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https://read.qxmd.com/read/30786354/-reconstruction-of-neglected-achilles-tendon-rupture-flexor-hallucis-longus-transfer-versus-gastrocnemius-turn-down-flaps
#1
F Zhao, Y L Hu, C Jiao, D Jiang, Q W Guo
Objective: To compare the outcome of either flexor hallucis longus transfer or turn-down of proximal Achilles tendon tissue repair in treating chronic Achilles tendon rupture. Methods: The clinical data of 21 patients who underwent repair of Myerson type Ⅲ chronic Achilles tendon rupture at Peking University Sports Medicine Research Institute from May 2012 to March 2015 were retrospectively analyzed. Among them, 11 cases were treated with flexor hallucis longus (FHL) transfer, and 10 cases were treated with gastrocnemius turn-down flaps repair...
February 19, 2019: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/30786335/-comparative-observation-of-thulium-laser-resection-of-the-prostate-tangerine-technique-and-transurethral-resection-of-the-prostate-for-the-treatment-of-benign-prostatic-hyperplasia-of-various-sizes
#2
Y Tian, G H Luo, X S Yang, S J Xia, Z L Sun
Objective: To compare the efficiency and safety of thulium laser resection of the prostate-tangerine technique (TmLRP-TT) and transurethral resection of the prostate (TURP) for the treatment of benign prostatic hyperplasia (BPH) of various sizes. Methods: Clinical data of 249 BPH patients received TmLRP-TT or TURP were retrospectively collected. Patients were divided into small prostate group [prostate volume (PV)<40 ml], medium prostate group (40 ml≤PV<80 ml) and large prostate group (PV ≥ 80 ml) based on transrectal ultrasound (TRUS) results...
February 12, 2019: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/30786324/intensity-modulated-radiation-therapy-dose-prescription-and-reporting-sum-and-substance-of-the-international-commission-on-radiation-units-and-measurements-report-83-for-veterinary-medicine
#3
Carla Rohrer Bley, Valeria S Meier, Juergen Besserer, Uwe Schneider
Institutions' adherence to protocol, quality assurance, and radiation parameter reporting are key to adequately interpret and compare treatment outcomes in radiation oncology. In 2017, the editorial board for Veterinary Radiology & Ultrasound adapted author guidelines on "technical information for radiation therapy (RT)". These guidelines provide a framework to report the RT treatment process in manuscripts resulting from veterinary clinical trials. In spite of this framework, however, in implementing IMRT, we have identified different "interpretations" of the extended prescription and reporting recommendations of the International Commission on Radiation Units and Measurements (ICRU 83), even within our small team...
February 20, 2019: Veterinary Radiology & Ultrasound
https://read.qxmd.com/read/30786318/-alternative-psychoses-and-forced-normalization-after-seizure-control-by-anticonvulsants-with-special-consideration-of-the-new-anticonvulsants
#4
Walter Fröscher, Tilman Steinert
In the case of alternative psychosis and forced normalization, the patient alternates between periods of clinically manifest seizures and normal behavior, and other periods of seizure freedom (or significant seizure reduction) accompanied by psychosis or behavioral disturbances. Unlike the clinically defined alternative psychosis, forced normalization is based on EEG findings. In clinical practice and in the literature, both terms are mostly used synonymously, and they also describe the same clinical pictures...
February 20, 2019: Fortschritte der Neurologie-Psychiatrie
https://read.qxmd.com/read/30786308/effectiveness-of-insulin-analogs-compared-with-human-insulins-in-pregnant-women-with-diabetes-mellitus-systematic-review-and-meta-analysis
#5
Leyna Leite Santos, Jamilly Leite Santos, Luciano Timbó Barbosa, Ivan do Nascimento da Silva, Célio Fernando de Sousa-Rodrigues, Fabiano Timbó Barbosa
Diabetes during pregnancy has been linked to unfavorable maternal-fetal outcomes. Human insulins are the first drug of choice because of the proven safety in their use. However, there are still questions about the use of insulin analogs during pregnancy. The objective of the present study was to determine the effectiveness of insulin analogs compared with human insulin in the treatment of pregnant women with diabetes through a systematic review with meta-analysis. The search comprised the period since the inception of each database until July 2017, and the following databases were used: MEDLINE, CINAHL, EMBASE, ISI Web of Science, LILACS, Scopus, SIGLE and Google Scholar...
