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https://read.qxmd.com/read/30786242/estrogen-stress-and-depression-cognitive-and-biological-interactions
#1
Kimberly M Albert, Paul A Newhouse
This article reviews the interactions of estrogen changes and psychosocial stress in contributing to vulnerability to major depressive disorder (MDD) in women. Estrogen modulates brain networks and processes related to changes in stress response, cognition, and emotional dysregulation that are core characteristics of MDD. Synergistic effects of estrogen on cognitive and emotional function, particularly during psychosocial stress, may underlie the association of ovarian hormone fluctuation and depression in women...
February 20, 2019: Annual Review of Clinical Psychology
https://read.qxmd.com/read/30786001/functional-genetic-variation-in-the-anti-m%C3%A3-llerian-hormone-pathway-in-women-with-polycystic-ovary-syndrome
#2
Lidija K Gorsic, Matthew Dapas, Richard S Legro, M Geoffrey Hayes, Margrit Urbanek
CONTEXT: PCOS is a highly heritable, common endocrine disorder characterized by hyperandrogenism, irregular menses and polycystic ovaries. PCOS is often accompanied by elevated levels of anti-Müllerian hormone (AMH). AMH inhibits follicle maturation. AMH also inhibits steroidogenesis through transcriptional repression of CYP17A1. We recently identified 16 rare PCOS-specific pathogenic variants in AMH. OBJECTIVE: To test whether additional members of the AMH signaling pathway also contribute to the etiology of PCOS...
February 20, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/30785992/female-pattern-hair-loss-and-androgen-excess-a-report-from-the-multidisciplinary-androgen-excess-and-pcos-committee
#3
E Carmina, R Azziz, W Bergfeld, H F Escobar Morreale, W Futterweit, H Huddleston, R A Lobo, E Olsen
OBJECTIVE: To determine the current state of knowledge and provide evidence-based recommendations that could be valid for all specialists taking care of female pattern hair loss (FPHL), a common form of hair loss in women that is characterized by the reduction of hair density in the central area of the scalp, while the frontal hairline is generally well conserved. PARTICIPANTS: An expert task force appointed by Androgen Excess and PPCOS society, which included specialists from dermatology, endocrinology, and reproductive endocrinology...
February 20, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/30785517/immune-mediated-diseases-in-patients-with-celiac-disease-and-their-relatives-a-comparative-study-of-age-and-sex
#4
Lorete Maria da Silva Kotze, Luiz Roberto Kotze, Isabela Moreno, Renato Nisihara
BACKGROUND: Up to 15% of other immune-mediated diseases (IMDs) can occur in patients with CD throughout their lives and are associated with multiple factors, including sex and sex hormone levels. Moreover, sex is associated with differences in clinical presentation, onset, progression, and outcomes of disorders. OBJECTIVE: To investigate the prevalence of IMDs at diagnosis in patients with celiac disease (CD) and their first-degree relatives and to compare the findings between female and male patients of different age...
October 2018: Arquivos de Gastroenterologia
https://read.qxmd.com/read/30785024/recurrence-in-early-breast-cancer-analysis-of-data-from-3-765-australian-women-treated-between-1997-and-2015
#5
Robin Stuart-Harris, Jane E Dahlstrom, Ruta Gupta, Yanping Zhang, Paul Craft, Bruce Shadbolt
BACKGROUND: Evidence suggests recent improvements in outcome in early breast cancer (EBC). AIM: To analyse recurrence in women with EBC from our region from 1997 to 2015. METHODS: We analysed recurrence in 3,765 women with EBC. Median follow up was 83·0 months. 62·5% had a symptomatic presentation. 81·8% were hormone receptor positive and 38·5% were node positive. Lymphovascular invasion (LVI) was present in 24·3%. Of the 2,686 women entered from 2002 onwards tested for HER2 status, 72·7% had a luminal tumour, 15·2% had a HER2+ tumour and 12·1% had a triple negative (TN) tumour...
