keyword
https://read.qxmd.com/read/38419037/inhibition-of-mmp8-effectively-alleviates-manic-like-behavior-and-reduces-neuroinflammation-by-modulating-astrocytic-cebpd
#21
JOURNAL ARTICLE
Tzu-Yun Wang, Eddie Feng-Ju Weng, Yun-Chen Hsu, Lu-Ping Shiu, Teng-Wei Huang, Hsuan-Cheng Wu, Jau-Shyong Hong, Shao-Ming Wang
There is an intrinsic relationship between psychiatric disorders and neuroinflammation, including bipolar disorder. Ouabain, an inhibitor of Na+ /K+ -ATPase, has been implicated in the mouse model with manic-like behavior. However, the molecular mechanisms linking neuroinflammation and manic-like behavior require further investigation. CCAAT/Enhancer-Binding Protein Delta (CEBPD) is an inflammatory transcription factor that contributes to neurological disease progression. In this study, we demonstrated that the expression of CEBPD in astrocytes was increased in ouabain-treated mice...
February 28, 2024: Journal of Neuroinflammation
https://read.qxmd.com/read/38395698/disruption-of-the-na-k-atpase-purinergic-p2x7-receptor-complex-in-microglia-promotes-stress-induced-anxiety
#22
JOURNAL ARTICLE
Songqiang Huang, Wanting Dong, Xiaoqian Lin, Kangtai Xu, Kun Li, Siping Xiong, Zilong Wang, Xiaowei Nie, Jin-Song Bian
Na+ /K+ -ATPase (NKA) plays an important role in the central nervous system. However, little is known about its function in the microglia. Here, we found that NKAα1 forms a complex with the purinergic P2X7 receptor (P2X7R), an adenosine 5'-triphosphate (ATP)-gated ion channel, under physiological conditions. Chronic stress or treatment with lipopolysaccharide plus ATP decreased the membrane expression of NKAα1 in microglia, facilitated P2X7R function, and promoted microglia inflammatory activation via activation of the NLRP3 inflammasome...
February 16, 2024: Immunity
https://read.qxmd.com/read/38371502/fenugreek-derived-diosgenin-as-an-emerging-source-for-diabetic-therapy
#23
REVIEW
Yamini Tak, Manpreet Kaur, Abhishek Chitranashi, Mahesh Kumar Samota, Preeti Verma, Manoj Bali, Chiranjeev Kumawat
Diabetes is a chronic metabolic disease that endangers the entire body's tissues and organs. Diabetes impairs glucose and insulin regulation in the human body by causing pancreatic cell damage. Diabetes modifies pathways such as serine/threonine protein kinase (Akt) and Protein kinase C (PKC)/- glucose transporter 4 (GLUT4), peroxisome proliferator-activated receptor (PPAR) glucose absorption, and inhibits α-amylase and α-glucosidase, Sodium/glucose cotransporter 1 (SGLT-1), and Na+ -K+ -ATPase activity...
2024: Frontiers in Nutrition
https://read.qxmd.com/read/38351352/effect-of-sulfate-on-the-osmoregulatory-and-physio-biochemical-responses-of-gift-oreochromis-niloticus-juveniles-reared-in-potassium-deficient-medium-saline-waters
#24
JOURNAL ARTICLE
Shivangi Bhatt, Subrata Dasgupta, Subodh Gupta, Narottam Prasad Sahu, Vattiringal Jayadradhan Rejish Kumar, Tincy Varghese
The inland saline waters were continuously observed to have low potassium concentrations compared to their seawater counterpart of the same salinity. We hypothesize that the toxic effect of sulfate may manifest in low potassium saline (LPSW) waters compared to brackish water of the same salinity. Thus, LC50 trials were performed in GIFT (genetically improved farmed tilapia) fry (0.5 ± 0.02 g) to determine the acute sulfate toxicity in freshwater (FW, 0.5 g L-1 ), artificial seawater (ASW, 10 g L-1 ), and LPSW (10 g L-1 )...
