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Remote ischemic conditioning

Mehmet Sipahi, Mucahit Gunaydin, Tugrul Kesicioglu, Murat Usta, Berna Tezcan Yavuz, Canberk Tomruk
PURPOSE: To evaluate the effect of remote ischemic conditioning (RIC) on ovarian ischemia/reperfusion injury in a rat model. METHODS: A total of 36 Wistar albino rats with a body weight of 220-250 g were used for this study. Right adnexal torsion was performed for 180 min, and at the end of the period, the adnex was released and the abdomen was reclosed for 180 min for reperfusion. Torsion and detorsion procedures were applied to all rats except group 1 (sham, control)...
April 12, 2019: Archives of Gynecology and Obstetrics
Georgios Amanakis, Petra Kleinbongard, Gerd Heusch, Andreas Skyschally
Ischemic conditioning maneuvers, when induced either locally in the heart or remotely from the heart, reduce infarct size. However, infarct size reduction can be assessed no earlier than hours after established reperfusion. ST-segment elevation and its attenuation might reflect cardioprotection by ischemic conditioning online. Pigs were subjected to regional myocardial ischemia/reperfusion (1 h/3 h). Ischemic conditioning was induced prior to ischemia either locally (preconditioning; IPC; n = 15) or remotely (remote preconditioning; RIPC; n = 21), remotely during ischemia (remote perconditioning; RPER; n = 18), or locally at reperfusion (postconditioning; POCO; n = 9)...
April 1, 2019: Basic Research in Cardiology
Thomas Stiermaier, Jan-Oluf Jensen, Karl-Philipp Rommel, Suzanne de Waha-Thiele, Georg Fuernau, Steffen Desch, Holger Thiele, Ingo Eitel
RATIONALE: Remote ischemic conditioning (RIC) and/or ischemic postconditioning (PostC) may protect the myocardium from ischemia-reperfusion injury in patients with ST-elevation myocardial infarction (STEMI). OBJECTIVE: To determine whether combined intrahospital RIC and PostC or PostC alone in addition to primary percutaneous coronary intervention (PCI) reduce long-term clinical events after STEMI. METHODS AND RESULTS: The present study is a post-hoc analysis of a prospective trial which randomized 696 STEMI patients with symptoms <12 hours 1:1:1 to either combined RIC and PostC in addition to primary PCI, PostC alone in addition to primary PCI, or conventional PCI (control)...
April 1, 2019: Circulation Research
Anna E Mattlage, Ellen N Sutter, Marghuretta D Bland, Swati M Surkar, Jeffrey M Gidday, Jin-Moo Lee, Tamara Hershey, Ling Chen, Catherine E Lang
Remote limb ischemic conditioning (RLIC) is a technique in which tissues distant from the target organ are exposed to brief, sub-lethal bouts of ischemia. The effects of remotely applied ischemic conditioning are systemically transferred to the target organ, and typically manifested as protection from subsequent ischemic injury. Previous studies in our lab have found and confirmed that RLIC enhances learning and retention during motor training on a balance task. The current study tested the effect of RLIC dose (number of cycles) on learning enhancement in young, healthy adults...
March 26, 2019: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
Pedro L Valenzuela, Rosalía Martín-Candilejo, Guillermo Sánchez-Martínez, Joao Carlos Bouzas Marins, Pedro de la Villa, Manuel Sillero-Quintana
Valenzuela, PL, Martín-Candilejo, R, Sánchez-Martínez, G, Bouzas Marins, JC, de la Villa, P, and Sillero-Quintana, M. Ischemic preconditioning and muscle force capabilities. J Strength Cond Res XX(X): 000-000, 2019-This study analyzed the effects of ischemic preconditioning (IPC) on muscle force capabilities. Sixteen male subjects participated in this randomized, crossover, sham-controlled study. They were assigned to either IPC (3 × 5 minutes at 220 mm Hg in both arms with 5-minute rests) or a sham intervention (SHAM) (occlusion pressure set at 10 mm Hg)...
