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JOURNAL ARTICLE
Patricia Alejandra Garrido Ruiz, Álvaro Otero Rodriguez, Luis Antonio Corchete, Victoria Zelaya Huerta, Alejandro Pasco Peña, Cristina Caballero Martínez, Joaquín González-Carreró Fojón, Inmaculada Catalina Fernández, Juan Carlos López Duque, Laura Zaldumbide Dueñas, Lorena Mosteiro González, María Aurora Astudillo, Aurelio Hernández-Laín, Emma Natalia Camacho Urkaray, María Amparo Viguri Diaz, Alberto Orfao, María Dolores Tabernero
Rhabdoid meningiomas (RM) are a rare meningioma subtype with a heterogeneous clinical course which is more frequently associated with recurrence, even among tumors undergoing-complete surgical removal. Here, we retrospectively analyzed the clinical-histopathological and cytogenetic features of 29 tumors, from patients with recurrent (seven primary and 14 recurrent tumors) vs. non-recurrent RM ( n = 8). Recurrent RM showed one (29%), two (29%) or three (42%) recurrences. BAP1 loss of expression was found in one third of all RM at diagnosis and increased to 100% in subsequent tumor recurrences...
May 16, 2024: Biology
#22
JOURNAL ARTICLE
George Bică, Otilia-Constantina Rogoveanu, Florin-Liviu Gherghina, Cătălina-Gabriela Pisoschi, Sandra-Alice Buteică, Cristina-Elena Biță, Iulia-Alexandra Paliu, Ion Mîndrilă
Iron oxide nanoparticles (IONPs) represent an important advance in the field of medicine with application in both diagnostic and drug delivery domains, offering a therapeutic approach that effectively overcomes physical and biological barriers. The current study aimed to assess whether oral administration of salicylic acid-functionalized iron oxide nanoparticles (SaIONPs) may exhibit beneficial effects in alleviating histological lesions in a murine monoiodoacetate (MIA) induced knee osteoarthritis model. In order to conduct our study, 15 Wistar male rats were randomly distributed into 3 work groups: Sham (S), MIA, and NP...
May 10, 2024: Biology
#23
REVIEW
Oana Neda-Stepan, Cătălina Giurgi-Oncu, Andreea Sălcudean, Elena Bernad, Brenda-Cristiana Bernad, Virgil Radu Enătescu
Postpartum depression (PPD) is a significant global health concern with profound implications for mothers, families, and societies. This systematic review aims to synthesize current research findings to understand better how personality traits, as assessed by the NEO Five-Factor Inventory (NEO-FFI), contribute to the development and progression of PPD. Conducted in January 2024, this review searched major databases like PubMed, PsycINFO, and Scopus up to December 2023, focusing on the NEO-FFI's role in evaluating PPD...
April 25, 2024: Diseases (Basel)
#24
Pasquale Bufano, Cristina Di Tecco, Alice Fattori, Teresa Barnini, Anna Comotti, Catalina Ciocan, Luca Ferrari, Francesca Mastorci, Marco Laurino, Matteo Bonzini
INTRODUCTION: Cognitive functions play a crucial role in individual's life since they represent the mental abilities necessary to perform any activity. During working life, having healthy cognitive functioning is essential for the proper performance of work, but it is especially crucial for preserving cognitive abilities and thus ensuring healthy cognitive aging after retirement. The aim of this paper was to systematically review the scientific literature related to the effects of work on cognitive functions to assess which work-related factors most adversely affect them...
2024: Frontiers in Psychology
#25
JOURNAL ARTICLE
Camila García-Navarrete, Catalina Kretschmar, Jorge Toledo, Karla Gutiérrez, María Paz Hernández-Cáceres, Mauricio Budini, Valentina Parra, Patricia V Burgos, Sergio Lavandero, Eugenia Morselli, Daniel Peña-Oyarzún, Alfredo Criollo
The primary cilium, hereafter cilium, is an antenna-like organelle that modulates intracellular responses, including autophagy, a lysosomal degradation process essential for cell homeostasis. Dysfunction of the cilium is associated with impairment of autophagy and diseases known as "ciliopathies". The discovery of autophagy-related proteins at the base of the cilium suggests its potential role in coordinating autophagy initiation in response to physiopathological stimuli. One of these proteins, beclin-1 (BECN1), it which is necessary for autophagosome biogenesis...
