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Chiro-Inositol AND Insulin

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https://read.qxmd.com/read/30756365/metabolic-and-hormonal-effects-of-a-combined-myo-inositol-and-d-chiro-inositol-therapy-on-patients-with-polycystic-ovary-syndrome-pcos
#1
Marcin Januszewski, Tadeusz Issat, Alicja A Jakimiuk, Malgorzata Santor-Zaczynska, Artur J Jakimiuk
OBJECTIVES: To evaluate the effects of a combined Myo-inositol (MI) and D-chiro-inositol (DCI) therapy on the hormonal and metabolic parameters of women with PCOS. Prospective clinical study. Clinical Study registration number - EUPAS25705 Material and methods: Seventy women diagnosed with PCOS according to the Rotterdam criteria were enrolled in this study. Patients received a combined therapy of one tablet that contained 550 mg of inositol (myo-inositol (MI) and D-chiro-inositol (DCI) in a ratio of 10:1) twice a day for 6 months...
2019: Ginekologia Polska
https://read.qxmd.com/read/30612488/treatment-with-d-chiro-inositol-and-alpha-lipoic-acid-in-the-management-of-polycystic-ovary-syndrome
#2
Franca Fruzzetti, Anna Capozzi, Alessandro Canu, Stefano Lello
To evaluate the effects of the combination of d-chiro inositol and alpha lipoic acid on menstrual cycles and insulin sensitivity in women with polycystic ovary syndrome (PCOS). Forty-one women with PCOS and 31 controls have been enrolled in the study. The menstrual cycle, BMI, homeostasis model assessment index (HOMA-I), and insulin secretion in response to an OGTT were evaluated before and after 6 months of treatment. During the observation period, the patients have been asked to not modify their diet and physical activity...
January 7, 2019: Gynecological Endocrinology
https://read.qxmd.com/read/30570133/inositol-for-subfertile-women-with-polycystic-ovary-syndrome
#3
REVIEW
Marian G Showell, Rebecca Mackenzie-Proctor, Vanessa Jordan, Ruth Hodgson, Cindy Farquhar
BACKGROUND: Subfertile women are highly motivated to try different adjunctive therapies to have a baby, and the widespread perception is that dietary supplements such as myo-inositol (MI) and D-chiro-insoitol (DCI) are associated with only benefit, and not with harm. Many fertility clinicians currently prescribe MI for subfertile women with polycystic ovary syndrome (PCOS) as pre-treatment to in vitro fertilisation (IVF) or for ovulation induction; however no high-quality evidence is available to support this practice...
December 20, 2018: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/30564926/inositol-for-the-prevention-of-gestational-diabetes-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#4
REVIEW
Amerigo Vitagliano, Gabriele Saccone, Erich Cosmi, Silvia Visentin, Francesco Dessole, Guido Ambrosini, Vincenzo Berghella
PURPOSE: Inositol (ISL) embraces a family of simple carbohydrates with insulin-sensitizing properties, whose most common isoforms are Myo-inositol (MYO) and D-chiro inositol (DCI). The aim of the present study was to assess the efficacy and safety of ISL supplementation during pregnancy for the prevention of gestational diabetes (GDM). METHODS: We conducted a systematic literature search in electronic databases until October 2017. We included all randomized controlled trials (RCTs) comparing pregnant women with GDM who were randomized to either ISL (i...
December 18, 2018: Archives of Gynecology and Obstetrics
https://read.qxmd.com/read/30558466/the-influence-of-different-inositol-stereoisomers-supplementation-in-pregnancy-on-maternal-gestational-diabetes-mellitus-and-fetal-outcomes-in-high-risk-patients-a-randomized-controlled-trial
#5
Claudio Celentano, Barbara Matarrelli, Giulia Pavone, Ester Vitacolonna, Peter A Mattei, Vincenzo Berghella, Marco Liberati
OBJECTIVE: To identify the effects of different dietary inositol stereoisomers on insulin resistance and the development of gestational diabetes mellitus (GDM) in women at high risk for this disorder. DESIGN: A preliminary, prospective, randomized, placebo controlled clinical trial. PARTICIPANTS: Nonobese singleton pregnant women with an elevated fasting glucose in the first or early second trimester were studied throughout pregnancy. INTERVENTION: Supplementation with myo-inositol, d-chiro-inositol, combined myo- and d-chiro-inositol or placebo...