February 13, 2024: Environmental Science and Pollution Research International
https://read.qxmd.com/read/38350944/deleting-ip6k1-stabilizes-neuronal-sodium-potassium-pumps-and-suppresses-excitability
#25
JOURNAL ARTICLE
Hongfu Jin, Aili Liu, Alfred C Chin, Chenglai Fu, Hui Shen, Weiwei Cheng
Inositol pyrophosphates are key signaling molecules that regulate diverse neurobiological processes. We previously reported that the inositol pyrophosphate 5-InsP7 , generated by inositol hexakisphosphate kinase 1 (IP6K1), governs the degradation of Na+ /K+ -ATPase (NKA) via an autoinhibitory domain of PI3K p85α. NKA is required for maintaining electrochemical gradients for proper neuronal firing. Here we characterized the electrophysiology of IP6K1 knockout (KO) neurons to further expand upon the functions of IP6K1-regulated control of NKA stability...
February 13, 2024: Molecular Brain
https://read.qxmd.com/read/38349487/thallium-toxicity-and-its-interference-with-potassium-pathways-tested-on-various-cell-lines
#26
JOURNAL ARTICLE
Ana Marija Marjanović Čermak, Stipe Mustać, Petra Cvjetko, Ivan Pavičić, Domagoj Kifer, Erim Bešić, Ana-Marija Domijan
Thallium (Tl) is a highly toxic heavy metal whose mechanism of toxicity is still not completely understood. The aim of this study was to test Tl cytotoxicity on several cell lines of different tissue origin in order to clarify specific Tl toxicity to a particular organ. In addition, possible interference of Tl with cell potassium (K) transport was examined. Human keratinocytes (HaCaT), human hepatocellular carcinoma (HepG2), porcine kidney epithelial cells (PK15), human neuroblastoma (SH-SY5Y) and Chinese hamster lung fibroblast cells (V79) were treated with thallium (I) acetate in a wide concentration range (3...
February 13, 2024: Biological Trace Element Research
https://read.qxmd.com/read/38339183/the-cyst-epithelium-in-polycystic-kidney-disease-patients-displays-normal-apical-basolateral-cell-polarity
#27
JOURNAL ARTICLE
Samuel Loft Sandegaard, Andreas Riishede, Henrik Birn, Helle Hasager Damkier, Jeppe Praetorius
The main characteristic of polycystic kidney disease is the development of multiple fluid-filled renal cysts. The discovery of mislocalized sodium-potassium pump (Na,K-ATPase) in the apical membrane of cyst-lining epithelia alluded to reversal of polarity as a possible explanation for the fluid secretion. The topic of apical Na,K-ATPase in cysts remains controversial. We investigated the localization of the Na,K-ATPase and assessed the apical-basolateral polarization of cyst-lining epithelia by means of immunohistochemistry in kidney tissue from six polycystic kidney disease patients undergoing nephrectomy...
February 5, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38338935/bafilomycin-a1-molecular-effect-on-atpase-activity-of-subcellular-fraction-of-human-colorectal-cancer-and-rat-liver
#28
JOURNAL ARTICLE
Solomiia Bychkova, Mykola Bychkov, Dani Dordevic, Monika Vítězová, Simon K-M R Rittmann, Ivan Kushkevych
Bafilomycin A1 inhibits V-type H+ ATPases on the molecular level, which acidifies endo-lysosomes. The main objective of the study was to assess the effect of bafilomycin A1 on Ca2+ content, NAADP-induced Ca2+ release, and ATPase activity in rat hepatocytes and human colon cancer samples. Chlortetracycline (CTC) was used for a quantitative measure of stored calcium in permeabilized rat hepatocytes. ATPase activity was determined by orthophosphate content released after ATP hydrolysis in subcellular post-mitochondrial fraction obtained from rat liver as well as from patients' samples of colon mucosa and colorectal cancer samples...
