keyword
https://read.qxmd.com/read/38535499/modulation-of-the-mas-related-g-protein-coupled-receptor-x2-mrgprx2-by-xenobiotic-compounds-and-its-relevance-to-human-diseases
#1
REVIEW
Alicja Dziadowiec, Iwona Popiolek, Mateusz Kwitniewski, Grzegorz Porebski
Mast cells (MCs) are immune cells that reside in tissues; particularly in the skin, and in the gastrointestinal and respiratory tracts. In recent years, there has been considerable interest in the Mas-Related G Protein-Coupled Receptor X2 (MRGPRX2), which is present on the surface of MCs and can be targeted by multiple exogenous and endogenous ligands. It is potentially implicated in non-IgE-mediated pseudoallergic reactions and inflammatory conditions such as asthma or atopic dermatitis. In this paper, we review natural products and herbal medicines that may potentially interact with MRGPRX2...
March 13, 2024: Journal of Xenobiotics
https://read.qxmd.com/read/38507853/cnidii-fructus-a-traditional-chinese-medicine-herb-and-source-of-antiosteoporotic-drugs
#2
REVIEW
Tianshu Xu, Jiyuan Yin, Xuan Dai, Tianyuan Liu, Hanfen Shi, Yueyi Zhang, Shan Wang, Gaiyue Yue, Yanfei Zhang, Dandan Zhao, Sihua Gao, Marc Prentki, Lili Wang, Dongwei Zhang
BACKGROUND: Osteoporosis (OP) is a prevalent chronic metabolic bone disease for which limited countermeasures are available. Cnidii Fructus (CF), primarily derived from Cnidium monnieri (L.) Cusson., has been tested in clinical trials of traditional Chinese medicine for the management of OP. Accumulating preclinical studies indicate that CF may be used against OP. MATERIALS AND METHODS: Comprehensive documentation and analysis were conducted to retrieve CF studies related to its main phytochemical components as well as its pharmacokinetics, safety and pharmacological properties...
January 18, 2024: Phytomedicine
https://read.qxmd.com/read/38491973/isolating-antipathogenic-fungal-coumarins-from-coriaria-nepalensis-and-determining-their-primary-mechanism-in-vitro
#3
JOURNAL ARTICLE
Jun-You Jian, Yi-Min Fan, Jun Jin, Xi-Yue He, Ping Yi, Chun-Mao Yuan, Wei Gu, Zhan-Xing Hu, Lie-Jun Huang, Xiao-Jiang Hao
Through bioassay-guided isolation, eight undescribed coumarins ( 1 - 8 ), along with six reported coumarins ( 9 - 14 ), were obtained from Coriaria nepalensis. The new structures were determined by using IR, UV, NMR, HRESIMS, and ECD calculations. The results of the biological activity assays showed that compound 9 exhibited broad spectrum antifungal activities against all tested fungi in vitro and a significant inhibitory effect on Phytophthora nicotianae with an EC50 value of 3.00 μg/mL. Notably, compound 9 demonstrated greater curative and protective effects against tobacco balack shank than those of osthol in vivo ...
March 16, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38430778/dietary-supplementation-of-osthole-and-icariin-improves-the-production-performance-of-laying-hens-by-promoting-follicular-development
#4
JOURNAL ARTICLE
Wenwen Ding, Linhui Shangguan, Hongquan Li, Yinghui Bao, Fida Noor, Abdul Haseeb, Panpan Sun, Hua Zhang, Wei Yin, Kuohai Fan, Huizhen Yang, Zhenbiao Zhang, Na Sun
Osthole (Ost) and icariin (Ica) are extracted from traditional Chinese medicine Cnidium monnieri and Epimedii Folium, respectively, and both exhibit estrogen-like biological activity. This study aimed to determine the efficacy and safety of combining Ost with Ica on the production performance of laying hens and to explore their possible mechanisms. The production performance, egg quality, residues of Ost and Ica in eggs, serum reproductive hormone levels, expression of ovarian reproductive hormone receptor, proliferation of granulosa cells in small yellow follicles (SYF), and progesterone secretion in large yellow follicles (LYF) related genes and proteins expression were detected...
