Brittany L Taylor, Xiomara I Perez, James Ciprano, Chinyere Onyekachi Utaegbulam Freeman, Aaron Goldstein, Joseph Freeman
In the USA, approximately 500,000 bone grafting procedures are performed annually to treat injured or diseased bone. Autografts and allografts are the most common treatment options but can lead to adverse outcomes such as donor site morbidity and mechanical failure within 10 years. Due to this, tissue engineered replacements have emerged as a promising alternative to the biological options. In this study, we characterize an electrospun porous composite scaffold as a potential bone substitute. Various mineralization techniques including electrodeposition were explored to determine the optimal method to integrate mineral content throughout the scaffold...
September 2020: Regenerative Engineering and Translational Medicine
Xiaoyu Li, Guangda Li, Kaili Zhang, Zhengjun Pei, Santuan Zhao, Jinghua Li
Bone defect-related surgical procedures are traumatic processes carrying potential inflammation and infection risks in the clinic, which are associated with prolonged antibiotic therapy that promotes bacterial antibiotic-resistance. In the present study, Cu-loaded brushite bone cements were designed, and the properties of the bone cements were evaluated. The setting time of the cement was prolonged from 12 to 50 min as the copper content increased. All cements were anti-washout, and the injectable coefficient of the cements was approximately 88%...
October 28, 2020: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Adrian Rodriguez, Tamara da Silva Cunha, Allen L Rodgers, Giovanni Gambaro, Pietro Manuel Ferraro
INTRODUCTION: Relative supersaturation (SS) for calcium oxalate (CaOx), calcium phosphate (CaP) and uric acid (UA) has been used for assessing urinary crystallization and estimated by programs including EQUIL, JESS and Lithorisk. We compared outputs from these programs and their correspondence with stone composition. METHODS: SS of CaOx, CaP and UA, using EQUIL, JESS and Lithorisk were calculated from stone-forming patients. Pearson correlation coefficient were used to ascertain the correspondence between the outputs...
October 14, 2020: Journal of Endourology
Lena Schröter, Friederike Kaiser, Svenja Stein, Uwe Gbureck, Anita Ignatius
Calcium phosphate cements (CPCs) have been used to treat bone defects and support bone regeneration because of their good biocompatibility and osteointegrative behavior. Since their introduction in the 1980s, remarkable clinical success has been achieved with these biomaterials, because they offer the unique feature of being moldable and even injectable into implant sites, where they harden through a low-temperature setting reaction. However, despite decades of research efforts, two major limitations concerning their biological and mechanical performance hamper a broader clinical use...
September 23, 2020: Acta Biomaterialia
Carl Nunziato, John Williams, Ronald Williams
BACKGROUND: Treatments for unicameral bone cysts (UBCs) have high documented failure rates (27% to 63%) because of recurrence or persistence of the cyst, similar to nonoperative management. Recent evidence suggests that filling of the defect with a synthetic bone graft substitute (SBGS) supports the weakened cortex and promotes new bone growth. A calcium sulfate, brushite, calcium phosphate, composite graft material (PRODENSE, Wright Medical, Memphis, TN) has been evaluated as a substitute for autogenous or allogenous graft in animal and human studies...
September 22, 2020: Journal of Pediatric Orthopedics
Dan Wu, Michael Pujari-Palmer, Alicja Bojan, Anders Palmquist, Philip Procter, Caroline Öhman-Mägi, Stephen J Ferguson, Per Isaksson, Cecilia Persson
Augmentation materials, such as ceramic and polymeric bone cements, have been frequently used to improve the physical engagement of screws inserted into bone. While ceramic, degradable cements may ultimately improve fixation stability, reports regarding their effect on early fixation stability have been inconsistent. On the other hand, a newly developed degradable ceramic adhesive that can bond with tissues surrounding the screw, may improve the pullout performance, ensure early stability, and subsequent bony integration...
October 2020: Journal of the Mechanical Behavior of Biomedical Materials
Stylianos O Sarrigiannidis, Hanan Moussa, Oana Dobre, Matthew J Dalby, Faleh Tamimi, Manuel Salmeron-Sanchez
Brushite cements are promising bone regeneration materials with limited biological and mechanical properties. Here, we engineer a mechanically improved brushite-collagen type I cement with enhanced biological properties by use of chiral chemistry; d- and l-tartaric acid were used to limit crystal growth and increase the mechanical properties of brushite-collagen cements. The impact of the chiral molecules on the cements was examined with Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and scanning electron microscopy (SEM)...