January 29, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38338921/involvement-of-the-na-k-atpase-%C3%AE-1-isoform-and-endogenous-cardiac-steroids-in-depression-and-manic-like-behaviors
#29
JOURNAL ARTICLE
Noa Horesh, Ilana Pelov, Ilana Pogodin, Hiba Zannadeh, Haim Rosen, Anastasiia Leonidovna Mikhrina, Moran Dvela-Levitt, Vishnu Priya Sampath, David Lichtstein
Bipolar disorder (BD) is a severe and common chronic mental illness characterized by recurrent mood swings between depression and mania. The biological basis of the disease is poorly understood, and its treatment is unsatisfactory. Na+ , K+ -ATPase is a major plasma membrane transporter and signal transducer. The catalytic α subunit of this enzyme is the binding site for cardiac steroids. Three α isoforms of the Na+ , K+ -ATPase are present in the brain. Previous studies have supported the involvement of the Na+ , K+ -ATPase and endogenous cardiac steroids (ECS) in the etiology of BD...
January 29, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38334967/calcium-signaling-in-endothelial-and-vascular-smooth-muscle-cells-sex-differences-and-the-influence-of-estrogens-and-androgens
#30
REVIEW
Daniel Asunción-Alvarez, Javier Palacios, Roberto O Ybañez-Julca, Cristhian N Rodriguez-Silva, Chukwuemeka Nwokocha, Fredi Cifuentes, David J Greensmith
Calcium signaling in vascular endothelial cells (ECs) and smooth muscle cells (VSMC) is essential for the regulation of vascular tone. However, the changes to intracellular Ca2+ concentrations are often influenced by sex differences. Furthermore, a large body of evidence shows that sex hormone imbalance leads to dysregulation of Ca2+ signaling and this is a key factor in the pathogenesis of cardiovascular diseases. In this review, the effects of estrogens and androgens on vascular calcium-handling proteins are discussed, with emphasis on the associated genomic or non-genomic molecular mechanisms...
February 9, 2024: American Journal of Physiology. Heart and Circulatory Physiology
https://read.qxmd.com/read/38333315/bromocriptine-does-this-drug-of-parkinson-s-disease-have-a-role-in-managing-cardiovascular-diseases
#31
REVIEW
Lakshmi Venkata Simhachalam Kutikuppala, Sushil Sharma, Madhavrao Chavan, Gaurav Rangari, Arup Kumar Misra, Sai Ram Innamuri, Tejus Vijayakumar, Golla Varshitha
Cardiovascular disease (CVD) is the most common cause of morbidity and mortality worldwide. Bromocriptine is a partial antagonist for D1 dopamine receptors while also serving as a selective agonist on D2 dopamine receptors as a dopamine receptor agonist. Apart from prolactin inhibiting action, bromocriptine has some beneficial effects on the blood pressure, plasma norepinephrine levels and vascular resistance. Dopamine D2 receptor activation of bromocriptine is associated with the antihypertensive effect, which lowers blood pressure via inhibiting sympathetic nerve activity and Na/K ATPase activity...
February 2024: Annals of Medicine and Surgery
https://read.qxmd.com/read/38331106/toxic-responses-of-metabolites-produced-by-ostreopsis-cf-ovata-on-a-panel-of-cell-types
#32
JOURNAL ARTICLE
Rachelle Lanceleur, G E M I N Marin-Pierre, B L I E R Anne-Louise, Lisa Meslier, Damien Reveillon, Zouher Amzil, Eva Ternon, Olivier P Thomas, Valérie Fessard
Blooms of the dinoflagellate Ostreopsis cf. ovata are regularly associated with human intoxications that are attributed to ovatoxins (OVTXs), the main toxic compounds produced this organism and close analogs to palytoxin (PlTX). Unlike for PlTX, information on OVTXs'toxicity are scarce due to the absence of commercial standards. Extracts from two cultures of Mediterranean strains of O. cf. ovata (MCCV54 and MCCV55), two fractions containing or not OVTXs (prepared from the MCCV54 extract) and OVTX-a and -d (isolated from the MCCV55 extract) were generated...