December 17, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://read.qxmd.com/read/30513929/the-healing-promoting-properties-of-selected-cyclitols-a-review
#6
REVIEW
Agnieszka Owczarczyk-Saczonek, Lesław Bernard Lahuta, Magdalena Ligor, Waldemar Placek, Ryszard Józef Górecki, Bogusław Buszewski
INTRODUCTION: Myo -inositol and its derivatives cyclitols play an important role in the processes of cell regulation, signal transduction, osmoregulation, and ion channel physiology, and are a component of the cell membrane. Free cyclitols present in food or released during the degradation of galactosyl cyclitols by bacteria (in digestive tract) show some physiological benefits. AIM: The aim of this paper is to present and analyze the documented data about curative and healing properties of cyclitols...
December 3, 2018: Nutrients
https://read.qxmd.com/read/30270194/inositol-in-polycystic-ovary-syndrome-restoring-fertility-through-a-pathophysiology-based-approach
#7
REVIEW
Antonio Simone Laganà, Simone Garzon, Jvan Casarin, Massimo Franchi, Fabio Ghezzi
Myo-inositol (MI) and D-chiro-inositol (DCI) are insulin second messengers, and MI is involved in follicular gonadotropin pathways which orchestrate ovulation. The tissue-specific MI/DCI ratio is modulated by insulin through aromatase and is altered in insulin resistance (IR), with reduced epimerization of MI to DCI in insulin-sensitive tissues. In ovaries, the MI/DCI ratio is 100:1, but is dramatically reduced by insulin-stimulated epimerase in hyperinsulinemic women with polycystic ovary syndrome (PCOS). Inositols have proved to be effective in PCOS, improving metabolic and hormonal state, and restoring spontaneous ovulation...
November 2018: Trends in Endocrinology and Metabolism: TEM
https://read.qxmd.com/read/29786442/synthesis-of-c-glycoinositols-from-c-glycosylcrotylstannanes
#8
Ahmad S Altiti, David R Mootoo
A strategy for the synthesis of C-pseudodisaccharides that centers on the reaction of a C-linked crotyltin and a substituted pent-4-enal and a ring-closing metathesis-alkene dihydroxylation sequence on the derived crotylation products is illustrated in the preparation of analogues of the insulin modulatory inositol galactosamine-β-(1 → 4)-3-O-methyl-d- chiro-inositol (β-INS-2). The modularity of this approach and versatility of the pivotal crotylation products make this a potentially general methodology for diverse libraries of C-glycoinositols...
June 15, 2018: Journal of Organic Chemistry
https://read.qxmd.com/read/29774465/effect-of-inositol-stereoisomers-at-different-dosages-in-gestational-diabetes-an-open-label-parallel-randomized-controlled-trial
#9
RANDOMIZED CONTROLLED TRIAL
Federica Fraticelli, Claudio Celentano, Isaia Al Zecca, Giacoma Di Vieste, Basilio Pintaudi, Marco Liberati, Marica Franzago, Marta Di Nicola, Ester Vitacolonna
AIMS: Gestational diabetes mellitus (GDM) is the most common metabolic disorder of pregnancy. The aim of the study is to compare the effect of different dosages of inositol stereoisomers supplementation on insulin resistance levels and several maternal-fetal outcomes in GDM women. METHODS: Participants were randomly allocated to receive daily: 400 mcg folic acid (control treatment), 4000 mg myo-inositol plus 400 mcg folic acid (MI treatment), 500 mg D-chiro-inositol plus 400 mcg folic acid (DCI treatment) or 1100/27...
August 2018: Acta Diabetologica
https://read.qxmd.com/read/29344438/new-therapeutic-approaches-in-obesity-and-metabolic-syndrome-associated-with-polycystic-ovary-syndrome
#10
REVIEW
Fatima Saleem, Syed W Rizvi
Polycystic ovary syndrome (PCOS) is a pathophysiological disorder affecting reproductive and metabolic indices. PCOS is commonly associated with a high prevalence of insulin resistance and obesity; this association carries an increased risk of developing metabolic syndrome, type 2 diabetes mellitus (T2DM), and cardiovascular disease. Guidelines recommend lifestyle modification, metformin, hormonal contraceptives (HCs), and bariatric surgery as the main treatment options in obese patients with PCOS. Studies are being conducted to test the efficacy of existing treatment options as well as to discover new therapies...
