Ajinkya Nitin Nikam, Amrita Roy, Ruchira Raychaudhuri, Prerana D Navti, Soji Soman, Sanjay Kulkarni, Krishnaraj Somayaji Shirur, Abhijeet Pandey, Srinivas Mutalik
Topical drug delivery holds immense significance in dermatological treatments due to its non-invasive nature and direct application to the target site. Organogels, a promising class of topical drug delivery systems, have acquired substantial attention for enhancing drug delivery efficiency. This review article aims to explore the advantages of organogels, including enhanced drug solubility, controlled release, improved skin penetration, non-greasy formulations, and ease of application. The mechanism of organogel permeation into the skin is discussed, along with formulation strategies, which encompass the selection of gelling agents, cogelling agents, and additives while considering the influence of temperature and pH on gel formation...
2024: Current Pharmaceutical Design