keyword
https://read.qxmd.com/read/38167175/remote-ischemic-conditioning-reduces-adverse-events-in-patients-with-acute-ischemic-stroke-complicating-acute-myocardial-infarction-a-randomized-controlled-trial
#21
RANDOMIZED CONTROLLED TRIAL
Sijie Li, Xiurong Xing, Lanjing Wang, Jiali Xu, Changhong Ren, Yalin Li, Jing Wang, Zhi Liu, Heng Zhao, Wenbo Zhao, Xunming Ji
BACKGROUND: Acute ischemic stroke (AIS) complicating an acute myocardial infarction (AMI) is not uncommon, but can severely worsen the clinical prognosis. This study aimed to investigate whether remote ischemic conditioning (RIC) could provide clinical benefits to patients with AIS complicating AMI. METHODS: Subjects with AIS complicating AMI were recruited in this double-blind, randomized, controlled trial; assigned to the RIC and sham groups; and respectively underwent twice daily RIC and sham RIC for 2 weeks...
January 2, 2024: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/38117423/the-infarct-limiting-effect-of-remote-ischemic-conditioning-in-rats-is-not-affected-by-aspirin
#22
JOURNAL ARTICLE
M V Basalay, James M Downey, S M Davidson, D M Yellon
PURPOSE: Remote ischemic conditioning (RIC) has been shown to be a powerful cardioprotective therapy in animal models. However, a protective effect in patients presenting with acute myocardial infarction has failed to be confirmed. A recent pre-clinical study reported that aspirin which is routinely given to patients undergoing reperfusion therapy blocked the infarct-limiting effect of ischemic postconditioning. The present study was designed to test whether aspirin could also be blocking the infarct-limiting effect of RIC...
December 20, 2023: Cardiovascular Drugs and Therapy
https://read.qxmd.com/read/38099530/the-effect-of-remote-ischemic-postconditioning-on-quality-of-life-and-clinical-events-after-an-ischemic-stroke
#23
Thijs P Kerstens, Thijs R J Landman, Yvonne Schoon, Frederick J A Meijer, Michiel C Warlé, Frank-Erik de Leeuw, Dick H J Thijssen
OBJECTIVES: Repeated remote ischemic postconditioning (rIPostC) may be an easily applicable treatment following ischemic stroke to improve quality of life (QoL) and clinical outcomes. rIPostC consists of repeated, brief periods of limb ischemia (through inflation of a blood pressure cuff), followed by reperfusion. This study investigated the 1-year follow-up of rIPostC on QoL and clinical events. METHODS: As part of a randomized controlled trial, adult patients with an ischemic stroke within 24 hours after onset of symptoms were randomized to repeated rIPostC or sham-conditioning...
December 1, 2023: Current Neurovascular Research
https://read.qxmd.com/read/38096852/effect-of-remote-ischemic-postconditioning-on-left-ventricular-ejection-fraction-in-patients-with-st-segment-elevation-myocardial-infarction-undergoing-primary-percutaneous-coronary-intervention
#24
JOURNAL ARTICLE
Muhammad Fadil, Eryati Darwin, Hirowati Ali, Doni Firman, Muzakkir Amir, Andriany Qanitha
BACKGROUND: Ischemic conditioning may help patients with ST-segment elevation myocardial infarction (STEMI) to limit ventricular remodeling. OBJECTIVES: To investigate the effect of remote ischemic postconditioning (RIPC) on left ventricular function during primary percutaneous coronary intervention (PPCI) in patients with STEMI. MATERIAL AND METHODS: Pre- and post-test intervention study with a total of 60 STEMI patients. Patients were divided in two groups: with and without RIPC...
