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Young colorectal cancer

Maria Elena Martinez, James D Murphy, Scarlett Lin Gomez
No abstract text is available yet for this article.
February 15, 2019: Gastroenterology
Graeme P Young, Linda Rabeneck, Sidney J Winawer
No abstract text is available yet for this article.
February 16, 2019: Gastroenterology
Thi Thinh Nguyen, Trong Thuan Ung, Shinan Li, Sen Lian, Yong Xia, Sun Young Park, Young Do Jung
Metformin, an inexpensive, well-tolerated oral agent that is a commonly used first-line treatment for type 2 diabetes, has become the focus of intense research as a potential anticancer agent. In this study, we describe the inhibitory effect of metformin in interleukin 8 (IL-8) upregulation by lithocholic acid (LCA) in HCT116 colorectal cancer (CRC) cells. Pharmacological inhibition studies indicated that reactive oxygen species (ROS) were involved in LCA-induced IL-8 upregulation through activation of the transcription factor NF-κB...
February 14, 2019: Scientific Reports
Gabriele Bellio, Marina Troian, Arianna Pasquali, Nicolò De Manzini
BACKGROUND: Laparoscopy for locally advanced colorectal cancer is not standardized yet and its potential risks and benefits in elderly patients are still under debate. The aim of this study was to evaluate clinical and oncologic results of laparoscopic surgery for pT3/pT4 lesions in both old and young people. METHODS: Between 2006 and 2015, 115 patients aged <70 years and 112 patients aged ≥70 years underwent elective laparoscopic surgery for pT3/pT4 colorectal cancer presenting without distant metastasis at the Department of General Surgery, Trieste...
February 13, 2019: Minerva Chirurgica
Joon-Hyop Lee, Sohee Jung, Won Seo Park, Eun Kyung Choe, Eunyoung Kim, Rumi Shin, Seung Chul Heo, Jae Hyun Lee, Kwangsoo Kim, Young Jun Chai
Hypoxia-related gene (HRG) expression is associated with survival outcomes of colorectal cancer (CRC). Our aim was developing a nomogram predicting CRC overall survival (OS) with HRGs and clinicopathological factors. The Cancer Genome Atlas (TCGA) database was used as discovery cohort and two Gene Expression Omnibus databases (GSE39582 and GSE41258) served as validation cohorts. A genetic risk score model prognosticating OS was developed using mRNA expression level of HRGs. Nomogram predicting OS was developed using genetic risk score model and clinicopathological variables...
February 12, 2019: Scientific Reports
Winifred Lo, Bin Zhu, Arvind Sabesan, Ho-Hsiang Wu, Astin Powers, Rebecca A Sorber, Sarangan Ravichandran, Ina Chen, Lucas A McDuffie, Humair S Quadri, Joal D Beane, Kathleen Calzone, Markku M Miettinen, Stephen M Hewitt, Christopher Koh, Theo Heller, Sholom Wacholder, Udo Rudloff
INTRODUCTION: Hereditary diffuse gastric cancer (HDGC) is a cancer syndrome associated with variants in E-cadherin (CDH1), diffuse gastric cancer and lobular breast cancer. There is considerable heterogeneity in its clinical manifestations. This study aimed to determine associations between CDH1 germline variant status and clinical phenotypes of HDGC. METHODS: One hundred and fifty-two HDGC families, including six previously unreported families, were identified...
February 11, 2019: Journal of Medical Genetics
Alessandro Repici, Michael B Wallace, James E East, Prateek Sharma, Francisco C Ramirez, David H Bruining, Michele Young, David Gatof, Marcia Irene Mimi Canto, Norman Marcon, Renato Cannizzaro, Ralf Kiesslich, Matt Rutter, Evelien Dekker, Peter D Siersema, Manon Spaander, Limas Kupcinskas, Laimas Jonaitis, Raf Bisschops, Franco Radaelli, Pradeep Bhandari, Ana Wilson, Dayna Early, Neil Gupta, Michael Vieth, Gregory Y Lauwers, Matteo Rossini, Cesare Hassan
BACKGROUND & AIMS: Topically applied methylene blue dye chromoendoscopy is effective in improving detection of colorectal neoplasia. When combined with a pH- and time-dependent multi-matrix structure, a per-oral methylene blue formulation (MB-MMX) can be delivered directly to the colorectal mucosa. METHODS: We performed a phase 3 study of 1205 patients scheduled for colorectal cancer screening or surveillance colonoscopies (50-75 years old) at 20 sites in Europe and the United states, from December 2013 through October 2016...
