Yuan-Yuan Yong, Lu Yan, Bin-Ding Wang, Dong-Sheng Fan, Min-Song Guo, Lu Yu, Jian-Ming Wu, Da-Lian Qin, Betty Yuen-Kwan Law, Vincent Kam-Wai Wong, Chong-Lin Yu, Xiao-Gang Zhou, An-Guo Wu
BACKGROUND: Ferroptosis, a unique type of cell death triggered by iron-dependent lipid peroxidation, plays a critical role in the pathogenesis of Alzheimer's disease (AD), a debilitating condition marked by memory loss and cognitive impairment due to the accumulation of beta-amyloid (Aβ) and hyperphosphorylated Tau protein. Increasing evidence suggests that inhibitors of ferroptosis could be groundbreaking in the treatment of AD. METHOD: In this study, we established in vitro ferroptosis using erastin-, RSL-3-, hemin-, and iFSP1-induced PC-12 cells...
February 16, 2024: Phytomedicine