February 11, 2019: Breast: Official Journal of the European Society of Mastology
https://read.qxmd.com/read/30783806/spontaneous-regression-of-meningiomas-after-interruption-of-nomegestrol-acetate-a-series-of-three-patients
#6
Thibault Passeri, Pierre-Olivier Champagne, Anne-Laure Bernat, Shunya Hanakita, Henri Salle, Emmanuel Mandonnet, Sébastien Froelich
BACKGROUND: The relationship between increased meningioma incidence and growth and long-term hormonal therapy with cyproterone acetate (CPA) in women has been recently established in literature. Following the raise in awareness from hormonal treatment, we describe a potential relationship between the progesterone agonist nomegestrol acetate (NOMAC) and meningioma growth. METHODS: After implementation of a screening protocol to detect potential interactions between hormonal exposure and occurrence of meningioma, we identified patients taking NOMAC and newly diagnosed with a meningioma...
February 19, 2019: Acta Neurochirurgica
https://read.qxmd.com/read/30783737/the-impact-of-endopredict-%C3%A2-on-decision-making-with-increasing-oncological-work-experience-can-overtreatment-be-avoided
#7
Fabinshy Thangarajah, Christian Eichler, Julia Fromme, Wolfram Malter, Julia Caroline Radosa, Sebastian Ludwig, Julian Puppe, Stefan Paepke, Matthias Warm
BACKGROUND: Estimating distant recurrence risk in women with estrogen receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative early breast cancer is still challenging. EndoPredict® is a gene expression-based test predicting the likelihood of recurrent disease. We analyzed the difference in oncological decision making with and without the knowledge of gene expression tests. PATIENTS AND METHODS: This is a retrospective analysis including patients diagnosed with hormone-receptor positive, Her2 negative breast cancer between 2011 and 2015 at the Municipal Breast Cancer Centre Cologne, Germany...
February 19, 2019: Archives of Gynecology and Obstetrics
https://read.qxmd.com/read/30783444/analysis-of-detection-results-of-thyroid-function-related-indexes-in-pregnant-women-and-establishment-of-the-reference-interval
#8
Qi Zhou, Yanli Zhang, Jianhua Zhou, Xiangrong Yang, Yuqiang Huang, Huafeng Li, Chunling Ma
Detection results of free thyroxine (FT4), thyroid stimulating hormone (TSH) and thyroid peroxidase antibody (TPOAb) in pregnant women in Linyi region were investigated. A total of 22,235 healthy pregnant women admitted to Women and Children's Health Care Hospital of Linyi from October 2016 to October 2017 were selected and divided into the first-trimester, second-trimester and third-trimester pregnancy groups. Non-pregnant women in the same period were selected as the control group. Roche E601 electrochemiluminescence apparatus was applied to detect FT4, TSH and TPOAb, and statistical analysis was then carried out for the detected data...
March 2019: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/30782100/outcomes-of-endometrial-assessment-in-women-with-unscheduled-bleeding-on-hormone-replacement-therapy
#9
Salwa Abdullahi Idle, Haitham Hamoda
OBJECTIVE: This study correlates the transvaginal ultrasound findings with histopathology results in women who present with unscheduled bleeding on hormone replacement therapy. STUDY DESIGN: Retrospective analysis of 469 consecutive cases with unscheduled bleeding on hormone replacement therapy (203 patients on sequential hormone replacement therapy (seq-HRT) and 266 patients on continuous combined hormone replacement therapy (con-HRT)). MAIN OUTCOME MEASURES: Outcomes of endometrial assessment in women with unscheduled bleeding on hormone replacement therapy...
February 19, 2019: Post Reproductive Health
https://read.qxmd.com/read/30779515/perceptions-of-intra-uterine-device-users-in-mirebalais-haiti-a-mixed-methods-study
#10
Marie Boller, Meredith Jean-Baptiste, Christophe Millien, Theophile Renise, Marisa Nádas
INTRODUCTION: IUDs are safe, effective, and used worldwide to prevent unintended pregnancy. However, uptake in Haiti is low. There are limited data on IUD choice and experience in low resource settings; anecdotal reports from providers in Haiti have suggested that Haitian women are unlikely to choose to use or be satisfied with the IUD. The objective of this study is to explore the perceptions of a cohort of IUD users in Mirebalais, Haiti. METHODS: In June and July 2015, an IRB-approved mixed methods study of women over age eighteen with hormonal or copper IUDs inserted at Hôpital Universitaire de Mirebalais (HUM) was performed in Mirebalais, Haiti...