2023: Gaceta Médica de México
https://read.qxmd.com/read/38083285/automated-myocardial-infarction-screening-using-morphology-based-electrocardiogram-biomarkers
#25
JOURNAL ARTICLE
Dhaladhuli Jahnavi, Ashutosh Dash, Nirmalya Ghosh, Amit Patra
Ischemic heart disease (IHD), a critical and dreadful cardiovascular disease, is a leading cause of death globally. The steady progress of IHD leads to an irreversible condition called myocardial infarction (MI). The detection of MI can be done by observing the altered electrocardiogram (ECG) characteristics. Often, automated ECG analysis is preferred in place of visual inspection to reduce time and ensure reliable detection even when the recording quality is not very good. This paper presents an automated approach to classify recent MI, past MI, and normal sinus rhythm (NSR) classes based on the morphological features of the ECG...
July 2023: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://read.qxmd.com/read/38074868/a-bibliometric-and-visualized-analysis-of-hepatic-ischemia-reperfusion-injury-hiri-from-2002-to-2021
#26
JOURNAL ARTICLE
Xiaoqi Lin, Yanyu Zhou, Lina Ye, Baoshan Wang, Yingfu Jiao, Weifeng Yu, Po Gao, Liqun Yang
Hepatic ischemia-reperfusion injury (HIRI) is a complex pathological phenomenon dominated by the innate immune system and involves a variety of immune cells. This condition frequently occurs during hepatectomy, liver transplantation or hemorrhagic shock. HIRI represents an important factor in the poor prognosis of patients after liver surgery. However, there is still a lack of effective intervention to reduce the incidence of HIRI. In this study, we aimed to describe the overall structure of scientific research on HIRI over the past 20 years and provide valuable information and guidelines for future researchers...
November 2023: Heliyon
https://read.qxmd.com/read/38069355/neuroadaptive-biochemical-mechanisms-of-remote-ischemic-conditioning
#27
REVIEW
Ksenia Baranova, Natalia Nalivaeva, Elena Rybnikova
This review summarizes the currently known biochemical neuroadaptive mechanisms of remote ischemic conditioning. In particular, it focuses on the significance of the pro-adaptive effects of remote ischemic conditioning which allow for the prevention of the neurological and cognitive impairments associated with hippocampal dysregulation after brain damage. The neuroimmunohumoral pathway transmitting a conditioning stimulus, as well as the molecular basis of the early and delayed phases of neuroprotection, including anti-apoptotic, anti-oxidant, and anti-inflammatory components, are also outlined...
December 1, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37974299/obesity-induced-ly6c-high-and-ly6c-low-monocyte-subset-changes-abolish-post-ischemic-limb-conditioning-benefits-in-stroke-recovery
#28
JOURNAL ARTICLE
Il-Doo Kim, Hyunwoo Ju, Joseph Minkler, Ahmed Madkoor, Keun Woo Park, Sunghee Cho
Remote limb conditioning (RLC), performed by intermittent interruption of blood flow to a limb, triggers endogenous tolerance mechanisms and improves stroke outcomes. The underlying mechanism for the protective effect involves a shift of circulating monocytes to a Ly6CHigh proinflammatory subset in normal metabolic conditions. The current study investigates the effect of RLC on stroke outcomes in subjects with obesity, a vascular comorbidity. Compared to lean mice, obese stroke mice displayed significantly higher circulating monocytes (monocytosis), increased CD45High monocytes/macrophages infiltration to the injured brain, worse acute outcomes, and delayed recovery...
November 16, 2023: Journal of Cerebral Blood Flow and Metabolism
https://read.qxmd.com/read/37947084/rheo-erythrocrine-dysfunction-as-a-biomarker-for-remote-ischemic-conditioning-treatment-in-acute-ischemic-stroke-a-pilot-randomized-controlled-trial
#29
JOURNAL ARTICLE
Maria Kjølhede, Grethe Andersen, Jan Brink Valentin, Marlene Christina Nielsen, Morten Nørgaard Andersen, Mohammad Badruzzaman Khan, Jesper Nørgaard Bech, David C Hess, Rolf Ankerlund Blauenfeldt
No abstract text is available yet for this article.
