Read by QxMD icon Read

immunology and diabetes

Jingli Lu, Yan Liang, Junjie Zhao, Haiyang Meng, Xiaojian Zhang
IL-33/ST2 signal is important for the generation of forkhead box P3 (Foxp3)+ regulatory (Treg) cells, which contribute to immune homeostasis in the context of diseases. The aim of this study was to determine whether targeting IL-33/ST2 signal could establish immunological tolerance and prevent type 1 diabetes (T1D) in nonobese diabetic (NOD) mice. Female NOD mice treated with IL-33 for 4 weeks decreased the incidence and delayed the onset of autoimmune diabetes, whereas IL-33 did not revert blood glucose concentration and disease development in mice with new-onset diabetes...
February 16, 2019: International Immunopharmacology
Manshuk Yeltokova, Olga Ulyanova, Manarbek Askarov, Anna Chernyshova, Larissa Kozina
The search continues for pathogenetically effective measures in autoimmune processes for a number of complications of type 1 diabetes mellitus, in particular, diabetic retinopathy. However, there are few studies of the prognostic and therapeutic values of the systemic autoimmune response in this pathology after transplant of autologous mesenchymal stem cells. Here, we present a 40-year-old patient with complications of type 1 diabetes mellitus (diabetic retinopathy) after mesenchymal stem cell transplant. Based on peripheral blood results, we were able to calculate integral hematologic parameters, allowing us to indirectly assess the patient's immune system after autologous mesenchymal stem cell transplant...
January 2019: Experimental and Clinical Transplantation
K L Gupta, Navin Pattanashetti, Raja Ramachandran, Ritambhra Nada, Ritu Aggarwal, Ashsish Sharma
OBJECTIVES: Improvements in early graft survival and long-term graft function have made kidney transplant a more cost-effective alternative to dialysis. We aimed to assess renal transplant outcomes over a 9-month follow-up of recipients in a cost-limited setting (a tertiary care center in India). MATERIALS AND METHODS: Included patients in this prospective observational study were those who underwent renal transplant from July 2016 to February 2017 (8 months) and followed for 9 months...
January 2019: Experimental and Clinical Transplantation
Kyoko Ikumi, Mizuyu Odanaka, Hiroaki Shime, Masaki Imai, Satoshi Osaga, Osamu Taguchi, Emi Nishida, Hiroaki Hemmi, Tsuneyasu Kaisho, Akimichi Morita, Sayuri Yamazaki
Chronic low-grade inflammation can cause several metabolic syndromes. Patients with psoriasis, a chronic immunological skin inflammation, often develop diabetes. However, it is not clear to date how psoriasis leads to, or is correlated with, glucose intolerance. Here, we investigate whether psoriasis itself correlates with hyperglycemia in humans and mice. In patients, severity of psoriasis was correlated with high blood glucose levels and treatment of psoriasis by phototherapy improved insulin secretion. Imiquimod (IMQ)-induced systemic and cutaneous inflammation in mice, with features of human psoriasis, also resulted in hyperglycemia...
February 15, 2019: Journal of Investigative Dermatology
Miroslav Vujasinovic, Aleksandra Hedström, Patrick Maisonneuve, Roberto Valente, Henrik von Horn, J-Matthias Löhr, Stephan L Haas
BACKGROUND: Zinc is a key element in numerous proteins and plays an important role in essential cell functions such as defense against free radicals and DNA damage repair. Chronic pancreatitis (CP) is a chronic inflammation with progressive fibrosis of pancreas ultimately resulting in pancreatic exocrine insufficiency (PEI), which is associated with malnutrition. Studies analyzing zinc levels in patients with CP are sparse and lead to conflicting results. AIM: To investigate serum zinc levels in patients with CP of various etiologies...
February 7, 2019: World Journal of Gastroenterology: WJG
Yuanjun Li, Yedi Zhou
Ocular neovascular diseases are featured by abnormal angiogenesis in the eye, and they seriously threaten the human visual health. These diseases include proliferative diabetic retinopathy (PDR), age-related macular degeneration (AMD), retinopathy of prematurity (ROP), and retinal vein occlusion (RVO). In fact, ocular neovascular diseases represent the leading causes of vision impairment and blindness worldwide. Ocular neovascularization, the process of pathological vessel formation in eye, underlies ocular neovascular diseases...
2019: Tohoku Journal of Experimental Medicine
Ahmed M Elmansi, Mohamed E Awad, Nada H Eisa, Dmitry Kondrikov, Khaled A Hussein, Alexandra Aguilar-Pérez, Samuel Herberg, Sudharsan Periyasamy-Thandavan, Sadanand Fulzele, Mark W Hamrick, Meghan E McGee-Lawrence, Carlos M Isales, Brian F Volkman, William D Hill
Dipeptidyl peptidase 4 (DPP4) is an exopeptidase found either on cell surfaces where it is highly regulated in terms of its expression and surface availability (CD26) or in a free/circulating soluble constitutively available and intrinsically active form. It is responsible for proteolytic cleavage of many peptide substrates. In this review we discuss the idea that DPP4-cleaved peptides are not necessarily inactivated, but rather can possess either a modified receptor selectivity, modified bioactivity, new antagonistic activity, or even a novel activity relative to the intact parent ligand...
February 10, 2019: Pharmacology & Therapeutics
Glenn Choon Lim Wong, Vipin Narang, Yanxia Lu, Xavier Camous, Ma Shwe Zin Nyunt, Christophe Carre, Chrystal Tan, Chin Hui Xian, Joni Chong, Michelle Chua, Wilson How, Esther Mok, Paul Tambyah, Michael Poidinger, Brian Abel, Nicolas Burdin, Laurence Quemeneur, Nabil Bosco, Tze Pin Ng, Anis Larbi
Physical inactivity is one of the leading contributors to worldwide morbidity and mortality. The elderly are particularly susceptible since the features of physical inactivity overlap with the outcomes of natural aging - including the propensity to develop cardiovascular diseases, cancer, diabetes mellitus, sarcopenia and cognitive impairment. The age-dependent loss of immune function, or immunosenescence, refers to the progressive depletion of primary immune resources and is linked to the development of many of these conditions...
2019: Exercise Immunology Review
Silvina Yohena, Alberto Penas-Steinhardt, Clara Muller, Natalia I Faccinetti, Gloria E Cerrone, Silvia Lovecchio, Edgardo Ridner, Silvina Valdez, Gustavo Frechtel
LADA is determined by both a noninsulin-dependent clinical presentation and an autoimmune pathogenic process. GADA constitutes the most important marker, although IA-2A and ZnT8A also define LADA presentation. T2DM is the most prevalent type particularly over 65 years old. Studies about autoimmunity in this age group are scarce. OBJECTIVE: The aim of this work was to determine whether three autoantibodies for diabetes autoimmunity were present in elderly T2DM patients, and to assess the distinctive clinical features of autoantibody-positive patients...
February 11, 2019: Diabetes/metabolism Research and Reviews
Nikos Dimitrioglou, Maria Kanelli, Efstathia Papageorgiou, Theodore Karatzas, Dimitris Hatziavramidis
Type 1 diabetes mellitus (T1DM) is a disorder that decimates pancreatic β-cells which produce insulin. Direct pancreatic islet transplantation cannot serve as a widespread therapeutic modality owing to the need for lifelong immunosuppression and donor shortage. Therefore, several encapsulation techniques have been developed to enclose the islets in semipermeable vehicles that will allow oxygen and nutrient input as well as insulin, other metabolites and waste output, while accomplishing immunoisolation. Although encapsulation technology continues to face significant obstacles, recent advances in material science, stem cell biology and immunology potentially serve as pathways to success...
February 6, 2019: Drug Discovery Today
Jochen Seitz, Stefanie Trinh, Beate Herpertz-Dahlmann
Growing interest exists in the association of gut bacteria with diseases, such as diabetes, obesity, inflammatory bowel disease, and psychiatric disorders. Gut microbiota influence the fermentation of nutrients, body-weight regulation, gut permeability, hormones, inflammation, immunology, and behavior (gut-brain axis). Regarding anorexia nervosa (AN), altered microbial diversity and taxa abundance were found and associated with depressive, anxious, and eating disorder symptoms. Potential mechanisms involve increased gut permeability, low-grade inflammation, autoantibodies, and reduced brain cell neogenesis and learning...
March 2019: Psychiatric Clinics of North America
Helen M Roche
Dietary intake and nutritional status is an important environmental factor which can modulate metabolic-inflammation. In recent years, research has made significant advances in terms of understanding the impact of dietary components on metabolic-inflammation, within the context of obesity, type-2 diabetes (T2D) and CVD risk. Our work demonstrated that different fatty acids differentially modulate metabolic-inflammation, initially focusing on Nod-like receptor family, pyrin domain-containing three protein (NLRP3) inflammasome mediated IL-1β biology and insulin signalling...
February 1, 2019: Proceedings of the Nutrition Society
Carlos Alberto Velasco-Benítez, Ángeles Ruíz-Extremera, Audrey Mary Matallana-Rhoades, Sandra Carolina Giraldo-Lora, Claudia Jimena Ortíz-Rivera
Introduction: Although the association between diabetes mellitus type 1 (T1DM) and celiac disease (CD) is well established; there are only a few studies that focus on South American children, haplotypes and their possible associations. Objective: To determine the prevalence of CD markers in a group of children with T1DM and to analyze the associated clinical, immunological and genetic manifestations. Methods: A prevalence study focusing on children with T1DM who were assessed based on variables including sociodemographics, anthropometric information, disease characteristics, laboratory results and family medical history...
December 30, 2018: Colombia Médica: CM
Xiaoxiao Wan, Emil R Unanue
Development of human autoimmune disorders results from complex interplay among genetic, environmental, and immunological risk factors. Despite much heterogeneity in environmental triggers, the leading genes that give the propensity for tissue-specific autoimmune diseases, such as type 1 diabetes, are those associated with particular class II major histocompatibility complex alleles. Such genetic predisposition precipitates presentation of tissue antigens to MHC-II-restricted CD4 T cells. When properly activated, these self-reactive CD4 T cells migrate to the target tissue and trigger the initial immune attack...
December 2018: Precision clinical medicine
M Alexander, A Gupta, J S Mathad
Pregnancy is associated with insulin resistance similar to that found in type 2 diabetes mellitus (DM). The prevalence of gestational diabetes mellitus (GDM) in key tuberculosis (TB) endemic countries, such as India and China, has been increasing rapidly in the last decade and may be higher in human immunodeficiency virus (HIV) infected women. Pregnancy is also an independent risk factor for developing active TB; however, little is known about the interaction of GDM, HIV and TB. We review the epidemiology and immunology of GDM, and significant research gaps in understanding the interactions between GDM, pregnancy, and TB in women living with and those without HIV...
January 1, 2019: International Journal of Tuberculosis and Lung Disease
Marco Fabbri, Mikaela Frixou, Massimo Degano, Georgia Fousteri
Improvements in the immunological, molecular, and genetic technologies such as next-generation sequencing have led to an exponential increase in the number of monogenic immune dysregulatory syndromes diagnosed, where type 1 diabetes (T1D) forms part of the autoimmune manifestations. Here, we reviewed the mutations in the signal transducer and activator of transcription (STAT) protein family, namely gain-of-function (GOF) mutations in STAT1 and STAT3 as well as STAT5b deficiency, that show strong association to T1D susceptibility...
February 2019: Diabetes
Antonio Toniolo, Gianluca Cassani, Anna Puggioni, Agostino Rossi, Alberto Colombo, Takashi Onodera, Ele Ferrannini
There are 425 million people with diabetes mellitus in the world. By 2045, this figure will grow to over 600 million. Diabetes mellitus is classified among noncommunicable diseases. Evidence points to a key role of microbes in diabetes mellitus, both as infectious agents associated with the diabetic status and as possible causative factors of diabetes mellitus. This review takes into account the different forms of diabetes mellitus, the genetic determinants that predispose to type 1 and type 2 diabetes mellitus (especially those with possible immunologic impact), the immune dysfunctions that have been documented in diabetes mellitus...
January 2019: Reviews in Medical Microbiology: a Journal of the Pathological Society of Great Britain and Ireland
Xiaobo Hu, Cong Hu, Caiping Zhang, Min Zhang, Shiyin Long, Zhaohui Cao
Obesity is defined as a chronic and excessive growth of adipose tissue. It has been associated with a high risk for development and progression of obesity-associated malignancies, while adipokines may mediate this association. Adiponectin is an adipose tissue-derived adipokines, with significant anti-diabetic, anti-inflammatory, anti-atherosclerotic and anti-proliferative properties. Plasma adiponectin levels are decreased in obese individuals, and this feature is closely correlated with development of several metabolic, immunological and neoplastic diseases...
January 3, 2019: International Braz J Urol: Official Journal of the Brazilian Society of Urology
Laura M Jacobsen, Helena Elding Larsson, Roy N Tamura, Kendra Vehik, Joanna Clasen, Jay Sosenko, William A Hagopian, Jin-Xiong She, Andrea K Steck, Marian Rewers, Olli Simell, Jorma Toppari, Riitta Veijola, Anette G Ziegler, Jeffrey P Krischer, Beena Akolkar, Michael J Haller
OBJECTIVE: The capacity to precisely predict progression to type 1 diabetes in young children over a short time span is an unmet need. We sought to develop a risk algorithm to predict progression in children with high-risk human leukocyte antigen (HLA) genes followed in The Environmental Determinants of Diabetes in the Young (TEDDY) study. RESEARCH DESIGN AND METHODS: Logistic regression and 4-fold cross validation examined 38 candidate predictors of risk from clinical, immunologic, metabolic and genetic data...
January 10, 2019: Pediatric Diabetes
Bodo C Melnik, Gerd Schmitz
Milk consumption is a hallmark of western diet. According to common believes, milk consumption has beneficial effects for human health. Pasteurization of cow's milk protects thermolabile vitamins and other organic compounds including bioactive and bioavailable exosomes and extracellular vesicles in the range of 40-120 nm, which are pivotal mediators of cell communication via systemic transfer of specific micro-ribonucleic acids, mRNAs and regulatory proteins such as transforming growth factor-β. There is compelling evidence that human and bovine milk exosomes play a crucial role for adequate metabolic and immunological programming of the newborn infant at the beginning of extrauterine life...
January 3, 2019: Journal of Translational Medicine
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"