keyword
https://read.qxmd.com/read/38523383/the-role-of-proangiogenic-cytokines-in-predicting-sepsis-in-febrile-neutropenic-children-with-cancer
#21
JOURNAL ARTICLE
Selma Çakmakcı, Neriman Sarı, Çiğdem Sönmez, İnci Ergürhan İlhan
BACKGROUND: We assessed the relationship between sepsis occurrence and the serum levels of angiopoietin (Ang-1, Ang-2), vascular endothelial growth factor (VEGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) in pediatric patients with cancer-related febrile neutropenia. METHODS: Fifty-two children with malignant tumors who experienced 86 episodes of febrile neutropenia (FN) were examined between June 2016 and June 2018. Each FN episode was considered a separate event and the total number of FNs were recorded (86 FN episodes = FN group)...
2024: Turkish Journal of Pediatrics
https://read.qxmd.com/read/38521526/defining-the-hidden-burden-of-disease-in-rural-communities-in-bangladesh-cambodia-and-thailand-a-cross-sectional-household-health-survey-protocol
#22
JOURNAL ARTICLE
Meiwen Zhang, Nan Shwe Nwe Htun, Shayla Islam, Aninda Sen, Akramul Islam, Amit Kumer Neogi, Rupam Tripura, Lek Dysoley, Carlo Perrone, Rusheng Chew, Elizabeth M Batty, Watcharintorn Thongpiam, Jantana Wongsantichon, Chonticha Menggred, Sazid Ibna Zaman, Naomi Waithira, Stuart Blacksell, Marco Liverani, Sue Lee, Richard James Maude, Nicholas P J Day, Yoel Lubell, Thomas Julian Peto
INTRODUCTION: In low-income and middle-income countries in Southeast Asia, the burden of diseases among rural population remains poorly understood, posing a challenge for effective healthcare prioritisation and resource allocation. Addressing this knowledge gap, the South and Southeast Asia Community-based Trials Network (SEACTN) will undertake a survey that aims to determine the prevalence of a wide range of non-communicable and communicable diseases, as one of the key initiatives of its first project-the Rural Febrile Illness project (RFI)...
March 23, 2024: BMJ Open
https://read.qxmd.com/read/38521450/vaccine-derived-yellow-fever-in-an-immunocompromised-patient-on-anti-cd20-antibody-therapy-and-its-treatment-with-sofosbuvir
#23
Tobias Weirauch, Gerrit Burger, Dániel Cadar, Martin Gabriel, Julia Koepsell, Gundolf Schüttfort, Philipp de Leuw, Markus Bickel, Maria J G T Vehreschild, Timo Wolf, Nils Wetzstein
Yellow fever (YF) is a potentially lethal viral hemorrhagic fever that can be prevented with the 17D live attenuated YF vaccine. However, this vaccination can cause severe adverse reactions including vaccine-associated YF. Here, we describe the case of a 32-year-old female who was permanently immunosuppressed with an anti-CD20 antibody due to multiple sclerosis. Following YF vaccination, the patient developed, a variety of symptoms such as febrile temperatures, muscle and joint pain, headaches, and dysuria...
March 21, 2024: International Journal of Infectious Diseases: IJID
https://read.qxmd.com/read/38520034/etiology-clinical-presentation-and-outcomes-of-bacterial-meningitis-in-adult-patients-a-retrospective-study-in-lithuania-2018-2021
#24
JOURNAL ARTICLE
Greta Rynkevič, Emilijus Žilinskas, Dovilė Streckytė, Daiva Radzišauskienė, Rūta Mameniškienė
BACKGROUND Bacterial meningitis is a serious and life-threatening condition that requires prompt diagnosis and treatment. This retrospective study aimed to identify causes, presentation, and predictive factors for outcomes of community-acquired bacterial meningitis in 86 adults in Vilnius, Lithuania between 2018 and 2021. MATERIAL AND METHODS We performed a retrospective study of demographic, clinical, and laboratory records of 86 adult patients admitted to Vilnius University Hospital Santaros Clinics with a diagnosis of acute bacterial meningitis during the period of 2018-2021...
