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Young gastric cancer

Izuma Nakayama, Eiji Shinozaki, Seiji Sakata, Noriko Yamamoto, Junko Fujisaki, Yusuke Muramatsu, Toru Hirota, Kengo Takeuchi, Shunji Takahashi, Kensei Yamaguchi, Tetsuo Noda
Gastric cancer in young adults has been pointed out to comprise a subgroup associated with distinctive clinicopathological features, including an equal gender distribution, advanced disease and diffuse-type histology. Comprehensive molecular analyses of gastric cancers have led to molecular-based classifications and to specific and effective treatment options available. The molecular traits of gastric cancers in young adults await investigations, which should provide a clue to explore therapeutic strategies...
February 16, 2019: Cancer Science
Kyong Min Kang, Yo Seok Cho, Sa-Hong Min, Yoontaek Lee, Ki Bum Park, Young Suk Park, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim
BACKGROUND: The incidence and clinical presentation of internal hernia after gastrectomy have been changing in the minimally invasive surgery era. This study aimed to analyze the clinical features and risk factors for internal hernia after gastrectomy for gastric cancer. METHODS: We retrospectively analyzed internal hernia after gastrectomy for gastric cancer in 6474 patients between January 2003 and December 2016 at Seoul National University Bundang Hospital. Multivariable logistic regression was performed to evaluate risk factors...
February 13, 2019: Gastric Cancer
Seonhwa Lee, Hae-June Lee, Hyunji Kang, Eun-Ho Kim, Young-Cheol Lim, Hyejin Park, Sang Moo Lim, Yong Jin Lee, Jung Min Kim, Jin Su Kim
The authors identified that chemo-brain was induced after trastuzumab (TZB) therapy. In addition, atorvastatin (ATV) could rescue chemo-brain during trastuzumab (TZB) therapy. Enhanced therapeutic effect of TZB was confirmed after ATV therapy. We also investigated that there was no hair loss side effect due to ATV therapy. In an animal model, 150 μg TZB and five serial doses of 20 mg/kg ATV were administered. 18 F-fluorodeoxyglucose Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) data were acquired...
February 11, 2019: Journal of Clinical Medicine
Winifred Lo, Bin Zhu, Arvind Sabesan, Ho-Hsiang Wu, Astin Powers, Rebecca A Sorber, Sarangan Ravichandran, Ina Chen, Lucas A McDuffie, Humair S Quadri, Joal D Beane, Kathleen Calzone, Markku M Miettinen, Stephen M Hewitt, Christopher Koh, Theo Heller, Sholom Wacholder, Udo Rudloff
INTRODUCTION: Hereditary diffuse gastric cancer (HDGC) is a cancer syndrome associated with variants in E-cadherin (CDH1), diffuse gastric cancer and lobular breast cancer. There is considerable heterogeneity in its clinical manifestations. This study aimed to determine associations between CDH1 germline variant status and clinical phenotypes of HDGC. METHODS: One hundred and fifty-two HDGC families, including six previously unreported families, were identified...
February 11, 2019: Journal of Medical Genetics
Kichul Yoon, Nayoung Kim, Youngmi Park, Bo Kyung Kim, Ji Hyun Park, Cheol Min Shin, Dong Ho Lee, Young-Joon Surh
The role of macrophage migration inhibitory factor (MIF) and autophagy in gastric cancer is not clear. We determined H. pylori infection status of the subjects and investigated the expression of MIF and autophagy markers (Atg5, LC3A and LC3B) in human gastric tissue at baseline. Then H. pylori eradication was done for H. pylori positive patients and MIF and Atg5 levels were investigated on each follow-up for both H. pylori-eradicated and H. pylori negative patients. Baseline tissue mRNA expression of MIF, Atg5, LC3A and LC3B was measured by real-time PCR in 453 patients (control 165, gastric dysplasia 82, and gastric cancer 206)...