February 2019: Revista Brasileira de Ginecologia e Obstetrícia
https://read.qxmd.com/read/30786306/the-use-of-mobile-educational-tools-to-improve-antimicrobial-prescription-for-the-treatment-of-acute-pyelonephritis-in-pregnancy-a-retrospective-cross-sectional-study
#6
Vicente Sperb Antonello, Marjane Caroline Cunegatto, Elisa Tasca Rosin, Júlia Xavier Castilhos, Fabrícia Gamba Beduschi, Daniela Benzano Bumaguin, Ivan Carlos Ferreira Antonello, Mirela Foresti Jimenez
OBJECTIVE:  To analyze the prescription of antimicrobial agents for pregnant women admitted into the obstetrics service who presented with acute pyelonephritis. METHODS:  Three cross-sectional studies were performed comparing the prescription of antimicrobials for pyelonephritis in pregnant women in the time periods evaluated (2010-2011: 99 patients evaluated; 2013: 116 patients evaluated; 2015: 107 patients evaluated), at the Hospital Fêmina, Porto Alegre, in the state of Rio Grande do Sul, Brazil...
February 2019: Revista Brasileira de Ginecologia e Obstetrícia
https://read.qxmd.com/read/30786274/hemodynamic-response-of-the-three-macular-capillary-plexuses-in-dark-adaptation-and-flicker-stimulation-using-optical-coherence-tomography-angiography
#7
Peter L Nesper, Hee Eun Lee, Alaa E Fayed, Gregory W Schwartz, Fei Yu, Amani A Fawzi
Purpose: To assess retinal microvascular reactivity during dark adaptation and the transition to ambient light and after flicker stimulation using optical coherence tomography angiography (OCTA). Methods: Fifteen eyes of 15 healthy participants were dark adapted for 45 minutes followed by OCTA imaging in the dark-adapted state. After 5 minutes of normal lighting, subjects underwent OCTA imaging. Participants were then subjected to a flashing light-emitting diode (LED) light and repeat OCTA...
February 1, 2019: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/30786260/assessing-image-artifacts-from-radiotherapy-electromagnetic-transponders-with-metal-artifact-reduction-imaging
#8
Robert V Bergen, Lawrence Ryner
Image artifacts due to 14 gauge radiotherapy electromagnetic (EM) transponders were assessed on conventional spin echo images, and corrected using metal artifact reduction techniques: high bandwidth, view angle tilting (VAT), and slice encoding for metal artifact correction (SEMAC). Large areas of signal loss and/or pile-up were produced in an area extending up to 15.3 mm in radius for 14G transponders in standard imaging. Using high bandwidth imaging with VAT, in-plane artifact sizes were reduced by up to 35%...
February 17, 2019: Magnetic Resonance Imaging
https://read.qxmd.com/read/30786255/maternal-outcomes-by-race-during-postpartum-readmissions
#9
Aleha Aziz, Cynthia Gyamfi-Bannerman, Zainab Siddiq, Jason D Wright, Dena Goffman, Jean-Ju Sheen, Mary E D'Alton, Alexander M Friedman
BACKGROUND: Maternal race may be an important risk factor for postpartum readmissions and associated adverse outcomes. OBJECTIVE: To determine the association of race with serious complications during postpartum readmissions. STUDY DESIGN: This repeated cross sectional analysis utilized the National (Nationwide) Inpatient Sample from the Healthcare Cost and Utilization Project from 2012 to 2014. Women ages 15 to 54 readmitted postpartum after a delivery hospitalization were identified by Centers for Disease Control and Prevention criteria...
February 13, 2019: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/30786252/associations-between-aerobic-and-muscle-strengthening-exercise-with-depressive-symptom-severity-among-17-839-u-s-adults
#10
Jason A Bennie, Megan J Teychenne, Katrien De Cocker, Stuart J H Biddle
For the prevention and management of chronic diseases, global physical activity guidelines state that an adult should engage in regular moderate-to-vigorous aerobic physical activity (MVPA; e.g. walking, cycling, running) and muscle-strengthening exercise (MSE; e.g. strength/resistance training). However, the associations between combined MVPA-MSE with chronic health conditions are rarely examined in large population studies. In particular, little is known associations between combined MVPA-MSE with depressive disorders, one of the leading causes of disability worldwide...
