Jing Wang, Wei-Lien Wang, Hongxia Sun, Lei Huo, Yun Wu, Hui Chen, Qiong Gan, Jeanne M Meis, Nolan Maloney, Alexander J Lazar, Esther C Yoon, Constance T Albarracin, Savitri Krishnamurthy, Lavinia P Middleton, Erika Resetkova, Wendong Yu, Dongfeng Tan, Wei Lu, Luisa Maren Solis Soto, Shufang Wang, Ignacio I Wistuba, Anil V Parwani, Victor G Prieto, Aysegul A Sahin, Zaibo Li, Qingqing Ding
When a sarcomatous neoplasm is identified in the breast, distinguishing metaplastic carcinoma, malignant phyllodes tumor (MPT), and primary sarcoma is a diagnostic challenge, especially on small biopsies, as all these tumors may have overlapping morphological features, thoroughly grossing with histological examination and immunohistochemical staining being the standard approach to aid in classifying these lesions. Recently, we identified a highly sensitive and specific breast carcinoma marker TRPS1 with high expression in metaplastic breast carcinoma...
March 2022: Human Pathology