Rolf Ankerlund Blauenfeldt, Niels Hjort, Jan Brink Valentin, Anne-Mette Homburg, Boris Modrau, Birgitte Forsom Sandal, Martin Faurholdt Gude, Kristina Dupont Hougaard, Dorte Damgaard, Marika Poulsen, Tove Diedrichsen, Marie Louise Schmitz, Paul von Weitzel-Mudersbach, Alex Alban Christensen, Krystian Figlewski, Erik Lerkevang Grove, Margrét Katrín Hreiðarsdóttir, Henning Morthorst Lassesen, Daniel Wittrock, Søren Mikkelsen, Ulla Væggemose, Palle Juelsgaard, Hans Kirkegaard, Martin Rostgaard-Knudsen, Niels Degn, Sigrid Breinholt Vestergaard, Andreas Gammelgaard Damsbo, Ane Bull Iversen, Janne Kærgård Mortensen, Jesper Petersson, Thomas Christensen, Anne Brink Behrndtz, Hans Erik Bøtker, David Gaist, Marc Fisher, David Charles Hess, Søren Paaske Johnsen, Claus Ziegler Simonsen, Grethe Andersen
IMPORTANCE: Despite some promising preclinical and clinical data, it remains uncertain whether remote ischemic conditioning (RIC) with transient cycles of limb ischemia and reperfusion is an effective treatment for acute stroke. OBJECTIVE: To evaluate the effect of RIC when initiated in the prehospital setting and continued in the hospital on functional outcome in patients with acute stroke. DESIGN, SETTING, AND PARTICIPANTS: This was a randomized clinical trial conducted at 4 stroke centers in Denmark that included 1500 patients with prehospital stroke symptoms for less than 4 hours (enrolled March 16, 2018, to November 11, 2022; final follow-up, February 3, 2023)...
October 3, 2023: JAMA