May 21, 2024: Biochimica et Biophysica Acta. Molecular Basis of Disease
#26
JOURNAL ARTICLE
Catalina Núñez, Jaime Delgadillo, Michael Barkham, Alex Behn
No abstract text is available yet for this article.
May 23, 2024: European Psychiatry: the Journal of the Association of European Psychiatrists
#27
JOURNAL ARTICLE
Rory P Downham, Benedict Gannon, Diana Catalina Palacio Lozano, Hugh E Jones, Christopher H Vane, Mark P Barrow
Polycyclic aromatic compounds (PACs), including polycyclic aromatic hydrocarbons (PAHs) and heteroatom-containing analogues, constitute an important environmental contaminant class. For decades, limited numbers of priority PAHs have been routinely targeted in pollution investigations, however, there is growing awareness for the potential occurrence of thousands of PACs in the environment. In this study, untargeted Fourier transform ion cyclotron resonance mass spectrometry was used for the molecular characterisation of PACs in a sediment core from Chiswick Ait, in the River Thames, London, UK...
May 14, 2024: Journal of Hazardous Materials
#28
JOURNAL ARTICLE
Catalina Moreno-Rabié, Rocharles Cavalcante Fontenele, Nicolly Oliveira-Santos, Fernanda Nogueira-Reis, Tim Van den Wyngaert, Reinhilde Jacobs
UNLABELLED: This study investigates the effects of antiresorptive drugs and risk factors for medication-related osteonecrosis of the jaws in osteoporotic patients undergoing tooth extraction. Among the findings, antiresorptive-treated patients had thicker lamina dura and longer healing times. Additionally, corticosteroid intake and multi-rooted teeth carried a higher osteonecrosis risk. Bone sequestrum indicated osteonecrosis. PURPOSE: To describe the effects of antiresorptive drugs (ARD) in the maxilla and mandible and risk factors for medication-related osteonecrosis of the jaws (MRONJ) in osteoporotic patients undergoing tooth extractions using clinical data and cone beam computed tomography (CBCT)...
May 20, 2024: Osteoporosis International
#29
JOURNAL ARTICLE
Monalisa Muchatuta, Shama Patel, Catalina Gonzalez Marquez, Kaushila Thilakasiri, Sreenidhi Vanyaa Manian, Jennifer Chan, Ngassa Mssika, Taryn Clark, Taylor Burkholder, Nikkole Turgeon, Vinay N Kampalath, Nivedita Poola, O Agatha Offorjebe, Adeline Dozois, Gimbo Hyuha, Oluwarotimi Vaughan-Ogunlusi, Carol McCammon, Katie Wells, Megan Rybarczk, Maria Paula Castillo, Adebisi Anthonia Adeyeye, Chris A Rees, Sanjukta Dutta, Stephanie Chow Garbern
BACKGROUND: Global emergency medicine (GEM) is situated at the intersection of global health and emergency medicine (EM), which is built upon a history of colonial systems and institutions that continue to reinforce inequities between high-income countries (HICs) and low- and middle-income countries (LMICs) today. These power imbalances yield disparities in GEM practice, research, and education. APPROACH: The Global Emergency Medicine Academy (GEMA) of the Society for Academic Emergency Medicine formed the Decolonizing GEM Working Group in 2020, which now includes over 100 worldwide members...