March 23, 2024: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://read.qxmd.com/read/38518846/risk-factors-for-resistant-gram-positive-bacteremia-in-febrile-neutropenic-patients-with-cancer
#25
JOURNAL ARTICLE
Minkyeong Lee, Chan Mi Lee, Ja Min Byun, Dong-Yeop Shin, Youngil Koh, Junshik Hong, Pyoeng Gyun Choe, Wan Beom Park, Nam Joong Kim, Sung-Soo Yoon, Myoung-Don Oh, Chang Kyung Kang, Inho Kim
BACKGROUND: Gram-positive bacteria are frequently resistant to empirical beta-lactams in febrile neutropenic patients with cancer. As microbiology and antibiotic susceptibility changes, we reevaluated the risk factors for resistant Gram-positive bacteremia in febrile neutropenic patients with cancer. METHODS: Episodes of bacteremic febrile neutropenia in Seoul National University Hospital from July 2019 to June 2022 were reviewed. Resistant Gram-positive bacteria were defined as a pathogen susceptible only to glycopeptide or linezolid in vitro (e...
March 20, 2024: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/38518789/interim-safety-and-immunogenicity-of-covid-19-omicron-ba-1-variant-containing-vaccine-in-children-in-the-usa-an-open-label-non-randomised-phase-3-trial
#26
JOURNAL ARTICLE
Avika Dixit, Richard Bennett, Kashif Ali, Carl Griffin, Robert A Clifford, Mark Turner, Rosanne Poston, Kelly Hautzinger, Anne Yeakey, Bethany Girard, Wen Zhou, Weiping Deng, Honghong Zhou, Sabine Schnyder Ghamloush, Barbara J Kuter, Karen Slobod, Jacqueline M Miller, Frances Priddy, Rituparna Das
BACKGROUND: Variant-containing mRNA vaccines for COVID-19 to broaden protection against SARS-CoV-2 variants are recommended based on findings in adults. We report interim safety and immunogenicity of an omicron BA.1 variant-containing (mRNA-1273.214) primary vaccination series and booster dose in paediatric populations. METHODS: This open-label, two-part, non-randomised phase 3 trial enrolled participants aged 6 months to 5 years at 24 US study sites. Eligible participants were generally healthy or had stable chronic conditions, without known SARS-CoV-2 infection in the previous 90 days...
March 19, 2024: Lancet Infectious Diseases
https://read.qxmd.com/read/38517658/effectiveness-and-safety-of-primary-prophylaxis-of-granulocyte-colony-stimulating-factor-during-dose-dense-chemotherapy-for-urothelial-cancer-clinical-practice-guidelines-for-the-use-of-g-csf-2022
#27
JOURNAL ARTICLE
Keita Uchino, Shingo Tamura, Shoji Kimura, Keisuke Shigeta, Takahiro Kimura, Yukinori Ozaki, Hiroshi Nishio, Kenji Tsuchihashi, Eiki Ichihara, Makoto Endo, Shingo Yano, Dai Maruyama, Tetsuhiro Yoshinami, Nobuyuki Susumu, Munetaka Takekuma, Takashi Motohashi, Mamoru Ito, Eishi Baba, Nobuaki Ochi, Toshio Kubo, Yutaro Kamiyama, Shinji Nakao, Shinobu Tamura, Hitomi Nishimoto, Yasuhisa Kato, Atsushi Sato, Toshimi Takano, Yuji Miura
Granulocyte colony-stimulating factor (G-CSF) decreases the incidence, duration, and severity of febrile neutropenia (FN); however, dose reduction or withdrawal is often preferred in the management of adverse events in the treatment of urothelial cancer. It is also important to maintain therapeutic intensity in order to control disease progression and thereby relieve symptoms, such as hematuria, infection, bleeding, and pain, as well as to prolong the survival. In this clinical question, we compared treatment with primary prophylactic administration of G-CSF to maintain therapeutic intensity with conventional standard therapy without G-CSF and examined the benefits and risks as major outcomes...
March 22, 2024: International Journal of Clinical Oncology
https://read.qxmd.com/read/38515362/the-first-case-of-a-korean-patient-with-a-mutation-confirmed-tumor-necrosis-factor-receptor-associated-periodic-syndrome
#28
Seok-Jin Lee, Jee Yeon Baek, Ji Young Lee, Ji-Man Kang, Jong Gyun Ahn
Tumor necrosis factor receptor-associated periodic syndrome (TRAPS, OMIM: #142680) is a rare autoinflammatory disease (AID) with recurrent febrile episodes. To our knowledge, we report herein the first case of a patient with TRAPS in South Korea whose symptoms included fever, arthralgia, abdominal pain, rash, myalgia, cough, and lymphadenopathy. A pathogenic de novo mutation, c.175T>C (p.Cys59Arg), in the tumor necrosis factor receptor superfamily member 1A ( TNFRSF1A ) gene, was confirmed by gene sequencing...