March 15, 2019: Journal of Strength and Conditioning Research
Patrick M Pilz, Ouafa Hamza, Olof Gidlöf, Ines F Gonçalves, Eva Verena Tretter, Sandra Trojanek, Dietmar Abraham, Stefan Heber, Paul M Haller, Bruno K Podesser, Attila Kiss
AIMS: Remote ischemic conditioning (RIC) is considered a potential clinical approach to reduce myocardial infarct size and ameliorate adverse post-infarct left ventricular (LV) remodeling, however the mechanisms are unknown. The aim was to clarify the impact of RIC on Neuregulin-1 (NRG-1)/ErbBs expression, inflammation and LV hemodynamic function. METHODS AND RESULTS: Male Sprague-Dawley rats were subjected to 30 min occlusion of the left coronary artery (LCA) followed by 2 weeks of reperfusion and separated into three groups: (1) sham operated (without LCA occlusion); (2) Myocardial ischemia/reperfusion (MIR) and (3) remote ischemic perconditioning group (MIR + RIPerc)...
March 6, 2019: International Journal of Cardiology
Elżbieta Gadula-Gacek, Mateusz Tajstra, Jacek Niedziela, Łukasz Pyka, Mariusz Gąsior
Electrical storm (ES) is a life-threatening condition with diverse clinical presentation, caused by recurrent malignant ventricular arrhythmia--≥3 episodes of ventricular tachycardia (VT) or ventricular fibrillation within 24hours and is associated with high mortality. The aim of this study was analysis of clinical profile, treatment, and prognosis of patients with ES admitted to a high-volume cardiovascular center. We present results of a single-center, retrospective, ongoing observational registry enrolling consecutive patients presenting with ES admitted between 2006 and 2017...
February 25, 2019: American Journal of Cardiology
Thijs Landman, Yvonne Schoon, Michiel Warlé, Frank-Erik De Leeuw, Dick Thijssen
BACKGROUND: Remote ischemic postconditioning (rIPostC) refers to the observation that repeated, short periods of ischemia protect remote areas against tissue damage during and after prolonged ischemia. Based on previous observations of a potential neuroprotective effect of rIPostC, the aim of this study is to evaluate whether repeated rIPostC after an ischemic stroke can reduce infarct size, which could be translated to an improvement in clinical outcomes. METHODS/DESIGN: We will enroll 200 ischemic stroke patients to daily rIPostC or sham conditioning during hospitalization into a randomized single-blind placebo-controlled trial...
March 15, 2019: Trials
Xiuling Jin, Liangrong Wang, Liling Li, Xiyue Zhao
Remote ischemic pre-conditioning (RIPC) may have a protective effect on myocardial injury associated with cardiac bypass surgery (CPB). The objective of the present study was to investigate the effect of RIPC on ischemia/reperfusion (I/R) injury and to assess the underlying mechanisms. A total of 241 patients who underwent valve replacement were randomly assigned to receive either RIPC (n=121) or control group (n=120). The primary endpoint was peri-operative myocardial injury (PMI), which was determined by serum Highly sensitive cardiac troponin T (hsTnT)...
March 2019: Experimental and Therapeutic Medicine
Li You, Ying-Ying Pan, Meng-Yao An, Wen-Hua Chen, Ying Zhang, Yan-Na Wu, Yan Li, Kai Sun, Yong-Qiang Yin, Jian-Shi Lou
BACKGROUND Cardiac remote ischemic conditioning (RIC) is a noninvasive cardioprotective method in ischemia-reperfusion injury and acute myocardial infarction (AMI). The aims of this study were to investigate the effects of RIC in a rat model of AMI. MATERIAL AND METHODS Adult male Sprague-Dawley rats included the AMI group that underwent ligation of the left anterior descending (LAD) coronary artery (n=24), the RIC group that consisted the AMI rat model treated with RIC once daily in the left hind limb until days 1, 7 and 14 (n=24), and the sham group (n=24)...
March 8, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Linlin Guo, Da Zhou, Di Wu, Jiayue Ding, Xiaoduo He, Jingfei Shi, Yunxia Duan, Tingting Yang, Yuchuan Ding, Xunming Ji, Ran Meng
Objective: We aimed to evaluate the safety and effectiveness of short-term remote ischemic postconditioning (RIPC) in acute stroke monkey models. Methods: Acute stroke monkeys were allocated to four groups based on the number of limbs exposed to RIPC. RIPC was initiated by 5-min cuff inflation/deflation cycles of the target limb(s) for 5-10 bouts. Vital signs, skin integrity, brain MRI, and serum levels of cardiac enzymes (myoglobin, creatine kinase [CK], CK-muscle/brain [CK-MB]), one inflammatory marker (high-sensitivity C-reactive protein [hsCRP], and one endothelial injury marker (von Willebrand factor [vWF]) were assessed...
February 2019: Annals of Clinical and Translational Neurology
Takashi Honda, Quan He, Fangfei Wang, Andrew N Redington
Remote ischemic conditioning (RIC) is acutely cardioprotective in ischemia-reperfusion injury. We aimed to evaluate the effect of RIC on septic cardiomyopathy and associated multi-organ failure in a lipopolysaccharide (LPS)-induced sepsis mouse model. Balb/c mice were divided into sham, LPS, and LPS + RIC groups. LPS 10 mg/kg or saline control was injected intraperitoneally. RIC was performed by four cycles of 5 min ischemia and 5 min reperfusion of the left lower limb just before the LPS injection. Cardiac function on echocardiography, circulating mediators, blood biochemistry, and MAPK signalling was assessed...
March 5, 2019: Basic Research in Cardiology
Rebecca Ward, Weiguo Li, Yasir Abdul, LaDonya Jackson, Guangkuo Dong, Sarah Jamil, Jessica Filosa, Susan C Fagan, Adviye Ergul
Diabetes increases the risk and worsens the progression of cognitive impairment via the greater occurrence of small vessel disease and stroke. Yet, the underlying mechanisms are not fully understood. It is now accepted that cardiovascular health is critical for brain health and any neurorestorative approaches to prevent/delay cognitive deficits should target the conceptual neurovascular unit (NVU) rather than neurons alone. We have recently shown that there is augmented hippocampal NVU remodeling after a remote ischemic injury in diabetes...
February 25, 2019: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Raquel B Santos, Inês Silveira, Maria Trêpa, Bruno Brochado, Rui Magalhães, Patrícia Rodrigues, Maria J Sousa, André Luz, João Silveira, Aníbal Albuquerque, Severo Torres, Adelino F Leite-Moreira, Henrique Carvalho
AIM: Remote ischemic conditioning may reduce acute kidney injury (AKI) in patients undergoing a coronary intervention. As preinfarct angina (PIA) might act as a preconditioning stimulus in patients with ST-elevation myocardial infarction (STEMI), we aimed to study whether PIA reduces AKI in accordance to pre-existing chronic kidney disease. PATIENTS AND METHODS: We conducted a retrospective study including 891 consecutive STEMI patients who underwent primary coronary intervention from January 2008 to March 2016...
February 7, 2019: Coronary Artery Disease
Ren Gong, Yan-Qing Wu
OBJECTIVE: This systematic review was designed to evaluate the efficacy of remote ischemic conditioning (RIC) with primary percutaneous coronary intervention (PCI) versus primary PCI alone for ST-segment elevation myocardial infarction (STEMI). SEARCH STRATEGY: Computerized search for trials from PubMed, EMBASE, CENTRAL and Cochrane Database of Systematic Reviews databases. SELECTION CRITERIA: Trials investigating RIC plus primary PCI (group A) versus primary PCI alone (group B)...
