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Nasal polyp

Nam-Kyung Yeo, Woo Joo Park, Daeo-Woon Eom, Mi Young Oh, Ji Hwan Lee
BACKGROUND: Oral steroids are recommended for the treatment of nasal polyps (NPs), but prolonged use is avoided because of side effects. Topical steroids can also control NPs without significant complications; however, the response to this is partially successful, and additional therapies are needed to treat glucocorticoid-resistant NPs. Azathioprine (AZA) and its first metabolite 6-mercaptopurine (6-MP) are important immunosuppressants used for the therapy of various diseases. The aim of this study was to investigate the effects of AZA and 6-MP on inflammatory cytokines in organ-cultured NPs...
February 12, 2019: International Forum of Allergy & Rhinology
Kachorn Seresirikachorn, Nichana Suwanparin, Chanyanuch Srisunthornphanich, Wirach Chitsuthipakorn, Dichapong Kanjanawasee, Kornkiat Snidvongs
OBJECTIVE: To assess the prognostic factors that predict favorable outcomes of low-dose macrolides (LDMs) in treating chronic rhinosinusitis (CRS). METHODS: Randomized controlled trials studying the effects of LDMs in treating CRS were included. Data were pooled for meta-analysis. Primary outcome was Sino-Nasal Outcome Test (SNOT). Six prognostic factors: CRS subtypes, serum immunoglobulin (Ig)E level, membered lactone ring of macrolides, concurrent endoscopic sinus surgery (ESS), and dosage and duration of the LDMs were assessed by subgroup analyses...
February 11, 2019: Laryngoscope
Yi Wei, Renqiang Ma, Jia Zhang, Xingmei Wu, Guodong Yu, Xianting Hu, Jian Li, Zhuofu Liu, Wendong Ji, Huabin Li, Weiping Wen
Background: Periostin has been shown to be upregulated in chronic rhinosinusitis with nasal polyps (CRSwNP), especially in the CRSwNP patients with asthma. However, the underlying mechanism that how periostin contributes to the polyp genesis remains unclear. Methods: In this study, we collected 63 CRSwNP patients' nasal polyps (NPs) and 25 control subjects' uncinated tissues. The expressions of periostin, thymic stromal lymphopoietin (TSLP), and other proinflammatory cytokines were examined using IHC staining, qRT-PCR, Western blot (WB), ELISA and FACS...
December 2018: Journal of Thoracic Disease
Suat Bilici, Zehra Cinar, Ozgur Yigit, Mustafa Cakir, Enes Yigit, Hafize Uzun
PURPOSE: The aim of this study is to investigate serum and tissue procalcitonin (PCT) levels in patients with nasal polyps. METHODS: The study was designed to be prospectively controlled and included 26 patients chronic rhinosinusitis with nasal polyp (CRSwNP) endoscopically diagnosed and as a control group 25 chronic rhinosinusitis without nasal polyp (CRSsNP). NP specimens, nasal mucosal tissue and venous blood samples of both groups were collected and PCT levels determined by Elisa method...
February 9, 2019: European Archives of Oto-rhino-laryngology
Weigang Gan, Fengjuan Yang, Yiping Tang, Danmei Zhou, Di Qing, Juanjuan Hu, Shixi Liu, Feng Liu, Juan Meng
BACKGROUND: Little is known regarding the role of the microbiome of the paranasal sinuses and its contribution to sinus mucosal health and disease. Consequently, we examined the microbiome of chronic rhinosinusitis patients with polyps (CRSwNP) and a control population to provide new insights into the microbiota associated with the pathogenesis of CRSwNP. METHODS: Fifty-nine CRSwNP patients and 27 controls were enrolled in the study. The bacterial communities of the middle meatus were detected using 16S ribosomal RNA (rRNA)-targeted Illumina MiSeq sequencing after microbial DNA was extracted from swabs...
February 5, 2019: International Forum of Allergy & Rhinology
Neil Bhattacharyya, Sara Villeneuve, Vijay N Joish, Caroline Amand, Leda Mannent, Nikhil Amin, Paul Rowe, Jaman Maroni, Laurent Eckert, Tony Yang, Asif Khan
OBJECTIVES/HYPOTHESIS: Establish treatment patterns and economic burden in US patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) versus without chronic rhinosinusitis (CRS). Determine comparative costs of subgroups with high clinical burden. STUDY DESIGN: Observational, retrospective, case-control study. METHODS: This study matched patients with CRSwNP to patients without CRS (1:1) using the Truven Health MarketScan US claims database...
February 5, 2019: Laryngoscope
Mihaela Mitroi, Dana Albulescu, Alina Capitanescu, Anca Oana Docea, Gabriela Musat, George Mitroi, Ovidiu Zlatian, Aristidis Tsatsakis, George Tzanakakis, Demetrios A Spandidos, Daniela Calina
The present study focused on the assessment of the inflammatory infiltrate that characterizes nasal polyps in patients with chronic rhinosinusitis and nasal polyposis. Inflammatory cell type was determined using specific markers. This evaluation was made possible by determining the expression of the following markers: CD20, a marker of B lymphocytes [using activated T cells (ATC) armed with CD20 antibody]; CD3, a marker of T lymphocytes (using ATC armed with anti‑CD3 antibody); CD45, the leukocyte common antigen (using ATC armed with anti‑CD45 antibody; and CD34, for the microvasculature of the nasal polyp (using anti‑CD34 antibody)...