November 5, 2018: Annals of Global Health
https://read.qxmd.com/read/30779300/melasma-how-hormones-can-modulate-skin-pigmentation
#11
REVIEW
Angela Filoni, Maria Mariano, Norma Cameli
We described-along with a genetic predisposition and exposure to sunlight, as the main factors for melasma development-pregnancy, hormonal therapies, and oral contraceptive pills. Whilst hormonal alteration or therapies are frequently reported in literature in association with melasma, studies analyzing the laboratoristic correlation are limited. We review data published on hormones variations both in women and males with melasma and report some peculiar clinical cases that further demonstrate how the relationship between hormone secretion and melasma development is difficult to be defined...
February 18, 2019: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/30778332/testosterone-promotes-glioblastoma-cell-proliferation-migration-and-invasion-through-androgen-receptor-activation
#12
Dulce Carolina Rodríguez-Lozano, Ana Gabriela Piña-Medina, Valeria Hansberg-Pastor, Claudia Bello-Alvarez, Ignacio Camacho-Arroyo
Glioblastomas (GBM) are the most frequent and aggressive human brain tumors due to their high capacity to migrate and invade normal brain tissue. Epidemiological data report that GBM occur in a greater proportion in men than in women (3:2), suggesting the participation of sex hormones in the development of these tumors. It has been reported an increase in testosterone (T) levels in patients with GBM. In addition, androgen receptor (AR) is overexpressed in human GBM, and genetic silencing of AR, and its pharmacological inhibition, induce GBM cell death in vivo and in vitro ...
2019: Frontiers in Endocrinology
https://read.qxmd.com/read/30777407/thrombotic-and-hemorrhagic-burden-in-women-gender-related-issues-in-the-response-to-antithrombotic-therapies
#13
REVIEW
Giulia Renda, Giuseppe Patti, Irene Marthe Lang, Jolanta M Siller-Matula, Elaine M Hylek, Giuseppe Ambrosio, Sylvia Haas, Raffaele De Caterina
Thrombotic and bleeding risks, as well as the incidence and presentation of cardiovascular events and related outcomes, appear to differ between genders, partly in relation to variability in age, comorbidities and body size. Women experience frequent fluctuations of pro-thrombotic activity during their lifetime, related to menstrual cycles, the use of oral contraceptives, pregnancy, menopause, and hormone replacement therapy, all with potential impact on the clinical manifestations of atherosclerotic disease...
February 8, 2019: International Journal of Cardiology
https://read.qxmd.com/read/30777072/factors-influencing-oncologists-prescribing-hormonal-therapy-in-women-with-breast-cancer-a-qualitative-study-in-c%C3%A3-rdoba-argentina
#14
Yolanda Eraso
BACKGROUND: Hormonal therapy is an integral component for breast cancer treatment in women with oestrogen receptor positive tumours in early-stage and advanced cases of the disease. Little is known about what factors influence oncologists' prescribing practices, especially non-biological factors, although this information may have important implications for understanding inequalities in health care quality and outcomes. This paper presents findings from research on factors influencing oncologists' prescribing hormonal therapy for women with early and advanced cases of breast cancer in the city of Córdoba, Argentina...
February 18, 2019: International Journal for Equity in Health
https://read.qxmd.com/read/30776573/stress-related-genetic-polymorphisms-in-association-with-peripartum-depression-symptoms-and-stress-hormones-a-longitudinal-population-based-study
#15
Alkistis Skalkidou, Inger Sundström Poromaa, Stavros I Iliadis, Anja C Huizink, Charlotte Hellgren, Eva Freyhult, Erika Comasco
Individual differences in the response of the stress system to hormonal changes during pregnancy and the postpartum period render some women susceptible to developing depression. The present study sought to investigate peripartum depression and stress hormones in relation to stress-related genotypes. The Edinburgh Postnatal Depression Scale was used to assess peripartum depressive symptoms in a sample of 1629 women, followed from pregnancy week seventeen to six months postpartum. Genotypes of ninety-four haplotype-tag single nucleotide polymorphisms (SNPs) in sixteen genes of the hypothalamus-pituitary-adrenal axis pathway were analyzed and data on psychosocial and demographic factors was collected...