February 22, 2024: Poultry Science
https://read.qxmd.com/read/38422703/discovery-of-novel-osthole-derivatives-exerting-anti-inflammatory-effect-on-dss-induced-ulcerative-colitis-and-lps-induced-acute-lung-injury-in-mice
#5
JOURNAL ARTICLE
Ying Zhou, Zhiteng Du, Qianqian Wu, Mi Guo, Zhichao Chen, Chenhui Sun, Xiaobo Li, Yu Zou, Zhiwei Zheng, Pan Chen, Won-Jea Cho, Young-Chang Cho, Nipon Chattipakorn, Yi Wang, Guang Liang, Qidong Tang
The modification based on natural products is a practical way to find anti-inflammatory drugs. In this study, 26 osthole derivatives were synthesized, and their anti-inflammatory properties were evaluated. The preliminary activity study revealed that most osthole derivatives could effectively inhibit inflammatory cytokines IL-6 secretion in LPS stimulated mouse macrophages J774A.1. Compound 7m exhibited the most effective anti-inflammatory activity (RAW264.7 IL-6 IC50 : 4.57 μM, 32 times more active than osthole) in vitro with no significant influence on cell proliferation...
February 22, 2024: European Journal of Medicinal Chemistry
https://read.qxmd.com/read/38389159/osthole-activates-the-cholinergic-anti-inflammatory-pathway-via-%C3%AE-7nachr-upregulation-to-alleviate-inflammatory-responses
#6
JOURNAL ARTICLE
Shu-Hang Li, Meng-Ying Li, Tao-Tao Yuan, Guo-Wei Wang, Jian-Bin Zeng, Zhimian Shi, Jian-Hang Liu, Jun-Cheng Su
Osthole (also known as Osthol) is the main anti-inflammatory coumarin found in Cnidium monnieri and severs as the exclusive quality-controlled component according the Chinese Pharmacopoeia. However, its underlying anti-inflammatory mechanism remains unknown. In this study, we demonstrated that Osthole treatment significantly inhibited the generation of TNF-α, but not IL-6 in the classical LPS-stimulated RAW264.7 macrophage model. In addition, LPS induced the activation of both MAPK and NF-κB signalling pathways, of which the former was dose-dependently restrained by Osthole via suppressing the phosphorylation of JNK and P38 proteins, while the phosphorylation of IκB and P65 proteins remained unaffected...
February 22, 2024: Chemistry & Biodiversity
https://read.qxmd.com/read/38368628/spectrum-effect-relationship-study-between-ultra-high-performance-liquid-chromatography-fingerprints-and-anti-hepatoma-effect-in-vitro-of-cnidii-fructus
#7
JOURNAL ARTICLE
Zhenguo Lv, Huizi Ouyang, Fanjiao Zuo, Minglei Ge, Mengxuan Wu, Lulu Zhao, Yameng Zhu, Xinxin Miao, Yu Bai, Yanxu Chang, Jun He
Cnidii Fructus, derived from the dried ripe fruit of Cnidium monnieri (L.) Cuss, has the effect of warming kidneys and invigorating Yang. This study established the spectrum-effect relationships between ultra-high-performance liquid chromatography (UHPLC) fingerprints and the antitumor activities of Cnidii Fructus on human hepatocellular carcinoma (HepG2) cells. In UHPLC fingerprints, 19 common peaks were obtained, and 17 batches of herbs had similarity >0.948. In Cell Counting Kit-8 (CCK-8) test, 17 batches of Cnidii Fructus extract significantly inhibited the proliferation of HepG2 cells to different degrees, showing different half-maximal inhibitory concentration (IC50 ) values...