June 2024: AEM Education and Training
#30
Erin E Gill, Baofeng Jia, Carmen Lia Murall, Raphaël Poujol, Muhammad Zohaib Anwar, Nithu Sara John, Justin Richardsson, Ashley Hobb, Abayomi S Olabode, Alexandru Lepsa, Ana T Duggan, Andrea D Tyler, Arnaud N'Guessan, Atul Kachru, Brandon Chan, Catherine Yoshida, Christina K Yung, David Bujold, Dusan Andric, Edmund Su, Emma J Griffiths, Gary Van Domselaar, Gordon W Jolly, Heather K E Ward, Henrich Feher, Jared Baker, Jared T Simpson, Jaser Uddin, Jiannis Ragoussis, Jon Eubank, Jörg H Fritz, José Héctor Gálvez, Karen Fang, Kim Cullion, Leonardo Rivera, Linda Xiang, Matthew A Croxen, Mitchell Shiell, Natalie Prystajecky, Pierre-Olivier Quirion, Rosita Bajari, Samantha Rich, Samira Mubareka, Sandrine Moreira, Scott Cain, Steven G Sutcliffe, Susanne A Kraemer, Yann Joly, Yelizar Alturmessov, Cphln Consortium, CanCOGeN Consortium, VirusSeq Data Portal Academic, Health Network, Marc Fiume, Terrance P Snutch, Cindy Bell, Catalina Lopez-Correa, Julie G Hussin, Jeffrey B Joy, Caroline Colijn, Paul M K Gordon, William W L Hsiao, Art F Y Poon, Natalie C Knox, Mélanie Courtot, Lincoln Stein, Sarah P Otto, Guillaume Bourque, B Jesse Shapiro, Fiona S L Brinkman
The COVID-19 pandemic led to a large global effort to sequence SARS-CoV-2 genomes from patient samples to track viral evolution and inform public health response. Millions of SARS-CoV-2 genome sequences have been deposited in global public repositories. The Canadian COVID-19 Genomics Network (CanCOGeN - VirusSeq), a consortium tasked with coordinating expanded sequencing of SARS-CoV-2 genomes across Canada early in the pandemic, created the Canadian VirusSeq Data Portal, with associated data pipelines and procedures, to support these efforts...
May 8, 2024: ArXiv
#31
JOURNAL ARTICLE
Zhi Xin Yau-Qiu, Sebastià Galmés, Pedro Castillo, Catalina Picó, Andreu Palou, Ana María Rodríguez
Placental leptin may impact foetal development. Maternal overnutrition has been linked to increased plasma leptin levels and adverse effects on offspring, whereas choline, an essential nutrient for foetal development, has shown promise in mitigating some negative impacts of maternal obesity. Here, we investigate whether a maternal obesogenic diet alters foetal growth and leptin levels in the foetal stomach, amniotic fluid (AF), and placenta in late gestation and explore the potential modulating effects of maternal choline supplementation...
May 18, 2024: Scientific Reports
#32
JOURNAL ARTICLE
Rocío Rosas-Alonso, Julian Colmenarejo-Fernández, Olga Pernía, Miranda Burdiel, Carlos Rodríguez-Antolín, Itsaso Losantos-García, Tania Rubio, Rocío Moreno-Velasco, Isabel Esteban-Rodríguez, Virginia Martínez-Marín, Paloma Yubero, Nicolas Costa-Fraga, Angel Díaz-Lagares, Rafael López-López, Eva Díaz-Martin, Juan F García, Catalina Vivancos Sánchez, Maria Luisa Gandía-González, Gema Moreno-Bueno, Javier de Castro, Inmaculada Ibánez de Cáceres
Glioblastoma (GB) is a devastating tumor of the central nervous system characterized by a poor prognosis. One of the best-established predictive biomarker in IDH-wildtype GB is O6-methylguanine-DNA methyltransferase (MGMT) methylation (mMGMT), which is associated with improved treatment response and survival. However, current efforts to monitor GB patients through mMGMT detection have proven unsuccessful. Small extracellular vesicles (sEVs) hold potential as a key element that could revolutionize clinical practice by offering new possibilities for liquid biopsy...
May 18, 2024: Scientific Reports
#33
JOURNAL ARTICLE
Stessy Kutchukian, Marie Chicaud, Mariela Corrales, Catalina Solano, Luigi Candela, Steeve Doizi, Dominique Bazin, Olivier Traxer, Frédéric Panthier
OBJECTIVES: To characterize and compare in vitro the surfaces of ureteral stents(STENTS) before utilization. METHODS: Our in vitro experiment included six unused STENTS models: three double-pigtail with side orifices(ImaJin and Stenostent(Coloplast©,France), TriaSoft(BostonScientific©,USA)), two double-pigtail without side orifice(Vortek-TumorStent (Coloplast©,France), Urosoft-TumorStent(Bard-Angiomed©,Germany)) and one single-pigtail(J-Fil(Rocamed©,Monaco))...
May 15, 2024: Fr J Urol
#34
JOURNAL ARTICLE
Catalina Biglione, Tania Hidalgo, Patricia Horcajada
Through this inspirational note, we would like to highlight the potential of nanoscaled metal-organic frameworks within the biomedical field. The unique properties of these materials that make them promising candidates for new nanomedicines are assessed here as well as the progression reached so far for combinational cancer therapies and theranostic, along with its most recent advances in nanomedicine. Finally, the perspective and challenges of these materials within this field is discussed.