August 17, 2020: ACS Applied Bio Materials
Mahdi Kahani, Sanaz Hariri Tabrizi, Alireza Kamali-Asl, Samaneh Hashemi
OBJECTIVES: Detection of urinary stone composition before treatment can help in its management. The purpose of this work is to study the feasibility of classifying the kidney stone compositions in vivo by dual-energy kidney, ureter, and bladder (DEKUB) X-ray imaging. METHODS: Six urinary stone compositions with nine diameters were simulated in a water phantom, and two 70- and 120-kVp images were acquired by radiography tally of the Monte Carlo code. Six image features among 10 were selected for classification of the kidney stones...
October 2020: Applied Radiation and Isotopes
Marina D S Chiari, Marcela C Rodrigues, Mirella F C Pinto, Douglas N Vieira, Flávio M Vichi, Oscar Vega, Wojciech Chrzanowski, Noriyuki Nagaoka, Roberto R Braga
OBJECTIVES: To synthesize and characterize brushite particles in the presence of acidic monomers (acrylic acid/AA, citric acid/CA, and methacryloyloxyethyl phosphate/MOEP) and evaluate the effect of these particles on degree of conversion (DC), flexural strength/modulus (FS/FM) and ion release of experimental composites. METHODS: Particles were synthesized by co-precipitation with monomers added to the phosphate precursor solution and characterized for monomer content, size and morphology...
November 2020: Materials Science & Engineering. C, Materials for Biological Applications
Maria A Polyakova, Marianna G Arakelyan, Ksenia S Babina, Edita G Margaryan, Inna A Sokhova, Vladlena Yu Doroshina, Nina E Novozhilova
Background: Currently various studies are conducted to improve the effect of existing and developing new remineralizing agents. One of the trends in remineralizing therapy is the development of toothpaste allowing brushite crystals formation in the demineralized lesions of hard tooth tissues. Aim: The aim of this study was to assess the effect of toothpaste, forming a brushite, on the functional acid resistance of enamel and the speed of its remineralization. Materials and Methods: This was a randomized controlled double-blind clinical study...
May 2020: Journal of International Society of Preventive & Community Dentistry
Charlotte Schillebeeckx, Kathy Vander Eeckt, Dieter Ost, Marcel Van den Branden, Steven Deconinck
Background: Phosphate stones can be divided into struvite (7%), apatite (20%), and brushite stones (2%). They often present as large staghorn calculi and, therefore, can be challenging to treat. Moreover, it is crucial to obtain a stone-free patient to prevent recurrence. Therefore, local chemolysis can be an interesting tool when complete surgical removal of the stone is impossible or as an adjuvant treatment for residual stone fragments after surgery. Case Presentation: We present a case of an 84-year old Caucasian man in whom local chemolysis therapy with a citric acid solution resulted in a rapid reduction of the stone load, making less invasive therapy possible...
2020: Journal of Endourology Case Reports
Tamara da Silva Cunha, Adrian Rodriguez, Ita Pfeferman Heilberg
INTRODUCTION: Large variations in demographic, economic and environmental factors might influence the worldwide distribution of urolithiasis, but scarce data are available concerning their associations with stone composition. We aimed to evaluate the frequency and composition of kidney stones and their associations with temperature, humidity, and human development index (HDI). MATERIALS AND METHODS: A total of 1,158 stones from distinct patients (47±14 years old, male/female 2:1) were included...
July 20, 2020: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
Benjamin Kruppke, Christiane Heinemann, Annett Gebert, Marcus Rohnke, Manuel Weiß, Anja Henß, Hans-Peter Wiesmann, Thomas Hanke
Aiming at the generation of a high strontium-containing degradable bone substitute, the exchange of calcium with strontium in gelatin-modified brushite was investigated. The ion substitution showed two mineral groups, the high-calcium containing minerals with a maximum measured molar Ca/Sr ratio of 80%/20% (mass ratio 63%/37%) and the high-strontium containing ones with a maximum measured molar Ca/Sr ratio of 21%/79% (mass ratio 10%/90%). In contrast to the high-strontium mineral phases, a high mass loss was observed for the calcium-based minerals during incubation in cell culture medium (alpha-MEM), but also an increase in strength owing to dissolution and re-precipitation...