February 7, 2019: Psychoneuroendocrinology
https://read.qxmd.com/read/30776252/the-occurrence-of-acute-cardiovascular-events-in-transgender-individuals-receiving-hormone-therapy-results-from-a-large-cohort-study
#16
Nienke M Nota, Chantal M Wiepjes, Christel J M de Blok, Louis J G Gooren, Baudewijntje P C Kreukels, Martin den Heijer
In hypogonadal/postmenopausal individuals, hormone therapy has been associated with an increased risk for cardiovascular events (CVEs). A steeply growing population that often receives exogenous hormones is transgender individuals. Although transgender individuals hypothetically have an increased risk of CVEs, there is little known about the occurrence of CVEs in this population.1 Therefore, we determined the incidences of acute/spontaneous strokes (ischemic/hemorrhagic, transient ischemic attack, or subarachnoid hemorrhage), myocardial infarctions (MIs), and venous thromboembolic events (VTEs) in transwomen and transmen receiving transgender hormone therapy (THT)...
February 18, 2019: Circulation
https://read.qxmd.com/read/30775688/investigation-of-anti-mullerian-hormone-amh-level-and-ovarian-response-in-infertile-women-with-endometriosis-in-ivf-cycles
#17
Leili Safdarian, Seyedeh Noushin Ghalandarpoor Attar, Ashraf Aleyasin, Marzieh Aghahosseini, Fateme Sadaf Sarfjoo, Sedigheh Hosseinimousa
Background: Endometriosis, can cause ovarian conflict and reduced ovarian reserve that could lead to lower response to assisted reproductive techniques. Objective: Current study was conducted to determine the association between level of anti-mullerian hormone (AMH) and the infertility treatment outcomes in infertile females with endometriosis versus the non-endometriosis infertile subject. Materials and Methods: In this case-control study, 64 infertile females who referred to Shariati Hospital from April 2015 to November 2017 were enrolled...
November 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://read.qxmd.com/read/30775685/the-effect-of-inflammatory-diseases-associated-with-opportunistic-urogenital-infection-on-the-hormonal-function-of-the-female-reproductive-system
#18
Abdrakhmanov Azat Rasimovich, Abdrakhmanov Rasim Mindrakhmanovich
Background: Sexually transmitted infections play a great role in formation of inflammatory diseases of female urogenital system. These diseases can cause a decrease in the level of female sex hormones, as well as the ratio of estrogens and androgens. Objective: To determine changes in the state of sex hormones in women with inflammatory diseases of ovaries associated with opportunistic urogenital flora. Materials and Methods: 136 women aged 18-39 yr participated in this cross-sectional clinical study...
November 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://read.qxmd.com/read/30774450/25-hydroxyvitamin-d-levels-and-its-relation-to-muscle-strength-maximal-oxygen-consumption-and-body-mass-index-in-young-and-middle-adulthood-women
#19
Hamid Arazi, Ehsan Eghbali
Introduction: Vitamin D is a potent secosteroid hormone that provides many health benefits. The ubiquitous nature of vitamin D receptor (VDR) suggests widespread effect. Purpose: The purpose of this study was to investigate the relationship between 25-hydroxyvitamin D (25OHD) levels and muscle strength, maximal oxygen consumption (VO2 max), and body mass index (BMI) in Iranian young and middle adulthood women. Participants and methods: A cross-sectional descriptive study was conducted in 182 healthy Iranian women within the age range of 26-60 years...
2019: International Journal of Women's Health
https://read.qxmd.com/read/30773990/bms-consensus-statement-the-risks-and-benefits-of-hrt-before-and-after-a-breast-cancer-diagnosis
#20
Jo Marsden
In women at population risk of breast cancer (i.e. most), short-term exposure to hormone replacement therapy (i.e. up to five years' use) for symptom relief exceeds its potential harms, including the associated, increased risk of breast cancer diagnosis. Many women and health care professionals, however, consider this to be unacceptably high, although the degree of risk conferred appears equivalent to, or less than that of, other lifestyle risk factors for this condition. In contrast, it is recommended that symptomatic women at high baseline risk due to a family history or a biopsy-confirmed high-risk benign breast condition and those with previous breast cancer should be managed initially with lifestyle changes and non-hormonal alternatives...
February 16, 2019: Post Reproductive Health
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