February 18, 2024: Biomedical Chromatography: BMC
https://read.qxmd.com/read/38351985/the-effect-of-osthole-on-transient-receptor-potential-channels-a-possible-alternative-therapy-for-atopic-dermatitis
#8
JOURNAL ARTICLE
Natalia Karolina Kordulewska, Angelika Król-Grzymała
INTRODUCTION: Chronic recurrent skin inflammation and severe itching in patients with atopic dermatitis (AD) significantly impair their quality of life. The H4 histamine receptor plays a key role in histamine-induced itching. During the skin inflammation associated with AD, pro-inflammatory mediators (interleukins, cytokines) are released from neurons. Ultimately, a cascade of reactions leads to the activation and sensitization of transient receptor potential channels (TRP), which exacerbate the inflammation and itching associated with AD...
2024: Journal of Inflammation Research
https://read.qxmd.com/read/38295666/osthole-impairs-mitochondrial-metabolism-and-the-autophagic-flux-in-colorectal-cancer
#9
JOURNAL ARTICLE
Jisoo Song, Jiyeon Ham, Wonhyoung Park, Gwonhwa Song, Whasun Lim
BACKGROUND: Osthole is active constituent of Cnidium monnieri (L.) Cuss. with various physiological functions including anti-inflammation and anti-lipedemic effects. However, the regulatory activity of osthole in colorectal cancer development, focusing on mitochondrial metabolism, is not well known. HYPOTHESIS/PURPOSE: We hypothesized that osthole may suppress progression of colorectal cancer and aimed to determine the underlying mitochondrial metabolism and the autophagic flux...
January 21, 2024: Phytomedicine
https://read.qxmd.com/read/38234523/retracted-osthole-attenuates-bleomycin-induced-pulmonary-fibrosis-by-modulating-nadph-oxidase-4-derived-oxidative-stress-in-mice
#10
Oxidative Medicine And Cellular Longevity
[This retracts the article DOI: 10.1155/2021/3309944.].
2024: Oxidative Medicine and Cellular Longevity
https://read.qxmd.com/read/38225092/comparative-physiological-and-transcriptome-analysis-provide-insights-into-the-inhibitory-effect-of-osthole-on-penicillium-choerospondiatis
#11
JOURNAL ARTICLE
Duo Lai, Delin Wang, Xuehua Shao, Jian Qin, Qingli Zhuang, Hanhong Xu, Weiqiang Xiao
Blue mold induced by Penicillium choerospondiatis is a primary cause of growth and postharvest losses in the fruit of Phyllanthus emblica. There is an urgent need to explore novel and safe fungicides to control this disease. Here, we demonstrated osthole, a natural coumarin compound isolated from Cnidium monnieri, exhibited a strong inhibitory effect on mycelia growth, conidial germination rate and germ tube length of P. choerospondiatis, and effectively suppressed the blue mold development in postharvest fruit of P...
January 2024: Pesticide Biochemistry and Physiology
https://read.qxmd.com/read/38215001/elucidation-the-mechanism-of-the-active-ingredient-imperatorin-promoting-drug-absorption-in-cell-model
#12
JOURNAL ARTICLE
Wenjing Ta, Jie Wang, Jihong Song, Xingyue Li, Jianxiang Wang, Wen Lu
Imperatorin (IMP) is the main bioactive furanocoumarin of Angelicae dahuricae radix, which is a well-known traditional Chinese medicine. The purpose of this study was to elucidate the role of IMP in promoting absorption and the possible mechanism on the compatible drugs of Angelicae dahuricae radix. The influence of IMP on drugs' intestinal absorption was conducted by the Caco-2 cell model. The mechanism was studied by investigating the transcellular transport mode of IMP and its influence on P-glycoprotein (P-gp)-mediated efflux, protein expression of P-gp and tight junction, and cell membrane potential...
