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Merkel cell carcinoma parotid gland

Rebecca D Chernock, Eric J Duncavage
Salivary neuroendocrine carcinomas are rare and the overwhelming majority is high-grade. The parotid gland is the most commonly involved site followed by the submandibular gland. Most arise de novo but rare examples occurring as a high-grade transformation of another type of salivary gland neoplasm exist. There is significant morphologic and immunophenotypic overlap with neuroendocrine carcinomas of other sites, especially the skin. Like cutaneous neuroendocrine (or Merkel cell) carcinomas, approximately three-fourths are cytokeratin 20 positive...
March 2018: Head and Neck Pathology
James Badlani, Ruta Gupta, Joel Smith, Bruce Ashford, Sydney Ch'ng, Michael Veness, Jonathan Clark
Metastases to the parotid gland are the commonest cause of parotid malignancies in many regions of the world including Australia. The most common etiology of these metastases is head and neck cutaneous squamous cell carcinoma (HNcSCC) followed by melanoma of the head and neck. This article focuses on the management of the aforementioned pathologies including Merkel cell carcinoma (MCC).
March 2018: Surgical Oncology
T Bizzarro, R Buda, M Ricci, L Bernardi
No abstract text is available yet for this article.
December 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
Andreas Knopf, Murat Bas, Benedikt Hofauer, Naglaa Mansour, Thomas Stark
BACKGROUND: There are still controversies about the therapeutic strategies and subsequent outcome in head and neck Merkel cell carcinoma. METHODS: Clinicopathological data of 23 Merkel cell carcinomas, 93 cutaneous head and neck squamous cell carcinomas (HNSCCs), 126 malignant melanomas, and 91 primary parotid gland carcinomas were comprehensively analyzed. Merkel cell carcinomas were cytokeratin 20 (CK20)/neuron-specific enolase (NSE)/chromogranin A (CgA)/synaptophysin (Syn)/thyroid transcription factor-1 (TTF-1)/MIB1 immunostained...
January 2017: Head & Neck
Llucia Alos, Sofia Hakim, Ana-Belen Larque, Jorge de la Oliva, Leonardo Rodriguez-Carunchio, Miguel Caballero, Alfons Nadal, Carles Marti, Nuria Guimera, Maria-Teresa Fernandez-Figueras, Wim Quint, Jaume Ordi
High-grade neuroendocrine carcinomas (HGNECs) of the head and neck have the morphological appearance of undifferentiated carcinomas and could be histologically similar to human papillomavirus (HPV)-associated non-keratinizing squamous cell carcinomas of the head and neck. The aim of the study is to characterize histologically, immunohistochemically, and virologically these unusual neoplasms. Nineteen HGNECs of the head and neck (1 oropharyngeal, 5 sinonasal, 7 of the larynx, and 6 of the parotid gland) were reviewed and analyzed with a immunohistochemical panel, with special emphasis on cell cycle proteins...
September 2016: Virchows Archiv: An International Journal of Pathology
Jonathan Clark, Steven Wang
In many regions of the world, the most common type of parotid malignancy is metastatic malignancy. Metastatic cutaneous squamous cell carcinoma and metastatic melanoma are the most common pathologies that metastasize to the parotid gland and cervical lymph nodes. Other more rare metastatic malignancies from cutaneous primary sites include Merkel cell carcinoma, pleomorphic sarcoma (previously called malignant fibrous histiocytoma) and metastatic basal cell carcinoma. Systemic metastases can also occur from tumors such as renal cell carcinoma...
2016: Advances in Oto-rhino-laryngology
Vito D'Andrea, Alessandra Panarese, Filippo Maria di Matteo, Pasqualino Favoriti, Leonardo Favella, Stefano Arcieri, Angelo Filippini
INTRODUCTION: Up to the half of twentieth century, Chievitz organ was considered an embryonal organ, disappearing with growth. But Zenker, in 1953, demonstrated the existence of this organ in adult life, too4. REVIEW: In this article we review the embryology, the macroscopic and microscopic anatomy, the ultrastructure, the functional significance and the pathology of the Chievitz'Juxtaparotid Organ (CJO). The CJO is not a macroscopic apparent organ, but it looks like a nerve...