February 8, 2019: Gastroenterology
Long H Nguyen, Po-Hong Liu, Xiaobin Zheng, NaNa Keum, Xiaoyu Zong, Xiao Li, Kana Wu, Charles S Fuchs, Shuji Ogino, Kimmie Ng, Walter C Willett, Andrew T Chan, Edward L Giovannucci, Yin Cao
Background: Colorectal cancer (CRC) diagnosed before age 50 years, or young-onset CRC, is increasing globally with undefined etiology. A sedentary lifestyle is an emerging risk factor for CRC after age 50 years, but its role in young-onset CRC is unknown. Methods: We prospectively evaluated sedentary behaviors, primarily time watching television (TV), and risk of young-onset CRC among 89 278 women in the Nurses' Health Study II ages 25-42 years at recruitment (1991-2011)...
November 2018: JNCI cancer spectrum
Eric Smith, Yoko Tomita, Helen M Palethorpe, Stuart Howell, Maryam Nakhjavani, Amanda R Townsend, Timothy J Price, Joanne P Young, Jennifer E Hardingham
Aquaporin-1 (AQP1) is a homo-tetrameric transmembrane protein that facilitates rapid movement of water and ions across cell membranes. The clinical significance of AQP1 expression in colorectal carcinoma (CRC) is controversial. The aim of this study was to investigate the prognostic significance of AQP1 transcript expression and the association between expression and promoter methylation in normal colonic mucosa, CRC tissues and cell lines. Analysis of publicly available datasets from The Cancer Genome Atlas revealed that AQP1 expression was significantly decreased in CRC compared to normal mucosa (12...
February 9, 2019: Epigenetics: Official Journal of the DNA Methylation Society
Hyuna Sung, Rebecca L Siegel, Philip S Rosenberg, Ahmedin Jemal
BACKGROUND: Cancer trends in young adults, often under 50 years, reflect recent changes in carcinogenic exposures, which could foreshadow the future overall disease burden. Previous studies reported an increase in early onset colorectal cancer, which could partly reflect the obesity epidemic. We examined age-specific contemporary incidence trends in the USA for 30 common cancers, including 12 obesity-related cancers. METHODS: We obtained incidence data for invasive cancers among people aged 25-84 years diagnosed from Jan 1, 1995, to Dec 31, 2014, for 25 population-based state registries in the USA...
February 1, 2019: Lancet. Public Health
Raquel Hernández, Caterina Calderon, Alberto Carmona-Bayonas, Alejandra Rodríguez Capote, Carlos Jara, Airam Padilla Álvarez, María de Las Nieves Gómez-Camacho, Carmen Beato, Beatriz Castelo, Margarita Majem, María Del Mar Muñoz, Alejandra Ivars, Montserrat Mangas-Izquierdo, Jacobo Rogado-Revuelta, Paula Jimenez-Fonseca
BACKGROUND: Coping with cancer and the oncologist-patient relationship can vary depending on the patient's age. Our aim is to examine and compare young and elderly adults with non-metastatic, resected cancer. METHODS: Two groups of patients were selected, young (< 40 years) and elderly (> 70) with a diagnosis of non-metastatic, resected cancer requiring adjuvant chemotherapy from a pre-exiting, national database (NEOCOPING Study). Epidemiological variables were collected and subjects' emotional responses, perceptions of the physician-patient relationship, support network, fears, and regret about the decision to receive chemotherapy were assessed with questionnaires validated in previous studies: Mini-Mental Adjustment to Cancer, Brief Summary Inventory (18 items), European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire-C30, Shared Decision-Making Questionnaire-Physician's version, Shared Decision-Making Questionnaire-Patient's version, and Informed Risk (physician and patient versions)...
February 5, 2019: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
Alice Westwood, Amy Glover, Gordon Hutchins, Caroline Young, Scarlet Brockmoeller, Rachel Robinson, Lisa Worrilow, Dave Wallace, Kate Rankeillor, Julian Adlard, Philip Quirke, Nicholas West
Colorectal cancer (CRC) is common with 3% of cases associated with germline mutations in the mismatch repair pathway characteristic of Lynch syndrome (LS). The UK National Institute for Health and Care Excellence recommends screening for LS in all patients newly diagnosed with CRC, irrespective of age. The Yorkshire Cancer Research Bowel Cancer Improvement Programme includes a regional LS screening service for all new diagnoses of CRC. In the first 829 cases screened, 80 cases showed deficient mismatch repair (dMMR) including four cases showing areas with loss of expression of all four mismatch repair proteins by immunohistochemistry...
February 5, 2019: Journal of Clinical Pathology
Naciye Cigdem Arslan, Tayfun Bisgin, Canan Altay, Tugba Yavuzsen, Aziz Karaoglu, Aras Emre Canda, Sulen Sarioglu, Selman Sokmen
PURPOSE: The purpose of this study was to assess the feasibility and safety of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in elderly patients with peritoneal carcinomatosis of colorectal cancer. METHODS: Patients who underwent curative complete CRS and HIPEC for peritoneal carcinomatosis of colorectal cancer with minimum follow-up of 24 months were included in the analysis. Charlson comorbidity index and ECOG performance status were used to evaluate preoperative condition...