2019: PloS One
Hyuna Sung, Rebecca L Siegel, Philip S Rosenberg, Ahmedin Jemal
BACKGROUND: Cancer trends in young adults, often under 50 years, reflect recent changes in carcinogenic exposures, which could foreshadow the future overall disease burden. Previous studies reported an increase in early onset colorectal cancer, which could partly reflect the obesity epidemic. We examined age-specific contemporary incidence trends in the USA for 30 common cancers, including 12 obesity-related cancers. METHODS: We obtained incidence data for invasive cancers among people aged 25-84 years diagnosed from Jan 1, 1995, to Dec 31, 2014, for 25 population-based state registries in the USA...
February 1, 2019: Lancet. Public Health
Chaorui Wu, Nianchang Wang, Hong Zhou, Tongbo Wang, Dongbing Zhao
Background/Aims: Evidence regarding gastric cancer (GC) patients <40 years old is limited. The aim of the study was to identify risk factors affecting overall survival (OS) of young patients with nonmetastatic GC and to establish a nomogram for prognostic prediction using data from the Surveillance, Epidemiology and End Results (SEER) database. Furthermore, this study sought to externally validate this nomogram in an independent patient cohort. Patients and Methods: In this retrospective cohort study, the records of patients aged <40 years with nonmetastatic GC (n = 559), from the SEER database, between 2006 and 2015, were examined...
February 1, 2019: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
Jang Hyung Lee, Young Jae Kim, Yoon Woo Kim, Sungjin Park, Youn-I Choi, Yoon Jae Kim, Dong Kyun Park, Kwang Gi Kim, Jun-Won Chung
BACKGROUND: Gastric cancer is a common kind of malignancies, with yearly occurrences exceeding one million worldwide in 2017. Typically, ulcerous and cancerous tissues develop abnormal morphologies through courses of progression. Endoscopy is a routinely adopted means for examination of gastrointestinal tract for malignancy. Early and timely detection of malignancy closely correlate with good prognosis. Repeated presentation of similar frames from gastrointestinal tract endoscopy often weakens attention for practitioners to result in true patients missed out to incur higher medical cost and unnecessary morbidity...
February 4, 2019: Surgical Endoscopy
Wen-Long Guan, Lu-Ping Yuan, Xiang-Lei Yan, Da-Jun Yang, Miao-Zhen Qiu
Purpose: Several studies have reported controversial results about prognosis of gastric cancer in young age patients. The difference may partially result from variable definitions of young age. The aim of this study was to find out the relation between age and prognosis of gastric cancer patients, and to analyze the clinicopathological features and prognostic factors in young gastric cancer patients. Methods: Data queried for this analysis included GC patients from the Surveillance, Epidemiology, and End Results Program database from 1973 to 2014...
2019: Journal of Cancer
Hyun Cheol Chung, Hendrik-Tobias Arkenau, Jeeyun Lee, Sun Young Rha, Do-Youn Oh, Lucjan Wyrwicz, Yoon-Koo Kang, Keun-Wook Lee, Jeffrey R Infante, Sung Sook Lee, Margaret Kemeny, Ulrich Keilholz, Bohuslav Melichar, Alain Mita, Ruth Plummer, Denis Smith, Arnold B Gelb, Huiling Xiong, Janet Hong, Vikram Chand, Howard Safran
BACKGROUND: We evaluated the antitumor activity and safety of avelumab, a human anti-PD-L1 IgG1 antibody, as first-line switch-maintenance (1 L-mn) or second-line (2 L) treatment in patients with advanced gastric/gastroesophageal cancer (GC/GEJC) previously treated with chemotherapy. METHODS: In a phase 1b expansion cohort, patients without (1 L-mn) or with (2 L) disease progression following first-line chemotherapy for advanced GC/GEJC received avelumab 10 mg/kg intravenously every 2 weeks...