November 13, 2017: Curēus
https://read.qxmd.com/read/29183107/insulin-sensitising-drugs-metformin-rosiglitazone-pioglitazone-d-chiro-inositol-for-women-with-polycystic-ovary-syndrome-oligo-amenorrhoea-and-subfertility
#11
REVIEW
Lara C Morley, Thomas Tang, Ephia Yasmin, Robert J Norman, Adam H Balen
BACKGROUND: Polycystic ovary syndrome (PCOS) is characterised by infrequent or absent ovulation, and high levels of androgens and insulin (hyperinsulinaemia). Hyperinsulinaemia occurs secondary to insulin resistance and is associated with increased risk of cardiovascular disease and diabetes mellitus. Insulin-sensitising agents such as metformin may be effective in treating PCOS-related anovulation. OBJECTIVES: To evaluate the effectiveness and safety of insulin-sensitising drugs in improving reproductive and metabolic outcomes for women with PCOS undergoing ovulation induction...
November 29, 2017: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/29153661/pkb-akt-and-mapk-erk-phosphorylation-is-highly-induced-by-inositols-novel-potential-insights-in-endothelial-dysfunction-in-preeclampsia
#12
Rossella D'Oria, Luigi Laviola, Francesco Giorgino, Vittorio Unfer, Stefano Bettocchi, Marco Scioscia
PKB/Akt and MAP/ERK are intracellular kinases regulating cell survival, proliferation and metabolism and as such hold a strategical role in preeclampsia. In fact intracellular pathways related to immunological alterations, endothelial dysfunction and insulin resistance in preeclampsia converge on these molecules. Inositol second messengers are involved in metabolic and cell signaling pathways and are highly expressed during preeclampsia. To evaluate the pathophysiological significance of this response, the effect of myo-inositol and d-chiro inositol on the activation of PKB/Akt and MAPK/ERK was assessed in human endothelial cells in vitro...
October 2017: Pregnancy Hypertension
https://read.qxmd.com/read/29042448/myo-inositol-effects-in-women-with-pcos-a-meta-analysis-of-randomized-controlled-trials
#13
Vittorio Unfer, Fabio Facchinetti, Beatrice Orrù, Barbara Giordani, John Nestler
Myo-inositol (MI) supplementation in women with polycystic ovary syndrome (PCOS) has been evaluated over the last years. Many hormonal and reproductive impairments associated with this disorder seem relieved by the supplement. The objective of the meta-analysis was to assess the effects of MI alone or combined with d-chiro-inositol (DCI) on the endocrine and metabolic abnormalities of women with PCOS. Literature was retrieved from selected databases, MEDLINE, EMBASE, PubMed and Research Gate (up to November 2016)...
November 2017: Endocrine Connections
https://read.qxmd.com/read/28982033/d-chiro-inositol-phosphoglycans-in-preeclampsia-where-are-we-where-are-we-going
#14
REVIEW
Marco Scioscia
Preeclampsia results from a complex interaction between immunological alterations, endothelial dysfunction, and insulin resistance. Inositol second messengers are known to be involved in metabolic signaling and are highly expressed during preeclampsia. In the past two decades, several studies were published on different aspects where these molecules are involved. It appears that maternal increase of IPG-P content in all tissues and fluids reflects an increased production of inositol mediators on the fetal side in preeclampsia...
November 2017: Journal of Reproductive Immunology
https://read.qxmd.com/read/28642705/polycystic-ovary-syndrome-insights-into-the-therapeutic-approach-with-inositols
#15
REVIEW
Maria A Sortino, Salvatore Salomone, Michele O Carruba, Filippo Drago
Polycystic ovary syndrome (PCOS) is characterized by hormonal abnormalities that cause menstrual irregularity and reduce ovulation rate and fertility, associated to insulin resistance. Myo-inositol ( cis -1,2,3,5- trans -4,6-cyclohexanehexol, MI) and D-chiro-inositol ( cis -1,2,4- trans -3,5,6-cyclohexanehexol, DCI) represent promising treatments for PCOS, having shown some therapeutic benefits without substantial side effects. Because the use of inositols for treating PCOS is widespread, a deep understanding of this treatment option is needed, both in terms of potential mechanisms and efficacy...