April 2024: Yonsei Medical Journal
https://read.qxmd.com/read/38514061/idiopathic-hypereosinophilic-syndrome-in-a-professional-athlete
#29
JOURNAL ARTICLE
Sarah Shidid, Pakinam Mekki, Tamar A Smith-Norowitz
OBJECTIVE: To present the case of an athlete with hypereosinophilic syndrome (HES). CASE REPORT: We present a 25-year-old female athlete, with no significant past medical history, who had a two-month history of progressive dry cough, wheezing, exertional dyspnea, and chest pain. Physical examination revealed patient to be febrile to 101.6 degrees Fahrenheit and tachycardic to 120 beats per minute with new leukocytosis of 35.9x109 /L and eosinophilia of 24,000/μL...
January 2024: Annals of Clinical and Laboratory Science
https://read.qxmd.com/read/38513571/understanding-neurodevelopmental-trajectories-and-behavioral-profiles-in-scn1a-related-epilepsy-syndromes
#30
JOURNAL ARTICLE
Amber Postma, Crista A Minderhoud, Wim M Otte, Floor E Jansen, W B Gunning, Judith S Verhoeven, Marian J Jongmans, Janneke R Zinkstok, Eva H Brilstra
BACKGROUND: A pathogenic variant in SCN1A can result in a spectrum of phenotypes, including Dravet syndrome (DS) and genetic epilepsy with febrile seizures plus (GEFS + ) syndrome. Dravet syndrome (DS) is associated with refractory seizures, developmental delay, intellectual disability (ID), motor impairment, and challenging behavior(1,2). GEFS + is a less severe phenotype in which cognition is often normal and seizures are less severe. Challenging behavior largely affects quality of life of patients and their families...
March 20, 2024: Epilepsy & Behavior: E&B
https://read.qxmd.com/read/38512064/early-switch-from-intravenous-to-oral-antibiotic-therapy-in-patients-with-cancer-who-have-low-risk-neutropenic-sepsis-the-easi-switch-rct
#31
RANDOMIZED CONTROLLED TRIAL
Vicky Coyle, Caroline Forde, Richard Adams, Ashley Agus, Rosemary Barnes, Ian Chau, Mike Clarke, Annmarie Doran, Margaret Grayson, Danny McAuley, Cliona McDowell, Glenn Phair, Ruth Plummer, Dawn Storey, Anne Thomas, Richard Wilson, Ronan McMullan
BACKGROUND: Neutropenic sepsis is a common complication of systemic anticancer treatment. There is variation in practice in timing of switch to oral antibiotics after commencement of empirical intravenous antibiotic therapy. OBJECTIVES: To establish the clinical and cost effectiveness of early switch to oral antibiotics in patients with neutropenic sepsis at low risk of infective complications. DESIGN: A randomised, multicentre, open-label, allocation concealed, non-inferiority trial to establish the clinical and cost effectiveness of early oral switch in comparison to standard care...
March 2024: Health Technology Assessment: HTA
https://read.qxmd.com/read/38511952/evaluation-of-humoral-immune-response-after-yellow-fever-infection-an-observational-study-on-patients-from-the-2017-2018-sylvatic-outbreak-in-brazil
#32
JOURNAL ARTICLE
Andreza Parreiras Gonçalves, Letícia Trindade Almeida, Izabela Maurício de Rezende, Jordana Rodrigues Barbosa Fradico, Leonardo Soares Pereira, Dario Brock Ramalho, Marcelo Antônio Pascoal Xavier, Carlos Eduardo Calzavara Silva, Thomas P Monath, Angelle Desiree LaBeaud, Betania Paiva Drumond, Ana Carolina Campi-Azevedo, Olindo Assis Martins-Filho, Andréa Teixeira-Carvalho, Pedro Augusto Alves
Between 2016 and 2018, Brazil experienced major sylvatic yellow fever (YF) outbreaks that caused hundreds of casualties, with Minas Gerais (MG) being the most affected state. These outbreaks provided a unique opportunity to assess the immune response triggered by the wild-type (WT) yellow fever virus (YFV) in humans. The plaque reduction neutralization test (PRNT) is currently the standard method to assess the humoral immune response to YFV by measuring neutralizing antibodies (nAbs). The present study aimed to evaluate the humoral immune response of patients from the 2017-2018 sylvatic YF outbreak in MG with different disease outcomes by using PRNTs with a WT YFV strain, isolated from the 2017-2018 outbreak, and a vaccine YFV strain...
