Xiaoshuang Zhang, Yunhe Zhang, Boya Wang, Chuantong Xie, Jinghui Wang, Rong Fang, Hongtian Dong, Guangchun Fan, Mengze Wang, Yongtao He, Chenye Shen, Yufei Duan, Jiayin Zhao, Zhaolin Liu, Qing Li, Yuanyuan Ma, Mei Yu, Jian Wang, Jian Fei, Lei Xiao, Fang Huang
GSDMD-mediated pyroptosis occurs in the nigrostriatal pathway in Parkinson's disease animals, yet the role of GSDMD in neuroinflammation and death of dopaminergic neurons in Parkinson's disease remains elusive. Here, our in vivo and in vitro studies demonstrated that GSDMD, as a pyroptosis executor, contributed to glial reaction and death of dopaminergic neurons across different Parkinson's disease models. The ablation of the Gsdmd attenuated Parkinson's disease damage by reducing dopaminergic neuronal death, microglial activation, and detrimental transformation...
March 27, 2024: Brain, Behavior, and Immunity