keyword
https://read.qxmd.com/read/38536552/il-6-enhances-the-activation-of-pi3k-akt-mtor-gsk-3%C3%AE-by-upregulating-grpr-in-hippocampal-neurons-of-autistic-mice
#1
JOURNAL ARTICLE
Heli Li, Xinyuan Wang, Cong Hu, Jinru Cui, Hao Li, Xiaoping Luo, Yan Hao
Autism spectrum disorder (ASD) is a neurological disorder associated with brain inflammation. The underlying mechanisms could be attributed to the activation of PI3K signaling in the inflamed brain of ASD. Multiple studies highlight the role of GRPR in regulating ASD like abnormal behavior and enhancing the PI3K signaling. However, the molecular mechanism by which GRPR regulates PI3K signaling in neurons of individuals with ASD is still unclear. In this study, we utilized a maternal immune activation model to investigate the effects of GRPR on PI3K signaling in the inflamed brain of ASD mice...
March 27, 2024: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://read.qxmd.com/read/38536523/suitability-of-reduced-dose-glucocorticoids-therapy-regimen-for-antibody-associated-vasculitis-patients-with-tb-a-retrospective-study
#2
JOURNAL ARTICLE
Rui Wen, Jingni Xiao, Ning Ding, Yong Zhong, Qiong Yuan, Jiali Li, Qi Wang, Hebin Xie, Jiao Qin
INTENTION: Immunosuppressive therapy is the major treatment approach for patients with anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV). Due to impaired cellular immunological function and the use of glucocorticoids and immunosuppressants, AAV patients are predisposed to opportunistic infections, including tuberculosis (TB). This retrospective study aims to analyze the clinical characteristics of patients with AAV and TB and explore suitable glucocorticoid regimens for them...
March 27, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38536399/characteristics-of-enterococcus-species-bloodstream-infections-among-adults-with-and-without-onco-hematological-malignancies-experiences-from-the-national-center-of-hungary
#3
JOURNAL ARTICLE
Bence Marosi, Béla Kádár, Anna Bruzsa, Laura Kocsis, Katalin Kamotsay, János Sinkó, Bálint Gergely Szabó, Botond Lakatos
INTRODUCTION: Over the past decade, enterococcal bloodstream infection (BSI) shows increasing incidence globally among the elderly and in patients with comorbidities. In this study, we aimed to assess microbiological and clinical characteristics and long-term outcomes of BSIs caused by Enterococcus spp. in adult patients with and without active onco-hematological malignancies hospitalized at a national referral institute. METHODS: A prospective analysis of consecutive enterococcal BSI cases was conducted in the National Institute of Hematology and Infectious Diseases (Budapest, Hungary) between December 2019 and April 2022...
March 27, 2024: European Journal of Microbiology & Immunology
https://read.qxmd.com/read/38536099/correction-selective-inhibition-of-the-interaction-between-sars-cov-2-spike-s1-and-ace2-by-spidar-peptide-induces-anti-inflammatory-therapeutic-responses
#4
Ramesh K Paidi, Malabendu Jana, Rama K Mishra, Debashis Dutta, Kalipada Pahan
Paidi, R. K., M. Jana, R. K. Mishra, D. Dutta, and K. Pahan. 2021. Selective inhibition of the interaction between SARS-CoV-2 spike S1 and ACE2 by SPIDAR peptide induces anti-inflammatory therapeutic responses. J. Immunol. 207: 2521-2533.In the original Supplemental Fig. 2C, the "Control" image was duplicated from the "Spike S1 (heat inactivated)" image due to an error during figure preparation. The supplemental figure has been corrected in the online version of the article.