May 16, 2024: Drug Delivery and Translational Research
#35
JOURNAL ARTICLE
Rareș Iovanov, Andreea Cornilă, Cătălina Bogdan, Dana Hales, Ioan Tomuță, Marcela Achim, Andrada Tăut, Nela Iman, Tibor Casian, Sonia Iurian
Orodispersible tablets (ODTs) represent a growing category of dosage forms intended to increase the treatment acceptability for special groups of patients. ODTs are designed to rapidly disintegrate in the oral cavity and to be administered without water. In addition, ODTs are easy to manufacture using standard excipients and pharmaceutical equipment. This study adds to previously published research that developed an instrumental tool to predict oral disintegration and texture-related palatability of ODTs with different formulations...
May 14, 2024: European Journal of Pharmaceutical Sciences
#36
JOURNAL ARTICLE
Catalina Larrague, Facundo Miguel Galich, Tomas Martín Tavella, Nicolás Stramazzo, Nicolás Agustín Atala, Luciano Andrés Rossi, Ignacio Tanoira, Maximiliano Ranalletta
OBJECTIVE: This study aims to assess differences in clinical and surgical outcomes associated with the surgical treatment of midshaft clavicle fractures of different complexities based on fragment number. Additionally, the investigation seeks to present the outcomes of a series of patients who underwent surgery at our institution. MATERIALS AND METHODS: A retrospective analysis was conducted on the medical records of patients aged over 18 who underwent midshaft clavicle fracture surgery at our center from November 2009 to May 2021...
May 16, 2024: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
#37
Cristina Giossi, Jyotika Bahuguna, Jonathan E Rubin, Timothy Verstynen, Catalina Vich
Reactive inhibitory control is crucial for survival. Traditionally, this control in mammals was attributed solely to the hyperdirect pathway, with cortical control signals flowing unidirectionally from the subthalamic nucleus (STN) to basal ganglia output regions. Yet recent findings have put this model into question, suggesting that the STN is assisted in stopping actions through ascending control signals to the striatum mediated by the external globus pallidus (GPe). Here we investigate this suggestion by harnessing a biologically-constrained spiking model of the corticobasal ganglia-thalamic (CBGT) circuit that includes pallidostriatal pathways originating from arkypallidal neurons...
May 5, 2024: bioRxiv
#38
John B Moldovan, Huira C Kopera, Ying Liu, Marta Garcia-Canadas, Purificacion Catalina, Paola E Leone, Laura Sanchez, Jacob O Kitzman, Jeffrey M Kidd, Jose Luis Garcia-Perez, John V Moran
Alu elements are non-autonomous Short INterspersed Elements (SINEs) derived from the 7SL RNA gene that are present at over one million copies in human genomic DNA. Alu mobilizes by a mechanism known as retrotransposition, which requires the Long INterspersed Element-1 (LINE-1 or L1) ORF2 -encoded protein (ORF2p). Here, we demonstrate that HeLa strains differ in their capacity to support Alu retrotransposition. Human Alu elements retrotranspose efficiently in HeLa-HA and HeLa-CCL2 ( Alu -permissive) strains, but not in HeLa-JVM or HeLa-H1 ( Alu -nonpermissive) strains...
May 3, 2024: bioRxiv
#39
JOURNAL ARTICLE
Yamila Sanchez, Mariana Abigail Vasquez Callejas, Noelia Victoria Miret, Gabino Rolandelli, Catalina Costas, Andrea Silvana Randi, Alejandro Español
AIM: Triple negative breast cancer (TNBC) is usually treated with high doses of paclitaxel, whose effectiveness may be modulated by the action of environmental contaminants such as hexachlorobenzene. High doses of paclitaxel cause adverse effects such as low cellular selectivity and the generation of resistance to treatment due to an increase in the expression of multidrug resistance proteins (MRPs). These effects can be reduced using a metronomic administration scheme with low doses...
2024: Exploration of targeted anti-tumor therapy
#40
REVIEW
Henry Robayo-Amortegui, Alejandro Quintero-Altare, Catalina Florez-Navas, Isacio Serna-Palacios, Andrea Súarez-Saavedra, Ricardo Buitrago-Bernal, Julian Orlando Casallas-Barrera
No abstract text is available yet for this article.
2024: Frontiers in Medicine
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