keyword
https://read.qxmd.com/read/37963994/osthole-inhibits-gsk-3%C3%AE-ampk-mtor-pathway-controlled-glycolysis-and-increases-radiosensitivity-of-subcutaneous-transplanted-hepatocellular-carcinoma-in-nude-mice
#21
JOURNAL ARTICLE
Hui Huang, Jie Xue, Mei-Lin Xie, Tao Xie
PURPOSE: Osthole possesses anti-tumor activities. However, whether osthole can have a radiosensitization effect on hepatic cancer remains unclear. Here, an HCC-LM3 cells-inoculated subcutaneous transplanted tumor was adopted to explore the effect of osthole. METHODS: The tumor-bearing mice were treated with 100 mg/kg osthole for 12 days, 4 Gy irradiation twice, or their combination. The tumor volume and weight, lactic acid content, glycolytic enzyme activities, and protein expression of glycogen synthase kinase 3β (GSK-3β), p‑GSK-3β, mammalian target of rapamycin (mTOR), p‑mTOR, AMP-activated protein kinase (AMPK), p‑AMPK, glucose transporter 1/3, and pyruvate kinase M2 were determined...
November 14, 2023: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://read.qxmd.com/read/37946827/retracted-the-mechanism-of-osthole-in-the-treatment-of-gastric-cancer-based-on-network-pharmacology-and-molecular-docking-technology
#22
Applied Bionics And Biomechanics
[This retracts the article DOI: 10.1155/2022/5997895.].
2023: Applied Bionics and Biomechanics
https://read.qxmd.com/read/37945232/natural-product-osthole-can-significantly-disrupt-cell-wall-integrity-and-dynamic-balance-of-fusarium-oxysporum
#23
JOURNAL ARTICLE
Ke Hu, Rongyu Li, Feixu Mo, Yi Ding, Aiai Zhou, Xue Guo, Ruotong Li, Min Li, Minggui Ou, Ming Li
Dendrobium officinale Kimura et Migo is a traditional Chinese herbal medicinal plant. However, the frequent occurrence of soft rot disease (SRD) is one of the most harmful diseases in D. officinale production in recent years, which can seriously affect its yield and quality. In this study, the major pathogenic fungus (SR-1) was isolated from D. officinale with typical symptoms of SRD, and was identified as Fusarium oxysporum through morphological and molecular identification. The biological activities of five natural products were determined against F...
November 2023: Pesticide Biochemistry and Physiology
https://read.qxmd.com/read/37945229/molecular-mechanism-of-osthole-against-chitin-synthesis-of-ustilaginoidea-virens-based-on-combined-transcriptome-and-metabolome-analyses
#24
JOURNAL ARTICLE
Xianfeng Hu, Jian Wang, Yubo Zhang, Rongyu Li, Ming Li
Rice false smut, caused by the fungus Ustilaginoidea virens, is a destructive grain disease in rice-producing areas worldwide. To reveal the action mechanism of osthole against U. virens, the mycelial morphology, differential genes and metabolites of osthole-treated U. virens were determined using electron microscopy and multi-omics, respectively. The hyphae of osthole-treated U. virens were severely wrinkled and distorted with rough cell walls, uneven thickness, and protoplast aggregation. Calcium fluorescent white staining showed that osthole affected chitin synthesis in U...
November 2023: Pesticide Biochemistry and Physiology
https://read.qxmd.com/read/37895813/development-of-osthole-loaded-microemulsions-as-a-prospective-ocular-delivery-system-for-the-treatment-of-corneal-neovascularization-in-vitro-and-in-vivo-assessments
#25
JOURNAL ARTICLE
Yali Zhang, Jingjing Yang, Yinjian Ji, Zhen Liang, Yuwei Wang, Junjie Zhang
Osthole (OST), a natural coumarin compound, has shown a significant inhibitory effect on corneal neovascularization (CNV). But, its effect on treating CNV is restricted by its water insolubility. To overcome this limitation, an OST-loaded microemulsion (OST-ME) was created to improve the drug's therapeutic effect on CNV after topical administration. The OST-ME formulation comprised Capryol-90 (CP-90), Cremophor® EL (EL-35), Transcutol-P (TSP) and water, and sodium hyaluronate (SH) was also included to increase viscosity...