March 27, 2024: Journal of Immunology
https://read.qxmd.com/read/38536025/correction-dx5-cd49b-positive-t-cells-are-not-synonymous-with-cd1d-dependent-nkt-cells
#5
Daniel G Pellicci, Kirsten J L Hammond, Jonathan Coquet, Konstantinos Kyparissoudis, Andrew G Brooks, Katherine Kedzierska, Rachael Keating, Stephen Turner, Stuart Berzins, Mark J Smyth, Dale I Godfrey
Pellicci, D. G., K. J. L. Hammond, J. Coquet, K. Kyparissoudis, A. G. Brooks, K. Kedzierska, R. Keating, S. Turner, S. Berzins, M. J. Smyth, and D. I. Godfrey. 2005. DX5/CD49b-positive T cells are not synonymous with CD1d-dependent NKT cells. J. Immunol. 175: 4416-4425. Fig. 2A of this article contains flow cytometry comparing C57BL/6 WT mice and CD1d-/- mice for αβTCR versus DX5 or αβTCR versus CD49b staining in mouse thymus, spleen, liver, bone marrow, and peripheral lymph nodes (PLNs)...
March 27, 2024: Journal of Immunology
https://read.qxmd.com/read/38535182/the-host-response-to-coccidioidomycosis
#6
REVIEW
Theo N Kirkland, Chiung-Yu Hung, Lisa F Shubitz, Sinem Beyhan, Joshua Fierer
Coccidioidomycosis is an important fungal disease that is found in many desert regions of the western hemisphere. The inhaled organisms are highly pathogenic, but only half of infected, immunologically intact people develop symptomatic pneumonia; most symptomatic infections resolve spontaneously, although some resolve very slowly. Furthermore, second infections are very rare and natural immunity after infection is robust. Therefore, the host response to this organism is very effective at resolving the infection in most cases and immunizing to prevent second infections...
February 25, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38533694/the-engineered-exosomes-targeting-ferroptosis-a-novel-approach-to-reverse-immune-checkpoint-inhibitors-resistance
#7
REVIEW
Anqi Chen, Wenjie Zhang, Chuwen Jiang, Zhengting Jiang, Dong Tang
Immune checkpoint inhibitors (ICIs) have been extensively used in immunological therapy primarily due to their ability to prolong patient survival. Although ICIs have achieved success in cancer treatment, the resistance of ICIs should not be overlooked. Ferroptosis is a newly found cell death mode characterized by the accumulation of reactive oxygen species (ROS), glutathione (GSH) depletion, and glutathione peroxidase 4 (GPX4) inactivation, which has been demonstrated to be beneficial to immunotherapy and combining ferroptosis and ICIs to exploit new immunotherapies may reverse ICIs resistance...
March 27, 2024: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/38532889/immuno-hematological-and-biochemical-changes-in-patients-with-tuberculosis-in-dessie-comprehensive-specialized-hospital-dessie-ethiopia
#8
JOURNAL ARTICLE
Angesom Gebreweld, Temesgen Fiseha, Edosa Kebede, Zemenu Tamir, Brhane Gebremariam, Fikadu Miruts, Haftay Haileslasie
BACKGROUND: Tuberculosis (TB) is a serious worldwide health issue, particularly in developing nations like Ethiopia. Patients with tuberculosis experience a range of hematological, immunological, and biochemical alterations. The purpose of this study was to evaluate immunological, hematological, and biochemical alterations of newly diagnosed TB patients at Dessie comprehensive specialized hospital, Dessie, Ethiopia. METHODS: A comparative, cross-sectional study was carried out to evaluate the immuno-hematological and biochemical changes in patients with tuberculosis at Dessie comprehensive specialized hospital from January to July 2018...