March 21, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38511932/modeling-heartland-virus-disease-in-mice-and-therapeutic-intervention-with-4-fluorouridine
#33
JOURNAL ARTICLE
Jonna B Westover, Kie Hoon Jung, Cigdem Alkan, Kirsten M Boardman, Arnaud J Van Wettere, Craig Martens, Inioska Rojas, Philip Hicks, Aaron J Thomas, Manohar T Saindane, Gregory R Bluemling, Shuli Mao, Alexander A Kolykhalov, Michael G Natchus, Paul Bates, George R Painter, Tetsuro Ikegami, Brian B Gowen
UNLABELLED: Heartland virus (HRTV) is an emerging tick-borne bandavirus that causes a febrile illness of varying severity in humans, with cases reported in eastern and midwestern regions of the United States. No vaccines or approved therapies are available to prevent or treat HRTV disease. Here, we describe the genetic changes, natural history of disease, and pathogenesis of a mouse-adapted HRTV (MA-HRTV) that is uniformly lethal in 7- to 8-week-old AG129 mice at low challenge doses. We used this model to assess the efficacy of the ribonucleoside analog, 4'-fluorouridine (EIDD-2749), and showed that once-daily oral treatment with 3 mg/kg of drug, initiated after the onset of disease, protects mice against lethal MA-HRTV challenge and reduces viral loads in blood and tissues...
March 21, 2024: Journal of Virology
https://read.qxmd.com/read/38510886/the-use-of-granulocyte-colony-stimulating-factor-as-primary-prophylaxis-in-patients-undergoing-chemotherapy-an-experience-of-moroccan-oncologists
#34
JOURNAL ARTICLE
Mohamed Kaakoua, Soukayna Boujmadi, Rhizlane Belbaraka, Ismail Essadi
Febrile neutropenia (FN) is a frequent and serious emergency for oncologic patients undergoing chemotherapy. Using granulocyte colony-stimulating factor (G-CSF) as primary prophylaxis of febrile neutropenia is an integral part of the management of cancer patients. Our study aims to identify the challenges that prevent Moroccan oncologists from prescribing G-CSF for primary prevention. Seventy doctors participated in our study, with a participation rate of 35.35%. Twenty-two participants had at least five years of experience in oncology...
February 2024: Curēus
https://read.qxmd.com/read/38510651/chinese-medicine-phragmites-communis-lu-gen-for-acute-respiratory-tract-infections-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#35
Min Fang, Ling-Yao Kong, Guang-He Ji, Feng-Lan Pu, You-Zhu Su, Yu-Fei Li, Michael Moore, Merlin Willcox, Jeanne Trill, Xiao-Yang Hu, Jian-Ping Liu
Background: Acute respiratory tract infections (ARTIs) are the most common cause of morbidity and mortality worldwide, with most people experiencing at least one episode per year. Current treatment options are mainly symptomatic therapy. Antivirals, antibiotics, and glucocorticoids are of limited benefit for most infections. Traditional Chinese medicine has shown potential benefits in the treatment of ARTIs. Objective: The objective of this study was to determine the efficacy, effectiveness, and safety of Phragmites communis Trin...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38509227/viral-infections-in-pregnancy-and-impact-on-offspring-neurodevelopment-mechanisms-and-lessons-learned
#36
REVIEW
Emma F Yates, Sarah B Mulkey
Pregnant individuals with viral illness may experience significant morbidity and have higher rates of pregnancy and neonatal complications. With the growing number of viral infections and new viral pandemics, it is important to examine the effects of infection during pregnancy on both the gestational parent and the offspring. Febrile illness and inflammation during pregnancy are correlated with risk for autism, attention deficit/hyperactivity disorder, and developmental delay in the offspring in human and animal models...
