Lei Zhang, Jiaxin Liu, Yongliang Wang, Mengyao Wei, Xiaorui Liu, Yue Jiang, Xiaofei Wang, Zhongshi Zhu, Chen Niu, Shujuan Liu, Jiuzeng Cui, Tingting Chu, Wentao Lu, Xiyun Zhang, Xiaopeng An, Yuxuan Song
Sheep milk is rich in fat, protein, vitamins and minerals and is also one of the most important sources of natural bioactives. Several biopeptides in sheep milk have been reported to possess antibacterial, antiviral and anti-inflammatory properties, and they may prevent type 2 diabetes (T2D), disease and cancer. However, the precise mechanism(s) underlying the protective role of sheep milk against T2D development remains unclear. Therefore, in the current study, we investigated the effect of sheep milk on insulin resistance and glucose intolerance in high-fat diet (HFD)-fed mice, by conducting intraperitoneal glucose tolerance tests, metabolic cage studies, genomic sequencing, polymerase chain reaction, and biochemical assays...
March 2024: Food Research International