2024: Journal of Blood Medicine
https://read.qxmd.com/read/38532599/high-sensitivity-of-host-helios-neuropilin-1-treg-to-pretransplant-conditioning-hampers-development-of-ox40-bright-integrin-%C3%AE-7-regulatory-cells-in-acute-gastrointestinal-gvhd
#9
JOURNAL ARTICLE
Nikolett Lupsa, Barbara Érsek, Csenge Böröczky, Dávid Kis, Eszter Szarka, Katalin Lumniczky, Géza Sáfrány, Zoltán S Zádori, Árpád Szöőr, Edit I Buzás, Zoltán Pós
This study sought to compare the behavior of Treg subsets displaying different coexpression patterns of Neuropilin-1 (Nrp1) and Helios, under the influence of gut stress unrelated to hematopoietic stem cell transplantation, pretransplantation conditioning, and posttransplant gastrointestinal acute graft versus host disease (GI-aGvHD). Host CD4+ /CD25hi /Foxp3+ Treg cells, identified by flow cytometry, were isolated from various tissues of mice affected by these stressors. Expression of CD25, CTLA-4, CD39, OX40, integrin-β7, LAG3, TGFβ/LAP, granzyme-A, -B, and interleukin-10 was compared in four Treg subsets displaying Helios or Nrp1 only, both or none...
March 26, 2024: European Journal of Immunology
https://read.qxmd.com/read/38532465/bulk-rna-sequencing-for-analysis-of-post-covid-19-condition-in-adolescents-and-young-adults
#10
JOURNAL ARTICLE
Silke Lauren Sommen, Zhi Zhao, Sunniva Segtnan, Tonje Stiansen-Sonerud, Joel Selvakumar, Lise Beier Havdal, Johannes Gjerstad, Vegard Bruun Bratholm Wyller, Lise Lund Berven
BACKGROUND: Post COVID-19 condition (PCC) is a complication of SARS-COV-2 infection and can lead to long-term disability. METHODS: The present study was designed to analyse the gene expression patterns of PCC through bulk RNA sequencing of whole blood and to explore the potential molecular mechanisms of PCC. Whole blood was collected from 80 participants enrolled in a prospective cohort study following SARS-CoV-2 infected and non-infected individuals for 6 months after recruitment and was used for bulk RNA sequencing...
March 26, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38531818/inhibition-of-the-endoplasmic-reticulum-stress-associated-ire-1-pathway-alleviates-preterm-birth
#11
JOURNAL ARTICLE
Liyin Qiu, Hui Liu, Shali Chen, Yiting Wu, Jianying Yan
BACKGROUND: Premature birth (PTB) remains a major global health concern due to its association with neonatal morbidity and mortality. The unfolded protein response (UPR) within the endoplasmic reticulum (ER) is tightly regulated by Inositol-requiring enzyme type 1 (IRE-1), a pivotal cellular modulator. This study seeks to elucidate the role of the ER stress (ERS)-related IRE-1 pathway in PTB. METHODS: Human placental trophoblast cells HTR8/Svneo were exposed to the ER-stress inducer tunicamycin (TM)...
March 2024: American Journal of Reproductive Immunology: AJRI
https://read.qxmd.com/read/38531664/poor-clinical-outcomes-and-immunoevasive-contexture-in-cd161-cd8-t-cells-barren-human-pancreatic-cancer
#12
JOURNAL ARTICLE
Qiangda Chen, Hanlin Yin, Zhenlai Jiang, Taochen He, Yuqi Xie, Weilin Mao, Jiande Han, Siyao Liu, Wenhui Lou, Wenchuan Wu, Joseph R Habib, Jun Yu, Liang Liu, Ning Pu
BACKGROUND: The role of CD161 expression on CD8+ T cells in tumor immunology has been explored in a few studies, and the clinical significance of CD161+ CD8+ T cells in pancreatic ductal adenocarcinoma (PDAC) remains unclear. This study seeks to clarify the prognostic value and molecular characteristics linked to CD161+ CD8+ T cell infiltration in PDAC. METHODS: This study included 186 patients with confirmed PDAC histology after radical resection. CD161+ CD8+ T cell infiltration was assessed using immunofluorescence staining on tumor microarrays...