February 6, 2024: Toxicon: Official Journal of the International Society on Toxinology
https://read.qxmd.com/read/38326681/mechanisms-of-oxidative-response-during-biodegradation-of-malathion-by-s-oneidensis-mr-1
#33
JOURNAL ARTICLE
Qiaodong Pan, Yanhong Li, Jing Zhang, Ting Hu, Yu Hou, Shen Tang
Malathion, an extensively used organophosphorus pesticide, poses a high potential risk of toxicity to humans and the environment. Shewanella (S.) oneidensis MR-1 has been proposed as a strain with excellent bioremediation capabilities, capable of efficiently removing a wide range of hard-to-degrade pollutants. However, the physiological and biochemical response of S. oneidensis MR-1 to malathion is unknown. Therefore, this study aimed to examine how S. oneidensis MR-1 responds physiologically and biochemically to malathion while also investigating the biodegradation properties of the pesticide...
February 7, 2024: Environmental Science and Pollution Research International
https://read.qxmd.com/read/38325654/maternal-environmental-enrichment-protects-neonatal-brains-from-hypoxic-ischemic-challenge-by-mitigating-brain-energetic-dysfunction-and-modulating-glial-cell-responses
#34
JOURNAL ARTICLE
L E Durán-Carabali, F K Odorcky, L K Grun, F Schmitz, O V Ramires Junior, M R de Oliveria, K F Campos, E Hoeper, A V S Carvalho, S Greggio, G T Venturine, E R Zimmer, F Barbé-Tuana, A T S Wyse, C A Netto
There is evidence that maternal milieu and changes in environmental factors during the prenatal period may exert a lasting impact on the brain health of the newborn, even in case of neonatal brain hypoxia-ischemia (HI). The present study aimed to investigate the effects of maternal environmental enrichment (EE) on HI-induced energetic and metabolic failure, along with subsequent neural cell responses in the early postnatal period. Male Wistar pups born to dams exposed to maternal EE or standard conditions (SC) were randomly divided into Sham-SC, HI-SC, Sham-EE, and HI-EE groups...
February 5, 2024: Experimental Neurology
https://read.qxmd.com/read/38321284/chronic-exposure-to-tris-2-chloroethyl-phosphate-tcep-induces-brain-structural-and-functional-changes-in-zebrafish-danio-rerio-a-comparative-study-on-the-environmental-and-lc50-concentrations-of-tcep
#35
JOURNAL ARTICLE
Jesudass Sutha, Murugesh Gayathri, Mathan Ramesh
Tris (2-chloroethyl) phosphate (TCEP) is a crucial organophosphorus flame retardant widely used in many industrial and commercial products. Available reports reported that TCEP could cause various toxicological effects on organisms, including humans. Unfortunately, toxicity data for TCEP (particularly on neurotoxicity) on aquatic organisms are lacking. In the present study, Danio rerio were exposed to different concentrations of TCEP for 42 days (chronic exposure), and oxidative stress, neurotoxicity, sodium, potassium-adenosine triphosphatase (Na+ , K+ -ATPase) activity, and histopathological changes were evaluated in the brain...
February 7, 2024: Environmental Science and Pollution Research International
https://read.qxmd.com/read/38316820/female-tilapia-oreochromis-sp-mobilised-energy-differently-for-growth-and-reproduction-according-to-living-environment
#36
JOURNAL ARTICLE
Ros Suhaida Razali, Sharifah Rahmah, Yu Ling Shirly-Lim, Mazlan Abd Ghaffar, Suhairi Mazelan, Mohamad Jalilah, Leong-Seng Lim, Yu Mei Chang, Li Qun Liang, Young-Mao Chen, Hon Jung Liew
This study was conducted to investigate the energy mobilisation preference and ionoregulation pattern of female tilapia, Oreochromis sp. living in different environments. Three different treatments of tilapia as physiology compromising model were compared; tilapia cultured in recirculating aquaculture system (RAS as Treatment I-RAS), tilapia cultured in open water cage (Treatment II-Cage) and tilapia transferred from cage and cultured in RAS (Treatment III-Compensation). Results revealed that tilapia from Treatment I and III mobilised lipid to support gonadogenesis, whilst Treatment II tilapia mobilised glycogen as primary energy for daily exercise activity and reserved protein for growth...