July 12, 2020: Journal of Biomedical Materials Research. Part A
Da-Zhuang Lu, Yan-Bo Zhang, Wei Dong, Wen-Juan Bi, Xiao-Jie Feng, Li-Ming Wen, Hong Sun, Hui Chen, Lu-Yang Zang, Meng-Chun Qi
Various bone substitutes have been applied in sinus augmentation (SA) to overcome insufficient bone height at the posterior maxilla region caused by pneumatized sinus and severe alveolar bone resorption after teeth loss. However, their effectiveness in SA needs to be further elucidated. In this study, strontium-doped brushite (Sr-DCPD), a new bone substitute, together with bovine-derived hydroxyapatite (bHA) and synthetic hydroxyapatite (sHA) was used in rabbit maxillary SA with simultaneous implant installation...
July 3, 2020: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Emaan Alsubhe, Antonios D Anastasiou, Mozhdeh Mehrabi, El Mostafa Raif, Ali Hassanpour, Peter Giannoudis, Animesh Jha
The calcium phosphate is the main mineral constituent of bone. Although there has been significant amount of research on finding ideal synthetic bone, no suitable scaffold material has yet been found. In this investigation, the iron doped brushite (CaHPO4 ·2H2 O) has been investigated for osteogenic potential and mechanical properties. The synthesis of iron-oxide doping in the form of Fe2+,3+ -ions were carried out using the solution based method in which the ammonium hydrogen phosphate and calcium nitrate solutions were used in stoichiometric ratio for synthesizing CaHPO4 ·2H2 O, with doping concentrations of Fe2+,3+ -ions between 5 mol% and 30 mol%...
October 2020: Materials Science & Engineering. C, Materials for Biological Applications
(no author information available yet)
[This corrects the article DOI: 10.2147/IJN.S196666.].
2020: International Journal of Nanomedicine
Matteo Bargagli, Nasser A Dhayat, Manuel Anderegg, Mariam Semmo, Uyen Huynh-Do, Bruno Vogt, Pietro Manuel Ferraro, Daniel G Fuster
BACKGROUND AND OBJECTIVES: Nephrolithiasis is a common health problem in autosomal dominant polycystic kidney disease (ADPKD) and significantly contributes to patient morbidity. Recently, Tolvaptan has been introduced for the treatment of ADPKD, but whether it is associated with alterations of the urinary lithogenic risk profile remains unknown. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We conducted an analysis of participants enrolled in the Bern ADPKD registry, a prospective observational cohort study...
June 11, 2020: Clinical Journal of the American Society of Nephrology: CJASN
Lijun Wang, Christine V Putnis
ConspectusChemical reactions at the mineral-solution interface control important interfacial processes, such as geochemical element cycling, nutrient recovery from eutrophicated waters, sequestration of toxic contaminants, and geological carbon storage by mineral carbonation. By time-resolved in situ imaging of nanoscale mineral interfacial reactions, it is possible to clarify the mechanisms governing mineral-fluid reactions.In this Account, we present a concise summary of this topic that addresses a current challenge at the frontier of understanding mineral interfaces and their importance to a wide range of mineral re-equilibration processes in the presence of a fluid aqueous phase...
May 22, 2020: Accounts of Chemical Research
Oliver Bloom, Naveen Goddard, Basil Yannoulias, Simon Eccles
A cranioplasty has a number of known associated complications including infection for non-biological implants and bone flap resorption where autologous grafts are used. In recent years, bioactive ceramic cranial implants have been developed as a new reconstructive option. The OssDsign cranial plate (OssDsign AB, Uppsala, Sweden) was first introduced in 2010 and consists of an interconnected mosaic of hydroxyapatite tiles mounted onto a 3D-printed titanium mesh. Each tile is composed of a monetite, beta-calcium pyrophosphate, beta-tricalcium phosphate and brushite compound designed to mimic the process of coupled bone formation once implanted...
June 2020: JPRAS Open
Mehrez Hermassi, Cesar Valderrama, Oriol Font, Natalia Moreno, Xavier Querol, Narjès Harrouch Batis, Jose Luis Cortina
The sorption of phosphate by K-zeolites synthesized from fly ash (FA) by hydrothermal conversion is investigated in this study. The aim is the synthesis of Ca bearing K-zeolites to recover phosphate from urban and industrial wastewater effluents. The loaded zeolites are considered as a by-products rich in essential nutrients such K and P (KP1) with a potential use as slow release fertilizer. A number of synthesis conditions (temperature, KOH-solution/FA ratio, KOH concentration, and activation time) were applied on two FA samples (FA-TE and FA-LB) with similar glass content but different content of crystalline phases, to optimize the synthesis of a zeolitic sorbent suitable for the subsequent phosphate uptake...
April 26, 2020: Science of the Total Environment
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