January 12, 2024: Journal of Pharmacy and Pharmacology
https://read.qxmd.com/read/38214506/isolation-characterization-and-evaluation-of-oxypeucedanin-and-osthol-from-local-endemic-prangos-aricakensis-beh%C3%A3-et-and-yapar-root-as-antioxidant-enzyme-inhibitory-antibacterial-and-dna-protection-molecular-docking-and-dft-approaches
#13
JOURNAL ARTICLE
Serbay Şafak Gökçimen, Yaşar İpek, Lütfi Behçet, İbrahim Demirtaş, Tevfik Özen
Prangos species were previously used against many disorders due to their chemical component. Prangos aricakensis Behçet & Yapar is a newly discovered local endemic species in Turkey's eastern region, and there is no research on P. aricakensis in the literature. In this work, oxypeucedanin and osthol molecules have been isolated from the root part of P. aricakensis for the first time. Oxypeucedanin and osthol structures were elucidated by 1D and 2D NMR analysis. For the bioactivities determination, antioxidant (DPPH· and ABTS·+ scavenging), enzyme inhibition (AChE, BChE, tyrosinase, and urease), antibacterial and DNA protection activity studies were applied for both molecules and compared with standard drug molecules, after applying enzyme kinetic assays and in silico approaches to clarify the mechanism of action for both molecules with enzymes, using molecular docking and density functional theory (DFT)...
January 12, 2024: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/38202603/network-proximity-analysis-deciphers-the-pharmacological-mechanism-of-osthole-against-d-galactose-induced-cognitive-disorder-in-rats
#14
JOURNAL ARTICLE
Xue Wang, Xiaomei Fu, Xiurong Luo, Yiyi Lai, Chuipu Cai, Yanfang Liao, Zhao Dai, Shuhuan Fang, Jiansong Fang
Osthole, a natural coumarin found in various medicinal plants, has been previously reported to have neuroprotective effects. However, the specific mechanism by which Osthole alleviates dysmnesia associated with Alzheimer's disease (AD) remains unclear. This study aimed to investigate the neuroprotective properties of Osthole against cognitive impairment in rats induced by D-galactose and elucidate its pharmacological mechanism. The rat model was established by subcutaneously injecting D-galactose at a dose of 150 mg/kg/day for 56 days...
December 19, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38071875/fabrication-of-a-biochar-doped-monolithic-adsorbent-and-its-application-for-the-extraction-and-determination-of-coumarins-from-angelicae-pubescentis-radix
#15
JOURNAL ARTICLE
Changqing Yu, Tiantian Xie, Sihan Liu, Ligai Bai
A monolithic adsorbent was designed aiming to the structure of osthole and columbianadin, and fabricated using diallyl phthalate as the monomer and ethylene dimethacrylate as the crosslinker with the addition of bamboo biochar, via polymerization reaction in a stainless-steel tube. The prepared composite adsorbent packed in the tube was used as a solid-phase extraction column for the extraction and determination of two coumarins (osthole and columbianadin) in Angelicae Pubescentis Radix, combing with a C18 analytical column through an HPLC instrument, which show excellent matrix-removal ability and good selectivity to osthole and columbianadin...
December 6, 2023: Journal of Chromatography. A
https://read.qxmd.com/read/38055498/preparation-optimization-and-evaluation-of-osthole-transdermal-therapeutic-system
#16
JOURNAL ARTICLE
Muhammad Naeem, Taniya Iqbal, Muhammad Yousuf, Zarqa Nawaz, Sajjad Hussain, Abdulhakeem S Alamri, Charis M Galanakis, Atif Ali
In the current study, the solubility and permeability of Osthole-loaded microemulsion were enhanced, which increased bioavailability. In addition, Carbomer 940 was added for prolonged drug delivery. The microemulsion was prepared after the screening of Kukui oil, Labrasol (surfactant), and transcutol-P (co-surfactant). Pseudoternary phase diagrams were employed to find the microemulsion region. Box Behnken Design (BBD) was employed for optimizing microemulsions. Variables were related and compared using mathematical equations and response surface plots (RSP)...