February 4, 2019: Journal for Immunotherapy of Cancer
Mi Jung Kwon, Ho Suk Kang, Hyeon Tae Kim, Jin Woo Choo, Bo Hyun Lee, Sung Eun Hong, Kun Ha Park, Dong Min Jung, Hyun Lim, Jae Seung Soh, Sung Hoon Moon, Jong Hyeok Kim, Hye-Rim Park, Soo Kee Min, Jin Won Seo, Ji-Young Choe
BACKGROUND: Gastric 'indefinite for neoplasm/dysplasia' (IFND) is a borderline lesion that is difficult to diagnose as either regenerative or neoplastic. There is a need for guidance in the identification of a subset of patients, who have an IFND lesion with a higher risk of malignant potential, to enable risk stratification and optimal management. AIM: To determine the clinical and pathologic factors for the accurate diagnosis of gastric IFND lesions. METHODS: In total, 461 gastric lesions diagnosed via biopsy as IFND lesions were retrospectively evaluated...
January 28, 2019: World Journal of Gastroenterology: WJG
Seungho Ryu, Kyungeun Kim, Yoosoo Chang, Jiin Ahn, Hyo-Joon Yang, Ju Young Jung, Seokkyun Kim, Chong Il Sohn
BACKGROUND: We examined the association between body mass index (BMI) and development of endoscopic intestinal metaplasia (IM). METHODS: This retrospective cohort study included 142,832 Korean adults free of endoscopic IM and atrophic gastritis (AG) who underwent upper endoscopy at baseline and subsequent visits and were followed for up to 5 years. A parametric proportional hazards model was used to estimate the adjusted hazard ratio with 95% confidence interval (CI) for incident IM...
January 30, 2019: Cancer Epidemiology, Biomarkers & Prevention
Jung Hyun Jo, Soo Been Park, Semi Park, Hee Seung Lee, Chanyang Kim, Dawoon E Jung, Si Young Song
The expression of leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 (LINGO2) has been reported in Parkinson's disease; however, its role in other diseases is unknown. Gastric cancer is the second leading cause of cancer death. Cancer stem cells (CSC) are a subpopulation of cancer cells that contribute to the initiation and invasion of cancer. We identified LINGO2 as a CSC-associated protein in gastric cancers both in vitro and in patient-derived tissues. We studied the effect of LINGO2 on cell motility, stemness, tumorigenicity, and angiogenic capacity using cells sorted based on LINGO2 expression and LINGO2-silenced cells...
January 28, 2019: International Journal of Molecular Sciences
Seung Tae Kim, Sujin Lee, Minhwa Park, Se Hoon Park, Joon Oh Park, Ho Yeong Lim, Young Suk Park, Won Ki Kang, Esha A Gangolli, Hyeongchan Shin, Kyoung-Mee Kim, Simon J Hollingsworth, Peter G S Mortimer, Jeeyun Lee
MET amplification is a frequently observed genomic aberration in solid tumors. We conducted a phase I trial to evaluate dose-limiting toxicity (DLT) and recommended phase II dose (RP2D) for the combination therapy. The following dose levels were tested in this single-arm phase I study: docetaxel as an intravenous infusion over 1 hour at 60 mg/m2 once every 3 weeks of a 21-day schedule plus savolitinib (level 1, 200 mg qd; level 2, 400 mg qd; level 3, 600 mg qd; level 4800 mg qd). In total, there were 17 patients enrolled on to this study [7 gastric cancer (GC) patients, 5 melanoma patients, 3 sarcoma patients, and 2 rectal cancer patients]...
January 26, 2019: Translational Oncology
Ho Seok Seo, Go Eun Lee, Min Gon Kang, Kyu Hun Han, Eun Sun Jung, Kyo Young Song
BACKGROUND: The risk factors of lymph node (LN) metastasis are important factors to consider in endoscopic submucosal dissection in early gastric cancer (EGC). The aim of the study was to identify the correlation between mixed histology and LN metastasis in EGC. METHODS: A total of 1645 patients who underwent curative radical gastrectomy for EGC were divided into three groups (pure differentiated [pure D], mixed, and pure undifferentiated [pure UD]) according to histologic type...