September 22, 2023: Pharmaceuticals
https://read.qxmd.com/read/37888845/-in-vitro-cytotoxic-potential-of-aerial-parts-of-leutea-avicennae-mozaff-in-different-human-cancer-cell-lines
#26
JOURNAL ARTICLE
Mahsa Sabernavaei, Hamed Montazeri, Parastoo Mirzabeigi, Paria Sharafi-Badr, Mozhdeh Zamani, Abbas Hadjiakhoondi, Narguess Yassaa, Farzad Kobarfard
Medicinal plants such as Leutea avicennae Mozaff. (Apiaceae) have been shown some biological potential for preventing and treating diseases. Fractions and isolated compounds were tested on colon carcinoma (HT-29), cervical carcinoma (HeLa), breast carcinoma (MCF-7), and mouse embryonic fibroblast (NIH/3T3) cell lines. The BSLT method was used for the assessment of the general toxicity of the petroleum ether (PET), chloroform (CHCl3 ), ethyl acetate (EtOAc), and methanol (MeOH) fractions obtained from the aerial parts of L...
October 27, 2023: Natural Product Research
https://read.qxmd.com/read/37769856/osthole-protects-h9c2-cardiomyocytes-against-trastuzumab-induced-damage-by-enhancing-autophagy-through-the-p38mapk-mtor-signaling-pathway
#27
JOURNAL ARTICLE
Huan Hou, Yaping Yang, Rong Chen, Zhiping Guo
Trastuzumab (TRZ) is a novel targeted anti-tumor agent that significantly improve the survival of patients with human epidermal growth factor receptor (HER2) positive breast cancer. However, its clinical application is limited due to the side effects of cardiotoxicity. Osthol (OST), a coumarin derivative isolated from Cnidium monnieri (L.) Cusson, has previously demonstrated cardioprotective effects. The aim of this study was to observe the protective effect of OST on TRZ-induced cardiomyocytes damage and to explore its potential mechanism...
September 26, 2023: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://read.qxmd.com/read/37754693/contact-toxicity-antifeedant-activity-and-oviposition-preference-of-osthole-against-agricultural-pests
#28
JOURNAL ARTICLE
Fang Dong, Xin Chen, Xingyuan Men, Zhuo Li, Yujun Kong, Yiyang Yuan, Feng Ge
Osthole, the dominant bioactive constituent in the Cnidium monnieri , has shown acute pesticidal activities. However, its detailed toxicity, antifeedant, and oviposition preference effects against agricultural pests have not been fully understood, limiting its practical use. This study aimed to investigate the contact toxicity, antifeedant activity, and oviposition preference of osthole against three agricultural pests ( Tetranychus urticae , Myzus persicae , and Bactrocera dorsalis ). Our results showed that the Cnidium monnieri (L...
August 24, 2023: Insects
https://read.qxmd.com/read/37686018/gelma-hydrogel-as-a-promising-delivery-system-for-osthole-in-the-treatment-of-rheumatoid-arthritis-targeting-the-mir-1224-3p-ago1-axis
#29
JOURNAL ARTICLE
Weilin Zhang, Zhencong Li, Zhiwen Dai, Siyuan Chen, Weixiong Guo, Zhongwei Wang, Jinsong Wei
Rheumatoid arthritis (RA) is a multifaceted, chronic, progressive autoimmune disease. This study aims to explore the potential benefits of an enhanced drug delivery system utilizing optimized Gelatin Methacryloyl (GelMA) vectors in RA management. We evaluated the levels of miR-1124-3p and AGO1 in RA tissues and cell lines using qPCR, WB, and immunofluorescence. The effects of osthole on inflammatory response and joint morphology were determined by qPCR, H&E staining, and micro-CT. The data showed that miR-1224-3p was downregulated in RA tissues and HUM-iCell-s010RA cells, while the overexpression of miR-1224-3p in HUM-iCell-s010RA cells reduced the expression of IL-6 and IL-1β...
August 25, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37682453/signaling-pathways-involved-in-the-neuroprotective-effect-of-osthole-evidence-and-mechanisms
#30
REVIEW
Lovedeep Singh, Rajbir Bhatti
Neurodegenerative diseases constitute a major threat to human health and are usually accompanied by progressive structural and functional loss of neurons. Abnormalities in synaptic plasticity are involved in neurodegenerative disorders. Aberrant cell signaling cascades play a predominant role in the initiation, progress as well as in the severity of these ailments. Notch signaling is a pivotal role in the maintenance of neural stem cells and also participates in neurogenesis. PI3k/Akt cascade regulates different biological processes including cell proliferation, apoptosis, and metabolism...
