Peter Valent, Gregor Hoermann, Patrizia Bonadonna, Karin Hartmann, Wolfgang R Sperr, Sigurd Broesby-Olsen, Knut Brockow, Marek Niedoszytko, Olivier Hermine, Yannick Chantran, Joseph H Butterfield, Georg Greiner, Melody C Carter, Vito Sabato, Deepti H Radia, Frank Siebenhaar, Massimo Triggiani, Theo Gülen, Ivan Alvarez-Twose, Thomas Staudinger, Ludwig Traby, Karl Sotlar, Andreas Reiter, Hans-Peter Horny, Alberto Orfao, Stephen J Galli, Lawrence B Schwartz, Jonathan J Lyons, Jason Gotlib, Dean D Metcalfe, Michel Arock, Cem Akin
Physiologic levels of basal serum tryptase vary among healthy individuals, depending on the numbers of mast cells, basal secretion rate, copy numbers of the TPSAB1 gene encoding alpha tryptase, and renal function. Recently, there has been a growing debate about the normal range of tryptase because individuals with the hereditary alpha tryptasemia (HαT) trait may or may not be symptomatic, and if symptomatic, uncertainty exists as to whether this trait directly causes clinical phenotypes or aggravates certain conditions...
August 10, 2023: Journal of Allergy and Clinical Immunology in Practice