February 5, 2019: Molecular Medicine Reports
Pascal Ickrath, Agmal Scherzad, Norbert Kleinsasser, Chr Ginzkey, Rudolf Hagen, Stephan Hackenberg
T cell subpopulations in nasal polyps differ from peripheral lymphocytes in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). However, little is known about the modulatory influence of the inflamed nasal polyp epithelial cells on the phenotype of the T cells. The aim of the present study was to assess this interaction. Tissue and blood samples were collected from 16 patients undergoing paranasal sinus surgery. Polypoid tissue was cultured under air-liquid interface conditions. Subsequently, cluster of differentiation (CD)3/CD28 activated peripheral lymphocytes from the same patients were added...
February 2019: Biomedical Reports
Keng-Chung Shen, Yi-Tsen Lin, Chih-Feng Lin, Chin-Hao Chang, Te-Huei Yeh
BACKGROUND: The role of allergy in the development of chronic rhinosinusitis (CRS) in East Asians is not clear. AIMS/OBJECTIVES: The aim was to investigate the impact of allergies in the clinical characteristics of chronic rhinosinusitis. MATERIAL AND METHODS: A total of 138 CRS patients who underwent endoscopic sinus surgery were included. A brief history of rhinosinusitis symptoms, blood eosinophil count, blood-specific allergen tests, computed tomography (CT) scan findings, Lund-Mackay (LM) CT scores, and Sino-Nasal Outcome Test (SNOT-22) Questionnaire scores, and sinoscopy findings at 3 and 6 months postoperatively...
February 2, 2019: Acta Oto-laryngologica
Wanrawee Thaitrakool, Narittee Sukswai, Somboon Keelawat, Supinda Chusakul, Jesada Kanjanaumporn, Songklot Aeumjaturapat, Kornkiat Snidvongs
BACKGROUND: This study aims to compare histopathology of nasal polyp and ethmoid mucosa for diagnosing eosinophilic mucin rhinosinusitis (EMRS). METHODOLOGY: Patients with chronic rhinosinusitis with polyps (CRSwNP) were enrolled. Using eosinophilic mucin as a reference, histopathology of polyp apex, polyp pedicle and ethmoid mucosa was compared for density of tissue eosinophil and sensitivity for diagnosing EMRS. Associations with asthma were assessed for each site...
February 1, 2019: Rhinology
R Moreno-Luna, J Gonzalez-Garcia, J M Maza-Solano, E Molina-Fernandez, C D Pinheiro-Neto, A Del Cuvillo Bernal, C Langdon, S Sanchez-Gomez
BACKGROUND: We report a novel surgical technique based on an endonasal free mucosal graft (mucoplasty) for improving clinical results and local healing in chronic rhinosinusitis with nasal polyps (CRSwNP). METHODS: Patients diagnosed with bilateral CRSwNP scheduled for endoscopic sinus surgery were included. They underwent complete removal of anterior and posterior ethmoid cells, in addition to bilateral type III frontal sinusotomy. An endoscopic mucoplasty was performed in the left nasal cavity, whereas the right nasal cavity served as control...
January 28, 2019: Rhinology
Giuseppe Brescia, Paolo Sfriso, Gino Marioni
BACKGROUND/OBJECTIVE: The pathophysiological and prognostic role of blood inflammatory cells in chronic rhinosinusitis with nasal polyps (CRSwNP) emerging from recent studies was investigated. MATERIAL AND METHODS: The main available evidence and largely-recent publications were critically analyzed. RESULTS: Several authors reported a direct association between blood eosinophilia and CRSwNP recurrence rates. In some large series, a direct association between recurrent CRSwNP and blood basophil values emerged too...
January 28, 2019: Acta Oto-laryngologica
Jonas Jae-Hyun Park, Claus Bachert, Stefan Dazert, Karel Kostev, David Ulrich Seidel
BACKGROUND: In the outpatient setting in Germany, patients with rhinosinusitis usually present at general practices (GP) or ear, nose, and throat practices (ENT) for initial diagnosis and treatment. OBJECTIVES: The aim of this study was to analyze the referral patterns of rhinosinusitis patients in GPs and ENT practices in Germany, with respect to existing recommendations. MATERIAL AND METHODS: The study sample included patients from 940 GP and 106 ENT practices from Disease Analyzer database (IQVIA) who received an acute sinusitis (AS) or chronic sinusitis (CS), or nasal polyp (NP) in 2015...