September 8, 2023: Molecular Neurobiology
https://read.qxmd.com/read/37680712/review-on-the-protective-activity-of-osthole-against-the-pathogenesis-of-osteoporosis
#31
REVIEW
Jincai Chen, Xiaofei Liao, Juwen Gan
Osteoporosis (OP), characterized by continuous bone loss and increased fracture risk, has posed a challenge to patients and society. Long-term administration of current pharmacological agents may cause severe side effects. Traditional medicines, acting as alternative agents, show promise in treating OP. Osthole, a natural coumarin derivative separated from Cnidium monnieri (L.) Cusson and Angelica pubescens Maxim. f., exhibits protective effects against the pathological development of OP. Osthole increases osteoblast-related bone formation and decreases osteoclast-related bone resorption, suppressing OP-related fragility fracture...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/37673021/multifunctional-gomisin-b-enhances-cognitive-function-in-app-ps1-transgenic-mice-by-regulating-a%C3%AE-clearance-and-neuronal-apoptosis
#32
JOURNAL ARTICLE
Jinman Liu, Xue Zuo, Mingjun Huang, Jiansong Fang, Weirong Li, Qing Shi, Qi Wang, Yong Liang
This study aimed to investigate the potential effects of Gomisin B, a natural compound known for its inhibition of CYP3A4, on cognitive dysfunction in APP/PS1 transgenic mice with Alzheimer's disease (AD). Additionally, the study explored the combined effects of Gomisin B and Osthole (OST). The research involved male wild-type (WT) mice and 7-month-old APP/PS1 transgenic AD mice. The assessment of behavioral changes included the use of the open field test (OFT) and the Morris water maze (MWM). OST levels in brain tissue were quantified using LC-MS/MS, while levels of oxidative stress were measured through an assay kit...
September 4, 2023: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/37643205/the-therapeutic-effect-of-glycyrrhizic-acid-compound-ointment-on-imiquimod-induced-psoriasis-like-disease-in-mice
#33
JOURNAL ARTICLE
Yanwen Zhang, Qian Wang, Shuangyong Sun, Lingyan Jiang
Glycyrrhetinic acid, a drug with anti-inflammatory effects, enhanced the activity of antipsoriatic efficacy. In this research, an ointment with glycyrrhetinic acid was prepaired as the major component and several other herbal monomers (astilbin, osthole, and momordin Ic) have antipsoriatic activity as minor components. Then an Imiquimod-induced psoriasis-like mouse model was established and the damaged skin condition of the administered group, the changes in the spleen index and the secretion of inflammatory factors in mouse skin were observed...
2023: PloS One
https://read.qxmd.com/read/37586159/modulating-endoplasmic-reticulum-stress-in-app-ps1-mice-by-gomisin-b-and-osthole-in-bushen-yizhi-formula-synergistic-effects-and-therapeutic-implications-for-alzheimer-s-disease
#34
JOURNAL ARTICLE
Jinman Liu, Qihui Wu, Qiqing Wu, Guangcheng Zhong, Yong Liang, Yong Gu, Yunhui Hu, Wenjia Wang, Ning Hao, Shuhuan Fang, Weirong Li, Huafeng Pan, Qi Wang, Jiansong Fang
BACKGROUND: Alzheimer's disease (AD) is a prevalent neurodegenerative disorder with no effective cure. Targeting endoplasmic reticulum (ER) stress pathway may offer a novel approach to ameliorate cognitive deficits in AD. Bushen-Yizhi formula (BSYZ), a traditional Chinese medicine (TCM) prescription, has shown potential benefits for AD. To facilitate the development of new therapeutic agents for AD, it is important to identify the active components and the underlying mechanisms of BSYZ against AD...
August 12, 2023: Phytomedicine
https://read.qxmd.com/read/37543158/antidepressant-effects-of-coumarins-and-their-derivatives-a-critical-analysis-of-research-advances
#35
REVIEW
Nneka Augustina Akwu, Makhotso Lekhooa, Dou Deqiang, Adeyemi Oladapo Aremu
Coumarins and their derivatives are non-flavonoids polyphenols with diverse pharmacological activities including anti-depressant effects. This study systematically examines the antidepressant effects of coumarins and their derivatives in relation to time series of research progress in the pharmacological pathways, association with other diseases, toxicity and bliometric analysis. The review was approached using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) coupled with R package using Biblioshiny, a web interface for Bibliometrix analysis and VOSviewer software analytic tools...
