Lauren T Gallagher, Ian LaCroix, Alexander T Fields, Sanchayita Mitra, Amy Argabright, Angelo D'Alessandro, Christopher Erickson, Brenda Nunez-Garcia, Kimberly Herrera-Rodriguez, Yu Celine Chou, Benjamin W Stocker, Benjamin J Ramser, Otto Thielen, William Hallas, Christopher C Siliiman, Lucy Z Kornblith, Mitchell J Cohen
BACKGROUND: Platelets are well known for their roles in hemostasis, but they also play a key role in thromboinflammatory pathways by regulating endothelial health, stimulating angiogenesis, and mediating host defense through both contact dependent and independent signaling. When activated, platelets degranulate releasing multiple active substances. We hypothesized that the soluble environment formed by trauma platelet releasates attenuates thromboinflammation via mitigation of trauma induced endothelial permeability and metabolomic reprogramming...
May 20, 2024: Journal of Trauma and Acute Care Surgery