Mingwei Guo, Jun Zhang, Ying Ma, Zhenzhong Zhu, Hui Zuo, Jing Yao, Xia Wu, Dongmei Wang, Jian Yu, Meiyao Meng, Caizhi Liu, Yi Zhang, Jiangrong Chen, Jian Lu, Shuzhe Ding, Cheng Hu, Xinran Ma, Lingyan Xu
Sarcopenia is characterized of muscle mass loss and functional decline in elder individuals which severely affects human physical activity, metabolic homeostasis, and life quality. Physical exercise is considered effective in combating muscle atrophy and sarcopenia, yet it is not feasible to elders with limited mobility. PGC-1α4, a short isoform of PGC-1α, is strongly induced in muscle under resistance training, and promotes muscle hypertrophy. In the present study, we showed that the transcriptional levels and nuclear localization of PGC1α4 was reduced during aging, accompanied with muscle dystrophic morphology, and gene programs...
August 16, 2023: Aging Cell