March 26, 2024: Journal for Immunotherapy of Cancer
https://read.qxmd.com/read/38531662/impact-of-immunotherapy-time-of-day-infusion-on-survival-and-immunologic-correlates-in-patients-with-metastatic-renal-cell-carcinoma-a-multicenter-cohort-analysis
#13
MULTICENTER STUDY
Jimmy S Patel, Yena Woo, Amber Draper, Caroline S Jansen, Jennifer W Carlisle, Pasquale F Innominato, Francis A Lévi, Layla Dhabaan, Viraj A Master, Mehmet A Bilen, Mohammad K Khan, Michael C Lowe, Haydn Kissick, Zachary S Buchwald, David C Qian
BACKGROUND: Recent studies have demonstrated that earlier time-of-day infusion of immune checkpoint inhibitors (ICIs) is associated with longer progression-free survival (PFS) and overall survival (OS) among patients with metastatic melanoma and non-small cell lung cancer. These data are in line with growing preclinical evidence that the adaptive immune response may be more effectively stimulated earlier in the day. We sought to determine the impact of time-of-day ICI infusions on outcomes among patients with metastatic renal cell carcinoma (mRCC)...
March 26, 2024: Journal for Immunotherapy of Cancer
https://read.qxmd.com/read/38531576/efficacy-and-safety-of-natural-killer-cells-injection-combined-with-xelox-chemotherapy-in-postoperative-patients-with-stage-iii-colorectal-cancer-in-china-a-prospective-randomised-controlled-clinical-trial-study-protocol
#14
JOURNAL ARTICLE
Shan Geng, Xingrui Yu, Shaohong Yu
BACKGROUND: Colorectal cancer (CRC) is the second most frequently diagnosed cancer and the fifth leading cause of cancer-related death in China. However, resistance to multiple chemotherapeutics after surgery leads to failure of the main therapy to CRC. Natural killer (NK) cells are innate cytotoxic lymphocytes that exhibit strong cytotoxic activity against tumour cells. NK cell-based therapy, either alone or in combination with chemotherapy, has achieved favourable results and holds promise for addressing recurrence and metastasis in CRC patients after surgery...
March 25, 2024: BMJ Open
https://read.qxmd.com/read/38531186/effect-of-dietary-electrolyte-balance-and-arginine-to-lysine-ratio-on-hematological-antioxidant-and-immunological-traits-in-dual-purpose-breeding-hens-under-cyclic-heat-stress-condition
#15
JOURNAL ARTICLE
Youssef A Attia, Ahmed A Abdallah, Fulvia Bovera, Abd El-Hamid E Abd El-Hamid, Asmaa Sh El-Naggar, Rashed A Alhotan, Vincenzo Tufarelli, Reda M Zaki
A total of 245 hens and 35 cocks (32 weeks age) were assigned to seven treatment groups (five replicates with seven hens and one cock) to investigate the effect of dietary electrolyte balance (DEB) and arginine to lysine ratio (Arg/Lys) on birds' physiological and biochemical traits under cyclic heat stress (CHS) condition. Birds were housed in an environmentally controlled facility having four sectors. The first group (positive control, PC) was kept under thermoneutral conditions and fed diet with DEB of 180 mEq and Arg/Lys of 1...
March 21, 2024: Journal of Thermal Biology
https://read.qxmd.com/read/38530680/impact-of-asthma-medications-during-pregnancy-on-asthma-exacerbation-maternal-and-neonatal-outcomes
#16
JOURNAL ARTICLE
Sangmin Lee, Erin Hetherington, Richard Leigh, Kaylee Ramage, Amy Metcalfe
BACKGROUND: Asthma affects 5% to 13% of pregnant women, and many require daily pharmacotherapy to achieve asthma control; however, adherence to medication during pregnancy often decreases. OBJECTIVE: To understand the association between the use of or adherence to asthma medication with asthma exacerbation and maternal/neonatal outcomes. METHODS: Using linked population-based administrative databases from Alberta, Canada (2012-2018), pregnant women with asthma were categorized based on asthma medication use 1 year before pregnancy: short-acting β-agonists (SABA), inhaled corticosteroids (ICS), and ICS with long-acting β-agonists (ICS+LABA)...