February 5, 2024: Scientific Reports
https://read.qxmd.com/read/38309094/effect-of-caffeine-chitosan-nanoparticles-and-%C3%AE-lipoic-acid-on-the-cardiovascular-changes-induced-in-rat-model-of-obesity
#37
JOURNAL ARTICLE
Eman N Hosny, Hussein G Sawie, Howida S Abou-Seif, Yasser A Khadrawy
The current research aims to study the therapeutic efficacy of alpha-lipoic acid (α-LA) and caffeine-loaded chitosan nanoparticles (Caf-CNs) against cardiovascular complications induced by obesity. Rats were divided randomly into: control, high fat diet (HFD) induced obesity rat model, obese rats treated with α-LA and/or Caf-CNs. Triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), Interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) as well as activities of lactate dehydrogenase (LDH) and creatine kinase-MB (CK-MB) significantly increased in the serum of obese rats...
February 2, 2024: International Immunopharmacology
https://read.qxmd.com/read/38308916/astrocytic-na-k-atpases-in-physiology-and-pathophysiology
#38
JOURNAL ARTICLE
Daniela Pietrobon, Fiorenzo Conti
The Na+ , K+ ATPases play a fundamental role in the homeostatic functions of astrocytes. After a brief historic prologue and discussion of the subunit composition and localization of the astrocytic Na+ , K+ ATPases, the review focuses on the role of the astrocytic Na+ , K+ pumps in extracellular K+ and glutamate homeostasis, intracellular Na+ and Ca2+ homeostasis and signaling, regulation of synaptic transmission and neurometabolic coupling between astrocytes and neurons. Loss-of-function mutations in the gene encoding the astrocytic α2 Na+ , K+ ATPase cause a rare monogenic form of migraine with aura (familial hemiplegic migraine type 2)...
January 28, 2024: Cell Calcium
https://read.qxmd.com/read/38299213/activation-of-farnesoid-x-receptor-retards-expansion-of-renal-collecting-duct-cells-derived-cysts-via-inhibition-of-cftr-mediated-cl-secretion
#39
JOURNAL ARTICLE
Nipitpon Srimai, Kanlayanee Tonum, Sunhapas Soodvilai
The transcription factor farnesoid X receptor (FXR) regulates energy metabolism. Specifically, FXR functions to regulate CFTR-mediated Cl- secretion in intestinal epithelial cells. Therefore, this study aimed to investigate the role of FXR in CFTR-mediated Cl- secretion in renal tubular cells, and to further elucidate its effects on renal cyst formation and growth. CFTR-mediated Cl- transport was evaluated via short-circuit current ( I SC ) measurements in MDCK cell monolayers and primary rat inner medullary collecting duct (IMCD) cells...
February 1, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38289115/traditional-chinese-medicine-bufalin-inhibits-infectious-hematopoietic-necrosis-virus-infection-in-vitro-and-in-vivo
#40
JOURNAL ARTICLE
Jing-Zhuang Zhao, Li-Ming Xu, Lin-Fang Li, Guang-Ming Ren, Yi-Zhi Shao, Qi Liu, Tong-Yan Lu
Infectious hematopoietic necrosis virus (IHNV) causes infectious hematopoietic necrosis and severe economic losses to salmon and trout aquaculture worldwide. Currently, the only commercial vaccine against IHNV is a DNA vaccine with some biosafety concerns. Hence, more effective vaccines and antiviral drugs are needed to prevent IHNV infection. In this study, 1,483 compounds were screened from a traditional Chinese medicine monomer library, and bufalin showed potential antiviral activity against IHNV. The 50% cytotoxic concentration of bufalin was >20 µM, and the 50% inhibitory concentration was 0...
January 30, 2024: Microbiology Spectrum
keyword
keyword
110526
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.