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Testosterone AND DHEA

Aya T Nanba, Juilee Rege, Jianwei Ren, Richard J Auchus, William E Rainey, Adina F Turcu
Context: The ovaries and adrenals are sources of androgens in women. While dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), and testosterone (T) all decline with age, these C19 steroids correlate poorly with parameters of androgen action in postmenopausal women. Objective: To comprehensively compare androgen profiles in pre- and post-menopausal women. Methods: We quantified 19 steroids, including DHEA, DHEAS, T, androstenedione (A4), and the adrenal-specific 11-oxygenated C19 steroids (11oxyandrogens) 11β-hydroxytestosterone (11OHT), 11-ketotestosterone (11KT), 11β-hydroxyandrostenedione (11OHA4) and 11-ketoandrostenedione (11KA4) using liquid chromatography-tandem mass spectrometry in morning serum obtained from 100 pre- (age 20-40 years) and 100 post-menopausal (age ≥ 60 years) women...
February 8, 2019: Journal of Clinical Endocrinology and Metabolism
Sebastian Findeklee, Panagiotis Sklavounos, Lisa Stotz, Romina M Sima, Iulian Iordache, Carolin Spüntrup, Mariz Kasoha, Fabinshy Thangarajah, Erich-Franz Solomayer, Julia C Radosa
PURPOSE: Primary and secondary sterility have become an issue of increasing importance due to demographic and social changes in society. Data regarding the association between female androgen levels and the probability of successful conception after fertility treatment are sparse and contradictive. This study was designed to assess this clinical question. METHODS: In this retrospective single-center cohort study concentrations of androgens androstenedione, dehydroepiandrosteronsulfat (DHEAS) and testosterone (ng/ml) were investigated in the serum of patients presenting for sterility at the department of reproductive medicine of Saarland University hospital Homburg between January 2015 and December 2017...
February 8, 2019: Archives of Gynecology and Obstetrics
Eric Levesque, Patrick Caron, Louis Lacombe, Veronique Turcotte, David Simonyan, Yves Fradet, Armen Aprikian, Fred Saad, Michel Carmel, Simone Chevalier, Chantal Guillemette
BACKGROUND: In men with localized prostate cancer (PCa) who are undergoing radical prostatectomy (RP), it is uncertain whether their hormonal environment is associated with outcomes. The objective of the study was to examine the association between the steroid metabolome with prognostic factors and progression. PATIENTS AND METHODS: The prospective PROCURE cohort was recruited from 2007-2012, and comprises 1766 patients with localized PCa who provided blood samples prior to RP...
February 7, 2019: Cancer Epidemiology, Biomarkers & Prevention
Liang-Jen Wang, Sheng-Yu Lee, Miao-Chun Chou, Min-Jing Lee, Wen-Jiun Chou
The neuroendocrine system may affect the pathophysiology of gender differences in attention deficit/hyperactivity disorder (ADHD). This study examines whether the relationships among dehydroepiandrosterone sulfate (DHEA-S), free testosterone, or sex hormone-binding globulin (SHBG) and ADHD presentations exhibit gender differences. A total of 113 boys and 35 girls with ADHD (all drug naïve) and 46 and 26 healthy control boys and girls, respectively, were recruited. Blood samples were obtained to measure the serum levels of DHEA-S, free testosterone, and SHBG in each child...
January 24, 2019: Psychoneuroendocrinology
Silvia Baggio, Rossana Di Paola, Stefano Zaffagnini, Stefania Fino, Ricciarda Raffaelli, Massimo Franchi
Background To develop a diagnostic assessment tool, using clinical, biochemical and sonographic markers, to help clinicians in the differential diagnosis of functional oligomenorrhea (FO) and endocrine-metabolic oligomenorrhea (EMO). Methods Sixty-two adolescents with oligomenorrhea without evident hormonal imbalances or severe energy deficit were selected. They were divided into two groups (EMO and FO) and they all underwent the following assessment: physical examination (height, weight, presence of hirsutism or acne), blood exams and transabdominal ultrasonography...
January 26, 2019: Journal of Pediatric Endocrinology & Metabolism: JPEM
Branka Bašica, Ivan Mihaljević, Nikola Maraković, Radmila Kovačević, Tvrtko Smital
Glutathione S-transferases (GSTs) are multifunctional phase II detoxification enzymes with primary function of glutathione conjugation of various endogenous and exogenous compounds. Teleost-specific Gstr1 in zebrafish (Danio rerio) was previously shown to have high expression in toxicologically relevant tissues and high activity towards model substrates. The aim of this study was a detailed functional characterization of zebrafish Gstr1. Molecular docking analyses were used to get novel insight into structural characteristics of Gstr1 and elucidation of the mechanistic interactions with both GSH and various Gstr1 substrates or inhibitors...