December 27, 2018: Journal of Surgical Research
Ji-Hyeon Park, Jun-Young Yang, Yeon-Ho Park, Woon-Kee Lee
BACKGROUND/OBJECTIVE: The role of gastrectomy for stage IV gastric cancer (GC) has not yet been established. Thus, we aimed to compare the prognoses of patients with clinical stage IV GC who underwent gastrectomy with and without preoperative chemotherapy after precise recategorization of patients. METHODS: We retrospectively reviewed a total of 92 clinical stage IV GC patients who underwent gastrectomy with or without preoperative chemotherapy between 2010 and 2016 at a single institution...
January 23, 2019: Asian Journal of Surgery
Joohyun Hong, Youjin Kim, Jangho Cho, Sung Won Lim, Song Ee Park, Hee Kyung Kim, Hansang Lee, Soo Youn Cho, Ji-Yeon Kim, Jin Seok Ahn, Young-Hyuck Im, Yeon Hee Park
Breast cancer rarely metastasizes to the gastrointestinal tract, including the stomach. Due to the rarity of this metastasis, it is occasionally confused with a primary stomach malignancy. However, discriminating characteristic features with clinical implications may exist. The aim of the current study was to analyze the clinical features and prognosis of breast cancer with gastric metastasis. Between January 1994 and October 2016, 13 patients at Samsung Medical Center (Seoul, Korea) were clinically or pathologically determined to have breast cancer with gastric metastasis...
February 2019: Oncology Letters
Chul Kyu Roh, Yoon Young Choi, Seohee Choi, Won Jun Seo, Minah Cho, Eunji Jang, Taeil Son, Hyoung Il Kim, Hyeseon Kim, Woo Jin Hyung, Yong Min Huh, Sung Hoon Noh, Jae Ho Cheong
PURPOSE: Clinical implications of single patient classifier (SPC) and microsatellite instability (MSI) in stage II/III gastric cancer have been reported. We investigated SPC and the status of MSI and Epstein-Barr virus (EBV) as combinatory biomarkers to predict the prognosis and responsiveness of adjuvant chemotherapy for stage II/III gastric cancer. MATERIALS AND METHODS: Tumor specimens and clinical information were collected from patients enrolled in CLASSIC trial, a randomized controlled study of capecitabine plus oxaliplatin-based adjuvant chemotherapy...
February 2019: Yonsei Medical Journal
Young-Bae Kim, Ji Mi Ahn, Won Jung Bae, Chang Ohk Sung, Dakeun Lee
Notwithstanding remarkable treatment success with anti-PD-1 monoclonal antibody, oncogenic mechanism of PD-L1 regulation in gastric cancer (GC) remains poorly understood. We hypothesized that ARID1A might be related to tumor PD-L1 expression in GC. We found that tumor PD-L1 positivity was associated with loss of ARID1A and showed trend toward better survival of patients with various molecular subtypes of GC (experimental set, n = 273). Considering heterogeneous ARID1A expression, we validated this using whole tissue sections (n = 159) and found that loss of ARID1A was correlated with microsatellite instability-high (MSI-H), Epstein-Barr virus (EBV), and PD-L1 positivity...
January 21, 2019: International Journal of Cancer. Journal International du Cancer
Hyeong Su Kim, Jung Han Kim, Hyun Joo Jang, Boram Han, Dae Young Zang
Fibroblast growth factor receptor-2 (FGFR2) protein expression by immunohistochemistry has been reported in up to 60% of patients with gastric cancer (GC). However, the clicopathological impacts of high FGFR2 expression have not been consistent among studies. We conducted this meta-analysis to evaluate the pathological and prognostic significance of FGFR2 overexpression in patients with GC. A systematic search of the electronic databases including PubMed, PMC, EMBASE, and Google Scholar was performed. From ten studies, 4,294 patients were included in the pooled analyses of odds ratios (ORs) with 95% confidence intervals (CIs) for pathological features and hazard ratios (HRs) with 95% CIs for overall survival according to the FGFR2 expression status...
2019: Journal of Cancer
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