Sultana Monira Hussain, Ego Seeman, Hans G Schneider, Peter R Ebeling, Anna L Barker, Kevan Polkinghorne, Anne B Newman, Chenglong Yu, Paul Lacaze, Alice Owen, Cammie Tran, Mark R Nelson, Robyn Lorraine Woods, Bu B Yeap, David Clark, Lawrence J Beilin, John J McNeil
BACKGROUND: Aging increases fracture risk through bone loss and microarchitecture deterioration due to an age-related imbalance in bone resorption and formation during bone remodelling. We examined the associations between levels of phosphate, calcium, and alkaline phosphatase, and fracture risk in initially-healthy older individuals. METHODS: A post-hoc analysis of the Aspirin in Reducing Events in the Elderly (ASPREE) trial recruited 16,703 Australian participants aged ≥70 years and 2,411 US participants aged ≥65 years...
March 1, 2024: Journal of Clinical Endocrinology and Metabolism