January 27, 2019: Acta Oto-laryngologica
Hideaki Morita, Terufumi Kubo, Beate Rückert, Avinash Ravindran, Michael B Soyka, Arturo Ottavio Rinaldi, Kazunari Sugita, Marcin Wawrzyniak, Paulina Wawrzyniak, Kenichiro Motomura, Masato Tamari, Keisuke Orimo, Naoko Okada, Ken Arae, Kyoko Saito, Can Altunbulakli, Francesc Castro-Giner, Ge Tan, Avidan Neumann, Katsuko Sudo, Liam O'Mahony, Kenya Honda, Susumu Nakae, Hirohisa Saito, Jenny Mjösberg, Gunnar Nilsson, Kenji Matsumoto, Mübeccel Akdis, Cezmi A Akdis
BACKGROUND: Group 2 innate lymphoid cells (ILC2s) play critical roles in induction and exacerbation of allergic airway inflammation. Thus, clarification of the mechanisms that underlie the regulation of ILC2 activation has received significant attention. Although ILCs are divided into three major subsets that mirror helper effector T-cell subsets, counterpart subsets of regulatory T (Treg) cells have not been well characterized. OBJECTIVE: We sought to determine the factors that induce regulatory ILCs (ILCregs)...
January 22, 2019: Journal of Allergy and Clinical Immunology
Qian Li, Hongguang Pan, Lan Li, Juan Cao
RATIONALE: Malignant peripheral nerve sheath tumors (MPNSTs) are rare neoplasms with only a few reported cases affecting the nasal cavity, paranasal sinuses, and anterior skull base. PATIENT CONCERNS: A 12-year-old girl with a mass in her nose was admitted to the Department of Otorhinolaryngology of Shenzhen Children's Hospital. She had a 4-month history of progressive, unilateral right nasal obstruction, unilateral mucopurulent rhinorrhea, foul nasal odor, snoring, hyposmia, occasional epistaxis, and no headache, no facial numbness, without eye swelling and vision loss...
January 2019: Medicine (Baltimore)
Xi-Fu Wu, Wei-Feng Kong, Wei-Hao Wang, Lian-Xiong Yuan, Hui-Qing Xu, Min Qi, Shao-Li Zhou, Qin-Tai Yang
BACKGROUND: Enhanced recovery after surgery (ERAS) protocols are a series of perioperative care to optimize preoperative preparation, prevent postoperative complications, minimize stress, and speed up recovery. This study aimed to assess the impact of ERAS protocols for functional endoscopic sinus surgery (FESS) in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). METHODS: One hundred and two patients with CRSwNP undergoing FESS were randomly divided into the ERAS group and the control group...
February 5, 2019: Chinese Medical Journal
Rui Zheng, Kai Wang, Qintai Yang, Yang Chen, Dan Wang, Wenxiang Gao, Min Zhou, Yu-Jie Cao, Jianbo Shi, Yueqi Sun
BACKGROUND: Glucocorticoids (GC) therapeutic response in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) varies markedly. AIMS/OBJECTIVES: To compare the utility between subjective and objective assessment of GC sensitivity in reflecting the impact of GC on systemic and local eosinophilia in CRSwNP patients. MATERIAL AND METHODS: Twenty-six patients with CRSwNP were enrolled. All patients were given 30 mg of prednisone once daily for 7 days and subsequently classified into subjectively GC-sensitive and -insensitive subgroup or objectively GC-sensitive and -insensitive subgroup...
January 24, 2019: Acta Oto-laryngologica
Y Song, R Chen, M Y Fu
Objective: To observe the early therapeutic effect of low-dose clarithromycin for chronic nasosinusitis with nasal polyps. Method: Clarithromycin was 250mg a day and budesonide nasal apray was once a day.Follow-up time was 12 weeks. The number of postoperative clarithromycin+budesonide nasal apray treatment group and simple budesonide nasal apray treatment group were forty. The early therapeutic effect of patients was assessed by SNOT-20 and EAS score before treatment,2 weeks,4 weeks,8 weeks,and 12 weeks. Result: Before treatment,at 2 weeks and 12 weeks,there was no significant difference between the two groups in the results of the SNOT-20 score...
January 2019: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Z C Zhang, P Z Li, H Y Tang, L Cheng
Objective: To explore the correlation between peripheral blood eosinophils and tissue eosinophils in patients with chronic rhinosinusitis with nasal polyps(CRSwNP) in different periods. Method: This trial was a prospective study involved 342 patients with CRSwNP who were treated by endoscopic sinus surgery in the Huai'an First People's Hospital, Nanjing Medical University in 2008, 2012 and 2016. Nasal polyp resection specimens were stained by HE.Tissue eosinophils were counted per high-power field, and peripheral blood eosinophils were collected from blood routine examination before operation...
January 2019: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
T Wang, H R Zang, Y C Li
Objective: To evaluate the differences in CRS and normal subjects between chronic rhinosinusitis without nasal polys (CRSsNP) and chronic rhinosinusitis with nasal polys (CRSwNP) in the role of TGF-β-Smad pathways in the repair of mucosal epithelium. Method: Ethmoidal mucosal samples collected from CRS and healthy control patients were analyzed for TGF-β1, TGF-β receptorⅠ,TGF-β receptor Ⅱ, Smad3, phospho-Smad3, Smad7, and Smad anchor for receptor activation by Western blot. The proliferation of sinonasal epithelial cells at baseline after TGF-β1 and/or EGF stimulation was evaluated by the MTT assay...
January 2019: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
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