2023: Anais da Academia Brasileira de Ciências
https://read.qxmd.com/read/38007936/inhibition-of-furin-like-enzymatic-activities-and-sars-cov-2-infection-by-osthole-and-phenolic-compounds-with-aryl-side-chains
#17
JOURNAL ARTICLE
Yuka Kiba, Takashi Tanikawa, Tsuyoshi Hayashi, Hitoshi Kamauchi, Taishi Seki, Ryuichiro Suzuki, Masashi Kitamura
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), spread as a pandemic and caused damage to people's lives and countries' economies. The spike (S) protein of SARS-CoV-2 contains a cleavage motif, Arg-X-X-Arg, for furin and furin-like enzymes at the boundary of the S1/S2 subunits. Given that cleavage plays a crucial role in S protein activation and viral entry, the cleavage motif was selected as the target. Our previous fluorogenic substrate study showed that osthole, a coumarin compound, inhibits furin-like enzyme activity...
November 25, 2023: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/37995945/an-integrated-in-vitro-human-ipscs-derived-neuron-and-in-vivo-animal-approach-for-preclinical-screening-of-anti-seizure-compounds
#18
JOURNAL ARTICLE
Chunfang Zhao, Ben Rollo, Muhammad Shahid Javaid, Ziyu Huang, Wen He, Hong Xu, Patrick Kwan, Chunbo Zhang
INTRODUCTION: One-third of people with epilepsy continue to experience seizures despite treatment with existing anti-seizure medications (ASMs). The failure of modern ASMs to substantially improve epilepsy prognosis has been partly attributed to overreliance on acute rodent models in preclinical drug development as they do not adequately recapitulate the mechanisms of human epilepsy, are labor-intensive and unsuitable for high-throughput screening (HTS). There is an urgent need to find human-relevant HTS models in preclinical drug development to identify novel anti-seizure compounds...
November 22, 2023: Journal of Advanced Research
https://read.qxmd.com/read/37983944/inhibition-of-cutaneous-heat-sensitive-ca-2-permeable-transient-receptor-potential-vanilloid-3-channels-alleviates-uvb-induced-skin-lesions-in-mice
#19
JOURNAL ARTICLE
Yaxuan Qu, Xiaoying Sun, Ningning Wei, KeWei Wang
Ultraviolet B (UVB) radiation causes skin injury by trigging excessive calcium influx and signaling cascades in the skin keratinocytes. The heat-sensitive Ca2+ -permeable transient receptor potential vanilloid 3 (TRPV3) channels robustly expressed in the keratinocytes play an important role in skin barrier formation and wound healing. Here, we report that inhibition of cutaneous TRPV3 alleviates UVB radiation-induced skin lesions. In mouse models of ear swelling and dorsal skin injury induced by a single exposure of weak UVB radiation, TRPV3 genes and proteins were upregulated in quantitative real-time PCR and Western blot assays...
December 2023: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/37966481/optimization-of-osthole-as-a-pesticide-candidate-synthesis-crystal-structures-and-agrochemical-properties-of-acrylate-derivatives-of-isopropenyl-2-3-dihydrobenzofurans
#20
JOURNAL ARTICLE
Zili Ren, Min Lv, Huqi Liu, Houpeng Wen, Yuling Zhang, Hui Xu
For high-value-added application of osthole derivatives as a pesticide candidate in crop protection, by the use of osthole as a lead compound, a series of novel acrylate derivatives of isopropenyl 2,3-dihydrobenzofurans were prepared by the successive bromination, rearrangement, and esterization reactions. Three-dimensional structures of four compounds were determined by single-crystal X-ray diffraction. The possible mechanism for construction of this new isopropenyl 2,3-dihydrobenzofuran skeleton from the osthole was presented...
November 15, 2023: Journal of Agricultural and Food Chemistry
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