February 17, 2019: Preventive Medicine
https://read.qxmd.com/read/30786249/an-industry-perspective-a-streamlined-screening-strategy-using-alternative-models-for-chemical-assessment-of-developmental-neurotoxicity
#11
REVIEW
Jinpeng Li, Raja Settivari, Matthew J LeBaron, M Sue Marty
Developmental neurotoxicity (DNT) is an important endpoint for the safety assessment of chemicals. However, the current in vivo animal model for DNT assessment is resource-intensive and may not fully capture all mechanisms that may be relevant to DNT in humans. As a result, there is a growing need for more reliable, time- and cost-efficient approaches for DNT evaluation. Towards this end, many stem/progenitor cell-based in vitro models and alternative organism-based models are becoming available with the potential for high throughput screening of DNT...
February 17, 2019: Neurotoxicology
https://read.qxmd.com/read/30786238/molecular-mechanisms-of-plant-regeneration
#12
Momoko Ikeuchi, David Seth Favero, Yuki Sakamoto, Akira Iwase, Duncan Coleman, Bart Rymen, Keiko Sugimoto
Plants reprogram somatic cells following injury and regenerate new tissues and organs. Upon perception of inductive cues, somatic cells often dedifferentiate, proliferate, and acquire new fates to repair damaged tissues or develop new organs from wound sites. Wound stress activates transcriptional cascades to promote cell fate reprogramming and initiate new developmental programs. Wounding also modulates endogenous hormonal responses by triggering their biosynthesis and/or directional transport. Auxin and cytokinin play pivotal roles in determining cell fates in regenerating tissues and organs...
February 20, 2019: Annual Review of Plant Biology
https://read.qxmd.com/read/30786232/mammalian-respiratory-complex-i-through-the-lens-of-cryo-em
#13
Ahmed-Noor A Agip, James N Blaza, Justin G Fedor, Judy Hirst
Single-particle electron cryomicroscopy (cryo-EM) has led to a revolution in structural work on mammalian respiratory complex I. Complex I (mitochondrial NADH:ubiquinone oxidoreductase), a membrane-bound redox-driven proton pump, is one of the largest and most complicated enzymes in the mammalian cell. Rapid progress, following the first 5-Å resolution data on bovine complex I in 2014, has led to a model for mouse complex I at 3.3-Å resolution that contains 96% of the 8,518 residues and to the identification of different particle classes, some of which are assigned to biochemically defined states...
February 20, 2019: Annual Review of Biophysics
https://read.qxmd.com/read/30786227/inference-of-diets-of-early-hominins-from-primate-molar-form-and-microwear
#14
P S Ungar
Paleontologists use fossil teeth to reconstruct the diets of early hominins and other extinct species. Some evidence is adaptive: nature selects for tooth size, shape, and structure best suited to specific food types. Other evidence includes traces left by actual foods eaten, such as microscopic tooth wear. This critical review considers how molars work, how they are used, and how occlusal topography and dental microwear can be used to infer diet and food preferences in the past, particularly for hominins of the Pliocene and early Pleistocene...
February 20, 2019: Journal of Dental Research
https://read.qxmd.com/read/30786223/time-resolved-quantification-of-the-dynamic-extracellular-space-in-the-brain-study-of-cortical-spreading-depression
#15
Hui-Hui Zhao, Hong Du, Yujie Cai, Chao Liu, Zeyu Xie, Kevin C Chen
Extracellular diffusion in the brain is customarily characterized by two parameters, the extracellular space (ECS) volume fraction α and the diffusion tortuosity λ. How these two parameters are temporarily modified and correlated in a physiological/pathological event remains unclear to date. Using tetramethyl ammonium (TMA+ ) as the ECS ion tracer in a newly updated iontophoretic sinusoidal method, we studied in this work the dynamic α( t) and λ( t) in rat somatosensory cortex during spreading depression (SD)...