November 10, 2023: Journal of the American Heart Association
https://read.qxmd.com/read/37927203/remote-ischemic-conditioning-after-stroke-research-progress-in-clinical-study
#30
REVIEW
Bin Jiang, Xiaojie Wang, Jianping Ma, Aminah Fayyaz, Li Wang, Pei Qin, Yuchuan Ding, Xunming Ji, Sijie Li
BACKGROUND AND PURPOSE: Stroke is a leading cause of global morbidity and mortality, indicating the necessity and urgency of effective prevention and treatment. Remote ischemic conditioning (RIC) is a convenient, simple, non-intrusive, and effective method that can be easily added to the treatment regime of stroke patients. Animal experiments and clinical trials have proved the neuroprotective effects of RIC on brain injury including (examples of neuroprotective effects). This neuroprotection is achieved by raising brain tolerance to ischemia, increasing local cerebral blood perfusion, promoting collateral circulations, neural regeneration, and reducing the incidence of hematomas in brain tissue...
November 6, 2023: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/37893534/anti-inflammatory-and-antipruritic-effects-of-remote-ischaemic-postconditioning-in-a-mouse-model-of-experimental-allergic-contact-dermatitis
#31
JOURNAL ARTICLE
Ozgur Gunduz, Melike Sapmaz-Metin, Ruhan Deniz Topuz, Oktay Kaya, Cetin Hakan Karadag, Ahmet Ulugol
Background and Objectives: Allergic contact dermatitis is a common type IV hypersensitivity reaction characterised by redness, itching, oedema and thickening of the skin. It occurs in about 7% of the population and its incidence is increasing. It has been observed that the preconditioning of tissues by exposing them to transient ischemia increases resistance to subsequent permanent ischemia, and this phenomenon is called ischemic preconditioning. It has been shown that conditioning in one organ can also protect other organs...
October 12, 2023: Medicina
https://read.qxmd.com/read/37883446/pretreatment-with-remote-ischemic-conditioning-attenuates-testicular-damage-after-testicular-ischemia-and-reperfusion-injury-in-rats
#32
JOURNAL ARTICLE
Jiaxue Li, Zhibing Yan, Qifeng Wang, Shichao Wei, Quanhua Liu, Ting Liu, Zhaoyang Hu
Testicular torsion is a urological emergency. However, surgical detorsion of the torsed spermatic cord can cause testicular reperfusion injury. Although remote ischemic preconditioning (RIPC) has been convincingly shown to protect organs against ischemia/reperfusion (I/R) injury, little is known regarding the effect of RIPC on testicular torsion/detorsion-induced reperfusion injury. Therefore, we aimed to evaluate the effect of RIPC on testes after testicular I/R injury in a rat model in vivo. Male Sprague-Dawley rats were randomly classified into 4 groups: sham-operated (sham), testicular I/R (TI/R), or remote liver (RIPC liver) and limb (RIPC limb) ischemic preconditioning groups...
2023: PloS One
https://read.qxmd.com/read/37865833/remote-ischemic-conditioning-as-an-emerging-tool-to-improve-corticospinal-transmission-in-individuals-with-chronic-spinal-cord-injury
#33
JOURNAL ARTICLE
Yu-Kuang Wu, Jill M Wecht, Ona E Bloom, Gino S Panza, Noam Y Harel
PURPOSE OF REVIEW: Remote ischemic conditioning (RIC) involves transient blood flow restriction to one limb leading to systemic tissue-protective effects. RIC shares some potential underlying mechanisms with intermittent hypoxia (IH), in which brief bouts of systemic hypoxia trigger increases in growth factor expression and neural plasticity. RIC has shown promise in acute myocardial infarction and stroke but may be applicable toward chronic neuropathology as well. Consequently, this review discusses similarities and differences between RIC and IH and presents preliminary and ongoing research findings regarding RIC...
