Ashley Soucy, Christian Potts, Abigail Kaija, Anne Harrington, Marissa McGilvrey, George L Sutphin, Ron Korstanje, Benjamin Tero, Jacob Seeker, Ilka Pinz, Calvin Vary, Larisa Ryzhova, Lucy Liaw
BACKGROUND: RAB27A, a modulator of secretion, is expressed within vessels and perivascular adipose tissue. We hypothesized that loss of RAB27A would alter cardiovascular function. METHODS: Body weight of Rab27a ash mice was measured from 2 to 18 months of age, along with glucose resorption at 6 and 12 months of age and glucose sensitivity at 18 months of age. Body weight and cellular and molecular features of perivascular adipose tissue and aortic tissue were examined in a novel C57BL/6J Rab27a null strain...
April 25, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology