keyword
https://read.qxmd.com/read/38545112/mechanisms-of-inflammation-modulation-by-different-immune-cells-in-hypertensive-nephropathy
#1
REVIEW
Xiao-Min Hao, Yu Liu, Dilizhawaer Hailaiti, Yu Gong, Xu-Dong Zhang, Bing-Nan Yue, Ji-Peng Liu, Xiao-Li Wu, Ke-Zhen Yang, Jun Wang, Qing-Guo Liu
Hypertensive nephropathy (HTN) is the second leading cause of end-stage renal disease (ESRD) and a chronic inflammatory disease. Persistent hypertension leads to lesions of intrarenal arterioles and arterioles, luminal stenosis, secondary ischemic renal parenchymal damage, and glomerulosclerosis, tubular atrophy, and interstitial fibrosis. Studying the pathogenesis of hypertensive nephropathy is a prerequisite for diagnosis and treatment. The main cause of HTN is poor long-term blood pressure control, but kidney damage is often accompanied by the occurrence of immune inflammation...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38545107/maternal-gut-microbiota-in-the-health-of-mothers-and-offspring-from-the-perspective-of-immunology
#2
REVIEW
Xiaowen Lu, Zhan Shi, Lingling Jiang, Songying Zhang
Due to the physiological alteration during pregnancy, maternal gut microbiota changes following the metabolic processes. Recent studies have revealed that maternal gut microbiota is closely associated with the immune microenvironment in utero during pregnancy and plays a vital role in specific pregnancy complications, including preeclampsia, gestational diabetes, preterm birth and recurrent miscarriages. Some other evidence has also shown that aberrant maternal gut microbiota increases the risk of various diseases in the offspring, such as allergic and neurodevelopmental disorders, through the immune alignment between mother and fetus and the possible intrauterine microbiota...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38544428/glp-1-receptor-agonists-alleviate-colonic-inflammation-by-modulating-intestinal-microbiota-and-the-function-of-group-3-innate-lymphoid-cells
#3
JOURNAL ARTICLE
Hanxiao Sun, Jie Shu, Jupei Tang, Yue Li, Jinxin Qiu, Zhaoyun Ding, Binbin Xuan, Minghui Chen, Chenxin Gan, Jinpiao Lin, Ju Qiu, Huiming Sheng, Chuanxin Wang
Glucagon-like peptide-1 receptor agonists (GLP-1RAs), which are drugs used for treating type 2 diabetes, have been reported to exert anti-inflammatory effects on inflammatory bowel disease (IBD), the mechanism of which remains elusive. Here, we report that GLP-1RAs ameliorate dextran sulfate sodium (DSS)-induced colitis in both wild-type and T/B-cell-deficient mice through modulating group 3 innate lymphoid cells (ILC3s), a subset of innate lymphoid cells that regulate intestinal immunity. GLP-1RAs promote IL-22 production by ILC3, and the protective effect of GLP-1RAs on DSS-induced colitis was abrogated in ILC3-deficient RORgtgfp/gfp mice...
March 27, 2024: Immunology
https://read.qxmd.com/read/38540681/tricarboxylic-acid-cycle-intermediates-and-individual-ageing
#4
REVIEW
Natalia Kurhaluk
Anti-ageing biology and medicine programmes are a focus of genetics, molecular biology, immunology, endocrinology, nutrition, and therapy. This paper discusses metabolic therapies aimed at prolonging longevity and/or health. Individual components of these effects are postulated to be related to the energy supply by tricarboxylic acid (TCA) cycle intermediates and free radical production processes. This article presents several theories of ageing and clinical descriptions of the top markers of ageing, which define ageing in different categories; additionally, their interactions with age-related changes and diseases related to α-ketoglutarate (AKG) and succinate SC formation and metabolism in pathological states are explained...
February 22, 2024: Biomolecules
https://read.qxmd.com/read/38533515/tigit-acts-as-an-immune-checkpoint-upon-inhibition-of-pd1-signaling-in-autoimmune-diabetes
#5
JOURNAL ARTICLE
Prerak Trivedi, Gaurang Jhala, David J De George, Chris Chiu, Claudia Selck, Tingting Ge, Tara Catterall, Lorraine Elkerbout, Louis Boon, Nicole Joller, Thomas W Kay, Helen E Thomas, Balasubramanian Krishnamurthy
INTRODUCTION: Chronic activation of self-reactive T cells with beta cell antigens results in the upregulation of immune checkpoint molecules that keep self-reactive T cells under control and delay beta cell destruction in autoimmune diabetes. Inhibiting PD1/PD-L1 signaling results in autoimmune diabetes in mice and humans with pre-existing autoimmunity against beta cells. However, it is not known if other immune checkpoint molecules, such as TIGIT, can also negatively regulate self-reactive T cells...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38533501/causal-relationship-between-gut-microbiota-and-diabetic-nephropathy-a-two-sample-mendelian-randomization-study
#6
JOURNAL ARTICLE
Shuxiang Yan, Hua Wang, Baiyu Feng, Lin Ye, Anqun Chen
OBJECTIVE: Emerging evidence has provided compelling evidence linking gut microbiota (GM) and diabetic nephropathy (DN) via the "gut-kidney" axis. But the causal relationship between them hasn't been clarified yet. We perform a Two-Sample Mendelian randomization (MR) analysis to reveal the causal connection with GM and the development of DN, type 1 diabetes nephropathy (T1DN), type 2 diabetes nephropathy (T2DN), type 1 diabetes mellitus (T1DM), and type 2 diabetes mellitus (T2DM). METHODS: We used summary data from MiBioGen on 211 GM taxa in 18340 participants...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38533495/imidazole-propionate-ameliorates-atopic-dermatitis-like-skin-lesions-by-inhibiting-mitochondrial-ros-and-mtorc2
#7
JOURNAL ARTICLE
Ha Eun Kim, Jong Yeong Lee, Dong-Hoon Yoo, Hyo-Hyun Park, Eun-Ju Choi, Kyung-Hwa Nam, Jin Park, Jin Kyeong Choi
BACKGROUND: Imidazole propionate (IMP) is a histidine metabolite produced by some gut microorganisms in the human colon. Increased levels of IMP are associated with intestinal inflammation and the development and progression of cardiovascular disease and diabetes. However, the anti-inflammatory activity of IMP has not been investigated. This study aimed to elucidate the role of IMP in treating atopic dermatitis (AD). METHODS: To understand how IMP mediates immunosuppression in AD, IMP was intraperitoneally injected into a Dermatophagoides farinae extract (DFE)/1-chloro-2,4 dinitrochlorobenzene (DNCB)-induced AD-like skin lesions mouse model...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38530923/epistasis-between-hla-drb1-16-02-01-and-slc16a11-t-c-g-t-t-reduces-odds-for-type-2-diabetes-in-southwest-american-indians
#8
JOURNAL ARTICLE
Robert C Williams, Robert L Hanson, Bjoern Peters, Kendall Kearns, William C Knowler, Clifton Bogardus, Leslie J Baier
We sought to identify genetic/immunologic contributors of type 2 diabetes in an indigenous American community by genotyping all study participants for both high resolution HLA-DRB1 alleles and SLC16A11 to test their risk and/or protection for T2D. These genes were selected based on independent reports that HLA-DRB1*16:02:01 is protective for T2D and that SLC16A11 associates with T2D in individuals with BMI<35kg/m2, and here test the interaction of the two loci with a more complete dataset and perform a BMI sensitivity test...
March 26, 2024: Diabetes
https://read.qxmd.com/read/38530804/senescent-adipocytes-and-type-2-diabetes-current-knowledge-and-perspective-concepts
#9
REVIEW
Weronika Kruczkowska, Julia Gałęziewska, Mateusz Kciuk, Adrianna Gielecińska, Elżbieta Płuciennik, Zbigniew Pasieka, Lin-Yong Zhao, Yi-Jin Yu, Damian Kołat, Żaneta Kałuzińska-Kołat
Among civilization diseases, the number of individuals suffering from type 2 diabetes (T2DM) is expected to increase to more than a billion in less than 20 years, which is associated with, e.g., populational aging, poor diet, sedentary lifestyle, genetic predispositions, and immunological factors. T2DM affects many organs and is characterized by insulin resistance, high glucose levels, and adipocyte dysfunction, which are related to senescence. Although this type of cellular aging has beneficial biological functions, it can also act unfavorable since senescent adipocytes resist apoptosis, enhance cytokine secretion, downregulate cell identity genes, and acquire the senescence-associated secretory phenotype that renders a more oxidative environment...
January 1, 2024: Biomolecular Concepts
https://read.qxmd.com/read/38529589/metformin-alters-tumor-immune-microenvironment-improving-the-outcomes-of-breast-cancer-patients-with-type-2-diabetes-mellitus
#10
JOURNAL ARTICLE
Satomi Shiba, Michiko Harao, Akira Saito, Masako Sakuragi, Joji Kitayama, Naohiro Sata
This study investigated the clinical effect of metformin on breast cancer patients with preexisting type 2 diabetes mellitus (T2DM). We analyzed 177 patients with T2DM who underwent breast cancer surgery and assessed tumor-associated macrophages (TAMs) and tumor-infiltrating lymphocytes (TILs) in patients who underwent tumor resection with or without metformin treatment using multiplex immunohistochemistry (IHC). Patients who received metformin either pre- or postoperatively exhibited reduced distant organ recurrence and improved postoperative recurrence-free survival compared to those of patients who did not...
February 23, 2024: Journal of Breast Cancer
https://read.qxmd.com/read/38524870/tibial-cortex-transverse-transport-regulates-orai1-stim1-mediated-no-release-and-improve-the-migration-and-proliferation-of-vessels-via-increasing-osteopontin-expression
#11
JOURNAL ARTICLE
Lingchao Kong, Yangyang Li, Zhongfang Deng, Xiaoyu Chen, Yin Xia, Bing Shen, Rende Ning, Lesha Zhang, Zongsheng Yin
BACKGROUND: Diabetic foot is a major complication of diabetes. The bone transverse transport method could be applied in clinics for treatment, which could improve the metabolism of the tissues via lasting distraction forces. However, the process' specific regulating mechanism is still unknown. METHODS: Based on the notion that the healing of bones involves the recruitment of calcium ions, in this study, we established the model of tibial cortex transverse transport (TTT) on rats and then used tissue immunologic detection, such as the double fluorescent staining to explore the expression of the calcium channels' calcium release-activated calcium modulator 1 (Orai1)/stromal interaction molecule 1 (STIM1), which belong to the store-operated calcium entry (SOCE) signaling pathways on the tissues around the bone transport area...
March 2024: Journal of Orthopaedic Translation
https://read.qxmd.com/read/38524133/structure-guided-engineering-and-molecular-simulations-to-design-a-potent-monoclonal-antibody-to-target-ap2-antigen-for-adaptive-immune-response-instigation-against-type-2-diabetes
#12
JOURNAL ARTICLE
Abbas Khan, Muhammad Ammar Zahid, Anwar Mohammad, Abdelali Agouni
INTRODUCTION: Diabetes mellitus (DM) is recognized as one of the oldest chronic diseases and has become a significant public health issue, necessitating innovative therapeutic strategies to enhance patient outcomes. Traditional treatments have provided limited success, highlighting the need for novel approaches in managing this complex disease. METHODS: In our study, we employed graph signature-based methodologies in conjunction with molecular simulation and free energy calculations...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38524127/cd64-plays-a-key-role-in-diabetic-wound-healing
#13
JOURNAL ARTICLE
Xiuqin Zhang, Liuhong Yuan, Zhenyu Tan, Huiyan Wu, Feier Chen, Junjie Huang, Pengjun Wang, Brett D Hambly, Shisan Bao, Kun Tao
INTRODUCTION: Wound healing poses a clinical challenge in diabetes mellitus (DM) due to compromised host immunity. CD64, an IgG-binding Fcgr1 receptor, acts as a pro-inflammatory mediator. While its presence has been identified in various inflammatory diseases, its specific role in wound healing, especially in DM, remains unclear. OBJECTIVES: We aimed to investigate the involvement of CD64 in diabetic wound healing using a DM animal model with CD64 KO mice. METHODS: First, we compared CD64 expression in chronic skin ulcers from human DM and non-DM skin...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38524122/corrigendum-regulatory-t-cells-targeting-a-pathogenic-mhc-class-ii-insulin-peptide-epitope-postpone-spontaneous-autoimmune-diabetes
#14
Nyerhovwo Obarorakpor, Deep Patel, Reni Boyarov, Nansalmaa Amarsaikhan, Joseph Ray Cepeda, Doreen Eastes, Sylvia Robertson, Travis Johnson, Kai Yang, Qizhi Tang, Li Zhang
[This corrects the article DOI: 10.3389/fimmu.2023.1207108.].
2024: Frontiers in Immunology
https://read.qxmd.com/read/38518448/effect-of-dapagliflozin-on-collectins-and-complement-activation-in-plasma-from-patients-with-type-2-diabetes-and-albuminuria-data-from-the-dapkid-cohort
#15
JOURNAL ARTICLE
Mia Jensen, Mie K Eickhoff, Frederik Persson, Peter Rossing, Steffen Thiel, Søren W K Hansen, Yaseelan Palarasah, Per Svenningsen, Boye L Jensen
BACKGROUND: Sodium-glucose cotransporter 2 (SGLT- 2) inhibitors exert cardiovascular and kidney-protective effects in people with diabetes. Attenuation of inflammation could be important for systemic protection. The lectin pathway of complement system activation is linked to diabetic nephropathy. We hypothesized that SGLT-2 inhibitors lower the circulating level of pattern-recognition molecules of the lectin cascade and attenuate systemic complement activation. METHODS: Analysis of paired plasma samples from the DapKid crossover intervention study where patients with type 2 diabetes mellitus (T2DM) and albuminuria were treated with dapagliflozin and placebo for 12 weeks (10 mg/day, n=36)...
March 15, 2024: Immunobiology
https://read.qxmd.com/read/38518038/long-covid-s-impact-on-patients-workers-society-a-review
#16
JOURNAL ARTICLE
Kevin T Kavanagh, Lindsay E Cormier, Christine Pontus, Aaron Bergman, Wilmore Webley
The incidence of long COVID in adult survivors of an acute SARS-CoV-2 infection is approximately 11%. Of those afflicted, 26% have difficulty with day-to-day activities. The majority of long COIVD cases occur after mild or asymptomatic acute infection. Children can spread SARS-CoV-2 infections and can also develop long-term neurological, endocrine (type I diabetes), and immunological sequelae. Immunological hypofunction is exemplified by the recent large outbreaks of respiratory syncytial virus and streptococcal infections...
March 22, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38517889/insulin-receptor-signaling-engages-bladder-urothelial-defenses-that-limit-urinary-tract-infection
#17
JOURNAL ARTICLE
Laura Schwartz, Kristin Salamon, Aaron Simoni, Tad Eichler, Ashley R Jackson, Matthew Murtha, Brian Becknell, Andrew Kauffman, Sarah Linn-Peirano, Natalie Holdsworth, Vidhi Tyagi, Hancong Tang, Steve Rust, Hanna Cortado, Irina Zabbarova, Anthony Kanai, John David Spencer
Urinary tract infections (UTIs) commonly afflict people with diabetes. To better understand the mechanisms that predispose diabetics to UTIs, we employ diabetic mouse models and altered insulin signaling to show that insulin receptor (IR) shapes UTI defenses. Our findings are validated in human biosamples. We report that diabetic mice have suppressed IR expression and are more susceptible to UTIs caused by uropathogenic Escherichia coli (UPEC). Systemic IR inhibition increases UPEC susceptibility, while IR activation reduces UTIs...
March 21, 2024: Cell Reports
https://read.qxmd.com/read/38515750/an-antigen-specific-immunotherapeutic-aks-107-deletes-insulin-specific-b-cells-and-prevents-murine-autoimmune-diabetes
#18
JOURNAL ARTICLE
David G Alleva, Andrea R Delpero, Thillainaygam Sathiyaseelan, Sylaja Murikipudi, Thomas M Lancaster, Mark A Atkinson, Clive H Wasserfall, Liping Yu, Ramya Ragupathy, Rachel H Bonami, Todd C Zion
INTRODUCTION: The antigen-presenting cell function of insulin-reactive B cells promotes type 1 diabetes (T1D) in non-obese diabetic (NOD) mice by stimulating pathogenic T cells leading to destruction of insulin-producing β-cells of pancreatic islets. METHODS/RESULTS: To target insulin-reactive B cells, AKS-107, a human IgG1 Fc molecule fused with human insulin A and B chains, was engineered to retain conformational insulin epitopes that bound mouse and human B cell receptors but prevented binding to the insulin metabolic receptor...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38512037/-research-progress-of-cd93-b-lymphocyte-subsets-in-inflammation-and-inflammation-related-diseases
#19
JOURNAL ARTICLE
Changping Niu, Siyu Sun, Dongyan Liu
CD93 is expressed in progenitor B (pro-B) cells, precursor B (pre-B) cells and various immature B cells. It can interact with moesin, MMRN2 and other molecules to participate in cell migration, adhesion and phagocytosis, so it plays an important role in inflammation and angiogenesis. Detection of CD93+ B cell subsets has a crucial role in the diagnosis, treatment and prognosis monitoring of inflammation and inflammation-related diseases, such as Helicobacter pylori-related gastritis, sepsis, non-obese diabetes and periodontitis...
March 2024: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://read.qxmd.com/read/38503075/the-role-of-neutrophils-and-neutrophil-extracellular-traps-nets-in-stages-outcomes-and-pregnancy-complications
#20
REVIEW
Lida Aslanian-Kalkhoran, Amir Mehdizadeh, Leili Aghebati-Maleki, Shahla Danaii, Sima Shahmohammadi-Farid, Mehdi Yousefi
Neutrophils are the main components of innate immunity to eliminate infectious pathogens. Neutrophils play a role in several stages of the reproductive cycle, and their presence in the female reproductive system is highly regulated, so their function may change during pregnancy. Emerging evidence suggests that neutrophils are important at all stages of pregnancy, from implantation, placentation, and connective tissue regeneration to birth, as well as birth itself. Neutrophil extracellular traps (NETs) are defined as extracellular strands of unfolded DNA together with histone complexes and neutrophil granule proteins...
March 8, 2024: Journal of Reproductive Immunology
keyword
keyword
110405
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.