February 20, 2019: Journal of Neurophysiology
https://read.qxmd.com/read/30786215/laser-desorption-combined-with-laser-postionization-for-mass-spectrometry
#16
Luke Hanley, Raveendra Wickramasinghe, Yeni P Yung
Lasers with pulse lengths from nanoseconds to femtoseconds and wavelengths from the mid-infrared to extreme ultraviolet (UV) have been used for desorption or ablation in mass spectrometry. Such laser sampling can often benefit from the addition of a second laser for postionization of neutrals. The advantages offered by laser postionization include the ability to forego matrix application, high lateral resolution, decoupling of ionization from desorption, improved analysis of electrically insulating samples, and potential for high sensitivity and depth profiling while minimizing differential detection...
February 20, 2019: Annual Review of Analytical Chemistry
https://read.qxmd.com/read/30786205/lewis-acid-promoted-regio-and-diastereoselective-cross-coupling-of-aryl-substituted-1-2-diols-and-boronic-acids
#17
Heesun Yu, Ryangha Lee, Hyoungsu Kim, Dongjoo Lee
A Lewis acid-promoted highly regio- and diastereoselective C(sp3 )-C(sp2 ) cross-coupling reaction between unprotected aryl-substituted 1,2-diols and styryl-, aryl-, heteroaryl-, and polyarylboronic acids has been developed in a one-pot procedure. The regioselective opening of aryl-substituted cyclic boronic esters promoted by a Lewis acid, followed by subsequent intramolecular 1,4-transfer of the carbon ligand from boron to a resonance-stabilized benzylic carbenium ion minimizing the allylic 1,3-strain in a stereoselective fashion led to the corresponding α-substituted syn-phenylethyl alcohols...
February 20, 2019: Journal of Organic Chemistry
https://read.qxmd.com/read/30786187/once-daily-plazomicin-for-complicated-urinary-tract-infections
#18
Florian M E Wagenlehner, Daniel J Cloutier, Allison S Komirenko, Deborah S Cebrik, Kevin M Krause, Tiffany R Keepers, Lynn E Connolly, Loren G Miller, Ian Friedland, Jamie P Dwyer
BACKGROUND: The increasing multidrug resistance among gram-negative uropathogens necessitates new treatments for serious infections. Plazomicin is an aminoglycoside with bactericidal activity against multidrug-resistant (including carbapenem-resistant) Enterobacteriaceae. METHODS: We randomly assigned 609 patients with complicated urinary tract infections (UTIs), including acute pyelonephritis, in a 1:1 ratio to receive intravenous plazomicin (15 mg per kilogram of body weight once daily) or meropenem (1 g every 8 hours), with optional oral step-down therapy after at least 4 days of intravenous therapy, for a total of 7 to 10 days of therapy...
February 21, 2019: New England Journal of Medicine
https://read.qxmd.com/read/30786179/enhancing-the-treatment-of-patients-with-schizophrenia-through-continuous-care
#19
John Lauriello, Diana O Perkins
Schizophrenia is a chronic disorder that can be effectively controlled but will likely require lifelong treatment. Unfortunately, most patients experience numerous relapses, ongoing symptoms, and impairment, often because of treatment interruptions. Continuous treatment is imperative to prevent relapse and the potentially devastating consequences that can follow a return of psychotic symptoms. Clinicians must better monitor a common cause of relapse, nonadherence, and offer strategies to improve adherence. Strategies can target the patient, the environment, or treatment...
February 19, 2019: Journal of Clinical Psychiatry
https://read.qxmd.com/read/30786173/genitourinary-cancer-patients-have-worse-baseline-semen-parameters-than-healthy-sperm-bankers
#20
R Xu, G M Centola, C Tanrikut
BACKGROUND: While the spermatotoxic properties of cancer treatments such as chemotherapy and radiation therapy are widely recognized, the effect of malignancy itself on male fertility is not clearly understood. OBJECTIVES: To determine whether malignancy is associated with diminished semen quality prior to spermatotoxic treatment among sperm bankers. MATERIALS AND METHODS: Retrospective database review of de-identified records was obtained for all episodes of sperm banking performed at a cryobank from January 2004 to May 2017 for one of the following reasons: 'future use' (e...
February 20, 2019: Andrology
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