January 21, 2019: Journal of Cardiothoracic Surgery
Da Zhou, Jiayue Ding, Jingyuan Ya, Liqun Pan, Chaobo Bai, Jingwei Guan, Zhongao Wang, Kexin Jin, Qi Yang, Xunming Ji, Ran Meng
Our previous study revealed that remote ischemic conditioning (RIC) reduced the incidence of stroke or TIA in octo- and nonagenarians with intracranial atherosclerotic stenosis (ICAS). Herein, we aimed to investigate whether RIC would influence the progression of white matter hyperintensities (WMHs) and cognitive impairment in the same group of patients. Fifty-eight patients with ICAS were randomly assigned in a 1:1 ratio to receive standard medical treatment with RIC (n=30) versus sham-RIC (n=28). The RIC protocol consisted of 5 cycles of alternating 5-min ischemia and 5-min reperfusion applied in the bilateral upper arms twice daily for 300 days...
January 28, 2019: Aging
Rebekka Vibjerg Jensen, Ioanna Andreadou, Derek J Hausenloy, Hans Erik Bøtker
Ischemia reperfusion injury (IR injury) associated with ischemic heart disease contributes significantly to morbidity and mortality. O-linked β-N-acetylglucosamine (O-GlcNAc) is a dynamic posttranslational modification that plays an important role in numerous biological processes, both in normal cell functions and disease. O-GlcNAc increases in response to stress. This increase mediates stress tolerance and cell survival, and is protective. Increasing O-GlcNAc is protective against IR injury. Experimental cellular and animal models, and also human studies, have demonstrated that protection against IR injury by ischemic preconditioning, and the more clinically applicable remote ischemic preconditioning, is associated with increases in O-GlcNAc levels...
January 18, 2019: International Journal of Molecular Sciences
Chul-Ho Kim, Pavol Sajgalik, Erik Van Iterson, Jae Sy, Bruce D Johnson
This study investigated whether rIPC alters the typical changes in pulmonary arterial pressure, pulmonary gas exchange associated with exercise in hypoxia. METHODS: 16 healthy adults were randomized to either rIPC treatment (n = 8) or control (n = 8). Afterward, subjects performed supine ergometry at constant load (30 watts, 40˜50 rpm) for 25 min during hypoxia (12.5% O2 ). Following a 90˜120 min rest, either rIPC or sham treatment was performed, which was then followed by post-assessment exercise...
January 15, 2019: Respiratory Physiology & Neurobiology
Wenbo Zhao, Sijie Li, Changhong Ren, Ran Meng, Kunlin Jin, Xunming Ji
Despite great improvement during the past several decades, the management of stroke is still far from satisfactory, which warrants alternative or adjunctive strategies. Remote ischemic conditioning (RIC), an easy-to-use and noninvasive therapy, can be performed in various clinical scenarios (e.g., prehospital transportation, intrahospital, and at home), and it has been widely investigated for stroke management. RIC has been demonstrated to be well tolerated in patients with acute ischemic stroke and aneurysm subarachnoid hemorrhage, and it may benefit these patients by improving clinical outcomes; in patients with intracranial atherosclerosis, long-term repeated RIC could be safely performed and benefit patients by reducing recurrent ischemic stroke and transient ischemic attack, as well as improving cerebral perfusion status; long-term repeated RIC may also benefit patients with cerebral small vessel disease by slowing cognitive decline and reducing volume of white matter hyperintensities on brain MRI; in patients with severe carotid atherosclerotic stenosis undergoing stenting, preprocedural RIC could reduce the odds of new brain lesions on postprocedural MRI...
January 2019: Annals of Clinical and Translational Neurology
Christoph Emontzpohl, Christian Stoppe, Alexander Theißen, Christian Beckers, Ulf P Neumann, Georg Lurje, Cynthia Ju, Jürgen Bernhagen, René H Tolba, Zoltan Czigany
BACKGROUND: Macrophage migration inhibitory factor (MIF) is an important stress-regulating mediator of acute ischemia/reperfusion (I/R) injury and ischemic conditioning. The present study aimed to investigate whether MIF is involved in the effects of remote ischemic conditioning (RIC) in a rat model of orthotopic liver transplantation (OLT). METHODS: OLTs were performed in male Lewis rats (245-340 g). Recipients were allocated in a randomized fashion into three experimental groups: remote preconditioning-RIPC, remote postconditioning-RIPOST, control...
December 21, 2018: Shock
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