2015: Annali Italiani di Chirurgia
M Durbec, V Couloigner, S Tronche, S Albert, J Kanitakis, A Ltaief Boudrigua, O Malard, E Maubec, E Mourrain Langlois, B Navailles, L Peuvrel, B Phulpin, J-C Thimonier, F Disant, G Dolivet
Cutaneous head and neck tumors mainly comprise malignant melanoma, squamous cell carcinoma, trichoblastic carcinoma, Merkel cell carcinoma, adnexal carcinoma, dermatofibrosarcoma protuberans, sclerodermiform basalioma and angiosarcoma. Adapted management requires an experienced team with good knowledge of the various parameters relating to health status, histology, location and extension: risk factors for aggression, extension assessment, resection margin requirements, indications for specific procedures, such as lateral temporal bone resection, orbital exenteration, resection of the calvarium and meningeal envelopes, neck dissection and muscle resection...
December 2014: European Annals of Otorhinolaryngology, Head and Neck Diseases
M Penicaud, S Cammilleri, R Giorgi, D Taïeb, J J Grob, A Giovanni, P Dessi, N Fakhry
INTRODUCTION: Merkel cell carcinoma (MCC) is a rare neuroendocrine skin tumor. The aim of our study was to analyze the prognosis of patients operated on for CCM and having no lymph node involvement after analysis of sentinel lymph node (SLN). MATERIAL AND METHOD: This was a retrospective study of 10 cases of CCM stage I or II who received the SLN technique in our institution between 2003 and 2010. RESULTS Among the 10 patients, 7 had an identification of at least one SLN, among which the node could be surgically removed in 6 cases...
2013: Revue de Laryngologie—Otologie—Rhinologie
Paul W Shield, Heinrich Crous
This study reviewed the clinical presentation, cytologic findings, and the immunophenotype of 69 Merkel cell carcinoma (MCC) cases sampled by fine-needle aspiration (FNA).  Demographic and clinical data, the cytology findings, and results of ancillary testing were reviewed.  Median patient age was 78 years (37-104) with a 1:1.8 female to male ratio. The most common FNA sites sampled included lymph nodes in the neck, the axillary region, the inguinal region and the parotid gland. Most patients had a history of MCC (68%) and/or non-MCC malignancy (70%)...
November 2014: Diagnostic Cytopathology
Georg Haymerle, Alexandra Fochtmann, Rainer Kunstfeld, Johannes Pammer, Boban M Erovic
Merkel cell carcinoma is a rare, but highly aggressive skin tumor. We describe our single-institution experience with the diagnosis and treatment of Merkel cell carcinoma of unknown primary (MCCUP). We conducted a retrospective medical chart review of patients treated with MCCUP at the Vienna General Hospital between 2002 and 2011. Clinicopathologic variables and outcomes were analyzed. Of the entire cohort of 57 patients, 8 patients (14%) were diagnosed with MCCUP. Three patients presented with parotid gland involvement, four patients with positive inguinal lymph nodes and one with axillar lymph nodes...
February 2015: European Archives of Oto-rhino-laryngology
M Basati, K Kassam, A Messiha
Background. Merkel cell carcinoma of the head and neck is a rare and aggressive malignant tumour. Both the dermatological and surgical colleagues should be aware of this entity as lesions usually present on sun exposed areas of the skin such as the head and neck. Main Observation and Treatment. A 69-year-old male originally presented to the maxillofacial surgery department with a growing lesion on the left eyebrow. Histological analysis confirmed Merkel cell carcinoma and consequently surgical excision was carried out...
2013: Case Reports in Dermatological Medicine
Takeharu Kanazawa, Noriyoshi Fukushima, Hidetaka Tanaka, Juntaro Shiba, Hiroshi Nishino, Hiroyuki Mineta, Keiichi Ichimura
UNLABELLED: HASH(0x55cda7c1aa40) INTRODUCTION: Primary involvement of the salivary glands in small cell carcinoma is rare, and has one of the worst prognoses of salivary gland neoplasms. However, it has been reported that some cases have a favorable outcome, although the prognostic factors are still under consideration. Multidisciplinary therapy was usually required to achieve long-term survival. Recently, a resemblance of some small cell carcinomas of the salivary gland to cutaneous Merkel cell carcinoma was suggested; the latter have the potential for spontaneous regression, which is related to a favorable clinical outcome...