March 20, 2024: Pediatric Research
https://read.qxmd.com/read/38508484/predictors-of-invasive-bacterial-infection-in-febrile-infants-aged-2-to-6-months-in-the-emergency-department
#37
JOURNAL ARTICLE
Rebecca S Green, Laura F Sartori, Todd A Florin, Paul L Aronson, Brian E Lee, James M Chamberlain, Kathryn M Hunt, Kenneth A Michelson, Lise E Nigrovic
Our goal was to identify predictors of invasive bacterial infection (ie, bacteremia and bacterial meningitis) in febrile infants aged 2 to 6 months. In our multicenter retrospective cohort, older age and lower temperature identified infants at low risk for invasive bacterial infection who could safely avoid routine testing.
March 18, 2024: Journal of Pediatrics
https://read.qxmd.com/read/38507814/clinical-manifestations-of-dengue-in-children-and-adults-in-a-hyperendemic-region-of-colombia
#38
JOURNAL ARTICLE
Jorge Emilio Salazar Flórez, Katerine Marín Velasquez, Ángela María Segura Cardona, Berta Nelly Restrepo Jaramillo, Yuris Esther Ortega Díaz, Luz Stella Giraldo Cardona, Margarita Arboleda Naranjo
Dengue is the most common arboviral disease in the world. Traditionally, it has affected more adults, but the incidence in children has increased in recent years. Colombia is no stranger to this change; therefore, we aimed to find the differences in signs, symptoms, and clinical, hematological, and hemogram characteristics between children under 12 years old and individuals aged 12 years and older in an endemic region of Colombia in 2020-2022. The analyses were conducted with baseline data, corresponding to a cross-sectional design...
March 19, 2024: American Journal of Tropical Medicine and Hygiene
https://read.qxmd.com/read/38507063/asymptomatic-bacteriuria-prior-to-partial-and-radical-nephrectomy-to-screen-or-not-to-screen-results-from-the-national-and-multicenter-tocus-database
#39
JOURNAL ARTICLE
Elias Ayoub, Stessy Kutchukian, Pierre Bigot, Aurélien Dinh, Bastien Gondran-Tellier, Humphrey Robin, Marc Françot, Stéphane de Vergie, Jérôme Rigaud, Mathilde Chapuis, Laurent Brureau, Camille Jousseaume, Omar Karray, Fares T Kosseifi, Shahed Borojeni, Aurélien Descazeaud, Harrison-Junior Asare, Maxime Gaullier, Baptiste Poussot, Thibault Tricard, Michael Baboudjian, Éric Lechevallier, Pierre-Olivier Delpech, Héloïse Ducousso, Simon Bernardeau, Franck Bruyère, Maxime Vallée
INTRODUCTION: In the era of increased bacterial resistance, the main strategy is to reduce the prescription of antibiotics when possible. Nowadays, it is highly recommended to screen for asymptomatic bacteriuria (ABU), prior to urological surgery with potential mucosal breach or urine exposure. Screening and treating urinary colonization is a strategy widely adopted before radical and partial nephrectomy but without any evidence. Our main end point in this study is to analyze the relationship between preoperative urine culture and the risk of postoperative febrile urinary tract infection (UTI) or surgical-site infection (SSI) in partial or radical nephrectomy patients...
March 20, 2024: World Journal of Urology
https://read.qxmd.com/read/38506249/-better-at-home-mixed-methods-report-of-intricacies-in-pediatric-febrile-neutropenia-management
#40
JOURNAL ARTICLE
Eleanor T Smeallie, Sung W Choi, Rajen Mody, Timothy C Guetterman, Charles N Nessle
INTRODUCTION: Many febrile neutropenia (FN) episodes are low risk (LR) for severe outcomes and can safely receive less aggressive management and early hospital discharge. Validated risk tools are recommended by the Children's Oncology Group to identify LR FN episodes. However, the complex dynamics of early hospital discharge and burdens faced by caregivers associated with the FN episode have been inadequately described. METHODS: An adapted quality-of-life (QoL) survey instrument was administered by a convergent mixed methods design; qualitative and quantitative data from two sources, the medical record and the mixed methods survey instrument, were independently analyzed prior to linkage and integration...
March 2024: Cancer Medicine
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