Akshay Machanahalli Balakrishna, Ruth Ann Mathew Kalathil, Suma Pusapati, Auras Atreya, Aryan Mehta, Mridul Bansal, Vikas Aggarwal, Mir B Basir, Ajar Kochar, Alexander G Truesdell, Saraschandra Vallabhajosyula
There are limited and conflicting data on the initial management of intermediate-risk (or submassive) pulmonary embolism (PE). This study sought to compare the outcomes of catheter-directed thrombolysis (CDT) in combination with systemic anticoagulation (SA) to SA alone. A systematic search was conducted in MEDLINE, EMBASE, PubMed, and the Cochrane databases from inception to March 1, 2023 for studies comparing the outcomes of CDT + SA versus SA alone in intermediate-risk PE. The outcomes were in-hospital, 30-day, 90-day, and 1-year mortality; bleeding; blood transfusion; right ventricular recovery; and length of stay...
August 22, 2023: American Journal of Cardiology