2012: Journal of Medical Case Reports
Federico Maria Gioacchini, Valentina Postacchini, Oriana Simonetti, Annamaria Offidani, Giuseppe Magliulo, Massimo Re
The aim of this study was to perform a systematic literature review of Merkel cell carcinomas (MCCs) originating exclusively in the ear, nose and throat (ENT) district. An appropriate string was run on PubMed to retrieve articles dealing with ENT presentations of MCC. A double cross-check was performed on citations and full-text articles found using the selected inclusion and exclusion criteria. In total, 43 articles were finally included in the study, describing 51 cases of MCC involving the ENT region: 22/51 (43%) cases involving the ear; 20/51 (39%) cases involving the mucosal sites; 9/51 (18%) cases involving other ENT regions...
August 2013: European Archives of Oto-rhino-laryngology
Felix C Behan, Warren M Rozen, Jeremy Wilson, Shivam Kapila, Andrew Sizeland, Michael W Findlay
BACKGROUND: Locally advanced head and neck cancer often requires wide resections of the cheek and parotid gland, and in an ageing population preferred reconstructive options aim to avoid lengthy operating times or high risk surgery. While most large parotid defects traditionally require free flap reconstruction, we describe a new and versatile locoregional flap that has been shown to be reliable, simple and safe. METHODS: We describe the cervico-submental (CSM) keystone-design perforator island flap for head and neck reconstruction, including an analysis of 33 consecutive patients with a range of head and neck defects...
January 2013: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
Dario de Biase, Moira Ragazzi, Sofia Asioli, Vincenzo Eusebi
Merkel cell carcinoma is a neuroendocrine tumor, with characteristic morphological and immunohistochemical features. Originally reported as primary carcinoma of skin, it has been described in numerous other sites such as lymph nodes, oral cavity, breast, vaginal walls, and salivary glands. Recent studies have revealed in cutaneous Merkel cell carcinomas a clonally integrated polyomavirus, named Merkel cell polyomavirus. The aim of the present study was to verify the presence of Merkel cell polyomavirus in 5 cases of primary Merkel cell carcinomas of lymph nodes and 1 case of parotid gland to investigate similarities or differences among Merkel cell carcinomas from various sites...
July 2012: Human Pathology
Rebecca D Chernock, Eric J Duncavage, Douglas R Gnepp, Samir K El-Mofty, James S Lewis
High-grade neuroendocrine carcinoma of the salivary glands is a rare malignancy that can be difficult to distinguish from metastatic neuroendocrine (Merkel cell) carcinoma of the skin, which often occurs on the head and neck and may metastasize to lymph nodes in or adjacent to salivary glands, particularly the parotid gland. As the 2 tumors have morphologic and immunophenotypic overlap, additional diagnostic tools may be clinically useful. Merkel cell carcinoma is known to harbor Merkel cell polyomavirus in up to 80% of cases...
December 2011: American Journal of Surgical Pathology
Mahmoud Ghaderi, Jeffrey Coury, Jacqueline Oxenberg, Harvey Spector
Primary Merkel cell carcinoma (MCC) is a neuroendocrine tumor that typically affects older whites. It usually originates in the dermis, but in rare instances it has arisen in other primary sites, including the oral mucosa and the parotid gland. Explanations for the presence of MCC in these atypical locations have included theories of malignant transformation and neuroendocrine migration. We describe the case of a 35-year-old white woman who had an MCC in the parotid gland and no evidence of any other primary cutaneous lesion...
July 2010: Ear, Nose, & Throat Journal
D C Mulder, A J W P Rosenberg, P W Storm-Bogaard, R Koole
Small cell carcinomas of the salivary gland are rare. We present a case of spontaneous regression of an advanced merkel-cell-like small cell carcinoma of the parotid gland.
April 2010: British Journal of Oral & Maxillofacial Surgery
Wojciech Gawecki, Małgorzata Wierzbicka, Janusz Kaczmarek, Jakub Zurawski, Witold Szyfter
Merkel cell carcinoma is a rare malignant primary tumor of the skin, which develop typically in the elderly in the sun exposed areas of the skin, most commonly in the head and neck region. This tumor is very aggressive with a high rate of regional and distant metastases, marked propensity for local et regional recurrence, and very poor survival. Skin lesions are typically red or purple and present as a solitary dome-shaped nodule or indurated plaque. The recognition of such tumor in not difficult, but in same cases, when the tumor infiltrate deeper organs and structures it may cause some problems...
2007: Otolaryngologia Polska
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