October 2, 2023: Current Opinion in Neurology
https://read.qxmd.com/read/37850359/remote-ischemic-conditioning-and-outcomes-in-acute-ischemic-stroke-with-versus-without-large-artery-atherosclerosis
#34
RANDOMIZED CONTROLLED TRIAL
Yu Cui, Zhi-Mei Yuan, Quan-Ying Liu, Ying-Jia Wang, Hui-Sheng Chen
BACKGROUND: RICAMIS trial (The Remote Ischemic Conditioning for Acute Moderate Ischemic Stroke) has demonstrated efficacy of remote ischemic conditioning (RIC) in acute ischemic stroke. We conducted a post hoc analysis of RICAMIS to investigate whether large artery atherosclerosis (LAA) subtype contributed to the outcomes. METHODS: This is a post hoc analysis of the RICAMIS trial. Patients randomized to RIC group and Control group in full analysis set of RICAMIS were classified into LAA and non-LAA subtypes...
December 2023: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/37839518/randomized-feasibility-trial-of-remote-ischemic-conditioning-to-enhance-resuscitation-rice
#35
JOURNAL ARTICLE
Emily Bartlett, Sophie C Morse, Dana Morse, Lucy Goodson, Karen N Adams, Graham Nichol
RATIONALE: Restoration of blood flow after out-of-hospital cardiac arrest (OHCA) is associated with inflammation that causes cellular injury. The extent of this reperfusion injury (RI) is associated with the duration of ischemia and adequacy of resuscitation. Remote ischemic conditioning (RIC) consists of repeated application of non-lethal ischemia then reperfusion to a limb distal to the heart by inflating a blood pressure (BP) cuff. Trials in animal models in cardiac arrest and in humans with acute infarction show RIC reduces RI...
October 13, 2023: Resuscitation
https://read.qxmd.com/read/37815758/cardioprotective-strategies-after-ischemia-reperfusion-injury
#36
REVIEW
Honghong Zhang, Huilin Hu, Changlin Zhai, Lele Jing, Hongen Tian
Acute myocardial infarction (AMI) is associated with high morbidity and mortality worldwide. Although early reperfusion is the most effective strategy to salvage ischemic myocardium, reperfusion injury can develop with the restoration of blood flow. Therefore, it is important to identify protection mechanisms and strategies for the heart after myocardial infarction. Recent studies have shown that multiple intracellular molecules and signaling pathways are involved in cardioprotection. Meanwhile, device-based cardioprotective modalities such as cardiac left ventricular unloading, hypothermia, coronary sinus intervention, supersaturated oxygen (SSO2 ), and remote ischemic conditioning (RIC) have become important areas of research...
October 10, 2023: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://read.qxmd.com/read/37806221/influence-of-remote-ischemic-conditioning-and-nitrogen-monoxide-on-angiogenesis-and-microcirculation-in-a-mouse-ear-burn-model
#37
JOURNAL ARTICLE
Maxi von Glinski, Maria Voigt, Alexander Sogorski, Christoph Wallner, Mehran Dadras, Bjoern Behr, Marcus Lehnhardt, Ole Goertz
INTRODUCTION: Remote ischemic conditioning (RIC) has been shown to improve tissue resilience against ischemia. The aim of this study was to investigate the influence of RIC and its key factor, nitrogen monoxide (NO), on angiogenesis in a burn wound. MATERIALS AND METHODS: A unilateral burn injury on the ear of hairless mice (n = 48) was generated via a hot air jet in a contact-free manner. In four randomized groups, including the control (NoRIC group), RIC alone (RIConly group), RIC plus NO donor (ISDN group), and RIC plus NO synthase inhibitor (L-NAME group), the impact on angiogenesis, vessel diameter, blood flow, edema formation, and leukocyte-endothelial-cell interaction was evaluated over a 12-d period using intravital fluorescence microscopy...