December 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Kwangmin Kim, Young-Wan Kim, Hongjin Shim, Bo-Ra Kim, Hye Youn Kwon
Approximately 20% to 25% of patients with colorectal cancer (CRC) have distant organ metastasis at the time of initial diagnosis. The primary tumor location has been suggested as a prognostic factor for patients with metastatic CRC. In recent years, the distinction between right colon cancer (RCC) and left colon cancer (LCC) has been brought into focus due to their different outcomes, prognoses, and clinical responses to chemotherapy. In this article we aimed to review the underlying differences between metastatic RCC and LCC in terms of epidemiology, clinical features, and oncologic outcomes...
December 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Sang-Min Park, Chae Young Hwang, Sung-Hwan Cho, Daewon Lee, Jeong-Ryeol Gong, Soobeom Lee, Sohee Nam, Kwang-Hyun Cho
Cetuximab, a monoclonal antibody against epidermal growth factor receptor (EGFR), is being widely used for colorectal cancer (CRC) with wild-type KRAS. However, its responsiveness is still very limited and wild-type KRAS is not enough to indicate such responsiveness. Here, by analyzing the gene expression data of CRC patients treated with cetuximab monotherapy, we have identified DUSP4, ETV5, GNB5, NT5E, and PHLDA1 as potential targets to overcome cetuximab resistance. We found that knockdown of any of these 5 genes can increase cetuximab sensitivity in KRAS wild-type cells...
February 4, 2019: FEBS Journal
Rachel Carroll, Shanshan Zhao
BACKGROUND: Colorectal cancer (CRC) is common worldwide, with 140,250 diagnoses and 50,630 deaths estimated for the United States in 2018. Guidelines current to the most recent individuals in our analysis suggested regular screenings beginning at age 50 have reduced the incidence of CRC. However, the incidence continues to rise among those under 50. Less is known about survival following CRC diagnosis, but research has suggested that younger cases may also have worse survival. However, we hypothesize that younger individuals are generally healthier with fewer comorbidities, leading to the potential for better survival following diagnosis...
December 22, 2018: Clinical Colorectal Cancer
Anand Venugopal, Elena M Stoffel
PURPOSE OF REVIEW: Routine screening for colorectal cancer (CRC) in adults > 50 years of age has led to overall reductions in CRC incidence and CRC-related mortality. Yet CRC incidence among young adults age < 50 continues to increase without a clear explanation. This review examines the changing epidemiology of CRC and emerging evidence regarding the influence of genetic and lifestyle factors on risk for colorectal neoplasia. RECENT FINDINGS: Young-onset CRC (yCRC), defined as CRC diagnosed in individuals younger than age 50, is a heterogeneous disease...
February 2, 2019: Current Treatment Options in Gastroenterology
David Karsenti, Gaelle Tharsis, Pascal Burtin, Franck Venezia, Gilles Tordjman, Agnès Gillet, Joelle Samama, Karine Nahon-Uzan, Philippe Cattan, Maryan Cavicchi
BACKGROUND: Colonoscopy is considered a valid primary screening tool for colorectal cancer (CRC). The decreasing risk of CRC observed in patients undergoing colonoscopy is correlated with the adenoma detection rate (ADR). Due to the fact that screening programs usually start from the age of 50, very few data are available on the risk of adenoma between 40 and 49 years. However, the incidence of CRC is increasing in young populations and it is not uncommon in routine practice to detect adenomas or even advanced neoplasia during colonoscopy in patients under 50 years...
January 28, 2019: World Journal of Gastroenterology: WJG
Synne-Kristin H Bøhn, Lene Thorsen, Cecilie E Kiserud, Sophie D Fosså, Hanne C Lie, Jon H Loge, Torbjørn Wisløff, Hege S Haugnes, Kristin V Reinertsen
BACKGROUND: Chronic fatigue (CF) is scarcely explored among young adult cancer survivors (YACSs), and more knowledge is needed to develop targeted interventions for YACSs with CF. The present study aimed to investigate the prevalence of CF and associated factors in YACSs. Also, the change of fatigue with time was explored. MATERIAL AND METHODS: The present cross-sectional study is part of a nation-wide population based survey of Norwegian survivors of cancer in childhood, adolescence, and young adulthood (The NOR-CAYACS study)...
January 30, 2019: Acta Oncologica
Joseph J Y Sung, Han-Mo Chiu, Kyu-Won Jung, Jae Kwan Jun, Masau Sekiguchi, Takahisa Matsuda, Moe H Kyaw
BACKGROUND: The incidence of young-onset colorectal cancer (CRC) is reported to be increasing in the Western world. There are no population-based studies assessing the trend across Asia. METHODS: We performed a multinational cohort study involving four Asian countries/regions, namely Taiwan, Korea, Japan, and Hong Kong. The magnitude and direction of trend in the incidence of young-onset CRC (age < 50) were quantified using Joinpoint Regression Program to estimate average annual percentage change (AAPC)...
January 23, 2019: American Journal of Gastroenterology
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