2017: Frontiers in Pharmacology
https://read.qxmd.com/read/28039583/a-pilot-study-of-d-chiro-inositol-plus-folic-acid-in-overweight-patients-with-type-1-diabetes
#16
RANDOMIZED CONTROLLED TRIAL
Anna Rita Maurizi, Marika Menduni, Rossella Del Toro, Shadi Kyanvash, Daria Maggi, Chiara Guglielmi, Angelo Lauria Pantano, Giuseppe Defeudis, Elvira Fioriti, Silvia Manfrini, Paolo Pozzilli
AIMS: To improve insulin sensitivity, insulin-sensitizing drugs such as metformin are commonly used in overweight and obese T1D patients. Similarly to metformin, D-chiro-inositol (DCI), as putative mediator of intracellular insulin action, can act as insulin sensitizer. The aim of this pilot study was to evaluate the hypothesis that DCI plus folic acid may improve glucose control reducing insulin resistance in overweight or obese T1D patients. METHODS: A 24-week randomized control trial was carried out in 26 overweight or obese T1D patients, undergoing intensive insulin therapy...
April 2017: Acta Diabetologica
https://read.qxmd.com/read/27898267/combining-treatment-with-myo-inositol-and-d-chiro-inositol-40-1-is-effective-in-restoring-ovary-function-and-metabolic-balance-in-pcos-patients
#17
REVIEW
Giovanni Monastra, Vittorio Unfer, Abdel Halim Harrath, Mariano Bizzarri
Polycystic ovary syndrome (PCOS), a relevant cause of infertility, is a heterogeneous, endocrine disorder affecting up to 10-15% of women in reproductive age. Besides hyperandrogenism, insulin resistance (IR) plays a key role in such syndrome. Insulin-sensitizing drugs, such as Metformin, are effective in treating hyper-insulinemic PCOS patients. Recently, inositols - myo-inositol (MI) and D-chiro-inositol (DCI) - have shown to be an efficient and safe alternative in PCOS management, as both inositol isoforms are able to counteract downstream consequences of insulin resistance...
January 2017: Gynecological Endocrinology
https://read.qxmd.com/read/27882052/myoinositol-and-d-chiro-inositol-in-improving-insulin-resistance-in-obese-male-children-preliminary-data
#18
Mario Mancini, Alice Andreassi, Michela Salvioni, Fiore Pelliccione, Gianna Mantellassi, Giuseppe Banderali
Myoinositol and D-chiro inositol, which are inositol isomers, have been shown to possess insulin-mimetic properties and to improve insulin resistance, especially in women with polycystic ovary syndrome. However, it has not been determined if this relationship exists also in children. Based on these previous findings, we hypothesized that inositol could be effective in improving insulin sensitivity in children with insulin resistance. To evaluate this hypothesis, we administered both inositol formulations before carrying out an oral glucose tolerance test (OGTT) in a group of obese insulin-resistant male children with high basal insulin levels and compared the values obtained with an OGTT previously conducted without inositol, in the same group, with unchanged BMI...
2016: International Journal of Endocrinology
https://read.qxmd.com/read/27843451/effects-of-inositol-s-in-women-with-pcos-a-systematic-review-of-randomized-controlled-trials
#19
REVIEW
Vittorio Unfer, John E Nestler, Zdravko A Kamenov, Nikos Prapas, Fabio Facchinetti
Polycystic ovary syndrome (PCOS) is a common endocrine disorder, with complex etiology and pathophysiology, which remains poorly understood. It affects about 5-10% of women of reproductive age who typically suffer from obesity, hyperandrogenism, ovarian dysfunction, and menstrual irregularity. Indeed, PCOS is the most common cause of anovulatory infertility in industrialized nations, and it is associated with insulin resistance, type 2 diabetes mellitus, and increased cardiovascular risk. Although insulin resistance is not included as a criterion for diagnosis, it is a critical pathological condition of PCOS...
2016: International Journal of Endocrinology
https://read.qxmd.com/read/27807448/the-effectiveness-of-myo-inositol-and-d-chiro-inositol-treatment-in-type-2-diabetes
#20
Basilio Pintaudi, Giacoma Di Vieste, Matteo Bonomo
Inositol has been used as a supplement in treating several pathologies such as PCOS, metabolic syndrome, and gestational diabetes. Both myo-inositol and its isomer d-chiro-inositol showed insulin mimetic effects in conditions of insulin resistance. Type 2 diabetes (T2DM) is a condition typically caused by insulin resistance. There is a lack of evidence of inositol use in T2DM. We evaluated the effectiveness and safety of myo-inositol and d-chiro-inositol treatment in T2DM. This was a pilot study involving a consecutive sample of patients with T2DM with suboptimal glycemic control (HbA1c 7...
2016: International Journal of Endocrinology
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