Han Chiu, Anyelina Chau Fang, Yi-Hong Chen, Ru Xin Koi, Kai-Ching Yu, Li-Hung Hsieh, Yueh-Ming Shyu, Tarik Abdelkareem Mostafa Amer, Yi-Jen Hsueh, Yu-Ting Tsao, Yang-Jin Shen, Yun-Ming Wang, Hung-Chi Chen, Yu-Jen Lu, Chieh-Cheng Huang, Tsai-Te Lu
Dinitrosyl iron unit (DNIU), [Fe(NO)2 ], is a natural metallocofactor for biological storage, delivery, and metabolism of nitric oxide (NO). In the attempt to gain a biomimetic insight into the natural DNIU under biological system, in this study, synthetic dinitrosyl iron complexes (DNICs) [(NO)2 Fe(μ-SCH2 CH2 COOH)2 Fe(NO)2 ] ( DNIC-COOH ) and [(NO)2 Fe(μ-SCH2 CH2 COOCH3 )2 Fe(NO)2 ] ( DNIC-COOMe ) were employed to investigate the structure-reactivity relationship of mechanism and kinetics for cellular uptake of DNICs, intracellular delivery of NO, and activation of cytoprotective heme oxygenase (HO)-1...
April 22, 2024: JACS Au