHIP-PS into Chinese and to, assess the psychometric properties of a web-based version of the COHIP-PS (eCOHIP-PS/C). DESIGN: The eCOHIP-PS/C was first created using current guidelines...
August 7, 2020: International Journal of Paediatric Dentistry
Sydnee Cohen, Jolene R Bostwick, Vincent D Marshall, Kathleen Kruse, Gregory W Dalack, Paresh Patel
WHAT IS KNOWN AND OBJECTIVE: Metabolic syndrome is a well-documented adverse effect of second-generation antipsychotics (SGAs). Patients with metabolic syndrome are at an increased risk of potentially fatal cardiovascular events, including myocardial infarction and stroke. This elevated risk prompted the creation of a national guideline on metabolic monitoring for patients on SGAs in 2004. However, monitoring practices remained low at our clinic. To address this concern, a clinical decision support system was developed to alert providers of monitoring requirements...
August 7, 2020: Journal of Clinical Pharmacy and Therapeutics
Georgina C A Johnston, Jonathan M Lumsden
OBJECTIVE: To describe the prevalence and antimicrobial susceptibility of bacterial isolates cultured from surgical specimens of infected arytenoid cartilage and granulomas. STUDY DESIGN: Retrospective cohort study. ANIMALS: Thirty-three thoroughbred horses. METHODS: Hospital records were retrieved for all horses admitted to a referral hospital for arytenoid chondropathy surgery that had samples submitted for culture and sensitivity between 2005 and 2019...
August 7, 2020: Veterinary Surgery
Gil Hardy, Theodoric Wong, Hana Morrissey, Collin Anderson, Sissel J Moltu, Brenda Poindexter, Alexandre Lapillonne, Patrick A Ball
INTRODUCTION: Micronutrients (vitamins and trace elements) are essential to all nutrition. For children and neonates who are dependent upon nutrition support therapies for growth and development, the prescribed regimen must supply all essential components. This paper aims to facilitate interpretation of existing clinical guidelines into practical approaches for the provision of micronutrients in pediatric parenteral nutrition. METHODS: An international, interdisciplinary expert panel was convened to review recent evidence-based guidelines and published literature to develop consensus- based recommendation on practical micronutrient provision in pediatric parenteral nutrition...
August 7, 2020: JPEN. Journal of Parenteral and Enteral Nutrition
Ioana Agache, Claudio Rocha, Ana Pereira, Yang Song, Pablo Alonso-Coello, Ivan Solà, Jessica Beltran, Margarita Posso, Cezmi Akdis, Mubeccel Akdis, Knut Brockow, Tomas Chivato, Stefano Del Giacco, Thomas Eiwegger, Kilian Eyerich, Ana Giménez-Arnau, Jan Gutermuth, Emma Guttman-Yassky, Marcus Maurer, Graham Ogg, Peck Ong, Liam O'Mahony, Jürgen Schwarze, Thomas Werfel, Carlos Canelo-Aybar, Oscar Palomares, Marek Jutel
This systematic review evaluates the efficacy and safety of omalizumab for chronic spontaneous urticaria (CSU). Pubmed, EMBASE and Cochrane Library were searched for RCTs. Critical and important CSU-related outcomes were considered. The risk of bias and the certainty of the evidence were assessed using GRADE. Ten RCTs including 1620 subjects aged 12 to 75 years old treated with omalizumab for 16 to 40 weeks were evaluated. Omalizumab 150 mg: does not result in clinically meaningful improvement (high certainty) of the urticaria activity score (UAS)7 (mean difference (MD) -5; 95%CI -7...
August 7, 2020: Allergy
Francesco Bellinato, Martina Maurelli, Paolo Gisondi, Giampiero Girolomoni
Grover's disease (GD) is an itchy acantholytic disorder occurring on the trunk of middle-aged men. Based on the best evidence, this study aimed to provide a summary of the clinical characteristics, disease course and treatments of GD. A systematic review was performed according to PRISMA guidelines for original articles published between 01.01.1970-08.15.2019, assessing clinical features and/or any type of intervention for GD. A total of 263 articles were retrieved, and 116 original reports that were deemed relevant and satisfied the inclusion criteria were included in the analysis (88 case reports, 26 case series and two retrospective reviews)...
August 7, 2020: Journal der Deutschen Dermatologischen Gesellschaft: JDDG
Carolina M Perdomo, Marta García-Goñi, Lidia Sancho, José Joaquín Paricio, María D Lozano, Magdalena de la Higuera, María Currás, Javier Arbizu, Juan C Galofré
OBJECTIVE: A differential diagnosis of thyrotoxicosis is crucial as the treatment of the main causes of this condition can vary significantly. Recently published diagnostic guidelines on thyrotoxicosis embrace the presence of thyrotropin receptor (TSH-R) antibodies (TRAb) as the primary and most important diagnostic step. The application of diagnostic algorithms to aid in the treatment of hyperthyroidism supports using thyroid radionuclide scintigraphy (TRSt) in baffling clinical scenarios, when TRAb are absent or when third generation TRAb are not available...
August 7, 2020: Clinical Endocrinology
Adarsh Gopinathan, Mahreen Moidu, Minil Mukundan, Siju Ellickal Narayanan, Hariraj Narayanan, Navin Adhikari
Malaria is a communicable disease which is caused by protozoan's mainly Plasmodium species (P. falciparum, P. ovale, P. vivax, P. malariae and P. knowlesi). The increasing resistance of Plasmodium to available malarial drugs poses a great responsibility for the researchers in the field of malaria. To overcome this problem of resistance, this study aimed to design and synthesize a new class of antimalarial agent with chalcone as the main moiety. Chalcones, a member of flavanoid family, consist of two aromatic rings of 1,3-diphenyl-2-propen-1-one linked by a three carbon α,β-unsaturated carbonyl system...
August 6, 2020: Drug Development Research
H-W Ren, Y Wu, J-H Dong, W-M An, T Yan, Y Liu, C-C Liu
OBJECTIVE: To explore the CT imaging features/signs of patients with different clinical types of Coronavirus Disease 2019 (COVID-19) via the application of artificial intelligence (AI), thus improving the understanding of COVID-19. PANTIENTS AND METHODS: Clinical data and chest CT imaging features of 58 patients confirmed with COVID-19 in the Fifth Medical Center of PLA General Hospital were retrospectively analyzed. According to the Guidelines on Novel Coronavirus-Infected Pneumonia Diagnosis and Treatment (Provisional 6th Edition), COVID-19 patients were divided into mild type (7), common type (34), severe type (7) and critical type (10 patients)...
August 2020: European Review for Medical and Pharmacological Sciences
T Stöver, S Dazert, T K Hoffmann, S K Plontke, P Ambrosch, C Arens, C Betz, D Beutner, C Bohr, K-L Bruchhage, M Canis, A Dietz, O Guntinas-Lichius, R Hagen, W Hosemann, H Iro, J-P Klussmann, A Knopf, S Kramer, S Lang, M Leinung, T Lenarz, H Löwenheim, C Matthias, R Mlynski, H Olze, J Park, P Plinkert, A Radeloff, N Rotter, C Rudack, A Bozzato, J Schipper, M Schrader, S Strieth, B A Stuck, S Volkenstein, M Westhofen, G Wolf, B Wollenberg, T Zahnert, J Zenk
INTRODUCTION:  Since December 2019, the SARS-CoV-2 virus has been rapidly spreading worldwide. In Germany, an exponential increase in the number of infections was registered at the beginning of March 2020 and led to a call of the Ministry of Health to create more capacity for intensive medical treatment in hospitals. The aim of the present study was to determine the effects of the SARS-CoV-2 pandemic on Oto-Rhino-Laryngology (ORL) university hospitals regarding patient care. MATERIALS AND METHODS:  An online survey was sent out to all chairmen of the 39 ORL university hospitals in Germany...
August 6, 2020: Laryngo- Rhino- Otologie
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