January 9, 2019: Aquatic Toxicology
Wei-Bin Zhou, Nan Chen, Cheng-Jiang Li
BACKGROUND: Hyperandrogenemia is more common in puberty and reproductive age, but relatively rare in postmenopausal women. Postmenopausal virilization may result from androgen-producing tumors. Androgen-secreting adrenal tumors are rare in clinical practice and are diagnosed as adrenocortical carcinoma, most of which can co-secrete androgen and cortisol. Highly elevated serum testosterone level with normal adrenal androgens such as dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEAS) and androstenedione is usually regarded as ovary origin...
January 23, 2019: BMC Endocrine Disorders
Morten Ruge, Tea Skaaby, Anna-Maria Andersson, Allan Linneberg
BACKGROUND: Reduced total hours of sleep and low quality of sleep have been suggested to be associated with low levels of male hormones. Few studies have examined the association between excessive sleep and male reproductive hormones. OBJECTIVE: To investigate the association of total hours of sleep and quality of sleep with serum levels of total-, bioavailable- and free testosterone (tT, bT and fT), sex hormone binding globulin (SHBG) and dehydroepiandrosteron-sulfat (DHEAS)...
January 1, 2019: Endocrine Connections
Mina Amiri, Fahimeh Ramezani Tehrani, Razieh Bidhendi-Yarandi, Samira Behboudi-Gandevani, Fereidoun Azizi, Enrico Carmina
While several studies have documented an increased risk of metabolic disorders in patients with polycystic ovary syndrome (PCOS), associations between androgenic and metabolic parameters in these patients are unclear. We aimed to investigate the relationships between biochemical markers of hyperandrogenism (HA) and metabolic parameters in women with PCOS. In this systematic review and meta-analysis, a literature search was performed in the PubMed, Scopus, Google Scholar, ScienceDirect, and Web of Science from 2000 to 2018 for assessing androgenic and metabolic parameters in PCOS patients...
January 2019: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
Hikmet Can Çubukçu, Ömer Yavuz, Erdinç Devrim
Laboratory tests are an integral part of clinical decision making. Therefore, measurement uncertainty comes into prominence in the context of the accuracy of the laboratory result. This study aims to investigate measurement uncertainty of 14 immunoassay analytes, to compare them with different quality goals and to utilize them in the result interpretation. Measurement uncertainties of 14 immunoassay analytes were estimated by using internal and external quality control data by using Nordtest approach. Expanded uncertainties (U) were compared with allowable total error (TEa%), permissible relative deviation in the external quality assessment (PRDEQA %) and permissible expanded uncertainty for external quality assessment (pUEQAS %)...
January 10, 2019: Scandinavian Journal of Clinical and Laboratory Investigation
F Z Stanczyk, S Chaikittisilpa, I Sriprasert, A Rafatnia, M Nadadur, D R Mishell
OBJECTIVE: This study aimed to determine the effect of oophorectomy on baseline serum levels of androgens and estrogens in premenopausal and postmenopausal women. METHODS: Fourteen premenopausal and 10 postmenopausal women underwent total hysterectomy and bilateral oophorectomy for benign disease of the uterus. Serum levels of dehydroepiandrosterone sulfate (DHEAS), androstenedione (A), testosterone (T), dihydrotestosterone (DHT), 5α-androstane-3α,17β-diol-17β-glucuronide (3α-diol G), estrone (E1 ), estradiol (E2 ), and sex hormone-binding globulin (SHBG) were measured by highly specific immunoassays prior to surgery and 2 weeks afterward...
January 7, 2019: Climacteric: the Journal of the International Menopause Society
Kevin H Kensler, A Heather Eliassen, Bernard A Rosner, Susan E Hankinson, Myles Brown, Rulla M Tamimi
PURPOSE: Higher levels of circulating sex steroid hormones are associated with increased breast cancer risk, though their association with prognosis remains unclear. We evaluated the association between circulating sex hormone levels and breast cancer survival in two large cohorts. METHODS: We evaluated this association among 2073 breast cancer cases from the Nurses' Health Study (NHS) and Nurses' Health Study II (NHSII) cohorts. Women in this analysis provided a blood sample in 1989-1990 (NHS) or in 1996-1999 (NHSII) and were subsequently diagnosed with breast cancer...
January 2, 2019: Breast Cancer Research and Treatment
Mohammed H Hassan, Tarek Desoky, Hala M Sakhr, Romany H Gabra, Ali Helmi Bakri
The present cross-sectional, hospital-based study was carried out on 146 Egyptian male children, 73 males with autism who were comparable with another 73 healthy age- and sex-matched children, recruited from the outpatients' psychiatric clinics of the Neuropsychiatric and Pediatric Departments of South Valley and Assiut University Hospitals, Egypt. Neuropsychological assessments of autistic males were done using CARS, short sensory profile and intelligent quotients. Serum markers of mitochondrial dysfunction (lactate, pyruvate, and lactate to pyruvate ratio, creatine kinase (CK), L-carnitine, ammonia, lactate dehydrogenase, pyruvate kinase, alanine transaminase and aspartate transaminase), oxidative stress and blood levels of heavy metals (mercury, lead and aluminium) were measured...