March 7, 2024: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/38530358/gender-affirming-hormone-therapy-preserves-skeletal-maturation-in-young-mice-via-the-gut-microbiome
#17
JOURNAL ARTICLE
Subhashis Pal, Xochitl Morgan, Hamid Y Dar, Camilo Anthony Gacasan, Sanchiti Patil, Andreea Stoica, Yi-Juan Hu, M Neale Weitzmann, Rheinallt M Jones, Roberto Pacifici
Gender affirming hormone therapy (GAHT) is often prescribed to transgender (TG) adolescents to alleviate gender dysphoria, but the impact of GAHT on the growing skeleton is unclear. We found GAHT to improve trabecular bone structure via increased bone formation in young male mice and not to affect trabecular structure in female mice. GAHT modified gut microbiome composition in both male and female mice. However, fecal microbiota transfers (FMT) revealed that GAHT-shaped gut microbiome was a communicable regulator of bone structure and turnover in male, but not in female mice...
March 26, 2024: Journal of Clinical Investigation
https://read.qxmd.com/read/38529589/metformin-alters-tumor-immune-microenvironment-improving-the-outcomes-of-breast-cancer-patients-with-type-2-diabetes-mellitus
#18
JOURNAL ARTICLE
Satomi Shiba, Michiko Harao, Akira Saito, Masako Sakuragi, Joji Kitayama, Naohiro Sata
This study investigated the clinical effect of metformin on breast cancer patients with preexisting type 2 diabetes mellitus (T2DM). We analyzed 177 patients with T2DM who underwent breast cancer surgery and assessed tumor-associated macrophages (TAMs) and tumor-infiltrating lymphocytes (TILs) in patients who underwent tumor resection with or without metformin treatment using multiplex immunohistochemistry (IHC). Patients who received metformin either pre- or postoperatively exhibited reduced distant organ recurrence and improved postoperative recurrence-free survival compared to those of patients who did not...
February 23, 2024: Journal of Breast Cancer
https://read.qxmd.com/read/38528721/effect-of-l-methylfolate-supplementation-on-sleep-for-patients-with-reduced-methylenetetrahydrofolate-reductase-activity
#19
JOURNAL ARTICLE
Alex S Carmon, Russell J Amato, Seema M Patel, Shannon W Finks
INTRODUCTION: Clinicians have limited options outside controlled substances to address sleep disturbance, which left untreated can negatively affect patient outcomes in cardiovascular health, mental health, immunologic function, and more. For some, genetic factors may influence sleep disturbances. L-methylfolate, the active form of folate, plays a critical role in regulation of monoamine neurotransmitters known to have significant impact on sleep regulation: dopamine, serotonin, norepinephrine...
March 25, 2024: Journal of Dietary Supplements
https://read.qxmd.com/read/38528715/low-density-lipoprotein-receptor-related-protein-5-6-promotes-endometrial-cancer-progression-and-cancer-cell-immune-escape
#20
JOURNAL ARTICLE
Lifan Shen, Chen Zhang, Genhai Zhu
The study investigated the potential association of the low-density lipoprotein (LDL) genome with endometrial cancer progression based on the Gene Expression Omnibus data set and The Cancer Genome Atlas data set. Differential and weighted gene coexpression network analysis was performed on endometrial cancer transcriptome datasets GSE9750 and GSE106191. The protein-protein interaction network was built using LDL-receptor proteins and the top 50 tumor-associated genes. Low-density lipoprotein-related receptors 5/6 (LRP5/6) in endometrial cancer tissues were correlated with oncogenes, cell cycle-related genes, and immunological checkpoints using Spearman correlation...
April 2024: Journal of Biochemical and Molecular Toxicology
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