Yue Zhuo, Huiling Chen, Chenchen Liu, Yida Zhang, Jiansong Fang, Meng Li, Zhendong Wang, Qiyao Jiang, Liangwen Yu, Huafeng Pan, Qi Wang
BACKGROUND: Osthole (OST) is a bioactive natural coumarin derived from the plant Cnidium monnieri (L.) Cusson fruit (She Chuang Zi), which has various pharmacological and biological activities. OST contains an α,β-unsaturated lactone, which is an electrophilic group that tends to be metabolized into reactive metabolites (RMs). Then, RMs are able to covalently modify nucleophilic amino acid (AA) residues of target proteins. However, few researchers considered the contribution of the covalent modification induced by OST or its metabolites...
July 27, 2023: Current Drug Metabolism