January 2, 2019: Journal of Molecular Neuroscience: MN
Philippe Liere, Charlotte A Cornil, Marie Pierre de Bournonville, Antoine Pianos, Matthieu Keller, Michael Schumacher, Jacques Balthazart
Both systemic and local production contribute to the concentration of steroids measured in the brain. This idea was originally based on rodent studies and was later extended to other species including humans and birds. In quail, a widely used model in behavioral neuroendocrinology, it was demonstrated that all enzymes needed to produce sex steroids from cholesterol are expressed and active in the brain but the actual concentrations of steroids produced were never investigated. We carried out a steroid profiling in multiple brain regions and serum of sexually mature male and female quail by gas chromatography coupled to mass spectrometry...
December 26, 2018: Journal of Neuroendocrinology
Ladan Younesi, Zeinab Safarpoor, Azadeh Akbari Sene, Zahra Hosseini Jebelli, Ghazaleh Amjad
Polycystic ovarian syndrome (PCOS) is one of the most common endocrine disorders. The aim of this study was to find the correlation between color Doppler ultrasound and serum tests as auxiliary diagnostic criteria in areas where there is no possibility of some tests. A total of 108 patients were enrolled. They were divided into three groups including patients with PCOS, patients with PCOA ultrasound, patients with ovaries and normal hormone tests. Transvaginal sonography was performed from three groups and the results were evaluated in gray scale...
December 1, 2018: Endocrine Connections
Jan Idkowiak, Yasir S Elhassan, Pascoe Mannion, Karen Smith, Rachel Webster, Vrinda Saraff, Timothy G Barrett, Nicholas G Shaw, Nils Krone, Renuka P Dias, Melanie Kershaw, Jeremy M Kirk, Wolfgang Högler, Ruth E Krone, Michael W O'Reilly, Wiebke Arlt
OBJECTIVE: Androgen excess in childhood is a common presentation and may signify sinister underlying pathology. Data describing its patterns and severity are scarce, limiting the information available for clinical decision processes. Here, we examined the differential diagnostic value of serum dehydroepiandrosterone sulfate (DHEAS), androstenedione (A4), and testosterone (T) in childhood androgen excess. DESIGN: Retrospective review of all children undergoing serum androgen measurement at a single center over 5 years...
December 1, 2018: European Journal of Endocrinology
Takahiko Mitsui, Atsuko Araki, Chihiro Miyashita, Sachiko Ito, Tamiko Ikeno, Seiko Sasaki, Takeya Kitta, Kimihiko Moriya, Kazutoshi Cho, Keita Morioka, Reiko Kishi, Nobuo Shinohara, Masayuki Takeda, Katsuya Nonomura
OBJECTIVE: We investigated the association between the hormonal environment during the prenatal period using cord blood and gender-role play behavior in school-aged children. METHODS: A total of 879 school-aged children (433 males and 446 females) in a prospective cohort study of birth in Hokkaido were enrolled in analyses of the relationship between the levels of sex hormones in cord blood and the results from the Pre-school Activities Inventory (PSAI) questionnaire...
December 19, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
Dariyush Raeisi, Mohammad Erfan Zare, Atefeh Nasir, Hamidraza Sherkatolabbasieh, Shiva Shafeizadeh
Pathogenesis of systemic lupus erythematosus (SLE) is complex and multi-factorial. Among various suggested mechanisms for the disease, the hormonal theory has been considered as one of the most important mechanisms. Recently, the association of sex hormones with manifestations of antiphospholipid antibody syndrome (APLS) has been hypothesized. The aim of present study was to assess the serum levels of anticardiolipin antibody (ACA), sex hormones and prolactin in SLE female patients and their association with the disease...
August 12, 2018: Iranian Journal of Allergy, Asthma, and Immunology
Verica Milivojevic, Jonathan Covault, Gustavo A Angarita, Kristen Siedlarz, Rajita Sinha
BACKGROUND AND OBJECTIVES: Neuroactive steroids (NAS) may play a role in addiction, with observed increases in response to acute stress and drug use, but decreases with chronic substance use, suggesting that NAS neuroadaptations may occur with chronic substance use. However, levels of NAS in addicted individuals have not been systematically examined. Here, we evaluated a panel of NAS in men and women with cocaine use disorder (CUD) who participated in a clinical laboratory study of progesterone...
December 11, 2018: American Journal on Addictions
Alexandra Efthymiadou, Maria Bogiatzidou, Dimitra Kritikou, Dionisios Chrysis
OBJECTIVES: To assess whether the serum levels of anti-Müllerian hormone (AMH) are increased in girls with premature adrenarche because they are at a higher risk of developing polycystic ovary syndrome (PCOS) later in life. STUDY DESIGN: We measured serum levels of AMH, dehydroepiandrosterone sulfate (DHEAS), testosterone, sex hormone binding globulin, androstenedione, and 17-hyroxyprogesterone in 89 girls with premature adrenarche aged 6.98 ± 1.60 years, and in 55 prepubertal normal girls aged 6...
October 24, 2018: Journal of Pediatrics
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