October 6, 2023: Journal of Surgical Research
https://read.qxmd.com/read/37787796/remote-ischemic-conditioning-for-acute-stroke-the-resist-randomized-clinical-trial
#38
RANDOMIZED CONTROLLED TRIAL
Rolf Ankerlund Blauenfeldt, Niels Hjort, Jan Brink Valentin, Anne-Mette Homburg, Boris Modrau, Birgitte Forsom Sandal, Martin Faurholdt Gude, Kristina Dupont Hougaard, Dorte Damgaard, Marika Poulsen, Tove Diedrichsen, Marie Louise Schmitz, Paul von Weitzel-Mudersbach, Alex Alban Christensen, Krystian Figlewski, Erik Lerkevang Grove, Margrét Katrín Hreiðarsdóttir, Henning Morthorst Lassesen, Daniel Wittrock, Søren Mikkelsen, Ulla Væggemose, Palle Juelsgaard, Hans Kirkegaard, Martin Rostgaard-Knudsen, Niels Degn, Sigrid Breinholt Vestergaard, Andreas Gammelgaard Damsbo, Ane Bull Iversen, Janne Kærgård Mortensen, Jesper Petersson, Thomas Christensen, Anne Brink Behrndtz, Hans Erik Bøtker, David Gaist, Marc Fisher, David Charles Hess, Søren Paaske Johnsen, Claus Ziegler Simonsen, Grethe Andersen
IMPORTANCE: Despite some promising preclinical and clinical data, it remains uncertain whether remote ischemic conditioning (RIC) with transient cycles of limb ischemia and reperfusion is an effective treatment for acute stroke. OBJECTIVE: To evaluate the effect of RIC when initiated in the prehospital setting and continued in the hospital on functional outcome in patients with acute stroke. DESIGN, SETTING, AND PARTICIPANTS: This was a randomized clinical trial conducted at 4 stroke centers in Denmark that included 1500 patients with prehospital stroke symptoms for less than 4 hours (enrolled March 16, 2018, to November 11, 2022; final follow-up, February 3, 2023)...
October 3, 2023: JAMA
https://read.qxmd.com/read/37784006/third-generation-antiseizure-medication-in-the-treatment-of-benzodiazepine-refractory-status-epilepticus-in-poststroke-epilepsy-a-retrospective-observational-register-based-study
#39
JOURNAL ARTICLE
Yaroslav Winter, Katharina Sandner, Thomas Vieth, Gabriel Gonzalez-Escamilla, Sebastian V Stuckrad-Barre, Sergiu Groppa
BACKGROUND AND OBJECTIVE: Status epilepticus in poststroke epilepsy is a challenging condition because of multiple vascular comorbidities and the advanced age of patients. Data on third-generation antiseizure medication (ASM) in this condition are limited. The aim of this study was to evaluate the efficacy of third-generation ASMs in the second- or third-line therapy of benzodiazepine-refractory status epilepticus in poststroke epilepsy following acute ischemic stroke. METHODS: Data on the effectiveness of third-generation ASMs in patients with status epilepticus in poststroke epilepsy were gathered from two German Stroke Registries and the Mainz Epilepsy Registry...
October 2023: CNS Drugs
https://read.qxmd.com/read/37776451/intravital-imaging-of-leukocyte-endothelial-interaction-in-hindlimb-ischemia-reperfusion-injury-by-intravital-multiphoton-microscopy
#40
JOURNAL ARTICLE
Johannes Zeller, Karlheinz Peter, Steffen U Eisenhardt
Ischemia/reperfusion injury in skeletal muscle leads to sterile inflammation and affects structure and function permanently. However, the main understanding of the molecular and cellular mechanisms mainly relies on in vitro and ex vivo investigations. Recent advances in intravital microscopy allow for insights into dynamic processes at the cellular and subcellular level under both physiological and pathophysiological conditions. Real-time intravital imaging by two-photon microscopy (2P-IVM) has emerged as a powerful tool in the evaluation of the cell-cell interaction and molecular biology of leukocytes in live animals...
2024: Methods in Molecular Biology
keyword
keyword
110444
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.