August 3, 2023: European Journal of Pharmacology
https://read.qxmd.com/read/37521471/osthole-borneol-thermosensitive-gel-via-intranasal-administration-enhances-intracerebral-bioavailability-to-improve-cognitive-impairment-in-app-ps1-transgenic-mice
#36
JOURNAL ARTICLE
Fanchang Wu, Mingjun Huang, Xue Zuo, Ruiye Xie, Jinman Liu, Junyu Ke, Weirong Li, Qi Wang, Yong Liang
Alzheimer's disease (AD) poses a significant threat to the global elderly population. Traditional Chinese medicine (TCM) has been widely utilized in the treatment of AD. Osthole, a bioactive ingredient classified as an "emperor" in many TCM formulas, has been demonstrated to effectively alleviate AD symptoms. However, its low bioavailability in the brain has limited its clinical application. This study aimed to increase the intracerebral bioavailability of osthole by using borneol as a "courier," based on the classical "Emperor-Minister-Assistant-Courier" model, and to investigate the enhanced pharmacological performance of osthole on AD...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/37519003/covalent-modification-of-proteins-by-osthole-reactive-metabolites-using-proteomic-approaches
#37
JOURNAL ARTICLE
Yue Zhuo, Huiling Chen, Chenchen Liu, Yida Zhang, Jiansong Fang, Meng Li, Zhendong Wang, Qiyao Jiang, Liangwen Yu, Huafeng Pan, Qi Wang
BACKGROUND: Osthole (OST) is a bioactive natural coumarin derived from the plant Cnidium monnieri (L.) Cusson fruit (She Chuang Zi), which has various pharmacological and biological activities. OST contains an α,β-unsaturated lactone, which is an electrophilic group that tends to be metabolized into reactive metabolites (RMs). Then, RMs are able to covalently modify nucleophilic amino acid (AA) residues of target proteins. However, few researchers considered the contribution of the covalent modification induced by OST or its metabolites...
July 27, 2023: Current Drug Metabolism
https://read.qxmd.com/read/37450901/biosynthesis-of-the-plant-coumarin-osthole-by-engineered-saccharomyces-cerevisiae
#38
JOURNAL ARTICLE
Pingping Wang, Zhenjun Fan, Wenping Wei, Chengshuai Yang, Yan Wang, Xiao Shen, Xing Yan, Zhihua Zhou
Osthole is a coumarin compound found in the traditional Chinese medicine Cnidium monnieri . Extensive studies have shown that osthole exhibits many medicinal properties, and recently, researchers have found that it possesses potent airway-relaxation activity by inhibiting phosphodiesterase 4D activity, making it a potential novel bronchodilator that does not target β2-adrenoceptors for asthma treatment. Here, we report the complete biosynthesis of osthole in engineered yeast. We created an umbelliferone (UMB)-producing strain by reconstituting the complete UMB pathway in yeast...
July 14, 2023: ACS Synthetic Biology
https://read.qxmd.com/read/37436082/ethanol-extract-of-citrus-grandis-tomentosa-exerts-anticancer-effects-by-targeting-skp2-p27-pathway-in-non-small-cell-lung-cancer
#39
JOURNAL ARTICLE
Da Huang, Pei-En Wu, Zi-Jie Chen, Yan-Chun Pang, Zi-Wei Xu, Jingbo Tan, Zhi-Hua Jiang, Bing-Bing Yang, Ruoting Zhan, Hui Xu, Yong-Qiang Liu
SCOPE: This study aims to investigate the anticancer properties of Citrus grandis 'Tomentosa' (CGT) in non-small cell lung cancer (NSCLC). METHODS AND RESULTS: The ethanol extract of CGT (CGTE) is prepared by using anhydrous ethanol and analyzed by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS), revealing that the main chemical components in CGTE are flavonoids and coumarins, such as naringin, rhoifolin, apigenin, bergaptol, and osthole...
September 2023: Molecular Nutrition & Food Research
https://read.qxmd.com/read/37427324/osthole-attenuated-cytotoxicity-induced-by-6-ohda-in-sh-sy5y-cells-through-inhibition-of-jak-stat-and-mapk-pathways
#40
JOURNAL ARTICLE
Samira Barangi, Parisa Hosseinzadeh, Gholamreza Karimi, Zahra Tayarani Najaran, Soghra Mehri
OBJECTIVES: Natural coumarin called osthole is regarded as a medicinal herb with widespread applications in Traditional Chinese Medicine. It has various pharmacological properties, including antioxidant, anti-inflammatory, and anti-apoptotic effects. In some neurodegenerative diseases, osthole also shows neuroprotective properties. In this study, we explored how osthole protects human neuroblastoma SH-SY5Y cells from the cytotoxicity of 6-hydroxydopamine (6-OHDA). MATERIALS AND METHODS: Using the MTT assay and DCFH-DA methods, respectively, the viability of the cells and the quantity of intracellular reactive oxygen species (ROS) were evaluated...
2023: Iranian Journal of Basic Medical Sciences
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